Frequency of Tumor Necrosis Factor-α, Interleukin-6, and Interleukin-10 Gene Polymorphisms in Mexican Patients with Diabetic Retinopathy and Diabetic Kidney Disease by Patricia Elvira Sánchez-Valencia, Juan Daniel Díaz-García, Margarita Leyva-Leyva, Fabiola Sánchez-Aguillón, Nelly Raquel González-Arenas, Jesús Guillermo Mendoza-García, Erika Karina Tenorio-Aguirre, Mercedes Piedad de León-Bautista, Aurora Ibarra-Arce, Pablo Maravilla, Angélica Olivo-Díaz

“…Methods: This study included 203 patients with T2D, of which 102 had microvascular complications: 95 with DR, 50 with DKD, and 15 with diabetic neuropathy (the latter were not included in the statistical analysis); those with T2D without confirmed microvascular complications were considered as controls. Clinical and laboratory data were collected from the patient’s medical records. …”
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Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial by Brice Gaudilliere, Lei Xue, Amy S. Tsai, Xiaoxiao Gao, Tiffany N. McAllister, Martha Tingle, Gladys Porras, Igor Feinstein, Dorien Feyaerts, Franck Verdonk, Maximilian Sabayev, Julien Hedou, Edward A. Ganio, Eloïse Berson, Martin Becker, Camilo Espinosa, Yeasul Kim, Benoit Lehallier, Esther Rawner, Chunmiao Feng, Derek F. Amanatullah, James I. Huddleston, Stuart B. Goodman, Nima Aghaeepour, Martin S. Angst

“…Methods This double-blind, placebo-controlled study enrolled and randomized 38 patients undergoing major joint replacement surgery. …”
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Molecular Imaging of Fibroblast Activation Protein in Response to Cardiac Injury Using [⁶⁸Ga]Ga-DATA^5m.SA.FAPi by Victoria Weissenböck, Lukas Weber, Michaela Schlederer, Laura Silva Sousa, Anna Stampfer, Simge Baydar, Thomas Nakuz, Raffaella Calabretta, Ana Isabel Antunes Goncalves, Xiang Li, Frank Rösch, Bruno K. Podesser, Lukas Kenner, Marcus Hacker, Attila Kiss, Cecile Philippe

“…Our study aimed to evaluate [⁶⁸Ga]Ga-DATA^5m.SA.FAPi for PET imaging of replacement fibrosis following myocardial infarction (MI) or interstitial fibrosis associated with hypertrophy. …”
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Treatment failure and drug resistance among the newly reported HIV-infected patients in Taizhou City from 2020 to 2022 by LI Yan, WU Xuanhe, SHI Lu, LI Guixia, WANG Shanling, WANG Yating, CHEN Tailin, WANG Tingting, XIE Yali, SHEN Weiwei, LIN Haijiang, CHEN Xiaoxiao, HE Na

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Prolonged ECMO support in a pediatric patient with complex cardiac conditions during wartime in Kyiv, Ukraine by Rusnak Daniel, Condello Ignazio, Dohtiar Valerii, Varbanets Serhii, Alieksieieva Kristina, Luhovkin Serhii, Palokha Vladyslav, Zhoha Vadym, Bukhnei Neonila, Krashevska Lesia, Kutsenko Olha, Kupina Nataliia, Vnukov Oleksii

“…Eleven oxygenators were employed, with a total of ten replacements due to thrombosis and technical malfunctions. …”
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Dietary Supplementation with Whole-Fat or Defatted Antarctic Krill Powder Improves the Growth Performance, Body Coloration,  and Immune Capability of Red–White Koi Carp (<i>Cyprinu... by Hongmei Song, Yixin Liang, Yexin Yang, Chao Liu, Yi Liu, Xidong Mu, Xuejie Wang

“…A total of 630 red–white koi carp with an initial body mass of 13.5 ± 0.05 g were randomly divided into seven groups with three replicates per group and 30 fish per replicate. The control group was fed a basic diet (C0). The other six diets were supplemented with different levels of whole krill meal or defatted krill meal as replacements (10% whole fat, 20% whole fat, 30% whole fat, 10% defatted, 20% defatted, and 30% defatted) in the experimental groups, named W10, W20, W30, D10, D20, and D30, respectively, for a total duration of 60 days. …”
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Impact of vancomycin therapeutic drug monitoring on mortality in sepsis patients across different age groups: a propensity score-matched retrospective cohort study by Huaidong Peng, Ruichang Zhang, Shuangwu Zhou, Tingting Xu, Ruolun Wang, Qilin Yang, Xunlong Zhong, Xiaorui Liu

“…The primary outcome was 30-day mortality. To control for potential confounding factors and evaluate associations, we used Cox proportional hazards regression and propensity score matching (PSM). …”
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Derivação ventriculoatrial no tratamento da hidrocefalia em crianças Ventriculoatrial shunts in the treatment of hydrocephalus in children by Gilberto Machado de Almeida

“…After the analysis of the operatory conditions, of the complications and of the results, the folloying conclusions are withdrawn: 1) the ocurrence of pulmonary tromboembolic complications is quite rare after ventriculoatrial shunts, justifying the use of this technique for the treatment of hydrocephaly till others forms of treatment are available; 2) periodic cardiologic examinations should be performed in patients submitted to ventriculo-venous shunts in order to prevent right cardiac insuficiency; 3) the prevention of infectious complications and selection of the cases are fundamental for better post-operative results; 4) the physician responsible for treatment of hydrocephalic patients should warn the parents regarding the possibility of new sirguical interventions and be ready to re-operate as many times as necessary; 5) there is not justifycable the replacement of the atrial tube when its extremity reaches the level of the fourth thoracic vertebra; 6) there is not correct the assertion that an shunt has to remain always with the drainage process working fully; 7) in order to evaluate the prognosis of the mental development of the hydrocephalic patients, a group of data has to be considered as a whole, namely the neurological examination, cranial transilumination, etiology of the disease, electroencephalo-graphic tracings, Gesell test and, if possible, the measurement of the cerebral mantle; 8) a normal psychological development (IQ greater than 85) can be expected in about 40% of the patients with controled hydrocephalus.…”
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Enhancing fermentation quality and fiber decomposition of Phragmites australis silage by introducing Bacillus subtilis and lactic acid bacteria consortia by Yong Liu, Songbai Zhang, Junrui Liao, Nazir Ahmad Khan, Shaoxun Tang, Chuanshe Zhou, Zhiliang Tan, Asmaa Elnagar, Ibrahim F. Rehan, Ibrahim F. Rehan, Ibrahim F. Rehan, František Zigo, Abdelfattah Z. M. Salem, Abdelfattah Z. M. Salem

“…IntroductionAs a low-cost, high-fibre biomass resource, Phragmites australis (reed) has significant potential for feed applications, particularly as a partial replacement for conventional roughage in ruminant diets.MethodsThis study investigated the effects of integrating Bacillus subtilis (B. subtilis BNCC109047) with homofermentative/ heterofermentative lactic acid bacteria (LAB) consortia on the fermentation and nutritional quality of Phragmites australis (reed) silage. …”
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Geological characteristics and key technologies for exploration and development of the Yanchuannan coalbed methane field, Ordos Basin by Xipeng HE, Cui XIAO, Yuqiao GAO, Xin LI, Tao GUO, Xiao CAI

“…ObjectiveChina boasts abundant coalbed methane (CBM) resources, which serve as a crucial replacement for the reserve growth and production addition of natural gas resources. …”
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Short-chain PFASs dominance and their environmental transport dynamics in urban water systems: Insights from multimedia transport analysis and human exposure risk by Kunfeng Zhang, Abdul Qadeer, Sheng Chang, Xiang Tu, Hongru Shang, Moonis Ali Khan, Yingying Zhu, Qing Fu, Yanling Yu, Yujie Feng

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Impact of dietary supplementation with Antarctic krill meal on growth performance, biochemical parameters, and antioxidant status in Coho Salmon (Oncorhynchus kisutch) post-smolts by Hairui Yu, Leyong Yu, Leyong Yu, Abdur Rahman, Abdur Rahman, Abdur Rahman, Sattanathan Govindharajan, Sattanathan Govindharajan, Yuzhuo Zhang, Yuzhuo Zhang, Guoqing Wang, Guoqing Wang, Lingyao Li, Lingyao Li

“…Five experimental diets were formulated by substituting 0%, 3%, 6%, 9%, and 12% fish meal (protein source) with AKM (protein source), which were designated AKM0 (the control), AKM3, AKM6, AKM9, and AKM12, respectively. …”
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Clinical utility and safety of finerenone in patients with heart failure: Rationale and design of FINE registry by Gonzalo Luis Alonso Salinas, Amaia Martínez León, Diego Aguiar Cano, Alberto Esteban‐Fernández, José María Viéitez Flórez, Susana delPrado Díaz, Juan Górriz‐Magaña, Gregorio deLara Delgado, Rafael González‐Manzanares, Pedro Caravaca‐Pérez, Francisco J. Pastor‐Pérez, Sandra Valdivieso‐Moré, Juan Quiles, Inés Ponz, Vanessa Escolar, Edison Omar Boada Lincango, Néstor Báez‐Ferrer, Gonzalo Gallego, Luis Almenar, Luis Gutiérrez de la Varga, Pau Codina, Alejandro Recio Mayoral, Aleix Fort, María Jesús Pinilla Lozano, David González‐Calle, Inés Gómez‐Otero, Cristina Salazar Mosteiro, Marta Cobo, Jesús Piqueras‐Flores, Clara Bonanad, Ana Huerta, Maria Ferré Vallverdú, Pablo Díez‐Villanueva

“…Endpoints will include the incidence of HF exacerbations requiring intravenous therapy, hospitalizations, renal replacement therapy, and mortality due to cardiovascular or renal causes. …”
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Dynamic changes in AI-based analysis of endometrial cellular composition: Analysis of PCOS and RIF endometrium by Seungbaek Lee, Riikka K. Arffman, Elina K. Komsi, Outi Lindgren, Janette Kemppainen, Keiu Kask, Merli Saare, Andres Salumets, Terhi T. Piltonen

“…The ovulatory PCOS endometrium exhibited epithelial cell proportions similar to those of control and healthy women’s samples in every cycle phase, from the PE to the late SE, correlating with progesterone levels (control SE, r2 = 0.64, FDR < 0.001; PCOS SE, r2 = 0.52, FDR < 0.001). …”
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Synergetically integrated vertical farms by Tess Blom

“…Vertical farms achieve this by cultivating crops in vertically stacked hydroponic systems within an uniformly controlled indoor environment using active climate control systems and artificial light. …”
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Infrared illumination for difficult peripheral venous catheterisation in critically ill adult patients: the prospective, randomised, multicentre ICARE trial by Étienne Audureau, Sophie Demeret, Nicolas Mongardon, Damien Contou, Matthieu Schmidt, Muriel Fartoukh, Armand Mekontso Dessap, Daniel Da Silva, Frédérique Schortgen, Rachida Ouedraogo, Aline Alves, Amélie Bruant, Oumar Sy, Cécilia Tabra Osorio, Amélie Chenal, Laurence Krzyzaniak, Marianne Le Joncour, Latifa Ait Benaissa, Meriem Bouguerra, Stéphanie Tanguy Dubois, Eric Starczala, Chirine Petyt, Séverine Dezellus, Jean Francois Georger, Ann-Cécile Pallud, Damien Carras, Fabien Boussely

“…Our hypothesis is that infrared vein illumination could improve the success rate of peripheral venous catheterisation in critically ill patients at risk of difficult catheterisation.Methods and analysis This is a prospective, multicentre, randomised, open-label controlled trial. It will be conducted in France and will involve critically ill patients at risk of difficult peripheral catheterisation. …”
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Single-cell sequencing on PBMCs from patients with HA and HB with inhibitors reveals different immune responses to FVIII and FIX by Enhao Li, Zekun Li, Jinzeng Wang, Haoyang Wu, Yilun Xue, Can Lou, Zhenping Chen, Feng Liu, Wenman Wu, Qiulan Ding, Runhui Wu, Xuefeng Wang, Jing Dai

“…Abstract: Inhibitors are the most severe complication of replacement therapy in patients with hemophilia. Previous studies, along with our clinical observations, have identified distinct incidence rates and clinical manifestations of factor VIII (FVIII) and FIX inhibitors in patients with severe hemophilia A (HA) and HB. …”
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Association between glycemic variability and acute kidney injury incidence in patients with cerebral infarction: an analysis of the MIMIC-IV database by Yiming Hua, Yiming Hua, Ze Chen, Ze Chen, Ze Chen, Lele Cheng, Lele Cheng, Lele Cheng, Ning Ding, Ning Ding, Yifei Xie, Yifei Xie, Hao Wu, Hao Wu, Huaizhi Jing, Huaizhi Jing, Yu Xu, Yu Xu, Yue Wu, Yue Wu, Beidi Lan, Beidi Lan, Beidi Lan

“…Primary outcomes included AKI incidence and renal replacement therapy (RRT) initiation, with in-hospital mortality designated as the secondary endpoint. …”
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Voluntary Running and Estrous Cycle Modulate ΔFOSB in the Suprachiasmatic Nucleus of the Wistar Rat by Ayano Shiba, Marene H. Hardonk, Ewout Foppen, Tess Kool, Susanne E. la Fleur, Paul J. Lucassen, Chun-Xia Yi, Dirk Jan Stenvers, Joram D. Mul, Andries Kalsbeek

“…Remarkably, this cyclicity was absent in runners, where ΔFOSB-positive cell numbers remained comparable to those observed during proestrus in sedentary controls. Finally, estradiol replacement following ovariectomy in sedentary females lowered SCN ΔFOSB-positive cell numbers. …”
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MRI Compatibility Research of Ultrasonic Motor and Material for DBS Surgical Robot by PENG Renyuan, ZHANG Juzhong, WANG Zhisen, CHU Yuyi, WU Yuwen, PENG Haoran, LIN Jun, YANG Hongbo

“…Analytical improvements are proposed for the future design of the robot's control system: 1) Adjusting the drive signals of the 60 and 30 motors to reduce MRI imaging interference due to different compatibilities and sensitive frequencies. 2) Shielding exposed controllers during 1.5 T experiments to reduce electromagnetic leakage and improve image quality. 3) Replacing external communication cables with fiber optics to control indoor devices from outside, effectively blocking external electromagnetic interference. …”
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