Immune cell metabolic dysfunction in Parkinson’s disease by Julian R. Mark, Malú Gámez Tansey

“…While the etiology of PD remains multifactorial and complex, growing evidence suggests that cellular metabolic dysfunction is a critical driver of neuronal death. …”
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Research status of visuospatial dysfunction and spatial navigation by Rui Bao, Shijie Chang, Ruixiang Liu, Yunning Wang, Yifu Guan, Yifu Guan

“…Visuospatial function is a critical aspect of cognitive abilities, encompassing visual perception, attention, memory, and adaptive responses to spatial changes. …”
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Mitochondrial dysfunction in AMI: mechanisms and therapeutic perspectives by Jingle Shi, Yiding Yu, Huajing Yuan, Yan Li, Yitao Xue

“…In recent years, mitochondrial dysfunction during AMI has been increasingly recognized as a critical factor in cardiomyocyte death. …”
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Airway Epithelium Dysfunction in Cystic Fibrosis and COPD by Virginia De Rose, Kevin Molloy, Sophie Gohy, Charles Pilette, Catherine M. Greene

“…In this review, we address the evidence for a critical role of dysfunctional airway epithelial cells in chronic airway inflammation and remodelling in CF and COPD, highlighting the common mechanisms involved in the epithelial dysfunction as well as the similarities and differences of the two diseases.…”
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Microvascular endothelial dysfunction in vascular senescence and disease by Daniel A. Kasal, Daniel A. Kasal, Viviane Sena, Grazielle Vilas Bôas Huguenin, Grazielle Vilas Bôas Huguenin, Andrea De Lorenzo, Eduardo Tibirica

“…In addition, we discuss lifestyle changes targeting the connection between age-related inflammation and vascular dysfunction. Addressing microvascular ED represents a critical endeavor in order to prevent or delay vascular aging and associated diseases.…”
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Mitochondrial Dysfunction in Glycogen Storage Disorders (GSDs) by Kumudesh Mishra, Or Kakhlon

“…Potential strategies include antioxidants to mitigate oxidative stress, compounds that enhance mitochondrial biogenesis, and gene therapy to correct the underlying mitochondrial enzyme deficiencies. Mitochondrial dysfunction plays a critical role in the pathophysiology of GSDs. …”
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JAK2/STAT3/HMGCS2 signaling aggravates mitochondrial dysfunction and oxidative stress in hyperuricemia-induced cardiac dysfunction by Dewei Peng, Xiaoli He, Bowen Ren, Qian Wang, Lulu Peng, Yue Jiang, Shengqi Huo, Lintong Men, Wei Shi, Pengcheng Luo, Mengyin Zhu, Cuntai Zhang, Jiagao Lv, Li Lin, Sheng Li

“…Abstract Background High uric acid levels play a critical role in cardiovascular disease pathophysiology, being closely linked to their occurrence, progression, and prognosis. …”
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ENDOTHELIAL DYSFUNCTION IN MEN - A CLINICAL VIEW by I. A. Khripun, Z. R. Gtisova, H. S. Ibishev, A. S. Sultanmuradova, S. V. Vorobiev, M. I. Kogan

“…Endothelial dysfunction is an early marker for the development and progression of cardiovascular diseases. …”
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Microrheological Disorders in Critical Conditions by L. V. Gerasimov, V. V. Moroz, A. A. Isakova

“…Furthermore, the review summarizes the results of recent studies dealing with the contribution of microrheological disorders to the development of organ dysfunction in sepsis and other critical conditions. …”
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Intestinal Oxygenotherapy of Critical Conditions by V. A. Mazurok, A. S. Golovkin, I. I. Gorelov, A. E. Bautin, I. N. Menshugin, O. A. Slivin, D. S. Tarnovskaya, V. V. Ivanov, V. G. Nikiforov, K. A. Morozov, A. O. Marichev

“…The latent or mist diagnosed dysfunction of the small intestine is a common disorder in critically ill patients. …”
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Efferent Treatment for Critical Conditions by S. E. Khoroshilov, A. V. Nikulin

“…Accumulation of endogenous toxic substances is an integral component of any critical condition and accompanies severe injury, generalized infections, abdominal organ derangement. …”
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Persistent Critical Illness in Newborns by A. V. Golomidov, E. V. Grigoriev, V. G. Moses, K. B. Moses

“…The problem of persistent critical illness (PCI) in newborns is poorly understood. …”
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Impact of tadalafil on cardiovascular and organ dysfunction induced by experimental sepsis by Marcelo Almeida Nakashima, Gabrielle Delfrate, Lucas Braga Albino, Gustavo Ferreira Alves, Junior Garcia Oliveira, Daniel Fernandes

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Artificial liver support with Cytosorb and continuous veno-venous hemodiafiltration versus advanced organ support (ADVOS) for critically ill patients with hyperbilirubinemia and ac... by Kristina Schönfelder, Luisa Katharina Hirsch, Andreas Kribben, Michael Jahn, Bartosz Tyczynski, Justa Friebus-Kardash

“…Abstract Background As many as 30% of critically ill patients in intensive care units experience acute liver dysfunction with hyperbilirubinemia as a part of multiorgan failure that is associated with poor outcome. …”
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Antithymocyte globulin therapy in chronic lung allograft dysfunction by Akhilesh Ajay Padhye, Danielle Guffey, Andres Leon-Pena, Justin Segraves, Ramiro Fernandez, Gabriel Loor, Puneet Garcha, Tianshi David Wu, Gloria Li

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Levosimendan for sepsis-induced myocardial dysfunction: friend or foe? by Xinxin Du, Xinxin Du, Fang Xiong, Yafei Hou, Xiangyou Yu, Pengfei Pan

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Effect of endothelial responses on sepsis-associated organ dysfunction by Miao Wu, Yan Yan, Xinyu Xie, Jiawei Bai, Chengtai Ma, Xianjin Du, Sihan Zhou, Xiuyuan Hao

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The Intersection of Trauma and Immunity: Immune Dysfunction Following Hemorrhage by Nicholas Salvo, Angel M. Charles, Alicia M. Mohr

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Cerebellar contributions to tau-mediated cognitive and behavioral dysfunction by Lidiette Angeles-Perez, Chongyu Ren, Juliana Neniel, James Widner, Kunihiko Yamashiro, Yogesh Tak, Sushobhna Batra, Tommy Tan, Brian Nguyen, Marc Diamond, Hirofumi Fujita, Peter T. Tsai

“…We further demonstrate that a chemogenetic increase in PC excitability improves cognitive and behavioral dysfunction in P301S mutants. Together, these findings support critical roles for the cerebellum in regulating tauopathy-relevant cognitive and behavioral deficits while also informing potential therapeutic avenues for these conditions.…”
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Application of artificial intelligence in the management of patients with renal dysfunction by Bo Zhang, Xiaocong Jiang, Jie Yang, Jiajie Huang, Chaoming Hu, Yucai Hong, Hongying Ni, Zhongheng Zhang

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