NAHP for the Selection of Analgesic Treatments in Third Molar Surgery by Mónica Sofia Pallo Sarabia, Lenin Rubén Imbacuán Jiménez, Marjorie Elizabeth Valdivieso Villacís, Ximena Patricia Pallo Sarabia

“…Yet much of the research conducted fails to combine a systematic selection process with the uncertainty surrounding efficacy versus adverse events versus patientrelated considerations. …”
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The influence of “Efial” medicine on the chondrocytes functional state by N. А. Volkova, А. N. Goltsev, G. I. Borshevskiy, M. I. Borshevskaya

“…Adding the medicine at concentrations from 70 µg/ml to 1.5 µg/ml in a nutrient medium at plating and the on 3-rd cultivation day resulted in a reduction of glycosaminoglycans (GAG) and collagen type II content compared to the control (without medicine). Using the test medicine at concentrations from 0.15 µg/ml to 1.5 ng/ml caused the increase of GAG by 17.1±2.3 % (in conditions of adding at seeding) and by 19.4±2.5 (in conditions of adding on 3-rd cultivation day), and the increase in collagen type II content in the chondrocyte culture by 10.3±1.7 % (in conditions of adding on 3-rd cultivation day) and without effect in conditions of adding when seeding (0.1-1.7 x105 cells) versus the control. …”
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Machine Learning-Driven Transcriptome Analysis of Keratoconus for Predictive Biomarker Identification by Shao-Hsuan Chang, Lung-Kun Yeh, Kuo-Hsuan Hung, Yen-Jung Chiu, Chia-Hsun Hsieh, Chung-Pei Ma

“…<b>Methods:</b> We analyzed the GSE77938 (PRJNA312169) dataset for differential gene expression (DGE) and performed gene set enrichment analysis (GSEA) using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways to identify enriched pathways in keratoconus (KTCN) versus controls. Machine learning algorithms were then used to analyze the gene sets, with SHapley Additive exPlanations (SHAP) applied to assess the contribution of key feature genes in the model’s predictions. …”
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Examining gender as an issue of policy priority: a case study of four Kenyan health policy implementation strategies by Henry Owoko Odero, Doris Kwesiga, Sally Odunga, Damazo T. Kadengye, Sylvia Kiwuwa-Muyingo

“…BackgroundDespite global and national commitments to gender equity, including Sustainable Development Goal 5, health policy processes often fail to adequately integrate gender considerations. …”
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Insulin-like Growth Factor-1 and Myocardial Remodeling in Patients with Chronic Heart Failure of Ischemic Origin by A. N. Zakirova, N. E. Zakirova, D. F. Nizamova

“…The most significant structural-geometric rearrangement of LV and significant deficit of IGF-1 recorded in patients with class IV CHF (95,6±7,02 ng/ml with class IV CHF versus 178,3±11,36 ng/ml and 124,3±9,14 ng/ml with class II and III CHF; р&lt;0,05). …”
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Demonstration of the presence of the "deleted" MIR122 gene in HepG2 cells. by Ibrahim A Y Hamad, Yue Fei, Anastasia Z Kalea, Dan Yin, Andrew J P Smith, Jutta Palmen, Steve E Humphries, Philippa J Talmud, Ann P Walker

“…MicroRNA 122 (miR-122) is highly expressed in the liver where it influences diverse biological processes and pathways, including hepatitis C virus replication and metabolism of iron and cholesterol. …”
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Driving factors and management strategies for water quality improvement in Fuxian Lake, China: A case study on ecological restoration and sustainable management of plateau lakes by Huimei Wang, Nuruol Syuhadaa Mohd

“…By using a mixed-methods approach that integrates 34-year monitoring data (1990–2024) with principal component analysis (PCA), Statistical trend analyses (Mann-Kendall test with Sen’s slope), combined with geospatial visualization (GIS, kriging interpolation), Correlation networks (Pearson) and constrained ordination (Redundancy Analysis, RDA), we quantified the temporal-spatial dynamics of water quality parameters (TN, TP, COD), pinpointed dominant pollution pathways, and evaluated the cumulative efficacy of policy interventions versus climatic drivers. Our analysis demonstrates that stringent pollution source control, particularly in agricultural and urban runoff management, coupled with large-scale wetland restoration projects, has been instrumental in reducing nutrient inputs. …”
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DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer by Annalisa Di Cello, Maddalena Di Sanzo, Francesca Marta Perrone, Gianluca Santamaria, Erika Rania, Elvira Angotti, Roberta Venturella, Serafina Mancuso, Fulvio Zullo, Giovanni Cuda, Francesco Costanzo

“…The results demonstrate that DJ-1 levels are significantly higher in cases versus controls and in high- versus low-risk patients. …”
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Altered Chemokine Signalling in Endothelial Progenitor Cells from Acute Ulcerative Colitis Patients by L. De Toni, A. Di Nisio, S. Magagna, A. Michielan, M. Martinato, G. C. Sturniolo, R. D’Incà, C. Foresta, A. Garolla

“…We report an overall decrease of EPCs in UC patients (controls = 97,94 ± 37,34 cells/mL; acute = 31,10 ± 25,38 cells/mL; remitting = 30,33 ± 19,02 cells/mL; P<0.001 for both UC groups versus controls). …”
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The Cognivue Amyloid Risk Measure (CARM): A Novel Method to Predict the Presence of Amyloid with Cognivue Clarity by James E. Galvin, Michael J. Kleiman, Heather M. Harris, Paul W. Estes

“…Three Cognivue Clarity subtests differentiated between True Controls and pAD, and between cognitive impairment due to AD versus non-AD processes. …”
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The effect of surface-modified silver nanoparticles on the inflammatory component of the intragingival peri-implant area by D. Ya. Maksymov, O. M. Mishchenko

“…There was no statistically significant difference in bleeding level 0 between Groups 1 and 2, but the study group was significantly different from the control group (p < 0.001). According to the bleeding level 3, there was a statistically significant difference between Groups 1 and 2, the study group was (12.7 %) versus 48.5 % (p < 0.001). …”
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FUNCTIONAL STATE OF THE MASTICATORY MUSCLES OF PATIENTS WITH DEFECTS OF DENTITION, WHICH ARE COMPLICATED BY DENTOALVEOLAR DEFORMITIES by O. V. Bida, Yu. I. Zabuha

“…Values of “K” coefficient is significantly higher than in the control group, which indicates a significant negative trend of functional bioelectric activity 1,72 ± 0,03 and 1,79 ± 0,04 for right and left masseter muscles, respectively, versus 1,04 ± 0,04 and 1,05 ± 0,04 respectively for the right and left of the chewing muscles in the control group. …”
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Oxidative Damage to the Salivary Glands of Rats with Streptozotocin-Induced Diabetes-Temporal Study: Oxidative Stress and Diabetic Salivary Glands by M. Knaś, M. Maciejczyk, I. Daniszewska, A. Klimiuk, J. Matczuk, U. Kołodziej, D. Waszkiel, J. R. Ładny, M. Żendzian-Piotrowska, A. Zalewska

“…The unstimulated salivary flow in DM rats was reduced in the 2nd week, while the stimulated flow was decreased throughout the duration of the experiment versus control. OSI was elevated in both diabetic glands in the 1st and 2nd week, whereas 8-isoP and 8-OHdG were higher only in the parotid gland in the second week. …”
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Role of IL-6 in the immunopathogenesis of mild, moderate and severe TBI by A. O. Norka, S. V. Vorobyev, R. N. Kuznetsova, S. V. Lapin, Z. R. Korobova, D. N. Monashenko, Areg A. Totolian

“…An increased content was found in all patients with traumatic brain injury: 19.59 pg/mL in the group with mild traumatic brain injury; 103.6 pg/mL in the group with moderate traumatic brain injury; and 2225 pg/mL in the group with severe traumatic brain injury load versus 2.58 pg/mL in the control group. A direct correlation was found with the presence of basic myelin proteins in the cerebrospinal fluid, which indicates the degree of damage and neurodegeneration processes. …”
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Transdiagnostic Anxiety-Related Increases in Information Sampling are Associated With Altered Valuation by Amy M. Rapp, Brandon K. Ashinoff, Seth Baker, H. Blair Simpson, Guillermo Horga

“…To address this, computational models of inference and valuation were applied to data collected from a transdiagnostic sample of adults with and without an anxiety or compulsive disorder using a version of the beads task with enhanced experimental controls. Participants diagnosed with an anxiety or compulsive disorder (n = 35) and healthy controls (n = 23) completed the beads task with three majority-to-minority ratios of blue versus green beads (60:40, 75:25, 90:10). …”
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How to utilize far-red photons effectively: substitution or supplementation with photosynthetically active radiation? A case study of greenhouse lettuce by Zhengnan Yan, Xin Li, Zhixin Li, Jinxiu Song, Haijie Dou, Yanjie Yang, Geng Zhang

“…However, current relevant studies seldom consider comprehensive and systematic comparisons of the efficacy of different approaches: substitution versus supplementation. The present work aimed to compare the two aforementioned strategies, evaluate how they impact plant growth, development and metabolic processes, and analyse the light use efficiency. …”
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Toward Fine Horizontal Resolution Global Simulations of Aerosol Sectional Microphysics: Advances Enabled by GCHP‐TOMAS by Betty Croft, Randall V. Martin, Rachel Y.‐W. Chang, Liam Bindle, Sebastian D. Eastham, Lucas A. Estrada, Bonne Ford, Chi Li, Michael S. Long, Elizabeth W. Lundgren, Saptarshi Sinha, Melissa P. Sulprizio, Yidan Tang, Aaron vanDonkelaar, Robert M. Yantosca, Dandan Zhang, Haihui Zhu, Jeffrey R. Pierce

“…These nonlinear effects have the potential to revise current understanding of processes controlling global aerosol number and aerosol impacts on Earth's climate and air quality.…”
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Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer’s disease by Sulochan Malla, Sulochan Malla, Annie G. Bryant, Annie G. Bryant, Rojashree Jayakumar, Benjamin Woost, Nina Wolf, Andrew Li, Sudeshna Das, Sudeshna Das, Susanne J. van Veluw, Susanne J. van Veluw, Rachel E. Bennett, Rachel E. Bennett

“…Finally, comparing gene expression profiles between AD individuals with high- versus low-WMH burden showed an increased expression of pathways associated with immune function. …”
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Self-aligning prosthetic device for older patients with vascular-related amputations: protocol for a randomised feasibility study (the STEPFORWARD study) by Elizabeth Coleman, Catriona McDaid, Natasha Mitchell, Judith Watson, Kerry Bell, Cleveland Barnett, Martin Twiste, Fergus Jepson, Abayomi Salawu, Dennis Harrison, Natalie Vanicek

“…This trial will establish the feasibility of conducting a large-scale trial to assess the effectiveness and cost-effectiveness of a self-aligning prosthesis for older patients with vascular-related amputations and other health issues compared with a standard prosthesis.Methods and analysis This feasibility trial is a pragmatic, parallel group, randomised controlled trial (RCT) comparing standard treatment with a more rigid prosthesis versus a self-aligning prosthesis. …”
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Side of Onset in Parkinson’s Disease and Alterations in Religiosity: Novel Behavioral Phenotypes by Paul M. Butler, Patrick McNamara, Raymon Durso

“…In this paper we assess processing dynamics of religious cognition in patients with Parkinson’s disease (PD). …”
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