Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment by Xinyi Yang, Yingchao Liu, Jinghao Cao, Cuiyun Wu, Lusheng Tang, Wenxia Bian, Yuhan Chen, Lingyan Yu, Yunyi Wu, Sainan Li, Yuhuan Shen, Jun Xia, Jing Du

“…This paper systematically summarizes the molecular mechanisms by which PTMs and epigenetic alterations regulate NRF2, and elucidates its critical role in cellular defense and disease. By analyzing the impact of PTMs, such as phosphorylation, ubiquitination, and acetylation, as well as DNA methylation, histone modifications, and non-coding RNA interactions on NRF2 stability, activity, and expression, the study reveals the complex cellular protection network mediated by NRF2. …”
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Analysis of the Causes of Urban Sprawl in Iran by keramatollah Ziari, Saeed Zanganeh Shahraki, Negin Rajabzadeh, Mohsen Abbas Nejad Jelogir

“…Approximately 80 domestic articles on urban sprawl were gathered, analyzed, and coded using MAXQDA2020 software through a systematic process. …”
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Èdè Àyàn: The Language of Àyàn in Yorùbá Art and Ritual of Egúngún by Oláwọlé Fámúlẹ̀

“…In Yorùbá traditional festivals, ritual performances, and religious practices in general, the role of àyàn whose drumming or drum music imitate and code the natural language (Yorùbá), cannot be overemphasized. …”
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Multimorbidity frailty index and clinical outcomes among 42,989 older heart failure patients directly discharged from emergency departments: A nationwide retrospective cohort study by Wan-Ju Liao, Hsi-Yu Lai, Liang-Yi Lin, Cheng-Hsueh Wu, Fei-Yuan Hsiao, Liang-Kung Chen

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Experiences of People Diagnosed with High Levels of LDL Cholesterol and Atherosclerotic Cardiovascular Disease: Results from a Multinational Qualitative Study by Neil Johnson, Joe Vandigo, Fernanda de Carvalho, Celina Gorre, Tanya Hall, Susan E. Hennessy, Dhruv S. Kazi, Kornelia Kotseva, Patsy Petrie, David Kelly, Ankita Saxena, Elisabeth M. Oehrlein

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Knowledge, attitudes, and practices of healthcare providers toward ADR reporting regarding thiopurine drugs for the treatment of acute lymphoblastic leukemia at the University of G... by Eyuel Kassa, Mastewal Birhan, Mulugeta Ayalew, Aschalew Gelaw, Abdulkader Mohamedsaid Gidey, Degalem Tilahun Worku, Awole Mekonen, Ermias Teklehaimanot, Assefa Asnakew, Alazar Amare, Nega Berhane Tessemma

“…The collected data were coded, entered and analyzed using SPSS version 25. …”
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Long COVID in long-term care: a rapid realist review by Annette Berndt, Valorie A Crooks, Manoj Sivan, Simon Carroll, Maura MacPhee, Shannon Freeman, Karen Davison, Ian Fyffe, Janice Sorensen, Alison Andrews-Paul, Jennifer Walls, Benajir Shams, Akber Mithani

“…Objectives The goals of this rapid realist review were to ask: (a) what are the key mechanisms that drive successful interventions for long COVID in long-term care (LTC) and (b) what are the critical contexts that determine whether the mechanisms produce the intended outcomes?…”
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Whole-transcriptome sequencing reveals the global molecular responses and ceRNA regulatory network involved in programmed cell death of rice cultivars zyk639 and zyk-lm by Haipeng Zhang, Han Zheng, Weifang Liang, Junjie Zhang, Hongyu Zhao, Jianzhong Li, Yujie Zhou, Liujie Xie, Chulang Yu, Binfeng Dai, Liequan Zhong, Fan Hou, Chengyu Wang, Jianping Chen, Yong Yang

“…Abstract Background Programmed cell death (PCD) can be triggered by biotic stress or abiotic stress in rice, which is a crucial factor throughout the lifecycle. Long non-coding RNAs (lncRNAs) have important roles in a variety of biological processes. …”
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Enhancing emotional intelligence in medical education: a systematic review of interventions by Sabyasachi Maity, Samantha Michelle De Filippis, Alexander Aldanese, Melissa A. McCulloch, Alexis P. Sandor, Jan E. Perez Cajigas, Yiorgos Antoniadis, Te-keila D. T. Rochester, Lauren Elizabeth Carter, Alexander M. Preisig, Julia Ali Kobeissi, Narendra Nayak, Jaime E. Mendoza, Samal Nauhria

“…The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was applied to assess the quality of included studies. …”
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Core components of male-specific person-centred HIV care: a qualitative analysis from client and healthcare worker perspectives in Malawi by Sam Phiri, Khumbo Phiri, Julie Hubbard, Kathryn Dovel, Kelvin Balakasi, Elijah Chikuse, Augustine T Choko, Morna Cornell, Misheck Mphande, Isabella Robson, Marguerite Thorp, Thomas Coates

“…Interviews were audio recorded, translated into English, transcribed and coded in Atlas.ti V.9 and analysed using thematic analysis.Results 36 MLHIV and 20 HCWs (10 lay cadre and 10 nurses) were interviewed between February and July 2022. …”
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Serotonin receptor 5-HT2A as a potential target for HCC immunotherapy by Han Chong Toh, Olaf Rotzschke, Yi Wen Tan, Nicholas Da Zhi Ang, Wendy Lee, Ser Mei Koh, Rong En Tay, Charmaine Min Ho, Hui Chien Tay, Daniel Z Lopez, Qiao Rui Na, Kim Peng Tan, Jackwee Lim, Maichan Lau, Laurent Rénia

“…Hence, identifying new key molecular pathways suppressing T-cell responses within the liver is critical for the rational design of more effective combination immunotherapies for HCC.Methods We identified the 5-HT2A serotonin receptor as a potential target for HCC immunotherapy in a chemical screening approach and validated that targeting 5-HT2A signaling could be a viable approach for HCC immunotherapy via in vitro and in vivo studies.Results Disruption of 5-HT2A signaling using either a selective antagonist small molecule, ketanserin, or by knockout of its coding gene Htr2a augments the cytotoxic effector phenotype of mouse CD8 T cells activated in vitro with immunosuppressive liver non-parenchymal cells. …”
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SRSF3 and hnRNP A1-mediated m6A-modified circCDK14 regulates intramuscular fat deposition by acting as miR-4492-z sponge by Chunyu Qin, Fang Xu, Binglin Yue, Jincheng Zhong, Zhixin Chai, Hui Wang

“…Abstract The intramuscular fat (IMF) content of yak beef is critical for determining its quality. Circular RNAs (circRNAs) are a group of endogenous non-coding RNAs that have emerged as important factors in the regulation of IMF deposition. …”
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How many people die by suicide each year? Not 727,000: a systematic review and meta-analysis of suicide underreporting across 71 countries over 122 years by Nicola Meda, Nicola Meda, Ludovica Angelozzi, Matteo Poletto, Angelo Patane’, Josephine Zammarrelli, Irene Slongo, Fabio Sambataro, Fabio Sambataro, Fabio Sambataro, Diego De Leo, Diego De Leo, Diego De Leo, Diego De Leo

“…Contributing factors included stigma, religiosity, limited forensic resources, and inconsistent use of International Classification of Diseases (ICD) codes. Gender and age disparities were notable; Female suicides and those among younger or older individuals were more likely to be misclassified.DiscussionAddressing suicide underreporting requires improving death registration systems globally, particularly in LMICs. …”
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Unsupervised clustering for sepsis identification in large-scale patient data: a model development and validation study by Na Li, Kiarash Riazi, Jie Pan, Kednapa Thavorn, Jennifer Ziegler, Bram Rochwerg, Hude Quan, Hallie C. Prescott, Peter M. Dodek, Bing Li, Alain Gervais, Allan Garland

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The relationship and differences in the triglyceride-glucose index and all-cause mortality in patients with coronary heart disease combined with cerebrovascular and other comorbidi... by Xiao Zeng, Yuping Liu, Ping Shuai, Peiyuan He, Xiaoli Liu

“…These findings suggest that the TyG index may serve as a critical metabolic marker for prognostic evaluation in CHD patients, warranting further clinical attention.…”
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Burn injuries among paediatric patients treated at Mexican public hospitals: a retrospective cohort analysis of nationwide hospitalisation data by Taylor Wurdeman, John G Meara, Tanujit Dey, Tarsicio Uribe-Leitz, Jose Antonio Garcia Garcia, Diana D. Del Valle, Kevin Ashi, Jacques Bistre Varon, Juan Carlos Angulo-Lozano, Jaime Shalkow-Klincovstein

“…This retrospective cohort study provides an epidemiological analysis of paediatric burn injuries in Mexico using a nationwide hospitalisation database.Methods We conducted a retrospective cohort analysis of all paediatric burn patients aged 0–18 years (ICD-10 codes: T200–T329) who were hospitalised in the Mexican public sector using the Ministry of Health’s hospital discharge database for 2016, 2018 and 2020. …”
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Molecular cloning of PRD-like homeobox genes expressed in bovine oocytes and early IVF embryos by Barış Yaşar, Nina Boskovic, Marilin Ivask, Jere Weltner, Eeva-Mari Jouhilahti, Piibe Vill, Tiina Skoog, Ülle Jaakma, Juha Kere, Thomas R. Bürglin, Shintaro Katayama, Tõnis Org, Ants Kurg

“…Abstract Background Embryonic genome activation (EGA) is a critical step in early embryonic development, as it marks the transition from relying on maternal factors to the initiation of transcription from embryo’s own genome. …”
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Explaining the Comprehensive Human-To-Human Marketig System in the Health Tourism Industry by Ali Pourang, Meysam Shirkhodaie, Mahmood Yahyazadeh far, Mohsen Alizadeh San, Masoomeh Tavangar

“…Axial Coding: Grouping codes into 24 main categories based on common themes. …”
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tRNA-derived small RNA 3’ tRF-Ala CGC obstructs NK cytotoxicity via cleavage of membrane protein MICA in colorectal cancer by Jing Zhang, Chunlin Ou, Xin Li, Li Fu, Qizhi Luo, Jie Wang, Yizhou Zou

“…Transfer RNA (tRNA)-derived small RNA (tsRNA) represents a novel class of non-coding RNAs generated from tRNA cleavage, regulating gene expression at transcriptional and translational levels. …”
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A Smart Glass Telemedicine Application for Prehospital Communication: User-Centered Design Study by Zhan Zhang, Enze Bai, Yincao Xu, Aram Stepanian, Jared M. Kutzin, Kathleen Adelgais, Mustafa Ozkaynak

“…All qualitative data (eg, transcribed interviews and discussions) were iteratively coded and analyzed by at least 2 researchers using thematic analysis. …”
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