Supporting mental health of medical students: Needs and demands concerning an e-mental health application within medical education by Grüneberg, Catharina, Bäuerle, Alexander, Karanukaran, Sophia, Darici, Dogus, Jansen, Christoph, Dörrie, Nora, Benson, Sven, Teufel, Martin, Robitzsch, Anita

“…N=229 students were incorporated in the final data evaluation. The survey comprised standardized and established self-generated inquiries. …”
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Concept and Design of Cutting Tools for Osseodensification in Implant Dentistry by Alexander Isaev, Maria Isaeva, Oleg Yanushevich, Natella Krikheli, Olga Kramar, Aleksandr Tsitsiashvili, Sergey Grigoriev, Catherine Sotova, Pavel Peretyagin

“…Thereon, the structural model of osseodensification bur is first represented as a hypergraph. Based on the analysis of previous research, functional relationships between design parameters of osseodensification burs, osseodensification procedure conditions, and procedure performance data were established and, for the first time, described in the comprehensive form of a hypergraph. …”
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Pulmonary Embolism in COVID-19: Trends from a Single-Center Study Across Ten Pandemic Waves in Romania by Alexandra Herlo, Adelina Raluca Marinescu, Talida Georgiana Cut, Ruxandra Laza, Adina Maria Marza, Claudia Raluca Balasa Virzob, Cristian Iulian Oancea, Lucian-Flavius Herlo, Ioana-Melinda Luput-Andrica, Voichita Elena Lazureanu

“…Data on demographics, clinical features, inflammatory markers, comorbidities, and treatment were collected from medical records. …”
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Critical Review of the Methodological Shortcoming of Ambulatory Blood Pressure Monitoring and Cognitive Function Studies by Shahab Haghayegh, Ramon C. Hermida, Michael H. Smolensky, Mili Jimenez Gallardo, Claudia Duran-Aniotz, Andrea Slachevsky, Maria Isabel Behrens, David Aguillon, Hernando Santamaria-Garcia, Adolfo M. García, Diana Matallana, Agustín Ibáñez, Kun Hu

“…By examining the 28 recent studies included in a recent systematic review on the association between ABPM patterns with cognitive function and risk of dementia, our review revealed several significant limitations in study design, sample characteristics, ABPM protocol, cognitive assessment, and data analysis. The major concerns include a lack of diversity in study populations with underrepresentation of Blacks and Latinos, a predominant focus on Alzheimer’s disease or all-cause dementia without distinguishing other dementia subtypes, different and not standardized measures of cognition or dementia, prevalent use of 24 h monitoring without considering the adaption effect, inconsistent definitions of dipping status, and ignorance of individual differences in timings of daily activities such as bed and awakening times. …”
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Occurrence and risk assessment of per- and polyfluoroalkyl substances (PFASs) in water, sediment, soil, and moss: An environmental media study in Caohai, China by Luolin Bao, Chan Xu, Chan Zhang, Fenglian Zeng, Bangnian Xu, Chaoxuan Liao, Hongbo Yang

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Nutritionally physiological cell culture medium and 3D culture influence breast tumour proteomics and anti-cancer drug effectiveness by Xiaodan Zhang, Tianhong Cheng, Ellie Cho, Wenjia Lu, Delphine Denoyer, Paul McMillan, Kalyan Shobhana, Swati Varshney, Nicholas A. Williamson, Alastair Stewart

“…Many drugs have been discontinued during phase II/III breast cancer clinical trials due to lack of clinical efficacy, indicating shortcomings in predictive value of preclinical data. Nutrient availability in the tumour cell microenvironment and the dimensionality of in vitro tumour cells likely impact on drug responsiveness. …”
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Unlocking urban transportation carbon reduction potential: a dynamic evaluation of public transit adoption in response to carbon-centric policies by Ran Peng, Ran Peng, Ran Peng, Keyuan Ding, Keyuan Ding, Xueliang Liu, Xueliang Liu, Keyu Yao, Keyu Yao, Xu Zhou, Xu Zhou, Wei Zhang, Wei Zhang

“…The model was applied to cross-river travel in Wuhan, China, using 10,327 Origin-Destination (OD) survey data points collected between 2023 and 2024. Multiple optimization scenarios were simulated to assess responses to transit improvements.ResultsThe analysis revealed three distinct zones of carbon reduction potential: stable, unlocking, and re-stable. …”
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Personalized predictions of neoadjuvant chemotherapy response in breast cancer using machine learning and full-field digital mammography radiomics by Ye Ruan, Xingyuan Liu, Yantong Jin, Mingming Zhao, Xingda Zhang, Xiaoying Cheng, Yang Wang, Siwei Cao, Menglu Yan, Jianing Cai, Mengru Li, Bo Gao

“…ObjectiveThis study aimed to develop a comprehensive nomogram model by integrating clinical pathological and full-field digital mammography (FFDM) radiomic features to predict the efficacy of neoadjuvant chemotherapy (NAC) in breast cancer patients, thereby providing personalized treatment recommendations.MethodsA retrospective analysis was conducted on the clinical and imaging data of 227 breast cancer patients from 2016 to 2024 at the Second Affiliated Hospital of Harbin Medical University. …”
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Effectiveness of the guided self-change intervention for reducing alcohol use in adolescents with and without history of cannabis use by José Luis Carballo, José Luis Carballo, Miguel Ángel Martínez-León, Ainhoa Coloma-Carmona, Ainhoa Coloma-Carmona, Virtudes Pérez-Jover, Virtudes Pérez-Jover, Álvaro García del Castillo-López, Clara Sancho-Domingo, Antonia Pelegrín-Muñoz, Carlos van-der Hofstadt-Román, Carlos van-der Hofstadt-Román, Carlos van-der Hofstadt-Román

“…The consumer profile, including whether they have consumed one or more substances, may be a key variable in analyzing the effectiveness of interventions.MethodsThis study consists in a secondary analysis of data from a randomized controlled trial (PREVENALC) to examine the effectiveness of a brief intervention based on the Guided Self-Change Program (GSC) and its interaction with substance use profile. …”
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Evaluation of a telehealth service to support breast cancer prevention medication uptake: a protocol of a mixed methods study by Tim Spelman, Stephanie Best, Christobel Saunders, Paul A James, Sarah Latham, Louise A Keogh, Sarah Mason, Katrina Louise West, Wanda Cui, Sabine Deij, Sandy Minck, Catherine Poliness, Greg Wheeler, Kelly Anne Phillips

“…The Preventing Cancer with Medications (PCMed) Telehealth Service was therefore developed to provide this specialist support and to bridge the evidence–implementation gap. …”
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Myths and misconceptions of intimate partner violence among sexual and gender minorities: a qualitative exploration by Stefan Kurbatfinski, Stefan Kurbatfinski, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Nicole Letourneau, Susanne Marshall, Dawn McBride, Jason Novick, Keira Griggs, Arielle Perrotta, Arielle Perrotta, Morgan Daye, Carrie McManus, Kendra Nixon

“…This study sought to: (1) develop a compendium of myths and misconceptions that SGM individuals exposed to IPV and relevant service providers shared they encountered; (2) describe the impacts of these myths and misconceptions on SGM individuals experiencing IPV; and (3) make recommendations to address these myths and misconceptions.MethodsThis qualitative study used data from a larger project focused on SGM IPV where SGM individuals who experienced IPV (n = 18) and service providers who supported SGM individuals experiencing IPV (n = 8) were interviewed using semi-structured formats. …”
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MCTP2 is a novel biomarker promoting tumor progression and nodal metastasis in oral squamous cell carcinoma by Yudai Shimojukkoku, Ayami Tomishima, Takayuki Ishida, Yuka Kajiya, Yasunobu Oku, Koshiro Kawaguchi, Takahiro Tsuchiyama, Kaori Shima, Hideto Saijo, Tomonori Sasahira

“…In this study, we performed a comprehensive analysis using big data from over 500 head and neck cancer cases registered in The Cancer Genome Atlas (TCGA), expression profiling of 63 OSCC samples, and in vitro functional assessment using cell lines to elucidate MCTP2 involvement in OSCC. …”
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Expanding automated multiconformer ligand modeling to macrocycles and fragments by Jessica Flowers, Nathaniel Echols, Galen J Correy, Priyadarshini Jaishankar, Takaya Togo, Adam R Renslo, Henry van den Bedem, James S Fraser, Stephanie A Wankowicz

“…However, ligands can retain some degree of conformational flexibility even when bound to a receptor. In the Protein Data Bank, a small number of ligands have been modeled with distinct alternative conformations that are supported by macromolecular X-ray crystallography density maps. …”
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Outcomes and surgical technique of laparoscopic hysterectomy using an articulating laparoscopic instrument: a prospective observational study by Jun-Hyeong Seo, Won-Ji Kim, Chel Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Byeong-Gie Kim, Kazuyoshi Kato, Yi-Liang Lee, Yu-Li Chen, Yoo-Young Lee

“…The surgeries were performed by two surgeons, both experienced in laparoscopic hysterectomy. Data on patient demographics, clinical outcomes, as well as pathological and postoperative results, were collected prospectively for analysis.ResultsOf the 100 patients enrolled in this prospective observational study utilizing the articulating laparoscopic instrument for gynecologic surgery, 45 underwent hysterectomy with this instrument. …”
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High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born by Ann Hellström, Lotta Gränse, Marie Saric, Birgitta Sunnqvist, Agneta Wallin, Kristina Tornqvist, Eva Larsson, Eva Morsing, Gerd E Holmström, Pia Lundgren, Anna-Lena Hård, Lena Jacobson, Abbas Al-Hawasi, Lois LE Smith

“…We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort.Methods and analysis Infants with completed ROP screening, born at <24 GA weeks, 2007–2018 in Sweden were included. …”
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Novel parent survey measures sensory behaviors incorporating sensory modality and stimulus intensity by Connor Yee, Ellie Rather, Sakib Hoque, Joon Lee, Stephanie Marton, Jill Roth, Frederick L. Oswald, Kenneth J. Nobleza, Ankona Banerjee, Holly Harris, Ariel M. Lyons-Warren

“…Statistical tests were used to evaluate sensory processing patterns from SRQP results. Results: Data from 271 participants (69 % female, 83 % white, 84 % Hispanic) were included. …”
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Dual Fine-Grained network with frequency Transformer for change detection on remote sensing images by Zhen Li, Zhenxin Zhang, Mengmeng Li, Liqiang Zhang, Xueli Peng, Rixing He, Leidong Shi

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Subcutaneous electroencephalography monitoring for people with epilepsy and intellectual disability: co-production workshops by Edward Meinert, Madison Milne-Ives, Jennifer Sawyer, Liz Boardman, Sarah Mitchell, Brendan Mclean, Mark Richardson, Rohit Shankar

“…Remote electroencephalography (EEG) monitoring could capture objective data, but particular challenges and implementation strategies for this population need to be understood. …”
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Clinical, radiological, and radiomics feature-based explainable machine learning models for prediction of neurological deterioration and 90-day outcomes in mild intracerebral hemor... by Weixiong Zeng, Jiaying Chen, Linling Shen, Genghong Xia, Jiahui Xie, Shuqiong Zheng, Zilong He, Limei Deng, Yaya Guo, Jingjing Yang, Yijun Lv, Genggeng Qin, Weiguo Chen, Jia Yin, Qiheng Wu

“…We trained five ML models using filtered data, including clinical, traditional imaging, and radiomics indicators based on non-contrast computed tomography (NCCT). …”
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Implementation of a diagnostic decision aid for people with memory complaints and their general practitioners: a protocol of a before and after pilot trial by Marcel Olde Rikkert, Marieke Perry, Marjolein de Vugt, Rudolf W H M Ponds, Ron Handels, Job Metsemakers, Trudy van der Weijden, Frans R Verhey, Iris Linden, Claire Wolfs, Carmen Dirksen

“…Therefore, in the context of the Shared Decision-Making regarding Dementia Diagnosis project, a patient decision aid (PtDA) for ‘timely’ dementia diagnosis in general practice will be developed. This protocol will describe the planned before and after evaluation of its implementation.Methods and analysis In a mixed-methods pilot study, we will investigate decision-making processes and experiences regarding a diagnostic trajectory before and after the introduction of a PtDA for people with memory complaints, their significant others and their GPs. …”
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