Multiparametric performance comparison of dental composites for clear aligner attachments by Yunlin Guan, Jiarong Xu, Junhong Qiu, Hao Cai, Wenxuan Xia, Zhou Ye, Ting Sang

“…Conclusions Z250 underperformed in color stability, SBS, and durability versus Z350/P60, though demonstrated cost-effectiveness. …”
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The Efficacy of Conversational AI in Rectifying the Theory-of-Mind and Autonomy Biases: Comparative Analysis by Marcin Rządeczka, Anna Sterna, Julia Stolińska, Paulina Kaczyńska, Marcin Moskalewicz

“…ObjectiveThis study aimed to assess the effectiveness of therapeutic chatbots (Wysa and Youper) versus general-purpose language models (GPT-3.5, GPT-4, and Gemini Pro) in identifying and rectifying cognitive biases and recognizing affect in user interactions. …”
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MRI R2* and quantitative susceptibility mapping in brain tissue with extreme iron overload by Christoph Birkl, Marlene Panzer, Christian Kames, Anna Maria Birkl-Toeglhofer, Alexander Rauscher, Bernhard Glodny, Elke R. Gizewski, Heinz Zoller

“…Whole-brain referenced QSM leads to lower susceptibility values in aceruloplasminemia patients. QSM, if properly processed, provides reliable maps in iron overload brain regions. …”
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Immunological profiling in type 2 diabetes mellitus and type 2 diabetic kidney disease: insights from single-cell LacNAc sequencing by Mengyun Xiao, Zigan Xu, Xiaohui Zhu, Jing Chen, Ru Wang, Yaxuan Wang, Xiang Gao, Shaodong Luan, Xiaoyan Pu

“…However, the underlying mechanism remains unclear.MethodsWe employed single-cell LacNAc sequencing (scLacNAc-seq) to characterize immune cell populations, glycosylation patterns, and functional alterations in peripheral blood mononuclear cells (PBMCs), focusing on low-density granulocytes (LDGs), from patients with T2DM and T2DKD versus healthy controls (HC). In vitro cultures of primary human neutrophils under high glucose and high glucose plus serum from patients with T2DKD were used to assess NET formation via myeloperoxidase (MPO) detection. …”
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Multiomics-Based Profiling of the Fecal Microbiome Reveals Potential Disease-Specific Signatures in Pediatric IBD (PIBD) by Anita H. DeSantis, Kristina Buss, Keaton M. Coker, Brad A. Pasternak, Jinhua Chi, Jeffrey S. Patterson, Haiwei Gu, Peter W. Jurutka, Todd R. Sandrin

“…However, we observed a small number of differentially abundant taxa in UC versus healthy controls, including members of the Classes <i>Gammaproteobacteria</i> and <i>Clostridia</i> as well as members of the Family <i>Rikenellaceae</i>. …”
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Repurposing losartan potassium against rheumatoid arthritis via transdermally-delivered leciplexes: Accentuated efficacy through modulation of angiotensin II/AT1R/AT2R axis by Amira A. Hussein, Basmah N. Aldosari, Randa M. Zaki, Obaid Afzal, Adel A. Ali, Heba M. Aboud, Yasmin M. Ahmed, Demiana M. Naguib

“…The pharmacokinetic analysis disclosed a snowballed bioavailability of the optimized LST-LPXs gel by 3.08- and 1.2-fold versus the oral solution and crude gel, respectively. …”
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Compost and Biochar to Promote Soil Biological Activities under Sweet Potatoes Cultivation in a Subtropical Semiarid Region by Josabeth Navarro, Jahdiel Salazar, James Jihoon Kang, Jason Parsons, Chu-Lin Cheng, Alexandria Castillo, Engil Isadora Pujol Pereira

“…Sweet potato was cultivated during summer 2018 in McAllen, Texas, under control (no fertilizer), NPK (synthetic fertilizer), RC (yard-waste compost), and AC (compost produced under an enhanced composting process), and biochar (gasified walnut shell at 900°C), each with three replicates. …”
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Tripartite prehabilitation of patients with acute myeloid leukaemia and high-risk myelodysplastic syndromes during intensive chemotherapy before allogeneic haematopoietic stem cell... by Jean-Marie Boher, Norbert Vey, Colombe Saillard, Sarah Cuvelier, Charlène Villaron-Goetgheluck, Leonor Almeida-Lopez, Anne-Gaelle Le Corroller, Pauline Denis, Céline Rivieccio, Sarah Calvin, Cécile Bannier-Braticevic

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Experiences and perceptions of Chinese patients enrolled in a clinical trial assessing tuina and manual therapies for knee osteoarthritis: a nested qualitative study by Luping Liu, Lingyun Zhang, Sina Li, Meiling Cai, Siyu Han, Zhiwen Weng, Qianji Chen, Yixuan Gao, Xiaoming Yang, Yang Zhang, Duoduo Li, Changxin Liu, Ya’nan Sun, Xiyou Wang, Changhe Yu

“…Methods Participants with KOA were sampled using a simple sampling method from a randomized controlled trial of Tuina treatment versus manual physical therapy (MPT). …”
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The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells by Friederike Behler-Janbeck, Anke Baranowsky, Timur A. Yorgan, Michelle Y. Jaeckstein, Anna Worthmann, Marceline M. Fuh, Karthikeyan Gunasekaran, Gisa Tiegs, Michael Amling, Thorsten Schinke, Joerg Heeren

“…Overall, these data indicate that acetate regulates bone architecture via SCFA-Gpr41/43 signaling by modulating the osteogenic versus adipogenic differentiation of mesenchymal stem cells.…”
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The effects of dietary supplementation with red grape pomace treated with ozone gas on ruminal fermentation activities, nutrient digestibility, lactational performance, and blood m... by Behzad Asadnezhad, Rasoul Pirmohammadi, Yonesali Alijoo, Hamed Khalilvandi-Behroozyar, Hossein Abdi-Benmar, Deli Nazmín Tirado-González, Pedro Enrique Hernández Ruiz, Valente Velazquez Ordoñez, Maximilian Lackner, Abdelfattah Z.M. Salem

“…The digestibility coefficients of the DM and the NDF increased (P < 0.001) in diets containing RGP versus the control, but not for the crude protein and ether extract. …”
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Design of 20-deoxyingenol-esters-based PKC agonists and their lysosome biogenesis-enhancing activity by Jia-Jia Wan, Qiu-Yuan Yin, Mao Sun, Cui-Shan Zhang, Hao-Jing Zang, Pei-Tong Yao, Ming-Rui Yuan, Ding-Kang Chen, Feng Guo, Qun Chen, Bo-Wen Ouyang, Zi-Fei Xu, Ming-Ming Cao, Chong-Lin Yang, Xiao-Jiang Hao, Ying-Tong Di

“…At 20 μM, these derivatives enhanced autophagic flux by 2.45-fold and 2.31-fold versus vehicle control. Moreover, compounds 4 and 18 exhibited a dose-dependent increase in lysosome numbers, promoted TFEB nuclear translocation, and enhanced lysosome-mediated lipid droplet clearance. …”
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The impact of community-based, peer-led sexual and reproductive health services on knowledge of HIV status among adolescents and young people aged 15 to 24 in Lusaka, Zambia: The Y... by Bernadette Hensen, Sian Floyd, Mwelwa M Phiri, Ab Schaap, Lucheka Sigande, Melvin Simuyaba, Lawrence Mwenge, Rosemary Zulu-Phiri, Louis Mwape, Sarah Fidler, Richard Hayes, Musonda Simwinga, Helen Ayles

“…Across zones, knowledge of HIV status ranged from 63.6% to 81.2% in intervention zones and 35.4% to 63.0% in control zones. Adjusting for age, sex, and community, knowledge of HIV status was higher in the intervention arm compared to control (73.3% versus 48.4%, respectively, adjusted prevalence ratio (PR) 1.53 95% CI 1.36, 1.72; p < 0.001). …”
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Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With HIV on Antiretroviral Therapy by Chuen‐Yen Lau, Anna Lyndaker, Swati Shah, Paul Wakim, Amelia Mitchell, Cynthia Monroe, Alan Kim, Tracy L. Cropper, Govind Nair, Joseph Snow, Bryan R. Smith, Avindra Nath, Dima A. Hammoud

“…This could reflect a functional compensatory process versus minimal, below‐detection‐level dysfunction.…”
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The effect of the relative dose intensity of chemoradiotherapy on the effectiveness of therapy of locally advanced unresectable non-small cell lung cancer by A. E. Glukhareva, G. V. Afonin, I. V. Kolobaev, L. Yu. Grivtsova, S. A. Ivanov, A.  D.  Kaprin

“…The second year of follow-up demonstrated the advantage of the group of patients with RDI &gt;80 % in terms of local control and amounted to 48.1 % versus 34.7 %, respectively.Conclusion. …”
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Improving medication safety with proactive reconciliation in acute coronary syndrome patients: A randomized trial by Mahdieh Fatemi-Nejad, Maryam Mehrpooya, Davoud Ahmadimoghaddam, Kimia Shirmohammadi, Maryam Zamanirafe, Mahdis Sharifikia, Azadeh Eshraghi

“…Objective: This randomized controlled trial aimed to compare the effectiveness and time efficiency of proactive versus retroactive medication reconciliation models in preventing unintentional medication discrepancies in patients hospitalized with ACS. …”
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Effect of short PSG peptide fragments on the cytokine profile in Wistar rats during allogeneic transplantation <i>in vivo</i> by V. P. Timganova, M. S. Bochkova, K. Yu. Shardina, S. V. Uzhviyuk, E. V. Gutina, M. B. Rayev, A. V. Lyubimov, S. A. Zamorina

“…We used an original model of host-versus-graft response in male Wistar rats transplanted with bone marrow, without prior conditioning treatment of recipients. …”
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Effect of freezing and thawing on ejaculated sperm and subsequent pregnancy and neonatal outcomes in IVF by Qin Xie, Xueyi Jiang, Ming Zhao, Yating Xie, Yong Fan, Lun Suo, Yanping Kuang

“…To balance the baseline characteristics of the two groups, patients using frozen sperm were matched with control groups using a propensity score matching algorithm with a ratio of 1:3.ResultsAlthough sperm motility decreased from 82.04% to 75.70% (P &lt; 0.001) after the freezing–thawing process, the fertilization rate (68.27% for frozen sperm and 67.54% for fresh sperm), number of viable embryos (1.98 and 2.16), clinical pregnancy rate (44.7% and 51.8%), and live birth rate (40.3% and 42.4%) were comparable between the two groups (all P &gt; 0.05). …”
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The <i>LGALS1</i> gene polymorphism is not associated with galectin-1 levels in tumor tissue and blood of colon cancer patients by Olga I. Urazova, Gleb V. Reyngardt, Yulia V. Kolobovnikova, Anna V. Kurnosenko, Vadim S. Poletika, Olga A. Vasil'yeva, Aleksandra V. Avgustinovich

“…The plasma galectin-1 levels in the CRC patients with the AA genotype of the rs4820294 polymorphism were higher than in the healthy carriers (17.42 versus 12.92 ng/ml, p = 0.040). However, there were no significant differences in the content of galectin-1+ cells in the tumor and galectin-1 in plasma of the CRC patients depending on the genotype of the LGALS1 gene polymorphisms (p 0.05). …”
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Epilepsy is associated with the accelerated aging of brain activity in sleep by Peter N. Hadar, Mike Westmeijer, Mike Westmeijer, Haoqi Sun, Erik-Jan Meulenbrugge, Jin Jing, Luis Paixao, Ryan A. Tesh, Madalena Da Silva Cardoso, Pierrick Arnal, Rhoda Au, Chol Shin, Chol Shin, Soriul Kim, Robert J. Thomas, Sydney S. Cash, M. Brandon Westover

“…Subanalyses were conducted on a subset with NIH Toolbox cognitive testing for total, fluid, and crystallized composite cognition.Results138 patients with epilepsy (32 exclusively focal and 106 generalizable [focal seizures with secondary generalization]) underwent in-patient monitoring, and age-matched, non-epilepsy controls were analyzed. The mean BAI was higher in epilepsy patients vs controls and differed by epilepsy type: −0.05 years (controls) versus 5.02 years (all epilepsy, p &lt; 0.001), 5.53 years (generalizable, p &lt; 0.001), and 3.34 years (focal, p = 0.03). …”
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