The impact of top management team tenure heterogeneity on innovation efficiency of declining firms. by Xunjiang Huang, Qilin Gao, Deng Wang

“…The findings also provide practical guidelines for declining firms, such as replacing top management members and diluting equity, to achieve recovery. …”
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Visualizing androgen signaling and assessing its interaction with canonical Wnt signaling pathways in prostate development, morphogenesis, and regeneration. by Yao Mawulikplimi Adzavon, Dong-Hoon Lee, Alex Hiroto, Tae Ju Park, Gaeul Chu, Yunjeong Kim, Kristoffer Nikias, Cheong-Wun Kim, Dexter Hoi Long Leung, Chenmiao Liu, Hong Zeng, Zijie Sun

“…Although significant efforts have been devoted to understanding the critical role of AR, the cellular properties and functions of the AR-expressing cells acting as prostatic progenitors in controlling prostatic cell differentiation and growth still remain elusive. …”
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A Rare Hardware-related Complication after Deep Brain Stimulation: Two Cases of Twiddler’s Syndrome by Iroda Mammadinova, Seitzhan Aidarov, Nurtay Nurakay, Yerbol Makhambetov, Chingiz Nurimanov

“…After years of effective symptom control, both patients presented with worsening motor symptoms. …”
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Usability of a digital mindfulness training program for smoking cessation: A mixed-method single-center pilot study protocol (HowToMind). by Anastasia Demina, Agnès Soudry-Faure, Benjamin Petit, Nicolas Meunier-Beillard, Benoit Trojak

“…All participants will receive a combination of transdermal and oral nicotine replacement therapy and will be introduced to an eHealth app that provides a digital equivalent of an 8-week mindfulness training program. …”
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Combination of GLP-1 Receptor Activation and Glucagon Blockage Promotes Pancreatic β-Cell Regeneration In Situ in Type 1 Diabetic Mice by Liangbiao Gu, Dandan Wang, Xiaona Cui, Tianjiao Wei, Kun Yang, Jin Yang, Rui Wei, Tianpei Hong

“…Pancreatic β-cell neogenesis in vivo holds great promise for cell replacement therapy in diabetic patients, and discovering the relevant clinical therapeutic strategies would push it forward to clinical application. …”
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Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5. by Madhushika Ratnayake, Frank Plöger, Mauro Santibanez-Koref, John Loughlin

“…Chondrocytes harvested from cartilage of osteoarthritic patients who had undergone joint replacement were cultured with wildtype recombinant mouse and human GDF5 protein. …”
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Precise Generation of Human Induced Pluripotent Stem Cell–derived Cell Lines Harboring Disease-relevant Single Nucleotide Variants Using a Prime Editing System by Seiya Kanno, Kota Sato, Toru Nakazawa

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Study of the method of placing technical stations by Sattorov S.B.

“…All this makes it difficult to control the movement of trains and reduces the speed of moving cars on the railway transport. …”
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Anticoagulants in the treatment of superficial vein thrombosis of lower limbs: possibilities and limitations by I. S. Yavelov, K. A. Kaperiz, O. M. Drapkina

“…This article presents a critical analysis of the results of three prospective randomized controlled trials of anticoagulant use in patients with superficial vein thrombosis of lower limbs CALISTO using fondaparinux sodium, STEFLUX using different doses of parnaparin sodium, and SURPRISE comparing the effectiveness and safety of fondaparinux sodium and the preventive dose of the oral anticoagulant rivaroxaban.Evidence from these clinical trials suggests that low-dose anticoagulants should be used for at least 1.5 months in superficial vein thrombosis of lower limbs with thrombus localization beyond 3 cm from the saphenofemoral and/or saphenopopliteal junction. …”
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Current status and prospects of diagnosis and treatment of genetic kidney diseases in Chinese children by SHEN Qian

“…Drug treatment prima-rily aims to provide symptomatic support，control proteinuria，and delay kidney function decline. …”
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Evaluation of the potential therapeutic effect of africanized honeybee venom (Apis mellifera Linnaeus) on levodopa-induced dyskinesias in mice by CAMILA G. DANTAS, ADRIANO A.S. ARAÚJO, RICARDO LUIZ C. DE ALBUQUERQUE JUNIOR, EDNA A.F. CÂNDIDO, MARGARETE Z. GOMES, LUIZ P. DA COSTA

“…Abstract Levodopa-induced dyskinesia (LID) is a complication in patients with Parkinson’s disease and undergoing long-term levodopa replacement therapy. This study evaluated the the potential therapeutic effect of Africanized honey bee venom (Apis mellifera L.) on LID in mice. …”
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Application of CIPP flipped lining method in the rehabilitation of old gas pipelines by You Yun, Wang xinxin, Wang Zhongyi, Wang Yuyan, Chen Hao

“…Realizing the comprehensive excavation, demolition, and replacement of old pipes with new ones poses pain points such as high construction difficulty, repair costs, and uncertainty of routing construction planning. …”
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Online Learning as e-Learning: The Quality and Results (Critical Analysis) by A. V. Dozhdikov

“…It is noted that the thesis about the possibility of “complete replacement of traditional forms of education with online education without loss of quality” is distorted in the media, and the conclusions are based on insufficient data. …”
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Optimization of used cottonseed oil methyl ester production using response surface methodology by ABDULLATEEF JIMOH

“…Because of its similar and compatible fuel qualities to diesel fuel, biodiesel purchased from UCSO is becoming more and more significant as a replacement fuel for use in diesel engines. The amount of free fatty acids (FFA) determines how biodiesel is produced from oil. …”
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Losartan in postmenopausal women with essential arterial hypertension by O. N. Tkacheva, A. V. Barabashkina, I. M. Novikova, N. V. Sharashkina

“…To study losartan effectiveness and safety in postmenopausal women with essential arterial hypertension (EAH), and with or without hormone replacement therapy (HRT). Material and methods. In total, 58 postmenopausal women with EAH were followed up for 6 months after being administered antihypertensive therapy (AHT) with losartan, due to inadequate blood pressure (BP) control. …”
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Proanthocyanidin offers protection against diabetic nephropathy: elucidation of its mechanism of action using animal models by Dengpiao Xie, Huan Wang, Qing Ji, Jianting Wang

“…Conventional therapy for DN includes intensive control of blood glucose level and blood pressure and renin–angiotensin system blockade. …”
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Predictive Maintenance of HVAC Systems using Deep Learning for Optimized Building Energy Efficiency by Seyed Abolfazl Aghili, Amin Haji Mohammad Rezaei, Mostafa Khanzadi

“…Energy wastage is significant as a result of system faults, which indicates the importance of efficient control of energy in HVAC in saving energy as well as providing comfort to the occupants. …”
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Successful Management of Sepsis Following Liver Transplantation in an HIV-Positive Patient with Multiple Comorbidities: a case report by B. I. Kazymov, K. F. Alekberov, M. S. Yadrikhinskaya, A. D. Kuznetsova, A. O. Petrova, S. Yu. Shemakin

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Antiplatelet therapy de-escalation in a patient after percutaneous coronary intervention with a high risk of bleeding by A. A. Kassymova, J. A. Mansurova, L. K. Karazhanova, A. A. Chinybayeva

“…A 47-year-old patient of Kazakh nationality was hospitalized with gastrointestinal bleeding.Given bleeding type 3 by BARC (Bleeding Academic Research Consortium) associated with DAPT, it was decided to apply a strategy to de-escalate antiplatelet therapy under the control of platelet function testing (PFT) and genetic testing.In this case, replacement of ticagrelor with the weak P2Y12 receptor inhibitor clopidogrel was not possible as the patient appeared to be a carrier of the CYP2C19*2 polymorphism contributing to loss of function of the cytochrome P-450(CYP) enzyme.…”
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THE EFFICACY OF ANTIHYPERTENSIVE TREATMENT COMBINATION WITH ANXIOLYTICS IN HYPERTENSIVES WITH ANXIETY DISORDER by D. V. Kovalev, V. V. Skibitsky, A. N. Kurzanov, A. I. Ponomareva

“…Each group consequently during 1 year study received two types of medicines for 6 months each with cross-replacement: isolated AHT and combination AHT with AT (AHT+A). …”
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