Factors associated with chronic calcineurin inhibitor nephrotoxicity in children with minimal-change disease by Bei Jin, Ziji Lu, Cheng Cheng, Yuxin Pei, Lizhi Chen, Zhihui Yue, Aihua Lin, Shicong Yang, Ying Mo, Xiaoyun Jiang

“…Risk factors for chronic CNI nephrotoxicity included persistent nephrotic-range proteinuria for more than 30 days during CNI treatment, increased urinary NAG level, and CNI resistance. Multivariate analysis revealed that increased urinary NAG level and CNI resistance were the independent risk factors for chronic CNI nephrotoxicity in children with MCD.Conclusion MCD children who developed CNI resistance were susceptible to chronic CNI nephrotoxicity. …”
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United States and China Anthropogenic Methane Emissions: A Review of Uncertainties and Collaborative Opportunities by Jenna Behrendt, Steven J. Smith, Sha Yu, Shiqi Chen, Haiwen Zhang, Mengye Zhu, Jared Williams, Xinzhao Cheng, Anom Ashok Dule, Wenli Li, Ryna Cui, Nate Hultman

“…Key areas for collaboration include improving data collection, monitoring, and availability to develop more detailed emission factors that take into account local conditions and temporal sources of emissions. …”
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Smilebright^RO—Study Protocol for a Randomized Clinical Trial to Evaluate Oral Health Interventions in Children by Ruxandra Sava-Rosianu, Guglielmo Campus, Vlad Tiberiu Alexa, Octavia Balean, Ruxandra Sfeatcu, Alice Murariu, Alexandrina Muntean, Daniela Esian, Constantin Daguci, Simona Olaru-Posiar, Vanessa Bolchis, Antonia Ilin, Ramona Dumitrescu, Berivan Laura Rebeca Buzatu, Mariana Postolache, Nicoleta Toderas, Roxana Oancea, Daniela Jumanca, Atena Galuscan

“…Clinical outcomes will be evaluated using the caries incidence rate; this will be calculated for each tooth as the unit of analysis and evaluated using a multi-step approach. …”
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Patient preferences and shared decision making for the traditional Chinese medicine treatment of lung cancer: A discrete choice experiment study by Yue Teng, Yan Wei, Yingyao Chen, Juntao Yan, Shimeng Liu, Fuming Li, Shiyi Bao, Yanfeng Ren, Liu Liu, Yi Yang

“…The empirical data analyses of patients were performed using mixed logit models. …”
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Gastrointestinal Infection Before Immune Checkpoint Inhibition Hinders Treatment Efficacy and Increases the Risk of Colitis by Malek Shatila, Kian Abdul‐Baki, Andres Urias Rivera, Kei Takigawa, Irene Jeong‐Ah Lee, Andrew Sullivan, Tanvi Gupta, Linfeng Lu, Raakhi Menon, Ayesha Khan, Hamza Salim, Elliot Baerman, Carolina Colli Cruz, Cristina Natha, Varun Vemulapalli, Garrett Coleman, Krishnavathana Varatharajalu, Christopher Fan, Pablo Okhuysen, Anthony J. Olszanski, Yan Zhou, Hao Chi Zhang, Mehnaz Shafi, Yinghong Wang

“…Patients' demographic, IMC, and GI infection–related clinical data were collected. Results Thirty‐four of the 1132 patients (3.0%) included in the analysis had GI infections before ICI therapy. …”
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A Black Box Approach to EV Energy Consumption: Integrating Key Parameters for Drive Range Optimization by Muhammad Arsalan Jalees Abro, Abdul Sattar Larik, Ali Alqazzaz, Irfan Ahmed Halepoto, Mana Saleh Al Reshan, Asadullah Shaikh, Samar M. Alqhtani, Jotee Kumari Lohana

“…An EV model is created in AVL eSuite and, through simulation, as it plays a critical role in artificial intelligence (AI) workflows by providing a controlled environment, the model was validated using real-world data from Nissan Leaf SV Plus. The model’s results positively demonstrate the role of multi-parameter integration in energy consumption analysis and lay the groundwork for future advancements in optimizing EV drive range, contributing to the broader goal of sustainable and efficient electric mobility.…”
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Reducing Parkinson's disease incidence in patients with insomnia through acupuncture: A cohort study by Cheng-Hao Huang, Shun-Ku Lin, Mei-Chen Lin, Shih-Ya Hung

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Neutrophil and neutrophil-lymphocyte ratios as predictors of clinical characteristics in patients with Lymphangioleiomyomatosis by Lulu Yang, Lulu Yang, Lulu Yang, Liting Huang, Liting Huang, Liting Huang, Yingquan Luo, Siying Ren, Siying Ren, Siying Ren

“…Differences between the two groups were compared, and significantly different indicators were further analyzed.ResultsA total of 78 patients with LAM were included in the study, 42 of them developed pneumothorax from registration to the end of follow-up, and 36 did not develop pneumothorax. …”
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Risk factors and predictive models for post-operative moderate-to-severe mitral regurgitation following transcatheter aortic valve replacement: a machine learning approach by Zhenzhen Li, Jianing Fan, Jiajun Fan, Jiaxin Miao, Dawei Lin, Jingyan Zhao, Xiaochun Zhang, Wenzhi Pan, Daxin Zhou, Junbo Ge

“…Methods We retrospectively analyzed data from patients who underwent TAVR at our center between August 2014 and August 2023. …”
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Linking PFOS exposure to chronic kidney disease: A multimodal study integrating epidemiology, network toxicology, and experimental validation by Xulei Zuo, Shiyi Tan, Yuxi Zhang, Cong Zhang, Li Ma, Xiaoyu Hou, Wei Wang, Rongli Sun, Lihong Yin, Yuepu Pu, Juan Zhang

“…NHANES data (n = 9119) were analyzed to examine the association between serum PFOS levels and CKD prevalence. …”
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Reducing medicine-induced deterioration and adverse reactions (ReMInDAR) trial: study protocol for a randomised controlled trial in residential aged-care facilities assessing frail... by Nicole L Pratt, Lisa M Kalisch Ellett, Elizabeth Ellen Roughead, Renly Lim, Megan Corlis, Gaynor Parfitt, Debra Rowett, Luke Bereznicki, Ai Choo Kang, Tracy Merlin, Stacey Torode, Joseph Whitehouse, Andre Q Andrade, Rebecca Bilton, Justin Cousins, Lan Kelly, Camille Schubert, Mackenzie Williams

“…Pharmacist monitoring of changes in signs and symptoms of these adverse effects, which we describe as medicine-induced deterioration, may reduce the risk of developing frailty. The aim of this trial is to determine the effectiveness of a 12-month pharmacist service compared with usual care in reducing medicine-induced deterioration, frailty and adverse reactions in older people living in aged-care facilities in Australia.Methods and analysis The reducing medicine-induced deterioration and adverse reactions trial is a multicentre, open-label randomised controlled trial. …”
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Addressing the challenges and constraints of social protection policies for Peruvian women domestic workers: the ANITA project study protocol by Maria Lazo-Porras, Maria Kathia Cardenas, Nathaly Aya Pastrana, Christopher Meaney, Andrew David Pinto, Archna Gupta, María Sofía Cuba-Fuentes, Silvana Perez-Leon, Janeth Tenorio-Mucha, Sebastián García, Jill Portocarrero, Karina Romero Rivero, David Vera Tudela, Ayu Pinky Hapsari, Viviana Cruzado

“…We use a sequential mixed-methods design organised in four phases: (1) secondary data analysis (n=4216): using two Peruvian national surveys to characterise working conditions, health status and access to healthcare; (2) face-to-face survey (n=448): with DWs in three cities, using respondent-driven sampling to further characterise working and health conditions and to identify factors that influence knowledge of and access to social protection policies; (3) qualitative interviews (n=30–46): with DWs, leaders of DW organisations, employers and policymakers to gather different perspectives on the facilitators and barriers to access to social protection policies; and (4) deliberative dialogues (n=14–26): with DW, leaders of DW organisations, employers, policymakers and academics to identify key barriers to the implementation of social protection policies and to develop recommendations for overcoming these barriers.Ethics and dissemination Phase 1 and Phase 2 received ethical clearance from Universidad Peruana Cayetano Heredia in Peru and Unity Health Toronto in Canada. …”
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Emergency department presentations and admission for common mental disorders following agency-notified child maltreatment at 40-year follow-up: results from the Childhood Adversity... by Steve Kisely, Claudia Bull, Mike Trott, Urska Arnautovska, Dan Siskind, Nicola Warren, Jake Moses Najman

“…Method Queensland-wide administrative health data were linked to a prospective birth cohort, including agency-reported and substantiated notifications of child maltreatment. …”
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The Human-AI Frontier: An in-depth exploration of physicians' apprehension and Outlook Towards Artificial Intelligence in gastroenterology healthcare by Rania Hisham Elfaham, Saud Abdulaziz Alnaaim, Muazzam Sheriff Maqbul, Shireen Hisham Elfaham, Ghada Abdulrahman Alharbi, Waleed Ali Alshehri, Faisal Ali Almahyawi, Nawaf Meshal Aljadani, Razan Imad Bahkali, Arwa Alaa Eldeen Elbahaie, Ola Emad Shakrah, Mariam Aqeel Alzubaidi, Waleed Mohammed Alshehri, Essa Sultan Alsultan, Aghnar Thabet Adam Alzahrani

“…Data collection spanned three months using convenience sampling. …”
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Long-read sequencing identifies copy-specific markers of SMN gene conversion in spinal muscular atrophy by M. M. Zwartkruis, M. G. Elferink, D. Gommers, I. Signoria, L. Blasco-Pérez, M. Costa-Roger, J. van der Sel, I. J. Renkens, J. W. Green, J. V. Kortooms, C. Vermeulen, R. Straver, H. W. M. van Deutekom, J. H. Veldink, F. Asselman, E. F. Tizzano, R. I. Wadman, W. L. van der Pol, G. W. van Haaften, E. J. N. Groen

“…Methods To address this, we developed HapSMA, a method to perform polyploid phasing of the SMN locus to enable copy-specific analysis of SMN and its surrounding genes. …”
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‘You grow with the allergy’: a grounded theory study of families’ experiences with food allergy risk or diagnosis in early childhood by Christian Apfelbacher, Susanne Brandstetter, Julia Weigt, Madlen Hörold, Katharina Gerhardinger, Mara König, Magdalena Rohr

“…Given the limited previous research on parents’ experiences of food allergy prevention in early childhood, this study aimed to develop a grounded theory to understand the experiences and interactions of families whose children are at risk of, or have been diagnosed with, food allergy.Design Using a constructivist grounded theory approach, we used initial, focused and theoretical coding, as well as constant comparative analysis and memoing to interpret our data.Setting Thematic interviews were conducted in Germany between March and September 2022.Participant We included 28 carers (25 mothers and 3 fathers) of children aged 0–3 years diagnosed with food allergy or at risk of food allergy. …”
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The cervicovaginal microbiota patterns in Moroccan women infected with Human Papillomavirus and/or Chlamydia trachomatis by Leila Ferrera, Hanane Rogua, Nezha El Mansouri, Farid Kassidi, Corinna Bang, Ahmed Belmouden, Said Chouham, Mohamed Nejmeddine

“…Microbiota profiling was conducted using 16S rRNA gene amplicon sequencing. Data analysis in R/RStudio included alpha and beta diversity metrics, taxonomic composition, and community state types (CSTs) identified by hierarchical clustering. …”
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Assessing the impact of biosecurity compliance on farmworker and livestock health within a one health modeling framework by Arash Arjmand, Majid Bani-Yaghoub, Kiel Corkran, Pranav S. Pandit, Sharif S. Aly

“…Using literature-derived data on Salmonella transmission dynamics, the model is validated, and key parameters values are estimated. …”
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Emergency medical services education research priorities during COVID‐19: A modified Delphi study by Rebecca E. Cash, William J. Leggio, Jonathan R. Powell, Kim D. McKenna, Paul Rosenberger, Elliot Carhart, Adrienne Kramer, Juan A. March, Ashish R. Panchal, for the Pandemic Educational Effects Task Force

“…Data were collected from August 2020 to February 2021 over 5 rounds (3 electronic surveys and 2 live virtual meetings). …”
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Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity by Stephane Isnard, Stephane Isnard, Tsoarello Mabanga, Tsoarello Mabanga, Léna Royston, Léna Royston, Léna Royston, Carolina A. Berini, Carolina A. Berini, Simeng Bu, Simeng Bu, Orthy Aiyana, Orthy Aiyana, Hansen Feng, Hansen Feng, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Bertrand Lebouché, Cecilia T. Costiniuk, Cecilia T. Costiniuk, Joseph Cox, Joseph Cox, Guido Kroemer, Guido Kroemer, Guido Kroemer, Madeleine Durand, Jean-Pierre Routy, Jean-Pierre Routy, Jean-Pierre Routy, the Biobanque Québécoise de la COVID-19 (BQC-19)

“…The objective of our work was to assess whether circulating ACBP levels are associated with COVID-19 severity, using proteomics data from the plasma of 903 COVID-19 patients.MethodsSomalogic proteomic analysis was used to detect 5000 proteins in plasma samples collected between March 2020 and August 2021 from hospitalized participants in the province of Quebec, Canada. …”
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