The crosstalk between senescence, tumor, and immunity: molecular mechanism and therapeutic opportunities by Zehua Wang, Chen Chen, Jiaoyu Ai, Yaping Gao, Lei Wang, Shurui Xia, Yongxu Jia, Yanru Qin

“…Senescent immune cells create an immunosuppressive TME favoring tumor progression. In contrast, senescent tumor cells could promote a transition from immune evasion to clearance. …”
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A Differential Evolution-Oriented Pruning Neural Network Model for Bankruptcy Prediction by Yajiao Tang, Junkai Ji, Yulin Zhu, Shangce Gao, Zheng Tang, Yuki Todo

“…In addition, the EPNN also provides competitive and satisfactory classification performances in contrast with other commonly used classification methods.…”
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CLINICAL CHARACTERISTICS OF DEBUT AND RISK FACTORS OF PEDIATRIC MULTIPLE SCLEROSIS by Валерий Иванович Ларькин, Игорь Иванович Ларькин, Татьяна Аркадьевна Морозова, Степан Евгеньевич Аполлонов

“…«Old» lesions, without accumulation of contrast agent, were present in 80 % of patients. …”
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Exenatide Is an Effective Antihyperglycaemic Agent in a Mouse Model of Wolfram Syndrome 1 by Tuuli Sedman, Kertu Rünkorg, Maarja Krass, Hendrik Luuk, Mario Plaas, Eero Vasar, Vallo Volke

“…Glipizide (0.6 or 2 mg/kg) was not able to reduce the glucose level in wolframin-deficient animals. In contrast to other groups, wolframin-deficient mice had a lower insulin-to-glucose ratio during the intraperitoneal glucose tolerance test, indicating impaired insulin secretion. …”
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Proton magnetic resonance spectroscopy of neurometabo­lites in the hippocampi of aggressive and tame male rats by R. G. Gulevich, A. E. Akulov, S. G. Shikhevich, R. V. Kozhemyakina, I. Z. Plyusnina

“…Aspartate is one of the main excitement transmitter, and its elevated proportion in the brain of aggressive rats may favor more intense excitation than in unselected rats. In contrast, the elevated proportion of glutamine in aggressive rats vs. tame rats may be indicative of (1) a metabolic disturbance in the glutamate–glutamine cycle, which links neural and glial cells, and (2) decrease in the activity of glutaminase, the enzyme converting glutamine to glutamate (GABA precursor). …”
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Hygroscopic Growth Factors of Sub-micrometer Atmospheric Aerosols at Four Selected Sites in Thailand by Jindarat Pariyothon, Surat Bualert, Parkpoom Choomanee, Thitima Rungratanaubon, Thunyapat Thongyen, Narita Fakkaew, Chayaporn Phuetfoo, Jitlada Phupijit, Wladyslaw W. Szymanski

“…Particles in the urban and landlocked industrial areas had relatively low Gf values, suggesting that they originated mainly from fossil fuel combustion, in contrast to particles at other sites which can be attributed to coastal proximity.…”
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Inter-rater agreement and characterization of pleural line and subpleural fields in canine lung ultrasound: a comparative pilot study between high-frequency linear and curvilinear... by Kyle L. Granger, Liz Guieu, Søren R. Boysen

“…HFLUT demonstrated strong inter-rater agreement in B-mode (κ = 0.89) and near-perfect agreement in M-mode (κ = 1.00) for pleural line homogeneity. In contrast, CUT showed minimal agreement in both B-mode (κ = 0.34) and M-mode (κ = 0.37). …”
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Influence of Electrostatic Interactions on the Self-Assembly of Charged Peptides by Xue Sun, Bolan Wu, Na Li, Bo Liu, Shijun Li, Liang Ma, Hangyu Zhang

“…It is noteworthy that the Z5 hydrogel in normal saline (NS) shows exceptional self-healing properties, demonstrating the ability to recover its initial strength in seconds after the removal of shear force, thus rendering it an acceptable material for printing. In contrast, the strong salt shielding effect and the ionic cross-linking of Z5 hydrogels in PBS result in the bundling of peptide nanofibers, which impedes the recovery of the initial strength post-destruction. …”
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Transcranial Direct Current Stimulation Modulates Neurogenesis and Microglia Activation in the Mouse Brain by Anton Pikhovych, Nina Paloma Stolberg, Lea Jessica Flitsch, Helene Luise Walter, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger

“…Multisession tDCS at a sublesional charge density led to a polarity-dependent downregulation of the constitutive expression of Iba1 by microglia in the mouse cortex. In contrast, both anodal and, to an even greater extent, cathodal tDCS induced neurogenesis from the subventricular zone. …”
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Aqueous spice extracts as alternative antimycotics to control highly drug resistant extensive biofilm forming clinical isolates of Candida albicans. by Bindu Sadanandan, Vaniyamparambath Vijayalakshmi, Priya Ashrit, Uddagiri Venkanna Babu, Lakavalli Mohan Sharath Kumar, Vasulingam Sampath, Kalidas Shetty, Amruta Purushottam Joglekar, Rashmi Awaknavar

“…The morphology of C. albicans biofilm at different growth periods was also determined through bright field microscopy, phase contrast microscopy, and fluorescence microscopy. The results of this study indicated that the alternate approach in controlling high biofilm-forming, multi-drug resistant clinical isolates of C. albicans M-207 and S-470 using whole aqueous extracts of garlic, clove, and Indian gooseberry is a safe, potential, and cost-effective one that can benefit the health care needs with additional effective therapeutics to treat biofilm infections.…”
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Genetics of Endometrial Cancers by Tsuyoshi Okuda, Akihiko Sekizawa, Yuditiya Purwosunu, Masaaki Nagatsuka, Miki Morioka, Masaki Hayashi, Takashi Okai

“…Microsatellite instability is another important genetic event in this type of tumor. In contrast, p53 mutations or Her2/neu overexpression are more frequent in non-endometrioid tumors. …”
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Pawpaws prevent predictability: A locally dominant tree alters understory beta‐diversity and community assembly by Anna C. Wassel, Jonathan A. Myers

“…Dominant species can increase the importance of deterministic community assembly by competitively excluding species in a consistent way across local communities, resulting in low site‐to‐site variation in community composition (beta‐diversity) and nonrandom community structure. In contrast, dominant species could increase the importance of stochastic community assembly by reducing the total number of individuals in local communities (community size), resulting in high beta‐diversity and more random community structure. …”
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Effect of cold rolling rates on microstructure and corrosion behavior of selective laser melted 316L austenitic stainless steel bipolar plates by Zhiyue Shi, Rui Wang, Jin Qin, Yan Kang, Zhiqiang Yu, Zhijie Yan, Shaohua Zhang, Wei Zhang

“…The results indicate that cold deformation results in an increase in the fraction of low-angle grain boundaries (LAGBs), which significantly enhances corrosion resistance of SLMed 316L ASS. In contrast, the increase of dislocation density and the martensite phase resulting from high-speed deformation negatively impact corrosion resistance of SLMed 316L ASS in the simulated cathodic environment of proton exchange membrane fuel cells (PEMFCs). …”
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Hereditary Hemorrhagic Telangiectasia with Hepatic Vascular Malformations by Yujiro Nishioka, Nobuhisa Akamatsu, Yasuhiko Sugawara, Junichi Kaneko, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo

“…He had mild anemia with iron deficiency, and dynamic contrast-enhanced computed tomography revealed significant arteriovenous and arterioportal shunts throughout the liver. …”
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Diversity and occurrence of methylotrophic yeasts used in genetic engineering by A. S. Rozanov, E. G. Pershina, N. V. Bogacheva, V. Shlyakhtun, A. A. Sychev, S. E. Peltek

“…Although patent  legislation suggests free access to these yeasts, they have been distributed on a contract basis. Whereas their status  for commercial use is undetermined, the search for alternative stains for expression of recombinant protein continues.  …”
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Ultrasound Detection of Myocardial Ischemic Memory Using an E-Selectin Targeting Peptide Amenable to Human Application by Xiaoping Leng, Jianjun Wang, Andrew Carson, Xucai Chen, Huili Fu, Susanne Ottoboni, William R. Wagner, Flordeliza S. Villanueva

“…Ultrasound imaging after injection of MB SEL demonstrated persistent contrast enhancement of the previously ischemic region. …”
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Fluorescence engineering in metamaterial-assisted super-resolution localization microscope by Choi Kyu Ri, Li Shilong, Ozerov Igor, Bedu Frédéric, Park Dong Hee, Joo Bin Chan, Wu Jeong Weon, Nic Chormaic Síle, Lee Yeon Ui

“…Single-molecule localization microscopies have gained much attention for their efficient realization of a sub-diffraction-limit imaging with the resolution down to the 10-nm range. In contrast to conventional localization microscopes, which rely on particular fluorescent probes in specific conditions, metamaterial-assisted super-resolution microscopies can be implemented with any fluorescent dye under general conditions. …”
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Evidence for Bone Marrow Adult Stem Cell Plasticity: Properties, Molecular Mechanisms, Negative Aspects, and Clinical Applications of Hematopoietic and Mesenchymal Stem Cells Trans... by Ivana Catacchio, Simona Berardi, Antonia Reale, Annunziata De Luisi, Vito Racanelli, Angelo Vacca, Roberto Ria

“…In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. …”
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De la calle a la web: testimonios de la protesta artística de octubre 2019 y su continuidad en las plataformas digitales by Carolina Pizarro Cortés

“…Estas iniciativas constituyen narrativas abiertas que comparten cuatro rasgos específicos: (1) son elaboraciones de tercer orden, que integran y resignifican registros de eventos visuales; (2) vinculan los registros al espacio preciso en el que se despliega el evento visual; (3) generan un tipo de contacto con el/la usuario/a de la interfaz, que supera la observación pasiva y abre la posibilidad de interacción y (4) dan cuenta del proceso constructivo –tanto del registro de segundo orden como de la plataforma–, de modo que, en diferentes grados y medidas, exponen cómo hacer cosas con imágenes. …”
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A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine by Nalú Navarro-Alvarez, Beatriz M. M. Gonçalves, Alec R. Andrews, David H. Sachs, Christene A. Huang

“…Animals injected into the dermis and/or epidermis demonstrated a severe inflammatory response on the skin surface with massive swelling, redness within 12hrs of CFA injection, and severe skin necrosis within a week, preventing accurate induration measurements. In contrast to animals injected SC, animals receiving intradermal and/or intraepidermal injection of CFA showed signs of distress requiring pain medication. …”
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