Chlamydia trachomatis exploits sphingolipid metabolic pathways during infection of phagocytes by Adriana Moldovan, Fabienne Wagner, Fabian Schumacher, Dominik Wigger, David Komla Kessie, Marcel Rühling, Kathrin Stelzner, Regina Tschertok, Louise Kersting, Julian Fink, Jürgen Seibel, Burkhard Kleuser, Thomas Rudel

“…Identifying relevant targets offers new strategies to develop alternative treatment methods.…”
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A Multicomponent Strategy to Improve HIV Pre-Exposure Prophylaxis in a Southern US Jail: Protocol for a Type 3 Hybrid Implementation-Effectiveness Trial by Ank E Nijhawan, Jana Kholy, Julia L Marcus, Timothy P Hogan, Robin T Higashi, Jacqueline Naeem, Laura Hansen, Brynn Torres, Barry-Lewis Harris, Song Zhang, Douglas Krakower

“…An HIV risk prediction model based on EHR data to identify individuals most likely to benefit from PrEP has been developed and internally validated and is ready to be deployed. …”
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Increase in colonic propionate as a method of preventing weight gain in adults aged 20–40 years: iPREVENT, a multicentre, double-blind, randomised, parallel-group trial by Gary Frost, Joana C Vasconcelos, Jennifer E Pugh, Aisha Anjum, Katerina Petropoulou, George Thom, Louise McCombie, Martina Tashkova, Sumayya Alshehhi, Daphne Babalis, Leah Holroyd, Christina Prechtl, Tom Preston, Mike J Lean, Waljit Dhillo, A Toby Prevost, and Douglas Morrison

“…Total body water through dilution analysis of deuterated water. Other data observations: Changes in physical activity from baseline to 2, 6 and 12 months. …”
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Discovery of two new Cortinarius species in Southern China by Yuxiao Dang, Mengjia Zhu, Nemat O. Keyhani, Ziyi Wu, Chenghao Qiu, Jinming Xiong, Huili Pu, Longbing Lin, Chengjie Xiong, Zhiying Zhao, Minghai Zheng, Taichang Mu, Yongsheng Lin, Yanbin Huang, Xin Yuan, Chunjin Qiu, Xiaohong Ji, Junzhi Qiu, Yuxi Chen

“…The developed keys provide a reference for the further analysis of the evolution and geographic distribution of these fungi.…”
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RNA transcripts serve as a template for double-strand break repair in human cells by Manisha Jalan, Alessandra Brambati, Hina Shah, Niamh McDermott, Juber Patel, Yingjie Zhu, Ahmet Doymaz, Julius Wu, Kyrie S. Anderson, Andrea Gazzo, Fresia Pareja, Takafumi N. Yamaguchi, Theodore Vougiouklakis, Sana Ahmed-Seghir, Philippa Steinberg, Anna Neiman-Golden, Benura Azeroglu, Joan Gomez-Aguilar, Edaise M. da Silva, Suleman Hussain, Daniel Higginson, Paul C. Boutros, Nadeem Riaz, Jorge S. Reis-Filho, Simon N. Powell, Agnel Sfeir

“…Of the candidate polymerases, we identify DNA polymerase zeta (Polζ) as a potential reverse transcriptase that facilitates RT-DSBR. Furthermore, analysis of cancer genome sequencing data reveals whole intron deletions - a distinct genomic signature of RT-DSBR that occurs when spliced mRNA guides repair. …”
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Real-world experience of diagnosis, disability, and daily management in parents of children with different genetic developmental and epileptic encephalopathies: a qualitative study by Cristina Garcia-Bravo, Domingo Palacios-Ceña, Ángel Aledo-Serrano, Javier Güeita-Rodríguez, Juan Francisco Velarde-García, Juan Nicolas Cuenca-Zaldivar, Romain Marconnot, María Cristina Alonso-Blanco, Jorge Pérez-Corrales, Carmen Jimenez-Antona

“…An inductive thematic analysis was performed.Results Five themes emerged: (a) the diagnostic process, which describes the path from the time parents recognize the first symptoms until diagnostic confirmation is obtained; (b) the relationship with health professionals during the search for a diagnosis, which describes how the entire process is conditioned by the relationships established; (c) the world of disability, revealing how the disease and disability impact the life of the parents; (d) living day to day, the parents continuously change their plans in anticipation of the onset of a seizure; (e) the disease progression, a cause of great concern in the parents.Conclusions Our results show the need to develop recovery programs that integrate health and social interventions to support parents of children with DEE in the process of diagnosis and disease management.…”
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Spatial-temporal distribution patterns change of grassland formation in Inner Mongolia since the 1980s by Anan Zhang, Jiakui Tang, Na Zhang, Xuefeng Xu, Wuhua Wang, Xiaofan Li, Maojin Li, Kaihui Li, Mengquan Wu, Shuohao Cai

“…This study provides insights into grassland degradation from the perspective of formations, offering valuable data for grassland management and ecological conservation in Inner Mongolian.…”
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Pursuing circular economics through the integrated crop-livestock systems: An integrative review on practices, strategies and challenges post Green Revolution in Indonesia by Dewa Ketut Sadra Swastika, Atien Priyanti, Abdul Muis Hasibuan, Dewi Sahara, Nyoman Ngurah Arya, Afrizal Malik, Nyak Ilham, Apri Laila Sayekti, Joko Triastono, Robet Asnawi, Dedi Sugandi, Nur Qomariah Hayati, Atman Atman

“…This study employs an integrative literature review, encompassing secondary data analysis, research findings, and publications, to underscore the potential of ICLS in Indonesia and beyond. …”
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Inferring chromosome segregation error stage and crossover in trisomic disorders with application to Down syndrome by Zhenhua Li, Wenjian Yang, Gang Wu, Ti-Cheng Chang, Zhongshan Cheng, Meenakshi Devidas, Mary Shago, Andrew J. Carroll, Nyla A. Heerema, Julie M. Gastier-Foster, Brent L. Wood, Lauren Sanclemente, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Eleanor Feingold, Tracie C. Rosser, Emily G. Allen, Stephanie L. Sherman, Karen R. Rabin, Philip J. Lupo, Jun J. Yang

“…Mapping NDJ errors to meiotic/mitotic stages typically requires proband-parent comparison, limiting its applicability. Herein, we develop Mis-segregation Error Identification through Hidden Markov Models (MeiHMM), a method for inferring NDJ error stage and crossover events based on only genomic data of trisomic probands. …”
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A novel mortality risk score for emphysematous pyelonephritis: A multicenter study of the Global Research in the Emphysematous Pyelonephritis group by Hegel Trujillo-Santamaría, José Iván Robles-Torres, Jeremy Yuen-Chun Teoh, Yiloren Tanidir, José Gadú Campos-Salcedo, Edgar Iván Bravo-Castro, Marcelo Langer Wroclawski, W. S. Yeoh, Santosh Kumar, Juan Eduardo Sanchez-Nuñez, José Enrique Espinoza-Aznar, Deepak Ragoori, Saeed Bin Hamri, Ong Teng Aik, Cecil Paul Tarot-Chocooj, Anil Shrestha, Mohamed Amine Lakmichi, Mateus Cosentino-Bellote, Luis Gabriel Vázquez-Lavista, Boukary Kabre, Ho Yee Tiong, José Gustavo Arrambide-Herrera, Lauro Salvador Gómez-Guerra, Umut Kutukoglu, Joao Arthur Brunhara Alves-Barbosa, Jorge Jaspersen, Christian Acevedo, Francisco Virgen-Gutiérrez, Sumit Agrawal, Hugo Octaviano Duarte-Santos, Chai Chu Ann, Daniele Castellani, Vineet Gahuar

“…Patients diagnosed with EPN between 2013 and 2020 were retrospectively included. Data from 15 centers (70%) were used to develop the scoring system, and data from 7 centers (30%) were used to validate it. …”
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The Puzzling Long GRB 191019A: Evidence for Kilonova Light by G. Stratta, A. M. Nicuesa Guelbenzu, S. Klose, A. Rossi, P. Singh, E. Palazzi, C. Guidorzi, A. Camisasca, S. Bernuzzi, A. Rau, M. Bulla, F. Ragosta, E. Maiorano, D. Paris

“…We thus reanalyzed unpublished GROND multicolor ( $g^{\prime} r^{\prime} i^{\prime} z^{\prime} JH{K}_{s}$ ) data obtained between 0.4 and 15 days posttrigger. …”
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International perspective on research priorities and outcome measures of importance in the care of children with acute exacerbations of asthma: a qualitative interview study by Franz E Babl, Ricardo M Fernandes, Charmaine S Gray, Colin V E Powell, Simon Craig, Javier Benito, Yao Xu, Mark D Lyttle, Damian Roland, Suzanne Schuh, Stuart Dalziel, Jenny Couper, Shu-Ling Chong, Mike Johnson, Indumathy Santhanam, Baljit Cheema, Adriana Yock-Corrales

“…The interviews were recorded, and later transcribed. All data analyses were conducted in Nvivo by using thematic analysis.Results The length of stay in hospital and patient-focused parameters, such as timing to return to school and normal activity, were the most frequently highlighted outcome measures, with clinicians identifying the need to achieve a consensus on key core outcome measure sets. …”
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A prognostic nomogram that includes MPV in esophageal squamous cell carcinoma by Qiao He, Zhenglian Luo, Haiming Zou, Bo Ye, Lichun Wu, Yao Deng, Mu Yang, Dongsheng Wang, Qifeng Wang, Kaijiong Zhang

“…Finally, decision curve analysis (DCA) was used to confirm clinical validity. …”
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A web-based surveillance model of eosinophilic meningitis: future prediction and distribution patterns by Noppadol Aekphachaisawat, Kittisak Sawanyawisuth, Chalongchai Phitsanuwong, Sittichai Khamsai, Paiboon Chattakul, Verajit Chomtmongkol, Somsak Tiamkao, Panita Limpawattana, Vichai Senthong, Jarin Chindaprasirt, Chetta Ngamjarus

“…Background: web-based surveillance is a useful tool for predicting future cases of various emerging infectious diseases. There are limited data available on web-based surveillance and patterns of distribution of eosinophilic meningitis (EOM), which is an emerging infectious disease in various countries around the world.  …”
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Epidemiological and clinical features of lymphoproliferative diseases in the head and neck region by F. Sh. Kamolova, A. M. Mudunov, P. A. Zeynalova, L. Yu. Grivtsova, G. F. Allakhverdieva, R. I. Azizyan, A. A. Akhundov, I. A. Zaderenko, M. V. Bolotin, D. K. Stelmakh, V. I. Sokorutov, K. D. Il’kaev, V. T. Tsiklauri, I. M. Gelfand, M. B. Pak, O. L. Timofeeva, Yu. E. Ryabukhina, F. M. Abbasbeyli, Ts. Chzhao

“…Neoplastic process often develops in head and neck area, including the integumentary tissues, orbit, nasal cavity, paranasal sinuses, oral cavity, pharynx, salivary glands, thyroid gland, as well as neck lymph nodes. …”
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Deep Learning for Weed Detection and Segmentation in Agricultural Crops Using Images Captured by an Unmanned Aerial Vehicle by Josef Augusto Oberdan Souza Silva, Vilson Soares de Siqueira, Marcio Mesquita, Luís Sérgio Rodrigues Vale, Thiago do Nascimento Borges Marques, Jhon Lennon Bezerra da Silva, Marcos Vinícius da Silva, Lorena Nunes Lacerda, José Francisco de Oliveira-Júnior, João Luís Mendes Pedroso de Lima, Henrique Fonseca Elias de Oliveira

“…Artificial Intelligence (AI) has changed how processes are developed, and decisions are made in the agricultural area replacing manual and repetitive processes with automated and more efficient ones. …”
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Design and feasibility of acid gas reinjection with corrosion mitigation: A case study from Tahe Oilfield, China by Shijian Lu, Fei Yang, Ling Liu, Guojun Kang, Xulin Yu, Qingfang Li, Deyin Zhao, Lirong Yao, Qianlin Zhu

“…The implementation of this project provides important engineering experience and technical data for large-scale acid gas reinjection projects in China and has an important demonstration role.…”
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The Learn Together programme (part A): co-designing an approach to support patient and family involvement and engagement in patient safety incident investigations by Jane K. O’Hara, Jane K. O’Hara, Lauren Ramsey, Rebecca Partridge, Chris Redford, Siobhan McHugh, Gemma Louch, Penny Phillips, Laura Sheard, Ruth Simms-Ellis, Ruth Simms-Ellis, Justin Waring, Joe Langley

“…BackgroundWhilst patients and families can and do support patient safety in several ways, empirical evidence for the specific impact of involvement in patient safety incident investigations and their outcomes, has been limited, with little information about how to undertake involvement meaningfully.AimWe aimed to (i) develop a set of common principles to guide involvement of patients and families in patient safety incident investigations; (ii) develop a working programme theory for how these might be enacted; (iii) co-design guidance to support the meaningful involvement of patients and families in patient safety incident investigations.MethodsWe synthesised three existing data sets (a literature review, a documentary analysis of incident investigation policies and 42 interviews with patients, families, lawyers, incident investigators, and healthcare staff) relating to patient and family involvement in incident investigations. …”
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Regenerative potential of PRP-based scaffolds in chronic wound healing: Mechanisms, advances, and therapeutic insights by Farag M.A. Altalbawy, Bilal Abdul Majeed Mukhlif, Ahemad Hussen, Jaafaru Sani Mohammed, Renuka Jyothi S, Arshdeep Singh, Shakti Bedanta Mishra, Ashish Singh Chauhan, Mohammad Ebrahim Astaneh, Narges Fereydouni

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Triple cardiovascular disease detection with an artificial intelligence-enabled stethoscope (TRICORDER): design and rationale for a decentralised, real-world cluster-randomised con... by Azeem Majeed, Rasha Al-Lamee, Ceire Costelloe, Daniel B Kramer, Carla M Plymen, Carys Barton, Emanuela Falaschetti, Nicholas S Peters, Josephine Mansell, Patrik Bachtiger, Mihir A Kelshiker, Camille F Petri, Abdullah Alrumayh, Saloni Nakhare, Melanie T Almonte, Alexei Peters

“…Patient and outcome data will be captured from pooled primary and secondary care records, supplemented by qualitative and quantitative clinician surveys. …”
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