Comparative effectiveness of missed dose protocols of opioid agonist treatment in British Columbia, Canada: protocol for a population-based target trial emulation by Paul Gustafson, Robert W Platt, Bohdan Nosyk, Jeong Eun Min, Md Belal Hossain, Mohammad Ehsanul Karim, Shaun Seaman, Paxton Bach, Megan Kurz, Maria Eugenia Socías, Momenul Haque Mondol, Michelle Zanette

“…All data are deidentified, securely stored and accessed in accordance with provincial privacy regulations. …”
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Evaluating the value of machine learning models for predicting hematoma expansion in acute spontaneous intracerebral hemorrhage based on CT imaging features of hematomas and surrou... by Tianyu Yang, Tianyu Yang, Zhen Zhao, Yan Gu, Shengkai Yang, Yonggang Zhang, Lei Li, Ting Wang, Zhongchang Miao

“…Additionally, it aims to extract imaging features for developing machine learning models to predict hematoma expansion in acute spontaneous intracerebral hemorrhage (sICH).MethodsData from 183 patients with acute spontaneous hemorrhage, treated at Lianyungang Hospital Affiliated to Xuzhou Medical University between January 2020 and December 2023, were retrospectively analyzed. …”
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Construction of a C-reactive protein-albumin-lymphocyte index-based prediction model for all-cause mortality in patients on maintenance hemodialysis by Junmin Huang, Junfeng Hao, Huasheng Luo, Lu Chen, Hongying Luo, Huafeng Liu, Yongzhi Xu, Peng Wang

“…Multivariate logistic regression analysis was used to screen factors associated with death, and nomograms were developed to estimate the risk of death in MHD patients. …”
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Cell cycle checkpoint factor p15Ink4b is a novel regulator of osteoclast differentiation by Shunya Tsuji, Sora Mizukami, Akihiko Sakamoto, Kenji Takemoto, Tetsuya Seto, Kazuya Uehara, Kiminori Yukata, Takashi Sakai, Keiko Iwaisako, Norihiko Takeda, Ryoji Yanai, Masataka Asagiri

“…In this manuscript, we identified p15Ink4b, a member of the Ink4 family, as a novel regulator of osteoclastogenesis by comprehensive single-cell RNA sequence data reanalyzing. Furthermore, histological analysis and in vitro osteoclast differentiation assay revealed that p15Ink4b functionally regulates osteoclastogenesis. …”
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Detecting Important Features and Predicting Yield from Defects Detected by SEM in Semiconductor Production by Umberto Amato, Anestis Antoniadis, Italia De Feis, Anastasiia Doinychko, Irène Gijbels, Antonino La Magna, Daniele Pagano, Francesco Piccinini, Easter Selvan Suviseshamuthu, Carlo Severgnini, Andres Torres, Patrizia Vasquez

“…For the second objective, a regression/classification model based on Gradient Boosting has been developed. As a by-product, this latter model confirmed the results obtained by Odds Ratio analysis. …”
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A multimodal fusion system predicting survival benefits of immune checkpoint inhibitors in unresectable hepatocellular carcinoma by Jun Xu, Tengfei Wang, Junjun Li, Yong Wang, Zhangxiang Zhu, Xiao Fu, Junjie Wang, Zhenglin Zhang, Wei Cai, Ruipeng Song, Changlong Hou, Li-Zhuang Yang, Hongzhi Wang, Stephen T. C. Wong, Hai Li

“…Abstract Early identification of unresectable hepatocellular carcinoma (HCC) patients who may benefit from immune checkpoint inhibitors (ICIs) is crucial for optimizing outcomes. Here, we developed a multimodal fusion (MMF) system integrating CT-derived deep learning features and clinical data to predict overall survival (OS) and progression-free survival (PFS). …”
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Regulatory Genetic Networks by microRNAs: Exploring Genomic Signatures in Cervical Cancer by Carlos Pérez-Plasencia, Yaneth Citlalli Orbe-Orihuela, Armando Méndez-Herrera, Jessica Deas, Claudia Gómez-Cerón, Hilda Jiménez-Wences, Julio Ortiz-Ortiz, Gloria Fernández-Tilapa, Aldo Francisco Clemente-Soto, Jesús Ricardo Parra-Unda, Jesús Salvador Velarde-Felix, Mauricio Rodríguez-Dorantes, Oscar Peralta-Zaragoza

“…Researchers have widely utilized high-throughput technologies to analyze gene expression in cervical cancer, aiming to identify distinct molecular signatures of microRNAs and genes through genomic analysis. However, discrepancies among studies have been noted, possibly due to variations in sample collection, technological platforms, and data processing methods such as normalization and filtering. …”
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Optical correction of hyperopia in school-aged children: a scoping review protocol by Su-Hsun Liu, Tawna L Roberts, Gayathri Srinivasan, Kristen L Kerber, Vivian M Manh, Kristine Huang, Alexandra Williamson, Soumen Sadhu, Morgan C Ollinger, Zahra Tajbakhsh, Jennifer H Fisher, Nathan L Cheung, Jasmine Junge, Kevin C H Chan, Jameel Rizwana Hussaindeen, Patrick Simard, Kelsey R Trast, Christina E Morettin, Samantha Krueger, Augustine N Nti, Debora M Lee Chen

“…This scoping review aims to identify and map the current literature on optical correction and catalogue outcomes reported, particularly in the domains of vision, vision-related functional outcomes and quality of life (QoL) in school-aged children with hyperopia.Methods and analysis This protocol was developed in accordance with the Joanna Briggs Institute’s Manual for Evidence Synthesis. …”
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Application of Portable Near-Infrared Spectroscopy for Quantitative Prediction of Protein Content in <i>Torreya grandis</i> Kernels Under Different States by Yuqi Gu, Haosheng Zhong, Jianhua Wu, Kaixuan Li, Yu Huang, Huimin Fang, Muhammad Hassan, Lijian Yao, Chao Zhao

“…Outlier detection was performed using principal component analysis combined with Mahalanobis distance (PCA-MD) and concentration residual analysis. …”
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Translational framework for implementation evaluation and research: implementation strategies derived from normalization process theory by Carl R. May, Alyson Hillis, Bianca Albers, Laura Desveaux, Anthony Gilbert, Melissa Girling, Roman Kislov, Anne MacFarlane, Frances S. Mair, Sebastian Potthoff, Tim Rapley, Tracy L. Finch

“…While widely used taxonomies such as ERIC and EPOC have emerged from consensus exercises, few implementation strategies are explicitly derived from theory and tested against empirical data. This study develops a taxonomy of implementation strategies grounded in Normalization Process Theory (NPT), an implementation theory that explains how new practices become embedded and sustained. …”
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Upper Limb Neural Tension Test and Spinal Biomechanics: Insights from a Longitudinal Pilot Study by Massimo Rossi, Marianna Signorini, Ali Baram, Mario De Robertis, Gabriele Capo, Marco Riva, Maurizio Fornari, Federico Pessina, Carlo Brembilla

“…These findings suggest a functional link between brachial plexus neurodynamics and upper thoracic spine mobility, offering potential insights into the pathophysiology of cervicobrachial conditions and highlighting the potential role of manual therapy in addressing both neurodynamic and biomechanical impairments. The developed motion capture analysis method offers a novel approach to quantify fine spinal motion patterns.…”
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The Spatiotemporal Evolution and Driving Forces of the Urban Heat Island in Shijiazhuang by Xia Zhang, Yue Liu, Ruohan Chen, Menglin Si, Ce Zhang, Yiran Tian, Guofei Shang

“…Specifically, a multi-scale analysis model was developed to search for the optimum urban spatial scale, enabling a comprehensive assessment of the spatiotemporal evolution and drivers of the UHI in Shijiazhuang. …”
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Prognostic Factors and Initial Treatment Strategies for Patients with Head Trauma and Vital Signs of Shock by Masaki Yasuda, Makoto Ohtake, Taisuke Akimoto, Masayuki Okano, Yuya Imanishi, Takafumi Kawasaki, Jun Suenaga, Katsumi Sakata, Ichiro Takeuchi, Tetsuya Yamamoto

“…A retrospective analysis was conducted with the modified Rankin Scale score after 3 months as the primary outcome. …”
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Lessons from the Frontline: A Phenomenological Study into Faculty Members’ Experiences with Challenges of Remote Online Exams in Medical Sciences Universities by Mostafa Hadavinejad, Mahdieh Azin, Asieh Fatemidokht, Jalal Hassanshahi, Afsaneh Amiri Khorasani, Foad Iranmanesh

“…All interviews were analyzed using the seven-step thematic content analysis approach developed by Diekelmann and colleagues, utilizing MAXQDA software.Results: The thematic analysis of the interviews yielded four primary dichotomous concepts, eight principal themes (components), and 24 sub-themes. …”
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Tracking Pelagia noctiluca scyphomedusae by combining modeling and stable isotope approaches by Isabella D’Ambra, Isabella D’Ambra, Simona Saviano, Maria Assunta Ambrosio, Vincenzo Botte, Daniele Iudicone, Maria Grazia Mazzocchi, Louise Merquiol, Louise Merquiol, Louise Merquiol, Daniela Cianelli

“…Therefore, predictive models integrating SI analysis and ocean circulation data could improve early warning systems for jellyfish outbreaks, aiding coastal management.…”
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Heat and Mass Transfer in Shrimp Hot-Air Drying: Experimental Evaluation and Numerical Simulation by Jhony T. Teleken, Suélen M. Amorim, Sarah S. S. Rodrigues, Thailla W. P. de Souza, João P. Ferreira, Bruno A. M. Carciofi

“…In this study, a mathematical model was developed to describe the changes in moisture and temperature distribution in shrimp during hot-air drying. …”
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Integrative hydrologic modelling of soil and water conservation strategies: a SWAT-based evaluation of environmental resilience in the Merguellil watershed, Tunisia by Taoufik Hermassi, Fathia Jarray, Waad Tlili, Issam Achour, Mohamed Mechergui

“…Erosion hotspots were identified using sediment yield (SY) data. Six sub-watersheds were categorized from moderate to severe sediment severity classes and pinpointed as soil erosion hotspots, requiring immediate intervention. …”
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On Epistemological Boundaries of Turbulence Modeling Revealed through Stokes’ Reserved Stance on Reynolds’ RANS Equations by ZHANG Xiao-feng

“…While RANS remains indispensable in engineering analysis, Stokes’ implicit critique continues to highlight the unresolved fundamental challenges in fluid mechanics.…”
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The validity of a new resilience scale: the Japan Resilience Scale (J-RS) for mothers with a focus on cultural aspects by Mariko Takeuchi, Michiko Matsunaga, Akimitsu Miyake, Ryuichiro Egashira, Sayaka Hotta, Mai Nakano, Misaki Moriguchi, Fumihiko Yasuno, Masako Myowa, Keisuke Hagihara

“…Therefore, it is necessary to develop a scale that is adapted to the Japanese cultural milieu. …”
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Moderate-Intensity exercise has most beneficial effect on inflammatory response in fructose-induced mice (Mus musculus) by Nabilah Izzatunnisa, Faiq Amirul Hakim, Wildan Maulana Ishom Putra, Purwo Sri Rejeki, Lilik Herawati, Hermina Novida, Shariff Halim, Adi Pranoto

“…Blood samples were taken 24 hours after the last exercise, while adiponectin and TNF-α levels were measured using the ELISA method. Data analysis techniques using one-way ANOVA and Tukey's HSD post-hoc test. …”
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