Sunitinib Combined with Th1 Cytokines Potentiates Apoptosis in Human Breast Cancer Cells and Suppresses Tumor Growth in a Murine Model of HER-2pos Breast Cancer by Nirmala Ghimirey, Chase Steele, Brian J. Czerniecki, Gary K. Koski, Loral E. Showalter

“…We found that when a panel of five phenotypically diverse human breast cancer cell lines was subjected to treatment with sunitinib plus recombinant Th1 cytokines IFN-γ and TNF-α, synergistic effects were observed across a number of parameters including different aspects of apoptotic cell death. …”
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The features of Tat protein of human immunodeficiency virus type 1 (Retroviridae: <i>Lentivirus: Lentivirus humimdef1</i>) non-A6 variants, characteristic for the Russian Federation by Anna I. Kuznetsova, Anastasiia A. Antonova, Aleksey V. Lebedev, Ekaterina N. Ozhmegova, Anastasia V. Shlykova, Ilya A. Lapovok, Oxana V. Galzitskaya

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Practical Recommendations of Scientific Society for the Study of Human Microbiome and the Russian Gastroenterological Association on Use of Probiotics, Prebiotics, Synbiotics and Functional Foods in Treatment and Prevention of Gastroenterological Diseases in Children and Adults by V. T. Ivashkin, I. V. Maev, D. I. Abdulganieva, S. A. Alekseenko, A. V. Gorelov, I. N. Zakharova, O. Yu. Zolnikova, N. Yu. Ivashkina, N. V. Korochanskaya, S. N. Mammayev, E. A. Poluektova, A. S. Trukhmanov, D. V. Usenko, Yu. P. Uspensky, V. V. Tsukanov, O. S. Shifrin, I. V. Berezhnaya, K. V. Ivashkin, T. L. Lapina, R. V. Maslennikov, S. V. Nikolaeva, N. G. Sugyan, A. I. Ulyanin

“…Probiotics are live microorganisms that sustain health of the host when supplied in adequate amounts. Prebiotics include human-indigestible but accessible to gut microbiota substances expediting specific changes in the composition and/or activity of gastrointestinal microbiota that favour the host health. …”
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Effective Administration of Rituximab in Anti-MDA5 Antibody–Positive Dermatomyositis with Rapidly Progressive Interstitial Lung Disease and Refractory Cutaneous Involvement: A Case Report and Literature Review by Yuka Ogawa, Dai Kishida, Yasuhiro Shimojima, Koichi Hayashi, Yoshiki Sekijima

“…We describe the case of a 48-year-old man with dermatomyositis (DM) who demonstrated rapidly progressive interstitial lung disease (RP-ILD) and refractory cutaneous involvement together with high levels of anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5-Ab). …”
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Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells by K. Gouthamchandra, H.V. Sudeep, B.J. Venkatesh, K. Shyam Prasad

“…Food Science and Human Wellness…”
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Human Umbilical Cord Mesenchymal Stem Cells Encapsulated with Pluronic F-127 Enhance the Regeneration and Angiogenesis of Thin Endometrium in Rat via Local IL-1β Stimulation by Shuling Zhou, Yu Lei, Ping Wang, Jianying Chen, Liting Zeng, Ting Qu, Martin Maldonado, Jihua Huang, Tingting Han, Zina Wen, Erpo Tian, Xiangqian Meng, Ying Zhong, Jiang Gu

“…In this study, we aim to determine the role of Pluronic F-127 (PF-127) encapsulation of human umbilical cord mesenchymal stem cells (hUC-MSCs) in the regeneration of thin endometrium and its underlying mechanism. …”
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SPE-UHPLC-FLD Method for the Simultaneous Determination of Five Anthraquinones in Human Urine Using Mixed-Mode Bis(tetraoxacalix[2]arene[2]triazine) Modified Silica as Sorbent by Kai Hu, Yonghui Qiao, Zhifen Deng, Mingxia Wu, Wei Liu

“…Coupled with UHPLC-FLD, the developed method was successfully applied for the measuring of main anthraquinones in human urine after oral administration of the extracts of rhubarb. …”
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LincRNA Cox-2 Regulates Lipopolysaccharide-Induced Inflammatory Response of Human Peritoneal Mesothelial Cells via Modulating miR-21/NF-κB Axis by Yaoyao Bian, Lili Yang, Bin Zhang, Wen Li, Sen Wang, Shuling Jiang, Xi Chen, Wenlin Li, Li Zeng

“…The Cox-2 expression in peritoneal adhesion tissues and normal tissues was detected. The human peritoneal mesothelium cells (HPMCs) were treated with lipopolysaccharide (LPS) to induce inflammatory injury. …”
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Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery by Pawel Dudzic, Dawid Chomicz, Jarosław Kończak, Tadeusz Satława, Bartosz Janusz, Sonia Wrobel, Tomasz Gawłowski, Igor Jaszczyszyn, Weronika Bielska, Samuel Demharter, Roberto Spreafico, Lukas Schulte, Kyle Martin, Stephen R. Comeau, Konrad Krawczyk

“…The naïve human antibody repertoire has theoretical access to an estimated > 1015 antibodies. …”
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Interleukin-1β Enhances Umbilical Cord Mesenchymal Stem Cell Adhesion Ability on Human Umbilical Vein Endothelial Cells via LFA-1/ICAM-1 Interaction by Tsai-Yi Wu, Ya-Han Liang, Jiahn-Chun Wu, Hwai-Shi Wang

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Detection and Characterization of <i>Escherichia coli</i> and <i>Escherichia coli</i> O157:H7 in Human, Animal, and Food Samples from Kirkuk Province, Iraq by Hayman Abdullah Ameen Altaie, Maroua Gdoura Ben Amor, Burhan Ahmed Mohammed, Radhouane Gdoura

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Enterocytozoon bieneusi Identification Using Real-Time Polymerase Chain Reaction and Restriction Fragment Length Polymorphism in HIV-Infected Humans from Kinshasa Province of the Democratic Republic of Congo by Roger Wumba, Menotti Jean, Longo-Mbenza Benjamin, Mandina Madone, Kintoki Fabien, Zanga Josué, Sala Jean, Kendjo Eric, Guillo-Olczyk AC, Thellier Marc

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The Endocannabinoid, Anandamide, Acts as a Novel Inhibitor of LPS-Induced Inflammasome Activation in Human Gastric Cancer AGS Cell Line: Involvement of CB1 and TRPV1 Receptors by Sahar Sadat Sedeighzadeh, Hamid Galehdari, Mohammad Reza Tabandeh, Mehdi Shamsara, Ali Roohbakhsh

“…In conclusion, our results would indicate a novel anticancer effect of anandamide by attenuation of inflammasome activation and consequently reducing IL-1β production in human AGS cancer cell line via CB1R and TRPV1R.…”
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Antibacterial Activity of Peruvian Tarasa Species: A Comparative Study of the Antimicrobial Effects of Extracts From Three Different Tarasa Species, T. capitata, T. operculata and T. tenuis, Against Human Pathogens by Carmen R. Yauri, Annette N. Trombert, Antonio M. Lazarte

“…N-hexane extracts of T. capitata, Tarasa operculata and Tarasa tenuis were analysed and showed, for the first time, antimicrobial activities against human pathogens. GC/MS analysis identified several chemical compounds in the extracts that could be responsible for their antimicrobial activity. …”
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Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field ¹H NMR Investigation by Kayleigh Hunwin, Georgina Page, Mark Edgar, Mohammed Bhogadia, Martin Grootveld

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Label-Free Detection of Human Serum Using Surface-Enhanced Raman Spectroscopy Based on Highly Branched Gold Nanoparticle Substrates for Discrimination of Non-Small Cell Lung Cancer by Xiaowei Cao, Zhenyu Wang, Liyan Bi, Jie Zheng

“…In this study, a potential label-free serum test based on SERS spectroscopy was developed to analyze human serum for the diagnosis of the non-small cell lung cancer (NSCLC). …”
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Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway by Sun Kening, Chen Ping, Zhang Liang, Lu Zhidong, Jin Qunhua

“…Previous studies have reported that deguelin exhibits pro-apoptotic activity against human cancer cells. The current study aimed at further elaborating the anticancer effects of deguelin against multiple myeloma cells. …”
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Changes in the histological structure of tissues and organs of pikeperch (Sander lucioperca Linnaeus, 1758) and perch (Perca fluviatilis Linnaeus, 1758) from the Zaporizhzhia Reservoir under the influence of human impact by P. Korzhenevska, T. Sharamok, A. Doroshenko

“…Histo-morphometric parameters of percid tissues can be used in the future to assess the ecological state of water and the level of human impact of the Zaporizhzhia Reservoir, as well as be used as an additional indicator during the comprehensive assessment of the impact of anthropogenic factors on hydroecosystems.…”
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Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes by Chun-Yin Huang, Hsiu-Jung Lin, Hsin-Shui Chen, Shi-Yann Cheng, Horng-Chaung Hsu, Chih-Hsin Tang

“…In this study, we investigated the intracellular signaling pathways involved in thrombin-induced MMP-13 expression in human chondrocytes. We found that stimulation with thrombin led to increased secretion of MMP-13 in cultured human chondrocytes. …”
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Longitudinal Changes in Body Weight of Breastfeeding Mothers in the First Year after Delivery and its Relationship with Human Milk Composition: a Combined Longitudinal and Cross-sectional Cohort Study by Huijuan Ruan, Yajie Zhang, Qingya Tang, Xuan Zhao, Xuelin Zhao, Yi Xiang, Wei Geng, Yi Feng, Wei Cai

Subjects: “…Human milk…”
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