Physician‐Reported Facilitators and Barriers for Side Effect Management of Heart Failure Medications by Sabrina Mangal, Maryam Hyder, John Mancini, Kate Zarzuela, William McDonald, Monika Safford, Mark Lachs, Parag Goyal

“…Interviews were transcribed and coded using directed content analysis. For elicitation of potential side effects, limited patient communication and family discordance in reporting were key barriers, whereas guiding questions, measurement, and open channels of communication were key facilitators. …”
Get full text

Nfe2l1 dysfunction alters Parkinson’s disease-related gene expression and impairs neuronal differentiation under ubiquitin stress in neuronal differentiated P19 Cells by Hossein Khodadadi, Dawid Winiarczyk, Kamila Łuczyńska, Hiroaki Taniguchi

“…Knockdown of Nfe2l1 also decreased Neat1, a long non-coding RNA associated with PD pathology, and downregulated the neuronal marker Map2, indicating impaired neuronal differentiation. …”
Get full text

Emyooga Programme and Job Creation in Kabale District Uganda. by Niwasasira, Saviour

“…Quantitative data was analysed using descriptive and inferential statistics with SPSS Ver.14, while qualitative data was collected and organised into codes generated from the most common responses to enhance the interpretation of results. …”
Get full text

RNA-Seq analysis reveals the long noncoding RNAs associated with immunity in wild Myotis myotis bats by Sebastien Riquier, Samuel Carthy, Graham M. Hughes, Frederic Touzalin, Wilfried Haerty, Zixia Huang, Emma C. Teeling

“…The molecular basis and regulation of bats’ immune response is still not fully understood. Long non-coding RNAs (lncRNAs) represent an emerging class of molecules with critical regulatory roles in multiple biological processes, including immunity. …”
Get full text

Mitochondrial genome analysis of the endangered Oreocharis esquirolii: insights into evolutionary adaptation and conservation by Lang Chen, Rong-Rong Yan, Chong-Yi Yang, Li-Zhen Ling, Xin-Xiang Bai, Qi-Fei Ren, Guo-Xiong Hu

“…Positive selection signals were detected in seven coding genes of the O. esquirolii mitogenome, with a potential impact on environmental adaptation. …”
Get full text

A core driver gene set identified based on geMER reveals its potential driver mechanism in pan-cancer by Jing Gan, Yuncong Wang, Zhuoran Shi, Haoyu Hu, Manyi Xu, Xinrong Li, Wenbo Dong, Jiaheng He, Yusen Zhao, Yakun Zhang, Yue Sun, Caiyu Zhang, Qianyi Lu, Shangwei Ning, Yan Jin, Hui Zhi

“…Abstract Increasing evidence underscores the driving role of coding and non-coding variants in cancer development. …”
Get full text

Extracellular Vesicles From Follicular Fluid in Infertile Women: Size, Morphology and miRNA Content Analysis by Solène Ducarre, Regina Maria Chiechio, Gregory Moulin, Ester Butera, Aurélien Dupont, Christophe Penno, Abdelhak El Amrani, Claire Heichette, Pascale Even‐Hernandez, Valérie Marchi, Célia Ravel

“…These findings offer critical insights into the molecular signatures associated with these conditions. …”
Get full text

Integrating smartwatch-based out-of-hospital cardiac arrest detection into resuscitation systems: a focus group study of community responder perspectives by Marijn Eversdijk, Babette J.W. van der Eerden, Dick L. Willems, Willem J. Kop, Mirela Habibović, Marieke A.R. Bak

“…However, the perspectives of community responders, who play a critical role in early responding to resuscitation alerts, are not yet known. …”
Get full text

Narratives of Discovery as a catalyst for translational science education and training by Leah G. Pope, Daichi Shimbo, Harold A. Pincus, Muredach P. Reilly, Rita Charon

“…New education and training opportunities are critical for the development of a diverse and highly skilled translational science workforce. …”
Get full text

PBC-Transformer: Interpreting Poultry Behavior Classification Using Image Caption Generation Techniques by Jun Li, Bing Yang, Jiaxin Liu, Felix Kwame Amevor, Yating Guo, Yuheng Zhou, Qinwen Deng, Xiaoling Zhao

“…Accurate classification of poultry behavior is critical for assessing welfare and health, yet most existing methods predict behavior categories without providing explanations for the image content. …”
Get full text

Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity by Chuannan Fan, Qian Wang, Peter H. L. Krijger, Davy Cats, Miriam Selle, Olga Khorosjutina, Soniya Dhanjal, Bernhard Schmierer, Hailiang Mei, Wouter de Laat, Peter ten Dijke

“…Our findings establish SNAI1e as a critical driver of SNAI1 expression and TGF-β-induced cell plasticity.…”
Get full text

MicroRNAs as Promising Therapeutic Agents Against Prostate Cancer Resistant to Castration—Where Are We Now? by Mariana Ferreira, Mariana Morais, Rui Medeiros, Ana Luísa Teixeira

“…MicroRNAs are a conserved class of small, tissue-specific, non-coding RNAs that regulate gene expression to preserve cellular homeostasis. …”
Get full text

The Dual Role of Dietary Phytochemicals in Oxidative Stress: Implications for Oncogenesis, Cancer Chemoprevention, and ncRNA Regulation by Khalid Umar Fakhri, Deepti Sharma, Homa Fatma, Durdana Yasin, Manzar Alam, Neha Sami, Farhan Jalees Ahmad, Anas Shamsi, Moshahid Alam Rizvi

“…Oxidative stress (OS), resulting from an imbalance between reactive oxygen species (ROS) and the antioxidant defense system, plays a critical role in the initiation and progression of cancer. …”
Get full text

High Dose C6 Ceramide-Induced Response in Embryonic Hippocampal Cells by Federico Fiorani, Martina Mandarano, Samuela Cataldi, Alessandra Mirarchi, Stefano Bruscoli, Francesco Ragonese, Bernard Fioretti, Toshihide Kobayashi, Nario Tomishige, Tommaso Beccari, Claudia Floridi, Cataldo Arcuri, Elisabetta Albi

“…Ceramide is a critical molecule in both the physiology and pathology of the central nervous system. …”
Get full text

Genomic Analysis Reveals the Role of New Genes in Venom Regulatory Network of Parasitoid Wasps by Bo Zhang, Yifan Bu, Jiqiang Song, Bo Yuan, Shan Xiao, Fang Wang, Qi Fang, Gongyin Ye, Yi Yang, Xinhai Ye

“…New genes play a critical role in phenotypic diversity and evolutionary innovation. …”
Get full text

Distinct ARG profiles associated with class 1 integrons in municipal and industrial wastewater treatment plants by Yan Zhang, Zhiguo Su, Xuyang Qiu, He Liu, Donghui Wen, Lyujun Chen

“…Wastewater treatment plants (WWTPs) are critical reservoirs of ARGs and integrons, yet the integron-mediated dynamics of ARG transfer across different WWTP types remain poorly understood. …”
Get full text

Understanding Home Health Agencies' Perspectives Toward Telehealth Use Among Home Health Stakeholders in the Post–COVID-19 Era: Qualitative Interview Study by Daniel Spertus, Kiran Abraham-Aggarwal, Mark Aaron Unruh, Jiani Yu, Kathryn H Bowles, Michael P Thompson, Cisco Espinosa, Hye-Young Jung, Madeline R Sterling

“…Interviews were transcribed and analyzed thematically using both deductive codes from the PRISM framework and inductive codes to capture emergent themes. …”
Get full text

Association analyses of rare variants identify two genes associated with refractive error. by Karina Patasova, Annechien E G Haarman, Anthony M Musolf, Omar A Mahroo, Jugnoo S Rahi, Mario Falchi, Virginie J M Verhoeven, Joan E Bailey-Wilson, Caroline C W Klaver, Priya Duggal, Alison Klein, Jeremy A Guggenheim, Chris J Hammond, Pirro G Hysi, CREAM Consortium; the UK Biobank Eye; Vision Consortium

“…<h4>Results</h4>We found strong statistical evidence for association of SPHE with the SIX6 (p-value = 2.15 x 10-10, or Bonferroni-Corrected p = 4.41x10-06) and the CRX gene (p-value = 6.65 x 10-08, or Bonferroni-Corrected p = 0.001). The SIX6 gene codes for a transcription factor believed to be critical to the eye, retina and optic disc development and morphology, while CRX regulates photoreceptor specification and expression of over 700 genes in the retina. …”
Get full text

Determination method for horizontal load-bearing capacity of pile group for large LNG tank by Chengguo WEI, Hanwen WANG, Wentao LIU, Wei CUI, Wangyu ZHAN

“…Hence, the checking calculation for the horizontal load-bearing capacity of piles is particularly critical. Nevertheless, the existing empirical formulas given in pertinent codes lack accounting for the superposition effect of pile-soil interactions at different positions within pile groups. …”
Get full text

Motivation Theories and Constructs in Experimental Studies of Online Instruction: Systematic Review and Directed Content Analysis by Adam Gavarkovs, Erin Miller, Jaimie Coleman, Tharsiga Gunasegaran, Rashmi A Kusurkar, Kulamakan Kulasegaram, Melanie Anderson, Ryan Brydges

“…Two team members independently screened and coded the studies, focusing on the motivational theories that researchers used and the motivational constructs targeted by their design strategies. …”
Get full text