Systemic Sclerosis: A Key Model of Endothelial Dysfunction by Vincenzo Zaccone, Lorenzo Falsetti, Silvia Contegiacomo, Serena Cataldi, Devis Benfaremo, Gianluca Moroncini

“…Solid evidence supports the hypothesis that endothelial dysfunction is the key player in SSc vascular injury and a critical factor concurring to the initiation of SSc pathogenesis. …”
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Urine iodine concentration in hospitalised infants with thyroid dysfunction by Christy Hou, Michelle Jack, Annabelle Hobbs, Geoffrey Ambler, Yoon Hi Cho

“…Conclusions Extremely high random UIC can be helpful to confirm clinical suspicion of iodine excess in hospital-based infants, taken in the context of thyroid dysfunction in critical illness. The degree of thyroid dysfunction associated with high UIC in this clinically complex and often premature patient population may be better measured by the fT4 level rather than the degree of TSH elevation.…”
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Mechanisms of glutamate metabolic function and dysfunction in vascular dementia by Jiawen Wang, Yingmei Zhang, Ning Tian, Dongshan Ya, Jiaxin Yang, Yanlin Jiang, Xiaoxia Li, Xiaohui Lin, Bin Yang, Qinghua Li, Rujia Liao

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Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression by Nikola Pavlović, Marinela Križanac, Marko Kumrić, Katarina Vukojević, Joško Božić

“…In CKD, persistent mitochondrial dysfunction drives oxidative stress, fibrosis, and metabolic reprogramming, with epigenetic mechanisms (DNA methylation, histone modifications, non-coding RNAs) regulating genes critical for mitochondrial homeostasis, such as <i>PMPCB</i> and <i>TFAM</i>. …”
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Perspectives on mitochondrial dysfunction in the regeneration of aging skeletal muscle by Kai Wang, Mailin Gan, Yuhang Lei, Tianci Liao, Jiaxin Li, Lili Niu, Ye Zhao, Lei Chen, Yan Wang, Li Zhu, Linyuan Shen

“…A critical contributing factor is the loss of mitochondrial metabolism and function in MuSCs within skeletal muscle. …”
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Incidence of Right Ventricular Dysfunction in an Echocardiographic Referral Cohort by Jonah D. Garry, Shi Huang, Jeffrey Annis, Suman Kundu, Anna Hemnes, Matthew Freiberg, Evan L. Brittain

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Mitochondrial dysfunction in the regulation of aging and aging-related diseases by Xianhong Zhang, Yue Gao, Siyu zhang, Yiqi Wang, Xinke Pei, Yufei Chen, Jinhui Zhang, Yichen Zhang, Yitian Du, Shauilin Hao, Yujiong Wang, Ting Ni

“…Abstract Aging is an irreversible physiological process that progresses with age, leading to structural disorders and dysfunctions of organs, thereby increasing the risk of chronic diseases such as neurodegenerative diseases, diabetes, hypertension, and cancer. …”
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Defective Olfactomedin-2 connects adipocyte dysfunction to obesity by Aina Lluch, Jèssica Latorre, Isabel Espadas, Núria Oliveras-Cañellas, José M. Moreno-Navarrete, Estefanía Caballano-Infantes, Gitalee Sarker, Nicolás F. Malvido, Pablo Garrido-Gil, José L. Labandeira-García, Naoki Nakaya, Silvia Mora, Eduardo Chicano, Jaime López-Alcalá, María M. Malagón, Alejandro Martín-Montalvo, Birong Zhang, You Zhou, Ana I. Domingos, Miguel López, Johanna Pörschke, María Gómez-Serrano, Witold Szymanski, Johannes Graumann, Stanislav I. Tomarev, Ismael González-García, José M. Fernández-Real, Francisco J. Ortega

“…Extending these findings in vivo, both whole-body Olfm2 knockout and adipose-specific Olfm2 depletion in mice resulted in impaired adipose cell cycle gene expression, with the latter also displaying fat mass accretion and metabolic dysfunction. Collectively, our results underscore a critical role for OLFM2 in adipocyte biology, and support a causative link between reduced adipose OLFM2 and the pathophysiology of obesity.…”
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Transformer-based multimodal precision intervention model for enhancing diaphragm function in elderly patients by Ma Xinli, Zhao Jie, Yan Ming, Zhang Yanping, Li Fan, Jia Jing, Ding Lu

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Microbiota and metabolic dysfunction associated with steatotic liver disease by Q. Zhu, S. Francque, W. Kwanten

“…Disease progression in metabolic dysfunction-associated steatotic liver disease (MASLD) is driven by multiple mechanisms that act together in genetically predisposed subjects. …”
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Magnesium disturbances in critically ill children by Selma Amar, Sofia Martín Acedo, Santiago Rodríguez-Tubio, Claudia Olalla, Cristina De Ángeles, José Ángel Zamorano, Rosario Pérez, Blanca Ramírez, Jesús López-Herce, Rafael González

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Diagnosis of Sepsis in Critically Ill Patients by M. L. Romasheva, D. G. Proshin

“…Objective: to ascertain the informative value of determining procalcitonin in the diagnosis of critical conditions and in the evaluation of the efficiency of performed therapy.Subjects and methods. …”
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Left Ventricular Diastolic Dysfunction in the Intensive Care Unit: Trends and Perspectives by Lewis Ari Eisen, Pericles Davlouros, Dimitrios Karakitsos

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Assessment of Metabolic Dysfunction in Sepsis in a Retrospective Single-Centre Cohort by Julien Goutay, Juliette Perche, Aurelia Toussaint, Elodie Drumez, Michael Howsam, Claire Bourel, Benoit Brassart, Alexandre Pierre, Morgan Caplan, Arthur Durand, Marion Houard, Saad Nseir, Raphael Favory, Sébastien Preau

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Cardiac Dysfunction Indices and Their Prognostic Value in Acute Exacerbation COPD Patients by Ahmad B. Elden, Mohamed F. Abdelghany, Mostafa K. Ahmed, Dalia Tarek

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Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock by Priya A. Prasad, Armond M. Esmaili, Sandra Oreper, Alexander J. Beagle, Colin Hubbard, Katie E. Raffel, Yumiko Abe‐Jones, Margaret C. Fang, Kathleen D. Liu, Michael A. Matthay, Kirsten N. Kangelaris

Subjects: “…critical care…”
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Serum Uric Acid and Arterial pH in ICU Patients with Sepsis and their Correlation with SOFA Score: A Prospective Observational Study by Govind Shiddapur, Sonali Agarwal

Subjects: “…critical care…”
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Differentiation versus dysfunction: thyroid hormone, deiodinases and retinal photoreceptors by Lily Ng, Ye Liu, Young-Wook Cho, Hong Liu, Douglas Forrest

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Capital city relocation in Indonesia: compromise failure and potential dysfunction by Indra Perwira, Susi Dwi Harijanti, Mei Susanto, Muhammad Yoppy Adhihernawan

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Epigenetic Modulation by Lactylation in Sepsis: Linking Metabolism to Immune Dysfunction by Chen Y, Hu H, Wang C, Wu J, Zan J, Liu Y

“…Accumulating evidence suggests that elevated lactate levels contribute to immune dysfunction in sepsis by modulating the activity of various immune cells. …”
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