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Epigenetic regulation of bladder cancer in the context of aging
Published 2025-08-01“…In parallel, frequent mutations in chromatin modifiers (e.g., KDM6A, KMT2D) and overexpression of histone-modifying enzymes (e.g., EZH2) alter the tumor epigenome to promote immune evasion and tumor aggressiveness. At the non-coding RNA level, dysregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in BC contribute to aberrant proliferation, metastatic potential, and immune suppression, with aging-associated declines in miRNA processing further exacerbating these effects. …”
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542
MicroRNA-1303 in cancer pathogenesis and therapy: clinical implications for biomarker development and targeted treatment strategies
Published 2025-07-01“…A growing body of evidence highlights the critical role of non-coding RNAs, particularly microRNAs (miRNAs), in cancer biology. …”
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543
Characterization of small nucleolar RNA retaining transcripts in human normal and cancer cells
Published 2025-08-01“…Small nucleolar RNAs are non-coding RNAs typically encoded within the introns of both protein-coding and non-coding genes. …”
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544
The First Complete Mitogenome Characterization and Phylogenetic Implications of <i>Elops machnata</i> (Teleostei: Elopiformes: Elopidae)
Published 2025-06-01“…This study presents the first complete mitochondrial genome characterization of <i>Elops machnata</i> (Teleostei: Elopiformes: Elopidae), a basal teleost lineage critical for understanding early actinopterygian evolution. …”
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545
Principles in practice? A policy review of the IOC's environmental sustainability agenda
Published 2025-02-01“…This incorporates exploration of IOC documents such as policies, strategies, guidelines, reports, codes, and conference outputs. The IOC's ES agenda is interpreted as both strategy around ES, as a plan of action to achieve desired outcomes, and policies around ES, as matters of practice and principle to be enacted. …”
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546
Optimization of DD-110 Neutron Generator Output for Boron Neutron Capture Therapy Using Monte Carlo Simulation
Published 2025-04-01“…The entire system’s performance was modeled and simulated using the MCNPX code, focusing on parameters both in-air and in-phantom to evaluate its efficacy. …”
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547
Emergency and critical care medicine residents’ competency to identify patient ventilator asynchrony using a mechanical ventilator waveform analysis in Addis Ababa, Ethiopia: a mul...
Published 2025-02-01“…The completed data were collected via web links after being prepared using kobtoolbox. org, coded, manually checked, and exported to version 27 SPSS analysis. …”
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548
Highlanders: a qualitative study to explore the experiences of home care nurses in rural areas in Italy
Published 2024-06-01Get full text
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549
Investigating the impact of generative AI integration on the sustenance of higher-order thinking skills and understanding of programming logic
Published 2025-12-01“…However, smaller gains were observed in code optimization (t = 1.693, p = 0.103, d = 0.339) and evaluating solutions (t = 1.732, p = 0.096). …”
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550
Epigenetics of maternal-fetal interface immune microenvironment and placental related pregnancy complications
Published 2025-04-01“…Several epigenetic modifications are known, such as DNA methylation, histone modifications, non-coding RNA regulation, and RNA methylation. Recently, there has been increasing evidence that epigenetic modifications are critical for the immune microenvironment at the maternal-fetal interface. …”
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551
Adaptive Lossy Color Image Compression System Based on Hybrid Algorithm
Published 2024-12-01“…To address these challenges, image compression has emerged as a critical solution by decreasing the volume of the image without significantly degrading their quality. …”
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552
The role of SOX transcription factors in prostate cancer: Focusing on SOX2
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553
Cerebral ischemia-reperfusion injury: mechanisms and promising therapies
Published 2025-07-01“…Cerebral ischemia-reperfusion injury (Cerebral I/R injury) is a critical pathological process following ischemic stroke, closely associated with multiple mechanisms including oxidative stress, neuroinflammation, and neuronal apoptosis. …”
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554
Integrated WHT- and DFT-Based Multiuser Massive MIMO System for Secure RIS-Enabled mmWave Communications
Published 2025-01-01“…The four users achieved a bit error rate (BER) of <inline-formula> <tex-math notation="LaTeX">$1\times 10^{-3}$ </tex-math></inline-formula> using RA channel coding, MMSE, and 4-QAM digital modulation at a signal-to-noise ratio (SNR) of 20 dB.…”
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555
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The #BookTok Connection: Examining Cultural and Linguistic Identity Expression in Online Reading Communities
Published 2025-02-01“…This case study used thematic analysis to analyze participant interviews through open and axial coding to explore #BookTok engagement, framed through affinity spaces, transformative potential, and critical digital pedagogies. …”
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558
Host 3' flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation.
Published 2025-02-01“…To address these questions, a mutant HBV cell line HepDES-C1822G was established with a C1822G mutation in the pgRNA coding sequence, altering the sequence of 3' TR of (-) strand DNA while the 5' TR remained wild type (wt). …”
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559
The role of expansion and adaptability of face-space for individual differences in face identity processing
Published 2025-01-01Get full text
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560
WRTU-16T: Write-Enhanced Low-Power Radiation-Tolerant SRAM for Space Applications
Published 2025-06-01Get full text
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