Toward Fine Horizontal Resolution Global Simulations of Aerosol Sectional Microphysics: Advances Enabled by GCHP‐TOMAS by Betty Croft, Randall V. Martin, Rachel Y.‐W. Chang, Liam Bindle, Sebastian D. Eastham, Lucas A. Estrada, Bonne Ford, Chi Li, Michael S. Long, Elizabeth W. Lundgren, Saptarshi Sinha, Melissa P. Sulprizio, Yidan Tang, Aaron vanDonkelaar, Robert M. Yantosca, Dandan Zhang, Haihui Zhu, Jeffrey R. Pierce

“…These nonlinear effects have the potential to revise current understanding of processes controlling global aerosol number and aerosol impacts on Earth's climate and air quality.…”
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Identification of cerebrospinal fluid pharmacodynamic biomarkers and molecular correlates of brain activity in a Phase 2 clinical trial of the Alzheimer's disease drug candidate CT... by Valentina Di Caro, Eunah Cho, Hilary A. North, Jill Caldwell, Kiran Pandey, Duc Duong, Michael Grundman, Willem deHaan, Everard G. Vijverberg, Charlotte E. Teunissen, Anthony O. Caggiano, Nicholas T. Seyfried, Mary E. Hamby

“…RESULTS Biomarkers found through proteomics analyses to be significantly differentially abundant in CT1812‐ versus placebo‐treated participants supported pathway engagement and proof of mechanism for CT1812. …”
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Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

“…Here, to improve knowledge of the biological processes involved in trypanotolerance versus trypanosusceptibility, we identified bovine genes differentially expressed in five West African cattle breeds during an experimental infection by Trypanosoma congolense and their biological functions. …”
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The cerebellum is involved in implicit motor sequence learning by Mahyar Firouzi, Mahyar Firouzi, Mahyar Firouzi, Mahyar Firouzi, Kris Baetens, Kris Baetens, Catalina Duta, Catalina Duta, Chris Baeken, Chris Baeken, Chris Baeken, Frank Van Overwalle, Frank Van Overwalle, Eva Swinnen, Eva Swinnen, Eva Swinnen, Natacha Deroost, Natacha Deroost

“…Accuracy-based analyses revealed that anodal tDCS reduced the probability of correct responses occurring in random trials versus sequential trials by 1.17%, p = 0.009, whereas sham tDCS had no effect, p = 0.999.ConclusionOur finding of enhanced sequence-specific learning, but not general learning, suggests that the cerebellar network not only plays a role in error correction processes, but also serves a sequence-specific function within the integrated motor learning network that connects the basal ganglia and cerebellum.…”
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Microstructural integrity of autonomic central nervous tracts is linked to cardiovascular health by Janis M. Nolde, Alexander Rau, Elias Kellner, Horst Urbach, Cornelius Weiller, Fabian Bamberg, Jakob Weiss, Marco Reisert, Jonas A. Hosp

“…Introduction: The central autonomic network (CAN), which controls sympathetic and parasympathetic activity, plays a central role in the pathogenesis of cardiovascular disease and serves as a target for therapeutic approaches. …”
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Pomegranate juice treatment reverses carbon tetrachloride (CCl4)-induced increased acetylcholinesterase activity and cell death via suppression of oxidative stress in rats by Ömer Faruk Kalkan, Ahmet Türk, Cihan Çitil, Miraç Uçkun, Ahmet Özkaya, Ertan Yoloğlu, Yusuf Özay, Şeyda Çağri Bülbül, Zafer Şahin, Akın Kirbaş

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The effectiveness of using web quest strategies and digital stories in the development of critical thinking, higher level thinking skills, and the progress of fifth grade history l... by Reza Abbashassan Nasrolah, Mohammad hassani

“…The current study is a quasi-experimental study along with a pre-test-post-test design with a control group. The statistical population of the research is 860 fifth grade literature students, 45 of whom were selected by multi-stage cluster sampling and randomly divided into three groups of 15 (a control group of 15 and two experimental groups of the rest 30). …”
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Tumor treating fields combined with ionizing radiation inhibit the malignant phenotype of lung cancer brain metastasis cells by suppressing DNA damage repair pathways by Guilong Tanzhu, Haiqin Peng, Liu Chen, Gang Xiao, Jiaoyang Ning, Ling Chen, Rongrong Zhou

“…The experiments included four groups: Control, 6 Gy, TTFields, and 6 Gy + TTFields group. …”
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Effect of IL4-589C>T, FCGR2A-166His>Arg, DEFB1-20G>A, DEFB1-52G>A gene polymorphisms on TNFα, IL-1β, IL-4, and IL-10 contents in the patients with primary hip osteoarthrosis by A. M. Miromanov, T. V. Zabello, N. A. Miromanova

“…The data were statistically processed using STATISTICA 6.1 software package (StatSoft, USA), Microsoft Office Excel 2019 for Windows 10. …”
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Rapid tests to inform triage and antibiotic prescribing decisions for adults presenting with suspected acute respiratory infection: a rapid evidence synthesis of clinical effective... by Katie Scandrett, Jill Colquitt, Rachel Court, Fiona Whiter, Bethany Shinkins, Yemisi Takwoingi, Emma Loveman, Daniel Todkill, Paramjit Gill, Daniel Lasserson, Lena Al-Khudairy, Amy Grove, Yen-Fu Chen

“…Methods Searches for systematic reviews, randomised controlled trials and cost–utility studies were conducted in May 2023. …”
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MOLECULAR GENETIC TESTING OF ACCP-POSITIVE PATIENTS WITH RHEUMATOID ARTHRITIS AND HIGH INFLAMMATORY DISEASE ACTIVITY (A REMARCA STUDY) by I. A. Guseva, E. L. Luchikhina, N. V. Demidova, A. S. Avdeeva, N. E. Soroka, D. D. Abramov, M. V. Cherkasova, E. Yu. Samarkina, D. E. Karateev, E. L. Nasonov

“…We assume that the high inflammatory activity of RA may be determined by the genes, the products of which trigger inflammatory processes.Objective: to investigate allele and genotype distribution of gene polymorphic variants in active anti-cyclic citrullinated peptide (aCCP)-positive patients with RA from the REMARCA program versus a control group of healthy blood donors.Subjects and methods. …”
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Identification and validation of key biomarkers associated with immune and oxidative stress for preeclampsia by WGCNA and machine learning by Tiantian Yu, Tiantian Yu, Tiantian Yu, Guiying Wang, Guiying Wang, Guiying Wang, Xia Xu, Xia Xu, Xia Xu, Jianying Yan, Jianying Yan, Jianying Yan

“…KEGG analysis revealed that LEP was significantly enriched in “allograft rejection,” “antigen processing,” “ECM receptor interaction” and “graft versus host disease.” …”
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KEAP1 mutations as key crucial prognostic biomarkers for resistance to KRAS-G12C inhibitors by Linyan Tian, Chengming Liu, Sufei Zheng, Huiyang Shi, Fang Wei, Wenxin Jiang, Yucheng Dong, Haiyan Xu, Enzhi Yin, Nan Sun, Jie He, Yan Wang

“…Validation studies in NCI-H358 cells showed a marked increase in IC50 values for AMG510, MRTX849, and JAB-21822 after KEAP1 knockout (P < 0.0001), with IC50 values rising from 27.78 nm, 116.9 nm, and 118.7 nm in controls, respectively. Comparative analysis of differentially expressed genes in KEAP1 knockout cells versus controls, utilizing GO, KEGG, and Reactome pathway analyses, revealed substantial enrichment in pathways linked to extracellular matrix organization and cell adhesion processes. …”
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Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning by Raul Castellanos-Moreira, Diego Benavent, Alejandra López Robles, Ernesto Trallero-Araguás, Lucía Silva-Fernández, Juliana Restrepo, Jose A Román Ivorra, Maria Lopez Lasanta, Laura Cebrián, Leticia Lojo, Belén López-Muñíz, Julia Fernández-Melon, Belén Núñez, Raúl Veiga Cabello, Pilar Ahijado, Isabel De la Morena Barrio, Nerea Costas Torrijo, Belén Safont, Enrique Ornilla, Arantxa Campo, Jose L Andreu, Elvira Díez, Elena Bollo, David Vilanova, Sara Luján Valdés

“…This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with and without ILD using natural language processing (NLP) on electronic health records (EHR).Methods Observational case–control, retrospective and multicentre study based on the secondary use of unstructured clinical data from patients with adult RA and RAILD from nine hospitals between 2014 and 2019. …”
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Characterization of Netrin-1 and Its Receptors UNC5B and Neogenin-1 in a Rat Rotator Cuff Tear Model: Associations with Inflammatory Mediators and Neurite Extension by Kosuke Inoue, Kentaro Uchida, Mitsuyoshi Matsumoto, Ryo Tazawa, Etsuro Ohta, Akito Hattori, Tomonori Kenmoku, Yuka Ito, Yui Uekusa, Gen Inoue, Masashi Takaso

“…In injured tendons, <i>Ntn1</i> mRNA increased significantly at day 14 (<i>p</i> = 0.010) and 28 (<i>p</i> = 0.042), <i>Unc5b</i> at day 7 (<i>p</i> = 0.002) and 14 (<i>p</i> < 0.001), and <i>Neo1</i> at day 14 (<i>p</i> < 0.001) versus intact controls. Tenocyte exposure to 500 ng/mL netrin-1 induced transient upregulation of <i>Tnfa</i> (3 h, <i>p</i> = 0.023; 6 h, <i>p</i> = 0.009) and <i>Il6</i> (3 h–24 h, all <i>p</i> < 0.013), as well as <i>Mmp3</i> (3–24 h, <i>p</i> < 0.043) and <i>Mmp1</i> (6 h–24 h, <i>p</i> < 0.024); no induction was observed at 50 ng/mL. …”
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The role of collagen type VI alpha 6 chain as a potential tumor suppressor in breast cancer: an immune regulation perspective by Jian-Di Li, Li-Li Deng, Jia-Yuan Luo, Chao-Hua Mo, Bang-Teng Chi, Wan-Ying Huang, Rong-Quan He, Di-Yuan Qin, Chang Song, Wen Zou, Gang Chen

“…Integrated analysis confirmed COL6A6 downregulation in 4818 breast cancer tissues versus 1236 non-breast-cancer tissues (standardized mean difference =  − 1.27 [− 1.66, − 0.87]), supported by single-cell RNA sequencing. …”
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Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis by Ioannis Parodis, Julius Lindblom, Daniel Toro-Domínguez, Lorenzo Beretta, Maria O. Borghi, Jessica Castillo, Elena Carnero-Montoro, Yvonne Enman, Chandra Mohan, Marta E. Alarcón-Riquelme, Guillermo Barturen, Dionysis Nikolopoulos, Lorenzo Beretta, Barbara Vigone, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec, Divi Cornec, Sandrine Jousse-Joulin, Bernard Lauwerys, Julie Ducreux, Anne-Lise Maudoux, Carlos Vasconcelos, Ana Tavares, Esmeralda Neves, Raquel Faria, Mariana Brandão, Ana Campar, António Marinho, Fátima Farinha, Isabel Almeida, Miguel Angel Gonzalez-Gay Mantecón, Ricardo Blanco Alonso, Alfonso Corrales Martínez, Ricard Cervera, Ignasi Rodríguez-Pintó, Gerard Espinosa, Rik Lories, Ellen De Langhe, Nicolas Hunzelmann, Doreen Belz, Torsten Witte, Niklas Baerlecken, Georg Stummvoll, Michael Zauner, Michaela Lehner, Eduardo Collantes, Rafaela Ortega-Castro, Ma Angeles Aguirre-Zamorano, Alejandro Escudero-Contreras, Ma Carmen Castro-Villegas, Norberto Ortego, María Concepción Fernández Roldán, Enrique Raya, Inmaculada Jiménez Moleón, Enrique de Ramon, Isabel Díaz Quintero, Pier Luigi Meroni, Maria Gerosa, Tommaso Schioppo, Carolina Artusi, Carlo Chizzolini, Aleksandra Zuber, Donatienne Wynar, Laszló Kovács, Attila Balog, Magdolna Deák, Márta Bocskai, Sonja Dulic, Gabriella Kádár, Falk Hiepe, Velia Gerl, Silvia Thiel, Manuel Rodriguez Maresca, Antonio López-Berrio, Rocío Aguilar-Quesada, Héctor Navarro-Linares

“…Methods: We analyzed differentially expressed genes (DEGs) in peripheral blood from patients with active LN (n = 41) and active nonrenal lupus (n = 62) versus healthy controls (HCs) (n = 497) from the European PRECISESADS project (NTC02890121), and dysregulated gene modules in a discovery (n = 26) and a replication (n = 15) set of active LN cases. …”
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The Efficiency of Complex Differential Treatment of the Patients with Systemic Lupus Erythematous Considering the Features of Bone Tissue Structure Remodeling by Abrahamovych U., Tsyhanyk L., Abrahamovych O., Farmaha M., Romaniuk O.

“…Systemic lupus erythematous (SLE) is an autoimmune disease with peculiar plural and pathological processes in different organs and systems including bone tissue. …”
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Immunomodulatory effects of intratumoral cowpea mosaic virus and calreticulin nanoparticles in canine tumors: early results by Akansha Singh, Jessica Fernanda Affonso de Oliveira, Jessica Fernanda Affonso de Oliveira, Jessica Fernanda Affonso de Oliveira, Jessica Schrader, Deepan Kishore, Sri Vidhya Chandrasekar, Steven Fiering, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Nicole F. Steinmetz, Ashish Ranjan

“…CPMV, in particular, upregulated genes involved in antigen processing and immune activation while enhancing IFNγ+ CD4+ and CD8+ T cell populations. …”
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Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT by Zoë Hoare, Clare Wilkinson, Dyfrig A Hughes, Anthony Byrne, Annmarie Nelson, Julia Hiscock, Bee Wee, Marlise Poolman, Annie Hendry, Stella Wright, Paul Perkins, Anne Parkinson, Emily Holmes, Liz Reymond, Betty Foster, Julie O’Connor, Penney Lewis, Nia Goulden, Rossella Roberts, Sian Roberts

“…Objectives To determine if carer administration of as-needed subcutaneous medication for common breakthrough symptoms in people dying at home is feasible and acceptable in the UK, and if it would be feasible to test this intervention in a future definitive randomised controlled trial.Design We conducted a two-arm, parallel-group, individually randomised, open pilot trial of the intervention versus usual care, with a 1:1 allocation ratio, using convergent mixed methods.Setting Home-based care without 24/7 paid care provision, in three UK sites.Participants Participants were dyads of adult patients and carers: patients in the last weeks of their life who wished to die at home and lay carers who were willing to be trained to give subcutaneous medication. …”
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