Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages by Xiao-Nan Zheng, Hong-Yu Song, Hany M. Elsheikha, Chen-Ran Tian, Xing Tian, Qing Liu, Wen-Bin Zheng, Xing-Quan Zhu

“…Furthermore, KEGG pathway analysis identified critical m5C-regulated processes such as nucleocytoplasmic transport, DNA replication, and ATP-dependent chromatin remodeling. …”
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Integrative multi-omics analysis reveals the LncRNA 60967.1–PLCD4–ATRA axis as a key regulator of colorectal cancer progression and immune response by Yiyi Chen, Ningning Zhao, Lingna Xu, Xiya Jia, Fang Liu, Jian Huang, Xuhua Li, Yunfei Wang, Chuanxi Lai, Yanbin Shen, Fei Wang, Yiming Lv, Xuefeng Huang, Fan Zhang, Hongcang Gu, Sheng Dai

“…Our analysis revealed 1,394 differentially expressed long non-Coding RNAs (lncRNAs), 2,788 genes, 548 proteins, and 91 metabolites. …”
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Smi-miRmTERF regulates organelle development, retrograde signaling, secondary metabolism and immunity via targeting a subset of SmmTERFs in Salvia miltiorrhiza by Xiaoxiao Qiu, Hong Zhou, Jiang Li, Miaomiao Liu, Xian Pan, Butuo Zhu, Sixuan Zhang, Fanqi Meng, Caili Li, Shanfa Lu

“…Abstract MicroRNAs are a class of endogenous small non-coding RNAs, some of which can trigger phased secondary small interfering RNA (phasiRNA) production from target genes. …”
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Neural connectivity biotypes: predictors of clinical outcomes and improvement patterns of iTBS treatment in adolescents and young adults with depression by Xiaoyu Chen, Min Zhang, Fan Zhang, Yanling Zhou, Yuping Ning, Roger S McIntyre, Hanna Lu, Haiyan Liu, Yiying Chen, Xiaofeng Lan, Chengyu Wang, Weicheng Li, Zhibo Hu, Siming Mai, Yanan Yin, Zerui You, Guanxi Liu, Zhanjie Luo, Yexian Zeng, Yifang Chen, Robin Shao

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Explaining and Analyzing the Effect of Brand Value Components on Medical Tourism Development: A Case Study of Ahvaz Metropolis by Majid Goodarzi

“…To achieve this, the collected data were coded and entered into the SPSS version 25 and AMOS version 24 software, both of which are designed for structural equation modeling. …”
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Integrated promoter-capture Hi-C and Hi-C analysis reveals fine-tuned regulation of the 3D chromatin architecture in colorectal cancer by Ajay Kumar Saw, Ayush Madhok, Anupam Bhattacharya, Anupam Bhattacharya, Soumyadeep Nandi, Sanjeev Galande, Sanjeev Galande

“…We identified nine dysregulated genes, including long non-coding RNAs (MALAT1, NEAT1, FTX, and PVT1), small nucleolar RNAs (SNORA26 and SNORA71A), and protein-coding genes (TMPRSS11D, TSPEAR, and DSG4), all of which exhibited a substantial increase in expression in CRC cell lines compared to human embryonic stem cells (hESCs). …”
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Incidence, causes and prognostic outcomes of acute coma: a nationwide population-based retrospective cohort study in Taiwan by Chih-Ching Liu, Chih-Yuan Lin, Yue-Chune Lee, Jen-Feng Liang, Mingche Tsai, Meng-Ling Chang

“…This study demonstrates the efficacy of using CCS groups for aggregating International Classification of Diseases codes in acute coma research, providing critical insights for enhancing clinical management and outcomes.…”
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Antecedents of Trust in Sharing Economy Platforms: Prioritization Using the Best-Worst Method by Navid Khanjanzadeh Kakeroodi, Ali Adabi Firoozjaei, Soheil Nejat, Hamidreza Fallah Lajimi

“…Once the antecedents were identified, codes with similar concepts were grouped under specific sub-category names to form sub-categories. …”
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Designing a Paradigmatic Model of Child Marriage in Bandar Abbas City by Mehdieh Moradi, Yaser Rastergar, Mostafa Zahirinia

“…Data collection involved in-depth, semi-structured interviews, which were analyzed using a 3-step coding approach: open, axial, and selective coding. …”
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Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation by Lifeng Gan, Lifeng Gan, Lifeng Gan, Peiyue Luo, Peiyue Luo, Peiyue Luo, Junrong Zou, Junrong Zou, Wei Li, Wei Li, Wei Li, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Yiran Lu, Liying Zheng, Biao Qian, Biao Qian

“…Hypoxia-inducible factor (HIF), a key regulator of hypoxic adaptation, has been demonstrated to modulate hypoxic gene expression profiles and signaling networks, thereby serving as a potential therapeutic target. Long-stranded non-coding RNAs (lncRNAs), defined as non-coding RNAs exceeding 200 nucleotides in length, regulate various cellular processes by modulating gene expression at transcriptional, post-transcriptional, and epigenetic levels. …”
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A novel polypeptide encoded by circSPIRE1 promotes prostate cancer proliferation and migration by restraining the ubiquitin-dependent degradation of LRP5 by Jintao Hu, Juanyi Shi, Junjie Wang, Yunfei Xiao, Degeng Kong, Mingchao Gao, Tianlong Luo, Shizhong Xu, Zhihan Yuan, Xinyi Ma, Xueseng Dong, Jingang Huang, Cheng Liu, Kewei Xu

“…Abstract Background Circular RNAs (circRNAs) are increasingly implicated in tumor progression, but the roles of protein-coding circRNAs remain largely unexplored. This study characterizes a novel circRNA-encoded protein, rtSPIRE1, and investigates its mechanistic role in prostate cancer proliferation and migration, as well as its diagnostic and therapeutic potential. …”
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Association Between Gastroesophageal Reflux Disease and Periodontitis: A Longitudinal Follow-Up Study from the Korean National Health Screening Cohort by Na-Eun Lee, Kyeong Min Han, Dae Myoung Yoo, Ho Suk Kang, Ji Hee Kim, Joo-Hee Kim, Woo Jin Bang, Hyo Geun Choi, Ha Young Park, Nan Young Kim, Mi Jung Kwon

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A trans-acting sRNA SaaS targeting hilD, cheA and csgA to inhibit biofilm formation of S. Enteritidis by Chongyang Lyu, Haijing Hu, Linlin Cai, Shuwen He, Xinglian Xu, Guanghong Zhou, Huhu Wang

“…The biofilm formed by Salmonella Enteritidis plays a critical role in microbial cross-contamination. Small non-coding RNAs (sRNAs) have been demonstrated to be responsible for regulating the formation of biofilm. …”
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Impact of COVID-19 on Corporate Cash Holdings and Speed of Adjustment by Abbas Aflatooni, Mohammad Khatiri, Farzad Eivani

“…The results suggested that the increased cash adjustment speed represented a strategic response to avoid the financial consequences of the COVID-19 crisis.Keywords: Precautionary Motive, Speed of Adjustment, COVID-19, Trade-off Theory, Cash Holding.JEL classification codes: G31, G32 IntroductionCash management is a critical aspect of firm liquidity and performance. …”
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Modular and efficient assembly of CRISPR vectors and construction of an apple gene editing efficiency evaluation system by HOU Feifan, HUANG Chuanmi, HAO Pengbo, CONG Liu, BAI Tuanhui, SHI Jiangli, WANG Miaomiao, LIU Yu, ZHAO Yujie, WAN Ran, SHEN Yawen, ZHANG Hengtao, ZHANG Kunxi, ZHENG Xianbo, JIAO Jian

“…However, conventional gene editing systems exhibit critical limitations, including low efficiency vector assembly and inflexible modular architectures. …”
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The differential expression of MAGI2 in glomerulopathies and its application as a molecular discriminator of podocytopathies by Florian Siegerist, Eleonora Hay, Elke Hammer, Anna Iervolino, Claudia Weber, Juan Saydou Dikou, Eleni Stamellou, Linus Butt, Thomas Benzing, Thorsten Wiech, Paul T. Brinkötter, Uwe Zimmerman, Giovambattista Capasso, Christos Chatziantoniou, Christos E. Chadjichristos, Tobias B. Huber, Uwe Völker, Maximilian Schindler, Nicole Endlich

“…Results The expression of the gene coding for the scaffolding protein MAGI2 was examined across four species and demonstrated to be conserved within the podocyte filtration slit. …”
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Psychological correlates of COVID-19 vaccine attitudes among medical professionals: An exploratory data analysis by Aldo SITIBONDO, Aanuoluwapo AFOLABI, Jamel HAJJI, Abdulmohsen Mohammed Abdullah ALKHULAYFI, Izaddin Ahmad AZIZ, Zane Asher GREEN, Francesca BRUNO, Martina BARBERA, Murat YLDIRIM

“…Background: The emotional dimension of vaccine acceptance is a critical factor in understanding healthcare workers’ behavior during the COVID-19 pandemic. …”
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A de novo TNNI3K variant aggravates the pathogenicity of DMD-associated early-onset cardiomyopathy: a case report by Di Qie, Di Qie, Yang Zhai, Yang Zhai, Fan Yang, Fan Yang, Yifei Li, Yifei Li, Rong Xu, Rong Xu

“…BackgroundDystrophin is a DMD coding protein that serves as a connector maintaining the structural formation and functional hemostasis of myofilaments, which regulate the contraction of cardiomyocytes. …”
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The multidisciplinary approach to the treatment of paediatric chronic pain: a qualitative analysis through focus groups by Aldana Paola Ercolano, Sabrina Galvan, Tessa Louise Marchesan, Alessia Gavioli, Gerardo Papa, Mariarita Todaro, Lidia Berforini D’Aquino, Alessia Zanatta, Andrea Vianello

“… Background: Access to pain care is recognized as a fundamental human right, ratified by Law 38/2010 and supported by the professional codes of conduct for healthcare practitioners. Pain, defined by the International Association for the Study of Pain (IASP), as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. …”
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The Italian Perinatal Surveillance System SPItOSS: insights from Confidential Enquiries by Michele Antonio Salvatore, Silvia Salvi, Paola D’Aloja, Patrizia Vergani, Roberto Bellù, Carlo Dani, Federico Mecacci, Maria Rosa D’Anna, Sergio Ferrazzani, Giuseppe Battagliarin, Piermichele Paolillo, Simonetta Picone, Luca Ramenghi, Giovanni Vento, Serena Donati, The Italian Perinatal Surveillance System-SPItOSS Working Group

“…The International Statistical Classification of Diseases and related Health Problem-Perinatal Mortality was adopted for coding causes of death and contributing maternal and placenta-related conditions. …”
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