Impact of interventions on mpox transmission during the 2022 outbreak in Canada: a mathematical modeling study of three different cities by Fanyu Xiu, Carla M. Doyle, Jorge Luis Flores Anato, Jesse Knight, Linwei Wang, Joseph Cox, Daniel Grace, Trevor A. Hart, Terri Zhang, Shayna Skakoon-Sparling, Milada Dvorakova, Rita Shahin, Herveen Sachdeva, Nathan Lachowsky, Hind Sbihi, Darrell H.S. Tan, Michael A. Irvine, Sharmistha Mishra, Mathieu Maheu-Giroux

“…Methods: We estimated changes in sexual behaviors during the outbreak using 2022 data from the Engage Cohort Study, which recruited self-identified GBM in Montréal, Toronto, and Vancouver (n = 1,445). …”
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An Improved UAV RGB Image Processing Method for Quantitative Remote Sensing of Marine Green Macroalgae by Jinghu Li, Qianguo Xing, Liqiao Tian, Yingzhuo Hou, Xiangyang Zheng, Maham Arif, Lin Li, Shanshan Jiang, Jiannan Cai, Jun Chen, Yingcheng Lu, Dingfeng Yu, Jindong Xu

“…Red–green–blue (RGB) images (or videos) captured by consumer-level uncrewedaerial vehicle (UAV) cameras are widely used in high-resolution remote observations. However, digital number (DN) values of these RGB images usually have a nonlinear relationship with the incident radiance, which reduces the accuracy of quantitative remote sensing of macroalgae. …”
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The sensitivity of aerosol data assimilation to vertical profiles: case study of dust storm assimilation with LOTOS-EUROS v2.2 by M. Pang, M. Pang, J. Jin, T. Yang, X. Chen, A. Segers, B. Buyantogtokh, Y. Gu, J. Li, H. X. Lin, H. X. Lin, H. Liao, W. Han

“…Aerosol observation is constrained by its limited spatial and temporal coverage compared to that of models. On the other hand, models tend to possess higher uncertainties and biases compared to observations. …”
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Economic burden of Chagas disease in Brazil: a nationwide cost-of-illness studyResearch in context by Mônica Viegas Andrade, Kenya Valeria Micaela de Souza Noronha, Aline de Souza, Nayara Abreu Julião, André Soares Motta-Santos, Paulo Estevão Franco Braga, Henrique Bracarense, Yasmim Caroline Silva, Bruno Ramos Nascimento, Mariângela Carneiro, Francisco Rogerlândio Martins-Melo, Isis Eloah Machado, Pablo Perel, Yvonne Geissbühler, Caroline Demacq, Antônio Luiz Pinho Ribeiro

“…Given the universal health coverage model, understanding these costs can guide improvements and interventions aimed at reducing Chagas disease’s impact. …”
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Global Trajectories of Colorectal Cancer Burden From 1990 to 2021 and Projection to 2040 by Xiaolu Chen, Xuesi Dong, Yadi Zheng, Chenran Wang, Zilin Luo, Jiaxin Xie, Zeming Guo, Xiaoyue Shi, Xinyue Zhu, Yongjie Xu, Wei Cao, Fei Wang, Ni Li

“…Higher sociodemographic index, universal health coverage, health expenditure, and gross domestic product per capita were linked to decreasing trends (all p < 0.05). …”
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Safety and efficacy of edoxaban monotherapy after bioabsorbable polymer everolimus-eluting stent implantation in a human-like coronary atherosclerotic porcine model by Daisuke Kitano, Suguru Migita, Yuxin Li, Yutaka Koyama, Katsunori Fukumoto, Sayaka Shimodai-Yamada, Akira Onishi, Daiichiro Fuchimoto, Shunichi Suzuki, Yoshiyuki Nakamura, Atsushi Hirayama, Hiroyuki Hao, Yasuo Okumura

“…The objective of this study was to evaluate the safety and efficacy of DOAC monotherapy, specifically using factor Xa inhibitors such as edoxaban, in a low-density lipoprotein receptor knockout (LDL-R−/−) miniature pig model of human-like unstable coronary plaques compared to conventional dual-antiplatelet therapy (DAPT). …”
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Innovo GenMax MTB-RIF/INH: a moderate-complexity automated NAAT for rapid simultaneous detection of Mycobacterium tuberculosis complex and rifampin/isoniazid resistance by Xichao Ou, Bing Zhao, Huiwen Zheng, Ruida Xing, Qian Sun, Zhonghua Qin, Lixia Zhang, Kai Cui, Yuanyuan Song, Yang Zheng, Yang Zhou, Shengfen Wang, Hui Xia, Yanlin Zhao

“…Further optimization, particularly through expanded probe coverage, is needed to bridge this gap and ensure reliable detection in clinical settings.…”
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Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium by Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou

“…Safety and immunogenicity were assessed by clinical monitoring, bacterial load, fecal shedding, ELISA tests, and adhesion/blocking assays using fecal extracts. Protection was evaluated after challenging with wild-type and heterologous strains. …”
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HPV DNA screening and vaccination strategies in Tunisia by Anas Lahdhiri, Beya Benzina, Emna Ennaifer, Haifa Tounsi, Ahlem Gzara, Soumaya Rammeh-Rommani, Oumaima Laraj, Heger Arfaoui, Robyn Stuart, Amira Kebir, Slimane BenMiled

“…All approaches were combined with the vaccination program. Screening coverage rates of 15%, 25%, 33%, 50%, and 70% were tested for each approach. …”
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Comparing the protection of heterologous booster of inhaled Ad5-nCoV vaccine and hybrid immunity against Omicron BA.5 infection: a cohort study of hospital staff in China by Kai Wang, Ting Zeng, Zihao Guo, Jing Liang, Shengzhi Sun, Yongkang Ni, Chunyan Yan, Liang Yin, Lan Wang, Hui Li, Kailu Wang, Marc K.C. Chong, Naijun Tang, Jianghong Dai, Zhaohui Luo, Shi Zhao

“…Our findings supported the rollout of a heterologous vaccination strategy regardless of preexisting vaccine coverage.…”
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RAD-Seq-derived SSR markers: a new paradigm for genetic analysis and construction of genetically improved production populations in Pinus koraiensis by Pingyu Yan, Wanying Zhang, Junfei Hao, Xiaotian Miao, Jun Wu, Zixiong Xie, Zhixin Li, Lei Zhang, Hanguo Zhang

“…On the Basis of these insights, primers were designed and subjected to meticulous screening using bioinformatics methodologies, and their efficacy was subsequently verified. …”
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Prognostic factors of invasive fungal infections in pediatric intensive care units and changes in treatment outcomes before and after the COVID-19 pandemic: a multicenter retrospec... by Yuhui Du, Li Huang, Xiulan Lu, Jun Su, Lidan Cui, Qunqun Zhang, Liming He, Tian Li, Ling Gong, Guoping Lu, Yibing Cheng

“…Therefore, it is necessary to optimize invasive procedure management and provide early coverage for emerging pathogens in high-risk children.…”
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SLOW READING AS A METHOD FOR REVEALING IMPLICIT MEANINGS IN THE LITERARY WORK by Hryhorii D. Klochek, Mariia V. Foka

“…The considered scientific coverage of the problem of slow reading in the works by M. …”
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Evaluating snow depth retrievals from Sentinel-1 volume scattering over NASA SnowEx sites by Z. Hoppinen, Z. Hoppinen, R. T. Palomaki, G. Brencher, D. Dunmire, D. Dunmire, E. Gagliano, A. Marziliano, J. Tarricone, J. Tarricone, H.-P. Marshall

“…Sentinel-1 (S1) SAR data have been used previously in an empirical algorithm to generate snow depth products with near-global coverage, subweekly temporal resolution and spatial resolutions on the order of hundreds of meters to 1 km. …”
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Decentralized community-integrated research sites drive higher randomization rates: insights from a large-scale neurodegenerative disease trial by Seyed-Mahdi Khaligh-Razavi, Tyler E. Miller, Tyler E. Miller, Tyler E. Miller, Ralph Passarella, Ahmad Namvargolian

“…At the same time, this approach helped reach underrepresented groups, thereby improving both geographic coverage and trial generalizability while enhancing overall trial performance. …”
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Identification of long InDels through whole genome resequencing to fine map qIF05-1 for seed isoflavone content in soybean (Glycine max L. Merr.) by Jia Jia, Huan Wang, Ximeng Yang, Bo Chen, Ruqian Wei, Qibin Ma, Yanbo Cheng, Hai Nian

“…In this study, the parental lines were re-sequenced using the Illumina Solexa System with deep coverage. …”
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The implementation of Safety Management Systems in healthcare: a systematic review and international comparison by Zhivko Zhelev, Sian de Bell, Alison Bethel, Maria Clarke, Rob Anderson, Jo Thompson Coon

“…To work well, safety management systems need to be specific to the industry where they are being used, so this review asked: How are safety management systems being used in health care? …”
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Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets by Marina Papaiakovou, Andrea Waeschenbach, Olumide Ajibola, Sitara SR Ajjampur, Roy M. Anderson, Robin Bailey, Jade Benjamin-Chung, Maria Cambra-Pellejà, Nicolas R. Caro, David Chaima, Rubén O. Cimino, Piet Cools, Anélsio Cossa, Julia Dunn, Sean Galagan, Javier Gandasegui, Berta Grau-Pujol, Emma L. Houlder, Moudachirou Ibikounlé, Timothy P. Jenkins, Khumbo Kalua, Eyrun F. Kjetland, Alejandro J. Krolewiecki, Bruno Levecke, Adrian JF Luty, Andrew S. MacDonald, Inácio Mandomando, Malathi Manuel, Maria Martínez-Valladares, Rojelio Mejia, Zeleke Mekonnen, Augusto Messa, Harriet Mpairwe, Osvaldo Muchisse, Jose Muñoz, Pauline Mwinzi, Valdemiro Novela, Maurice R. Odiere, Charfudin Sacoor, Judd L. Walson, Steven A. Williams, Stefan Witek-McManus, D. Timothy J. Littlewood, Cinzia Cantacessi, Stephen R. Doyle

“…The genetic diversity of helminths and its potential impact on molecular diagnostics remain unclear. Using low-coverage genome sequencing, we assess the genetics of STHs within worm, faecal, and purified egg samples from 27 countries, identifying differences in the genetic connectivity and diversity of STH-positive samples across regions and cryptic diversity between closely related human- and pig-infective species. …”
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Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy by Hongmei Wang, Maribel Beaumont, Wendy Blumenschein, Laurence Fayadat-Dilman, Mingmei Cai, Jing Yuan, Douglas Wilson, Thierry O Fischmann, Jeanne Baker, Tanya Keenan, Daniel Malashock, Eunseon Ahn, Komal Pradhan, Jeffery Grein, Srishti Chakravorty, Soheila Bahmanjah, David Ban, Ellen Chien, Mark Hsieh, Todd Mayhood, Janica C Wong, Mark A McCoy, Sybil M G Williams, Wolfgang Seghezzi, Jin-Hwan Han

“…The mouse surrogate anti-TIGIT antibodies were identified and used to extensively investigate the mechanism of action of anti-TIGIT antibodies as monotherapy or in combination with anti-programmed cell death protein-1 (PD-1) antibody in vivo by gene expression profiling and flow cytometry analyses with a mouse syngeneic tumor model.Results Structural analyses with solution NMR and X-ray crystallography revealed that vibostolimab binds the CC’C’’FG loop interface of TIGIT, completely competing for the binding site of CD155 with a larger coverage area than another anti-TIGIT antibody tiragolumab, consistent with surface plasmon resonance analysis, though mouse models with similar antibodies revealed no functional difference in antitumor efficacy. …”
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Determinants and Experiences of Care‐Seeking for Childhood Pneumonia in a Rural Indian Setting: A Mixed‐Methods Study by Barsha Gadapani Pathak, Sarmila Mazumder, Yasir Bin Nisar, Aditya Bhatt, Mandeep Singh, Tarun Madhur, Ingvild Fossgard Sandøy

“…Quantitative data were analysed using logistic regression, while qualitative data were thematically analysed using the Three Delays Model. …”
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