Digital solution for salutogenic brain health: a pilot sequential multiple assignment randomised trial (SMART) protocol for clinical implementation by Nick Sevdalis, Nicholas Graves, Jing Xu, Bibhas Chakraborty, Wentao Zhou, Yuanxi Jia, Yanhong Dong, Nicole Yun Ching Chen, Claire See Ying Chang, Vanessa Phua, Xiang Cong Tham, Wei Fong Liau

“…However, there is a lack of a targeted solution for this population. This study aims to develop a digital solution for salutogenic brain health targeting this population, assess its clinical effectiveness and evaluate the implementation in primary care settings by local champions, that is, nurses.Methods and analysis A type-I hybrid effectiveness-implementation design with a sequential multiple-assignment randomised trial will be adopted. 160 adults aged 40–64 years old with chronic conditions hypertension, hyperlipidaemia and type-II diabetes will be recruited from three National University Polyclinics in Singapore. …”
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Giant extrachromosomal element “Inocle” potentially expands the adaptive capacity of the human oral microbiome by Yuya Kiguchi, Nagisa Hamamoto, Yukie Kashima, Lucky R. Runtuwene, Aya Ishizaka, Yuta Kuze, Tomohiro Enokida, Nobukazu Tanaka, Makoto Tahara, Shun-Ichiro Kageyama, Takao Fujisawa, Riu Yamashita, Akinori Kanai, Josef S. B. Tuda, Taketoshi Mizutani, Yutaka Suzuki

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Enhancing solar energy conversion efficiency: Thermophysical property predicting of MXene/Graphene hybrid nanofluids via bayesian-optimized artificial neural networks by Dheyaa J. jasim, Husam Rajab, As'ad Alizadeh, Kamal Sharma, Mohsen Ahmed, Murizah Kassim, S. AbdulAmeer, Adil A. Alwan, Soheil Salahshour, Hamid Maleki

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An interpretable machine learning-assisted diagnostic model for Kawasaki disease in children by Mengyu Duan, Zhimin Geng, Lichao Gao, Yonggen Zhao, Zheming Li, Lindong Chen, Pekka Kuosmanen, Guoqiang Qi, Fangqi Gong, Gang Yu

“…We collected demographic and laboratory data from 3650 patients (2299 with KD, 1351 with similar symptoms but different diseases) and employed 10 ML algorithms to construct the diagnostic model. …”
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Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets by Giulia Pecora, Camilla Mancini, Rossella Mazzilli, Virginia Zamponi, Stefano Telese, Stefano Scalera, Marcello Maugeri-Saccà, Ludovica Ciuffreda, Francesca De Nicola, Maurizio Fanciulli, Anna La Salvia, Massimiliano Mancini, Andrea Vecchione, Alessandra Siciliani, Mohsen Ibrahim, Diana Bellavia, Andrea Marcello Isidori, Antongiulio Faggiano, Rita Mancini, Claudia De Vitis

“…Clinical and pathological data were systematically documented at diagnosis and during follow-up. …”
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QUALITATIVE AND QUANTITATIVE ANALISIS OF ORGANIC ACIDS IN MIXTURE OF MULTIVITAMIN RAW MATERIAL by V. Yu. Zhilkina, A. I. Marakhova, Ya. M. Stanishevskiy

“…Thin layer chromatography method was confirmed to contain apple, citric and ascorbic acids. Quantitative analysis of the amount of organic acids and ascorbic acid was conducted by potentiometric titration method developed by the authors. …”
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COVID-19 mRNA vaccine immune response to the addition of osteopathic manipulative treatment with lymphatic pumps: a randomized controlled trial by Eric S. Martinez, Sebastien Fuchs, Hendrik Szurmant, Xunxuan Chen, Andrew Comer, Edward Lee, Raymond Hruby, Rebecca Giusti, Brian Loveless, Julieanne P. Sees, Paula Crone, Laura J. Peek, Gary Pestano, Bin Xie, Joseph Zammuto, Sir Robert Hostoffer, Jr., Jesus Sanchez, Jr.

“…COVID19-naïve subjects were selected for analysis based on data homogeneity. In this cohort, the OMT group showed significantly increased anti-SARS-CoV-2 spike protein antibody titers at 3 weeks vs controls (p = 0.038). …”
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An Integrated Approach Utilizing Single-Cell and Bulk RNA-Sequencing for the Identification of a Mitophagy-Associated Genes Signature: Implications for Prognostication and Therapeu... by Yuke Zhang, Li Ding, Zhijin Zhang, Liliang Shen, Yadong Guo, Wentao Zhang, Yang Yu, Zhuoran Gu, Ji Liu, Aimaitiaji Kadier, Jiang Geng, Shiyu Mao, Xudong Yao

“…<b>Conclusions</b>: This study analyzed mitophagy-related genes in PARD, predicting prognosis and aiding in subtype identification and immunotherapy response analysis. This approach offers new strategies for treating prostate cancer with specific molecular subtypes and helps develop potential biomarkers for personalized medicine strategies.…”
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Spinal Instability Neoplastic Score as a Predictor of Vertebral Fracture in Patients Undergoing Radiation Therapy for Spinal Metastases: A Single-Institution Study by Patrick Doyle, MS, Sarah Caplan, MS, Neil Klinger, MD, Kee-Young Shin, MS, Michael Groff, MD, Maeve Dillon-Martin, BS, Thomas Johnson, MS, Heejoo Kang, BS, Teresia Perkins, BS, Claire Novack, BS, Alexander Spektor, MD, Mai Anh Huynh, MD, PhD, Ellen Kim, MPH, Shyam Tanguturi, MD, Cara Richards, MSPAS, PA-C, Wenxin (Vincent) Xu, MD, David Kozono, MD, PhD, Ron Alkalay, PhD, David Hackney, MD, Tracy Balboni, MD, MPH

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Subacute exposure to apigenin induces changes in protein synthesis in the liver of Swiss mice by Łukasz S. Jarosz, Katarzyna Socała, Katarzyna Michalak, Kamila Bulak, Artur Ciszewski, Agnieszka Marek, Zbigniew Grądzki, Piotr Wlaź, Edyta Kowalczuk-Vasilev, Anna Rysiak

“…Apigenin is a natural flavonoid with various pharmacological properties. Available data indicate that it affects the metabolic processes and protein profile of cells, including hepatocytes. …”
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Effective Identification of Variety and Origin of Chenpi Using Hyperspectral Imaging Assisted with Chemometric Models by Hangxiu Liu, Youyou Wang, Yiheng Wang, Jingyi Wang, Hanqing Hu, Xinyi Zhong, Qingjun Yuan, Jian Yang

“…Convolutional neural networks (CNNs) were developed and compared with conventional machine learning models, including partial least-squares discriminant analysis (PLS-DA), support vector machines (SVMs), and a multilayer perceptron (MLP). …”
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<i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations by Gilberto Vargas-Alarcón, Óscar Pérez-Méndez, Rosalinda Posadas-Sánchez, Héctor González-Pacheco, Teresa Juárez-Cedillo, Galileo Escobedo, Victoria López-Olmos, José Manuel Fragoso

“…In recent years, data from genome-wide association studies (GWAS) have shown that the genes coding for transcriptional repressor GATA binding 1 (<i>TRPS1</i>) and tribbles pseudokinase 1 (<i>TRIB1</i>) play an important role in plasma lipid profiles and act as risk factors for coronary heart disease (CHD). …”
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SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway by Wei Zhang, Siyuan Qin, Xiaokang Li, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo, Yi Lu, Jian Zhang

“…The Cancer Genome Atlas (TCGA) database analysis reveals that aberrant expression of SMC4 exhibits a robust prognostic association with metastatic progression. …”
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Early detection of emerging SARS-CoV-2 Variants from wastewater through genome sequencing and machine learning by Xiaowei Zhuang, Van Vo, Michael A. Moshi, Ketan Dhede, Nabih Ghani, Shahraiz Akbar, Ching-Lan Chang, Angelia K. Young, Erin Buttery, William Bendik, Hong Zhang, Salman Afzal, Duane Moser, Dietmar Cordes, Cassius Lockett, Daniel Gerrity, Horng-Yuan Kan, Edwin C. Oh

“…To build our model, we sequence 3659 wastewater samples collected over two years from urban and rural locations in Southern Nevada. We then develop a multivariate independent component analysis (ICA)-based pipeline to transform mutation frequencies into independent sources. …”
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LncRNA RNF144A-AS1 gene polymorphisms and their influence on lung cancer patients in the Chinese Han population by Hongjiao Wu, Yuning Xie, Ang Li, Xiyao Liu, Liwen Guo, Fengjun Wu, Zhenbang Yang, Zhi Zhang, Xuemei Zhang

“…Collectively, these findings pave the way for developing targeted therapies and diagnostic tools based on RNF144A-AS1 and its variants.…”
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Deteriorative reactions of Pacific whiteleg shrimp (Litopenaeus vannamei) during chilled storage: enzymatic degradation, microbial activity, and quality changes by Jun Liang, Shutian Sun, Xinpei Qi, Zhenyu Han, Huijue Kong, Difei Luo, Xiaoyu Luo

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Application of Convolutional Neural Networks in an Automatic Judgment System for Tooth Impaction Based on Dental Panoramic Radiography by Ya-Yun Huang, Yi-Cheng Mao, Tsung-Yi Chen, Chiung-An Chen, Shih-Lun Chen, Yu-Jui Huang, Chun-Han Chen, Jun-Kai Chen, Wei-Chen Tu, Patricia Angela R. Abu

“…With the advancement of artificial intelligence (AI), the integration of clinical data and AI-driven analysis presents significant potential for supporting medical applications. …”
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Emergence of scaling in dockless bike-sharing systems for bike choice behavior by Ruiqi Li, Te Bai, Ankang Luo, Yu Yang, Linyuan Lü, Jingfang Fan, Yongping Zhang, Gang Lu, H Eugene Stanley

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Method to analyse and quantify the propensity of hair dyes to desorb from human hair fibre by Kristina Hetherington, Alenka Tidder, Bethany J. Tack, Meryem Benohoud, Dan Nowlan, Anwar Zahar, Xiaoguang Li, Darcy Prater, Jeanna C. Zguris, Tanu Tokle, Christopher M. Rayner, Richard S. Blackburn

“…Through screening of common back-extraction methods used in analysis of dyed textile artefacts, a new back-extraction methodology has been developed and adapted for application on dyed hair using a 2:1 (v/v) water:pyridine solvent system. …”
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Physical education curriculum systematizing based on action research: a collaborative network between teacher-researchers from public schools in Quixadá — Ceará, Brazil by Rener Victor Oliveira de Souza, Maurício Teodoro de Souza, Luciano Nascimento Corsino, Willian Lazaretti da Conceição, Carla Ulasowicz, Luciana Venâncio, Luciana Venâncio, Luiz Sanches Neto, Luiz Sanches Neto

“…Our qualitative itinerary has action research as a method of intervention, including class observations, group meetings and field diary. Data has been analyzed through thematic analysis, characterizing a collaborative network between participants. …”
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