Epidemiological features of multiple organ dysfunction syndrome in newborns in the Kemerovo region – Kuzbass by A. V. Golomidov, O. G. Kryuchkova, E. V. Grigoriev, A. A. Chernykh, K. V. Lukashov, E. V. Maltseva, V. G. Mozes, K. A. Golomidov, K. B. Moses

“…Theoretical and practical issues of the short-term and long-term prediction of the onset of multiple organ dysfunction syndrome (MODS) and its outcomes in newborns is a promising area of neonatology, since it allows a doctor to be warned about an impending catastrophe, and opens a «window of opportunity» for timely correction of treatment tactics and prevention of complications.The objective was to study the epidemiological features and medical consequences of multiple organ dysfunction syndrome in full-term and premature newborns born in critical condition.Materials and methods. …”
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The role of mitochondrial dysfunction in the pathogenesis of Alzheimer’s disease and future strategies for targeted therapy by Xin Li, Ziyang Wu, Xiaying Si, Jing Li, Guode Wu, Manxia Wang

“…Furthermore, Aβ deposition and abnormal tau proteins can disrupt mitochondrial dynamics through dysregulation of fission/fusion proteins, leading to excessive mitochondrial fragmentation and subsequent dysfunction. Additionally, hyperphosphorylated tau proteins can impair mitochondrial transport, resulting in axonal dysfunction in AD. …”
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Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running by Marie-Therese Lingitz, Hannes Kühtreiber, Lisa Auer, Michael Mildner, Claus G. Krenn, Clemens Aigner, Bernhard Moser, Christine Bekos, Hendrik Jan Ankersmit

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Psychophysiological Acute Effects of Functional Neurology Intervention on Vestibulo-Ocular Reflex Dysfunction by Guillermo Escribano-Colmena, Jorge Rey-Mota, Ana Isabel Beltrán-Velasco, Vicente Javier Clemente-Suárez

“…<b>Objectives</b>: The present study aimed to analyze the psychophysiological and neuromuscular reflex modifications following a single functional neurology intervention in individuals presenting vestibulo-ocular reflex (VOR) cancellation dysfunction. <b>Methods</b>: A total of 66 healthy participants, comprising an experimental group (<i>n</i> = 48; 22 females, 26 males; mean age 28.1 ± 7.8 years) and a control group (<i>n</i> = 18; 9 females, 9 males; mean age 28.6 ± 7.0 years), underwent comprehensive assessments at four distinct measurement moments: baseline, post-indicator muscle failure pre-intervention, immediately post-functional neurology intervention, and post-intervention indicator muscle failure, assessing neuromuscular (handgrip strength) and psychophysiological parameters, including blood oxygen saturation, heart rate, cortical arousal (critical flicker fusion threshold, CFFT), and pain perception (pressure pain threshold, PPT). …”
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The role of intermittent fasting in the treatment of cognitive dysfunction in type 2 diabetes mellitus by Chunying Cui, Daqing Song, Daqing Song, Yan Yang, Xinyu Wang, Renjun Lv, Shanjing Nie, Wenwen Xu

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Molecular mechanisms and functions of protein acetylation in sepsis and sepsis-associated organ dysfunction by Yang-Fan Xu, Ni Yang, Peng-Hui Hao, Ri Wen, Tie-Ning Zhang

“…The development of sepsis-associated organ dysfunction (SAODs) substantially worsens prognosis. …”
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Drug treatment for metabolic dysfunction-associated steatotic liver disease: Progress and direction by Da Zhou, Jiangao Fan, Yuanyuan Ji

“…Metabolic dysfunction-associated steatohepatitis (MASH) is the critical stage of MASLD, and early diagnosis and treatment of MASH are crucial for reducing the incidence of intrahepatic and extrahepatic complications. …”
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Endothelial dysfunction in chronic kidney disease: Mechanisms, biomarkers, diagnostics, and therapeutic strategies by Ji-Hung Wang, Yu-Li Lin, Bang-Gee Hsu

“…A multifaceted approach to managing endothelial dysfunction is critical for mitigating CV complications and improving patient outcomes in CKD.…”
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Mitochondrial Dysfunction in the Pathogenesis of Parkinson Disease: Current Concepts and Potential Therapeutic Strategies by Natalia G. Zhukova, Julia V. Kolobovnikova, Zaynutdinkhuzha F. Sayfitdinkhuzhaev

“…Current research suggests multiple mechanisms for PD development, but increasing evidence supports a critical role of mitochondrial dysfunction in PD pathogenesis. …”
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Evaluation of four-dimensional ultrasound for diagnosis of female pelvic floor dysfunction and prognosis by Shuhao Deng, Yicheng Zhu, Quan Jiang, Yuan Zhang

“…It can clearly display the pelvic cavity of the parturient and provide critical insight into the patient’s condition, thus providing a reliable basis for patient treatment.…”
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Adiponectin and gastric fundus: A potential target for gut–brain axis dysfunctions by R. Garella, F. Palmieri, F. Chellini, L. Tarchi, V. Ricca, G. Castellini, C. Sassoli, R. Squecco

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Evaluation of Cognitive Dysfunction Syndrome (CDS) in dogs and cats following chronic diseases by Mohammad Mehdi Sabzian, Ehsan Khaksar, Shahin Hassanpour, Bita Vazir

“…One of the problems of aging in dogs and cats is cognitive dysfunction syndrome (CDS), which is very similar to Alzheimer's disease in humans and can affect the well-being of pets and the quality of human-animal communication. …”
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Global research trends of neuroinflammation in perioperative neurocognitive dysfunction: a bibliometric analysis by Shiqian Huang, Yuxi Zhou, Jie Liu, Shujun Sun, Tianhao Zhang, Lulin Ma, Shiya Liu, Daling Deng, Shaofang Shu, Yu Wang, Yin Yuan, Xiangdong Chen

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Inhibitory circuit dysfunction as a potential contributor to cortical reorganization in Glioblastoma progression by Cristina Spalletti, Marta Scalera, Elisabetta Mori, Sabrin Haddad, Marco Mainardi, Daniele Cangi, Vinoshene Pillai, Elena Parmigiani, Silvia Landi, Matteo Caleo, Eleonora Vannini

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Insulin resistance-induced mitochondrial dysfunction and pyroptosis in trophoblasts: protective role of metformin by Runyu Du, Yu Bai, Ling Li, Ying Shao, Na Wu

“…Abstract Background Gestational diabetes mellitus (GDM) affects up to 14% of pregnancies globally, with insulin resistance (IR) playing a critical but often underappreciated role in its pathogenesis. …”
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Management of microaspiration and gastrointestinal dysfunction after lung transplantation: A narrative review by René Hage, Carolin Steinack, Macé M. Schuurmans

“…Increasing evidence implicates microaspiration, often secondary to gastroesophageal reflux disease (GERD) and gastrointestinal (GI) dysfunction, as a critical non-alloimmune driver of CLAD. …”
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Case Report: Ischemic brain infarction and cognitive dysfunction syndrome in an aged dog by Min-Hee Kang, Woo-Phil Jeong, Chan-Sik Nam, Jun-Won Yoon, Dong-Min Choi, Gwang-Seob Lee, Yeon-Jin Kim, Tae-Jung Dan, Hee-Myung Park

“…This case report describes a rare occurrence of canine cognitive dysfunction syndrome (CDS) accompanied by ischemic brain infarction, providing insights into the relationship between neurodegeneration and cerebrovascular pathology in aged dogs. …”
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Rearrangement of the liver ubiquitome and NEDDylome in metabolic dysfunction-associated steatotic liver disease by Teresa C. Delgado, Benoît Lectez, Marina Serrano-Maciá, Fernando Lopitz-Otsoa, Leire Uraga-Gracianteparaluceta, Ibon Martínez-Arranz, Jesús M. Arizmendi, Kerman Aloria, Mikel Azkargorta, Félix Elortza, James D. Sutherland, Rosa Barrio, Ugo Mayor, María Luz Martínez-Chantar

“…Proteomic analysis revealed impaired proteasome function, endoplasmic reticulum stress, and mitochondrial dysfunction, suggesting that dysregulation of ubiquitin-like PTMs plays a critical role in MASLD. …”
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An Overview of Treatment in Pediatric Bladder-bowel Dysfunction: A Single-Center Experience by Mahli Batuhan Özdoğar, Ömer Ergin, Hasan Turan, Özgür Özdemir Şimşek, Özgür Olukman

“…Effective management of constipation and lifestyle modifications were critical for treatment success. Conclusion: A stepwise treatment protocol focusing on bowel regulation, urotherapy, and individualized interventions provides effective symptom control and prevents disease progression in pediatric bladder-bowel dysfunction. …”
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The effectiveness of levosimendan in newborns with low cardiac output syndrome in the multiple organ dysfunction by A. V. Golomidov, O. G. Kryuchkova, E. V. Grigoriev, V. G. Moses, K. B. Moses

“…The combination of multiple organ dysfunction syndrome and low cardiac output syndrome (MODS + LCOS) is an unfavorable phenotype of a critical condition with a high risk of death, in which standard cardiotonic therapy is not always effective.The objective was to evaluate the effectiveness of levosimendan in the treatment of small cardiac output syndrome in newborns with multiple organ dysfunction syndrome. …”
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