Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture by Hui Chen, Hanqi Zhang, Chao Niu, Bianlin Wang, Biao Gao, Zhijun Liu, Guangmin Yao, Haji Akber Aisa

“…Their structures were elucidated by comprehensive spectroscopic data analysis, including LR-HSQMBC and 1H–15N HMBC, quantum 13C NMR DP4+ and ECD calculations, and single-crystal X-ray diffraction analysis. …”
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Optimization of anti-MRSA compound production by Streptomyces sp. AR05 using an integrated RSM-ANN-GA approach by Fateh Merouane, Amani Kifadji, Racha Mansouri, Meroua Safa Mechouche, Chemes El-Houda Messaad, Anfal Bellebcir

“…Sensitivity analysis of the ANN model identified peptone as the most influential factor, followed by pH and CaCO3. …”
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Transcriptional fingerprinting of regulatory T cells: ensuring quality in cell therapy applications by Zhang Cheng, Li-Jie Wang, Yuchi Honaker, Steven A. Cincotta, Claire E. Page, Sydney Vollhardt, Victor Yuan, S. Alice Long, Yuanyuan Xiao, Joshua N. Beilke, Joseph R. Arron, Jeffrey A. Bluestone

“…We further applied fingerprinting to bulk RNA sequencing (RNA-seq) data from endogenous and expanded Treg cells in a Phase 2 clinical trial for type 1 diabetes (T1D), demonstrating its ability to capture Treg identity and expansion in an independent study.DiscussionThis Treg fingerprinting method provides a powerful tool to molecularly characterize Treg products, potentially enabling correlative analysis with the safety and efficacy outcomes of Treg-based cell therapies.…”
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Evaluation and selection of sesame mutants (Sesamum indicum L.) for optimal nutritional profiles in seeds under field drought conditions☆ by Kouighat Mohamed, Moussaoui Fatima Ezzahra, Adiba Atman, Hafid Azzedine, Bouchyoua Abdelghani, El Fechtali Mohamed, Nabloussi Abdelghani

“…Targeted traits include seed moisture, ash content, oil content, total polyphenols, anthocyanins, flavonoids, total amino acids, and antioxidant activity. Data analysis revealed that specific mutants responded favorably to water deficit, with increased levels of polyphenols, anthocyanins, antioxidant activity, oil content, and moisture. …”
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The impact of the nocebo effect on discontinuation of statin therapy due to myopathy in patients with cardiovascular disease – a review by Jakub Stanek, Patrycja Sornek, Wiktoria Izdebska, Agata Borkowska, Radosław Ciesielski, Anna Kaźmierczak, Anna Kiełb, Anna Mich, Klaudia Perkowska, Igor Pawlak

“…Results: The collected data indicate that the nocebo effect plays a significant role in the reported muscle symptoms during statin use. …”
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Stress Evaluation of a Maritime A-Frame Using Limited Strain Measurements from a Real Deep-Sea Mining Campaign by Jiahui Ji, Chunke Ma, Ying Li, Mingqiang Xu, Wei Liu, Hong Zhen, Jiancheng Liu, Shuqing Wang, Lei Li, Lianjin Jiang

“…Additionally, a finite element model (FEM) of the A-Frame was developed to estimate the stress of the hot spots by integrating the measured strain data. …”
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COMBINATION OF INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS by O. V. Shadrivova, S. N. Khostelidi, Yu. V. Borzova, E. A. Desyatik, A. G. Volkova, M. O. Popova, O. S. Uspenskaya, O. S. Ruzhinskaya, T. V. Shneyder, T. S. Bogomolova, S. M. Ignatyeva, L. S. Zubarovskaya, B. V. Afanasyev, N. N. Klimko

“…Objective. Data analysis of the register of patients with invasive aspergillosis (IA), which was founded in Saint Petersburg (1998–2017), and clinical case description of successful treatment of IA and mucormycosis with lungs involvement in a patient with Hodgkin’s lymphoma.Materials and methods. …”
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It’s safe to move! A protocol for a randomised controlled trial investigating the effect of a video designed to increase people’s confidence becoming more active despite back pain... by Ian A Harris, Adrian C Traeger, James H McAuley, Siobhan M Schabrun, Benedict Martin Wand, Aidan Cashin, Christopher Michael Williams, Edel O'Hagan, Sean O'Neill

“…People over 18 years of age and fluent in English will be recruited via social media advertising. We developed a social media-based public health campaign to support recommendations for managing low back pain. …”
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A Delphi-based needs assessment to identify and prioritise procedural skills through consensus for simulation-based learning in neurosurgery by Adam F. Roche, Dara O. Kavanagh, Darach Crimmins, Vincent Healy, Gulam Zilani, Lars Konge, Leizl Joy Nayahangan, Danyal Z. Khan, Daniel Murray, Javier Francisco Cuello, Caitriona Cahir, Niamh Murphy, Claire M. Condron

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Stated preferences of adolescents and young adults for sexual and reproductive health services in Africa: a systematic review by Melaku Birhanu Alemu, Richard Norman, Jaya Dantas, Daniel Gashaneh Belay, Tsegaye G. Haile, Gavin Pereira, Gizachew A. Tessema

“…However, these insights reflect data from a limited range of African countries.…”
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Sleep Disorders and Reproductive Health: Mechanisms, Consequences, and Potential Interventions by Magdalena Rosa-Bończak Rosa, Patrycja Marta, Filip Maciej Huzarski, Klaudia Anna Pawełek, Gabriela Monika Ferfecka, Agata Ossolińska, Natalia Morawiecka, Lucyna Stolarska, Oliver Carlton, Weronika Kłosowicz

“…Materials and Methods This article is based on an analysis of scientific literature concerning the impact of sleep disturbances on reproductive health, utilizing data from databases such as PubMed, Frontiers, and Google Scholar. …”
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Genomic insights about the effect of sodium-glucose cotransporter 2 inhibitors: a systematic review by Pavitraa Saravana Kumar, Yogapriya Chidambaram, G. Shree Devi, Vettriselvi Venkatesan, Ramesh Sankaran, Nagendra Boopathy Senguttuvan, Thanikachalam Sadagopan, Dorairaj Prabhakaran

“…Studies were included if they explored the genomic or molecular impacts of SGLT2 inhibitors in HF. Data extraction and analysis focused on gene expression changes, circulating biomarkers, and potential genomic mechanisms.ResultsOf the 258 identified studies, three met the inclusion criteria. …”
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Small and medium-sized enterprises dynamic capabilities and competitive advantage: The mediating effect of digitalization by Murry Harmawan Saputra, Mohamad Nur Utomo, Kasmad Ariansyah, Yanuar Farida Wismayanti, Rahmat Husein Andri Ansyah, Koeswinarno, Suradi

“…Research Design & Methods: We utilized a survey method for the collection of primary data. The respondents were SME founders in the provinces of Central Java and North Kalimantan, Indonesia, with a minimum of one year of business engagement. …”
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Predictors of Success in Horizontal Strabismus Surgery: Insights from a Prospective Study by Aurellia Valmai Tjujitno, Reni Prastyani, Joni Susanto, Rozalina Loebis, Luki Indriaswati, Lely Retno Wulandari

“…The International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) for Macintosh version 27.0 was used for data analysis. Results: This study reviewed the medical records of 17 research samples (n=17). …”
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Advance care planning for vulnerable older adults within an Accountable Care Organization: study protocol for the IMPACT randomised controlled trial by Jennifer Gabbard, NM Pajewski, Kathryn E Callahan, Ajay Dharod, Kristie Foley, Keren Ferris, Adam Moses, Carl Grey, Jeff Williamson

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Comparative evaluation of hybrid and individual models for predicting soybean yellow mosaic virus incidence by Yunish Khan, Vinod Kumar, Amel Gacem, Anurag Satpathi, Parul Setiya, Kumari Surbhi, Ajeet Singh Nain, Dinesh Kumar Vishwakarma, Ahmad J. Obaidullah, Krishna Kumar Yadav, Ozgur Kisi

“…Specifically, six multivariate models Stepwise Multiple Linear Regression (SMLR), Artificial Neural Networks (ANN), Least Absolute Shrinkage and Selection Operator (LASSO), Ridge Regression (RR), Elastic Net (ELNET), and SMLR_ANN both direct and with Principal Component Analysis (PCA)-were developed using 20 years of data (2001 to 2020) to predict the severity of soybean disease in Pantnagar, Uttarakhand. …”
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Extracellular vesicles from human breast cancer-resistant cells promote acquired drug resistance and pro-inflammatory macrophage response by Patrick Santos, Caroline P. Rezende, Renan Piraine, Bianca Oliveira, Francielle B. Ferreira, Vinicius S. Carvalho, Rodrigo T. Calado, Matteo Pellegrini, Fausto Almeida

“…In addition, we show evidence that resistant EVs may downregulate immune system factors to evade detection and block cell death by apoptosis in sensitive breast cancer cells. Our data also reveals that human macrophages in contact with resistant EVs trigger a pro-inflammatory cytokine secretion profile, an effect that may be helpful for future immunotherapy studies.DiscussionThese findings are the first transcriptome-wide analysis of cells exposed to resistant EVs, supporting that resistant EVs are associated with the acquired drug resistance process during chemotherapy by modulating different aspects of sensitive cancer cells that coffer the chemoresistance.…”
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The Role of NK Cells in Cancer Immunotherapy: Mechanisms, Evasion Strategies, and Therapeutic Advances by Paula Morcillo-Martín-Romo, Javier Valverde-Pozo, María Ortiz-Bueno, Maurizio Arnone, Laura Espinar-Barranco, Celia Espinar-Barranco, María Eugenia García-Rubiño

“…<b>Methods:</b> A comprehensive literature review was conducted, prioritizing peer-reviewed studies from the last decade on NK cell biology, tumor immune evasion, and immunotherapeutic applications. The analysis includes data from preclinical models and clinical trials evaluating NK cell expansion strategies, cytokine-based stimulation, and CAR-NK cell therapy developments. …”
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Large decrease in syringe distribution following the introduction of fentanyl in King County, Washington by Sara N. Glick, Joe Tinsley, Laura Pritchard Wirkman, Apoorva Mallya, Peter Cleary, Matthew R. Golden, Thomas Fitzpatrick

“…Material and Methods: We collected routine program data from three SSPs in King County, Washington. …”
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Intraspecific Differentiation of <I>Francisella tularensis</I> Strains Using Molecular-Genetic Methods. Complex Approach by N. A. Osina, D. A. Sitmbetov, O. A. Morozov, E. G. Bulgakova, A. V. Osin, S. S. Chekmareva, E. V. Sazanova, A. M. Senichkina, O. Yu. Lyashova, T. A. Polunina, Ya. M. Krasnov, Z. L. Devdariani, S. A. Shcherbakova

“…The intraspecific identification of tularemia agent strains was carried out using the “F. tularensis-4c” system; analysis of the variability of the RD1 differentiation region, the sdhA gene, by applying the disk diffusion method using disks with erythromycin. …”
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