The effects of far-red light on medicinal Cannabis by Tyson J. Peterswald, Jos C. Mieog, Tobias Kretzschmar, Sarah J. Purdy

“…In Hindu Kush the concentration of THC was elevated by the addition of 4 h of total FR (“10L_2_2D”), and in Northern Lights total cannabinoid yields were increased by nearly 70% over the 12 L control (0.43 versus 0.25 g Plant− 1) by the addition of 2 h of FR in darkness after 10 h of light (“10L_2D”). …”
Get full text

Elevated Expression of <i>TGFB1</i> in PBMCs Is Associated with Intracranial Aneurysm Formation, but <i>TGFB3</i> Expression Implicated Rupture by Kinga Sutkowska, Olga Martyna Koper-Lenkiewicz, Marta Żebrowska-Nawrocka, Marta Jakoniuk, Tomasz Łysoń, Marzena Tylicka, Ewa Balcerczak, Joanna Matowicka-Karna, Joanna Kamińska

“…The expression of <i>TGFB1</i> was significantly higher in the IA versus C group, but <i>TGFB3</i> expression was significantly higher in the RIA versus C group. …”
Get full text

The Creation of Artificial Data for Training a Neural Network Using the Example of a Conveyor Production Line for Flooring by Alexey Zaripov, Roman Kulshin, Anatoly Sidorov

“…As a tool-platform solution, the concept of digital twins for simulating technological processes was considered, within which synthetic data is utilized. …”
Get full text

A Multimodal Approach for Early Identification of Mild Cognitive Impairment and Alzheimer&#x2019;s Disease With Fusion Network Using Eye Movements and Speech by Hasnain Ali Shah, Sami Andberg, Anne M. Koivisto, Roman Bednarik

“…In this study, we analyzed a multimodal clinical eye-tracking and speech dataset collected from 78 participants (37 controls, 20 MCI, and 21 AD) during the King-Devick test and a reading task to classify and diagnose MCI/AD versus healthy controls. …”
Get full text

Application of mass spectrometry to elucidate the pathophysiology of Encephalitozoon cuniculi infection in rabbits. by Guillaume Desoubeaux, Maria Del Carmen Piqueras, Ana Pantin, Sanjoy K Bhattacharya, Roman Peschke, Anja Joachim, Carolyn Cray

“…In addition, there was a significant increase of nine host proteins in blood samples from E. cuniculi-diseased rabbits in comparison with non-diseased control subjects undergoing various inflammatory processes. …”
Get full text

XSQ-Learning: Adaptive Similarity Thresholds for Accelerated and Stable Q-Learning by Ansel Y. Rodríguez González, Roberto E. López Díaz, Shender M. Ávila Sansores, María G. Sánchez Cervantes

“…Our experiments demonstrate that XSQ-Learning can reduce the required iterations by 36.83% compared to standard Q-learning and by 24.43% versus state-of-the-art similarity-based methods, while maintaining policy stability. …”
Get full text

Identification of Critical Molecular Pathways Induced by HDAC11 Overexpression in Cardiac Mesenchymal Stem Cells by Chongyu Zhang, Neal L. Weintraub, Yaoliang Tang

“…To investigate the effects of HDAC11 overexpression on the gene regulatory networks in CMSCs, we treated mouse CMSCs with an adenoviral vector encoding human HDAC11 (Ad-HDAC11) versus adenoviral GFP (Ad-GFP) as a control. Gene expression and pathway enrichment were assessed using RNA sequencing (RNA-seq), and HDAC11 overexpression was validated at the RNA and protein levels through qRT-PCR and Western blot. …”
Get full text

Quantifying the effects of water management decisions on streambank stability by Q. Wei, A. Brookfield, A. Layzell

“…Hydrological conditions, which are often controlled by water management decisions and infrastructure (e.g., reservoirs and dams), are a major factor affecting streambank erosion and stability. …”
Get full text

CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitis by Shenjian Ai, Artem Arutyunov, Joshua Liu, Jeremy D. Hill, Xiaoping Jiang, Robyn S. Klein

“…Using CCR2-deficient mice, we determined that CCR2 expression is not essential for CNS T cell recruitment or virologic control during acute WNV infection. However, transcriptomic analyses of forebrain CCR2+ versus CCR2− CD8 TRM during WNV recovery reveal that CCR2 signaling significantly regulates hippocampal CD8 TRM phenotype and function via extrinsic and intrinsic effects, limiting expression of CD103, granzyme A and IFN-γ, respectively, and increasing the percentages of virus-specific CD8 T cells. …”
Get full text

Prognostic Significance of Circulating and Endothelial Progenitor Cell Markers in Type 2 Diabetic Foot by Maria Sambataro, Elena Seganfreddo, Fabio Canal, Anna Furlan, Laura del Pup, Monia Niero, Agostino Paccagnella, Filippo Gherlinzoni, Angelo Paolo dei Tos

“…CD34+ and CD133+ were reduced in N, N1, and N2 versus C, and CD34+ were lower in N2 versus N1 (P=0.03). …”
Get full text

Gray Matter Differences in Adolescent Psychiatric Inpatients: A Machine Learning Study of Bipolar Disorder and Other Psychopathologies by Renata Rozovsky, Maria Wolfe, Halimah Abdul‐waalee, Mariah Chobany, Greeshma Malgireddy, Jonathan A. Hart, Brianna Lepore, Farzan Vahedifard, Mary L. Phillips, Boris Birmaher, Alex Skeba, Rasim S. Diler, Michele A. Bertocci

“…The most discriminative GMVs that contributed to the classification were in areas associated with movement, sensory processing, and cognitive control. Correlations between these GMVs and self‐reported mania, negative affect, or anxiety were observed in all inpatient groups. …”
Get full text

An investigation of plasma cell-free RNA for the detection of colorectal cancer: From transcriptome marker selection to targeted validation. by Emmalee J Northrop-Albrecht, Chung Wah Wu, Calise K Berger, William R Taylor, Patrick H Foote, Karen A Doering, Anna M Gonser, Aditya Bhagwate, Zhifu Sun, Douglas W Mahoney, Kelli N Burger, Lisa A Boardman, John B Kisiel

“…There were 895 exons that were differentially expressed (325 upregulated, 570 downregulated) among cancers versus controls. In phases 2 and 3, fewer markers were validated than expected in independent sets of patients, most of which were from previously published literature (FGA, FGB, GPR107, CDH3, and RP23AP7). …”
Get full text

Association Between Endothelial Alterations, Cardiac Function, and Outcomes From Health to Heart Failure: Insight From the STANISLAS, MEDIA‐DHF, and BIOSTAT‐CHF Cohorts by Jeremy Lagrange, Mohammad Jahangiri, Guillaume Baudry, Nathalie Mercier, Luca Monzo, Zohra Lamiral, Kévin Duarte, Jozine M ter Maaten, Faiez Zannad, Adriaan A. Voors, Nicolas Girerd

“…Results In patients with HFpEF, perlecan but not thrombomodulin was increased compared with controls (P<0.0001 versus P=0.73). In adjusted analysis, perlecan was associated with peak early mitral inflow velocity/peak early diastolic mitral annular velocity ratio and thrombomodulin with peak early diastolic mitral annular velocity in control individuals, whereas perlecan and thrombomodulin were associated with peak early mitral inflow velocity/peak early diastolic mitral annular velocity and left atrial volume index in patients with HFpEF (all P<0.03). …”
Get full text

Eggshell Quality Traits and Transcriptome Gene Screening Between Yunnong and Jingfen Chicken Breeds by Zijian Li, Hao Wu, Jing Fu, Maida Mushtaq, Muhammad Khan, Yong Liu, Zobia Azeem, Hongmei Shi, Yang He, Ru Zhang, Muhammad Aziz Ur Rahman, Jiajia Kang, Changrong Ge, Kun Wang

“…This study aimed to compare eggshell quality traits and identify genetic markers in YN chickens versus commercial Jingfen chickens (JF). A total of 400 chicks (200 per breed) were reared for 300 days under controlled conditions. …”
Get full text

Albumin treatment of critical conditions on the example of pre-eclampsia by O. M. Klygunenko, O. V. Kravets, O. O. Zozulya, O. O. Marzan, Yu. O. Ploshchenko, V. A. Sedinkin, D. M. Stanin

“…The use of albumin infusion in combination with low doses of furosemide according to the method developed by us has proven the possibility to correct the inflammatory process activity. So, with infusions on the 1st day postpartum, the IL-6 / IL-10 ratio was decreased and exceeded the norm for non-pregnant women by 866.7 % versus 1696.7 % in Group 1 women. …”
Get full text

A Randomized Open Clinical Study of the Atherosclerosis Treatment Information Video Effect on Adherence to Long-Term Therapy in Patients with Cardiovascular Diseases by Yu. V. Bulaeva, E. A. Naumova, O. N. Semenova, T. V. Kanaeva, K. A. Popov, А. R. Tyapayeva

“…After 1 month, 38 (70%) patients in the intervention group continued taking statins versus 29 (43%) respondents in the control group (p&lt;0.05), 3 months after discharge, 40 (80%) patients in the intervention group continued to take statins versus 33 (69%) control patients (p&lt;0.09).Conclusion. …”
Get full text

Efficacy of Hank's balanced salt solution compared to other solutions in the preservation of the periodontal ligament. A systematic review and meta-analysis. by Nathalia Carolina Fernandes Fagundes, Leonardo Oliveira Bittencourt, Marcela Baraúna Magno, Márcia Martins Marques, Lucianne Cople Maia, Rafael Rodrigues Lima

“…The searches, selection process, data extraction and Risk of Bias control were conducted according to Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. …”
Get full text

Peculiarities of the Lifestyle and Psychological State of Primary Schoolchildren with Bronchial Asthma by Alexandra M. Timofeeva

“…It is shown that the lifestyle of primary schoolchildren changed due to illness distorts the process of personality development and leads to the emergence of difficulties in the emotional and personality sphere: a reduced background of mood (35; 46.6% versus 11; 20%), blockage of experiences and difficulties in their verbalization (56; 75% versus 25; 46%), defensive-aggressive type of behavior in a stress situation (68; 91% versus 25; 46%), pronounced intrapersonal conflict (47; 62% versus 32; 59%), and communication problems (unsociability, restriction in communication, social fears). …”
Get full text

Changes in runoff from major alpine watersheds on the Qinghai-Tibetan plateau: A review by Guohui Li, Zongxing Li, Baoqing Zhang, Zongjie Li

“…This study systematically evaluates: (1) shifts in runoff recharge mechanisms under climate warming, (2) the relative contributions of precipitation, groundwater, and cryospheric meltwater to runoff generation, and (3) the differential impacts of climate change versus anthropogenic activities on hydrological processes. …”
Get full text

Crotonylation deficiency of S100A7 K49 promotes psoriatic keratinocyte proliferation through enhanced interaction with RAGE by Huifang Liang, Ying Wang, Junqin Li, Kaiming Zhang

“…To investigate the profile of lysine crotonylation and its pathogenic role in psoriasis, we conducted a comparative analysis of crotonylation-modified proteins in psoriatic lesions versus healthy controls. Mutant keratinocytes with crotonylation deficiency of S100A7 were generated to explore its functional effects in psoriasis. …”
Get full text