Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes. by Josine L Min, George Nicholson, Ingileif Halgrimsdottir, Kristian Almstrup, Andreas Petri, Amy Barrett, Mary Travers, Nigel W Rayner, Reedik Mägi, Fredrik H Pettersson, John Broxholme, Matt J Neville, Quin F Wills, Jane Cheeseman, GIANT Consortium, MolPAGE Consortium, Maxine Allen, Chris C Holmes, Tim D Spector, Jan Fleckner, Mark I McCarthy, Fredrik Karpe, Cecilia M Lindgren, Krina T Zondervan

“…In an independent cohort of 145/141 twins with ABD and WB longitudinal expression data, median variability in ABD due to familiality was greater for MetS-associated versus un-associated modules (ABD: 0.48 versus 0.18, P = 0.08; GLU: 0.54 versus 0.20, P = 7.8×10(-4)). …”
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The effect of vitamin D provision on biomarkers of inflammation in bronchial asthma in children by N. A. Belykh, I. V. Pisnyur, A. A. Nikiforov, L. V. Nikiforova

“…Therefore, the search for factors influencing this process, as well as biomarkers reflecting the degree of asthma control, is an urgent problem.   …”
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Webuye Health and Demographic Surveillance Systems Baseline Survey of Soil-Transmitted Helminths and Intestinal Protozoa among Children up to Five Years by A. A. Obala, C. J. Simiyu, D. O. Odhiambo, V. Nanyu, P. Chege, R. Downing, E. Mwaliko, A. W. Mwangi, D. Menya, D. Chelagat, H. D. N. Nyamogoba, P. O. Ayuo, W. P. O'Meara, M. Twagirumukiza, D. Vandenbroek, B. B. O. Otsyula, J. de Maeseneer

“…Community-based health promotion techniques are recommended for controlling these parasites.…”
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Experiences and perceptions of Chinese patients enrolled in a clinical trial assessing tuina and manual therapies for knee osteoarthritis: a nested qualitative study by Luping Liu, Lingyun Zhang, Sina Li, Meiling Cai, Siyu Han, Zhiwen Weng, Qianji Chen, Yixuan Gao, Xiaoming Yang, Yang Zhang, Duoduo Li, Changxin Liu, Ya’nan Sun, Xiyou Wang, Changhe Yu

“…Methods Participants with KOA were sampled using a simple sampling method from a randomized controlled trial of Tuina treatment versus manual physical therapy (MPT). …”
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Evaluation of Grouting Effectiveness on Cracks in Cement-Stabilized Macadam Layer Based on Pavement Mechanical Response Using FBG Sensors by Min Zhang, Hongbin Hu, Cheng Ren, Zekun Shang, Xianyong Ma

“…The developed methodology provides critical insights for grout material selection, construction process optimization, and post-treatment maintenance strategies, advancing quality control protocols in pavement rehabilitation engineering.…”
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Assessment of the Prevalence and Epidemic Spread of Strains of Ancient, and Modern Sublineages of the Mycobacterium tuberculosis Beijing Genotype in Omsk Region by O. A. Pasechnik, A. A. Vyazovaya, A. I. Bloch, I. V. Yarusova, M. P. Tatarintseva, I. V. Mokrousov

“…The spread of the epidemic and resistant Mycobacterium tuberculosis genotypes presents a serious threat to the implementation of the national tuberculosis control program in Russia. The study aimed to assess the trends in the development of the epidemic process of tuberculosis and the prevalence of strains of different sublineages and clusters of the M. tuberculosis Beijing genotype in the Omsk region. …”
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Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway by Mengming Hu, Matthew B. Veldman

“…Results LCM-seq comparison of uninjured versus 3-day post ON injury RGCs identified significant upregulation of the cholesterol synthesis pathway during axon regeneration. …”
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Risks and benefits of artificial intelligence deepfakes: Systematic review and comparison of public attitudes in seven European Countries by Nik Hynek, Beata Gavurova, Matus Kubak

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Driving factors and management strategies for water quality improvement in Fuxian Lake, China: A case study on ecological restoration and sustainable management of plateau lakes by Huimei Wang, Nuruol Syuhadaa Mohd

“…By using a mixed-methods approach that integrates 34-year monitoring data (1990–2024) with principal component analysis (PCA), Statistical trend analyses (Mann-Kendall test with Sen’s slope), combined with geospatial visualization (GIS, kriging interpolation), Correlation networks (Pearson) and constrained ordination (Redundancy Analysis, RDA), we quantified the temporal-spatial dynamics of water quality parameters (TN, TP, COD), pinpointed dominant pollution pathways, and evaluated the cumulative efficacy of policy interventions versus climatic drivers. Our analysis demonstrates that stringent pollution source control, particularly in agricultural and urban runoff management, coupled with large-scale wetland restoration projects, has been instrumental in reducing nutrient inputs. …”
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Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study by A. A. Vizel, D. A. Culver, I. Yu. Vizel, G. R. Shakirova, E. A. Bakunina

“…The only sign that statistically distinguished the groups was a high frequency of complaints about weakness in those who received vitamin E – 55% versus 30% (p < 0.05). The follow-up period for patients in both groups was a year or more (a control point). …”
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The Two-Stage Alzheimer’s Disease Automatic Diagnosis Algorithm Based on ST-MBV3 Model by Guiping Li, Zhenhao Jin, Minghui Deng, Junjie Gong, Piaoyi Zheng

“…Experimental results demonstrate impressive classification accuracies, including 98.6% for distinguishing between AD and normal control (NC), 95.97% for mild cognitive impairment (MCI) versus NC, 94.57% for AD versus MCI, and 93.12% for AD/MCI/NC classification. …”
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Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions by Kyle D. Gromer, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Colin Shearn, Swati Antala, Swati Antala, Joshua B. Wechsler, Carla M. Cuda, Cara L. Mack, Ronald J. Sokol, William J. Janssen, Richard M. Green, Harris Perlman, Deborah R. Winter, Sarah A. Taylor, Sarah A. Taylor

“…We aimed to distinguish the transcriptional profiles and roles of defined macrophage subset(s) in murine BA.MethodsWe used multiparameter flow cytometry and RNA-sequencing analysis to profile recruited CD11bhiCD64+ hepatic macrophages by cell surface expression of MHCII and Ly6c in the Rhesus rotavirus (RRV)-induced murine model of BA versus saline controls. Modulation of macrophage numbers via intra-peritoneal injections of clodronate-loaded liposomes was performed to determine the association between macrophage numbers and histologic injury (Ishak score).ResultsLy6c+ macrophages demonstrated the greatest increase in numbers and percent of total macrophages in murine BA versus saline controls whereas MHCII+ macrophages decreased. …”
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Perceiving visual negative stimuli in schizophrenia and bipolar disorder: Meta-analytic evidence of a common altered thalamic-parahippocampal-basal ganglia circuit by Alessandro Grecucci, Chiara Orsini, Gaia Lapomarda, Sara Sorella, Irene Messina

“…The activation likelihood estimation analysis included 41 experiments on schizophrenia (schizophrenia versus healthy controls) and 27 experiments on bipolar disorder (bipolar versus healthy controls). …”
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Increased Serum Concentrations of TNF-Like Weak Inducer of Apoptosis Predict Higher 28-Day Mortality in Patients with Sepsis by Ying Guo, Manyi Ren, Lili Ge, Chao Sun, Rui Li, Cheng’en Ma, Shujian Sui

“…The serum levels of TWEAK were significantly lower in septic patients compared to controls (417.4 ± 196.7 pg/ml versus 1243.8 ± 174.3 pg/ml, p<0.001). …”
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FUNCTIONAL STATE OF THE MASTICATORY MUSCLES OF PATIENTS WITH DEFECTS OF DENTITION, WHICH ARE COMPLICATED BY DENTOALVEOLAR DEFORMITIES by O. V. Bida, Yu. I. Zabuha

“…Values of “K” coefficient is significantly higher than in the control group, which indicates a significant negative trend of functional bioelectric activity 1,72 ± 0,03 and 1,79 ± 0,04 for right and left masseter muscles, respectively, versus 1,04 ± 0,04 and 1,05 ± 0,04 respectively for the right and left of the chewing muscles in the control group. …”
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Results of a cluster randomized trial testing the Systems Analysis and Improvement Approach to increase cervical cancer screening in family planning clinics in Mombasa County, Keny... by McKenna C. Eastment, George Wanje, Barbra A. Richardson, Emily Mwaringa, Shem Patta, Kenneth Sherr, Ruanne V. Barnabas, Kishorchandra Mandaliya, Walter Jaoko, R. Scott Mcclelland

“…Methods Twenty FP clinics in Mombasa County were randomized 1:1 to SAIA versus usual procedures. SAIA has five steps: (1) cascade analysis tool to understand the cascade and identify inefficiencies, (2) sequential process flow mapping to identify bottlenecks, (3) develop and implement workflow modifications (micro-interventions) to address identified bottlenecks, (4) assess the micro-intervention in the cascade analysis tool, and (5) repeat the cycle. …”
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Strategy to Reduce Mortality Rates of ST-elevation Acute Myocardial Infarction Using Prehospital Thrombolysis: A Meta-analysis by Barathkumar Ramadoss, Arun Pari, Sharanya Shre Ezhil Santhi, Sailatha Ravi, Ezhilarasan Ramanan

“…Data Sources: In December 2020, the Cochrane search strategy was used to analyze randomized control trials, nonrandomized control studies, and registry studies in PubMed, EMBASE, Cochrane Library, Google Scholar, ClinicalKey, and Clinical Trial Registries. …”
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Thermal behavior and switching losses of MOSFET in high-frequency transformer circuits by Jiale Cheng, Yinghao Zhang, Xiangqun Cheng, Kaixin Guo, Yuchen Wang, Mian Jiang, Yabin Wang, Yang Liu

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Tumour microenvironment markers in spontaneous and induced incubation of breast cancer biopsies by Yu. S. Gergenreter, N. B. Zakharova, O. L. Morozova

“…In group 2, a pronounced vascularization was more often observed: in 6 (40%) patients versus 1 (7%) in group 1 (p &lt; 0.05). In both groups, compared with the control, there was a statistically sig-nificant (p &lt; 0.05) increase in spontaneous production of TNF-α by 4.2 and 4.8 times, MCP-1 by 6.7 and 6.3 times, TGF-β1 – 2.2 and 2.5 times, VEGF 11.9 and 14.6 times; GM-CSF 15.6 and 13.4 times, G-CSF 96.8 and 79.5 times, respectively. …”
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Higher landing accuracy in expert pilots is associated with lower activity in the caudate nucleus. by Maheen M Adamson, Joy L Taylor, Daniel Heraldez, Allen Khorasani, Art Noda, Beatriz Hernandez, Jerome A Yesavage

“…Brain activity in bilateral caudate nucleus was examined for main effects of expertise during a "land" versus "do not land" decision with the no-decision control condition modeled as baseline. …”
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