Dual inhibition of LAG-3 and PD-1 with IBI110 and sintilimab in advanced solid tumors: the first-in-human phase Ia/Ib study by Chenyu Mao, Anwen Xiong, Jiong Qian, Wenxiang Wang, Ying Liu, Tao Zhang, Zhihai Wu, Haiqing Ni, Jia Lu, Sixiang Long, Li Zhao, Yuling Chen, Caicun Zhou, Nong Xu

“…No dose-limiting toxicity (DLT) was observed. The most common TRAE was anemia (17.9%, including 3.6% ≥ G3) in phase Ia dose escalation of IBI110 monotherapy (n = 28), aspartate aminotransferase increased (28.9%, all G1-G2) in phase Ib dose escalation of IBI110 plus sintilimab (n = 45), anemia (70.0%, all G1-G2) in phase Ib dose expansion in sqNSCLC (n = 20), and neutrophil count decreased (64.7%, including 17.6%≥ G3) in phase Ib dose expansion in GC (n = 17). …”
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L’infanticide féminin en question chez les Gaulois du Midi : l’apport des analyses ADN sur les nouveau-nés enterrés dans les habitats de l’âge du Fer by Bernard Dedet, Henri Duday, Philippe Gruat, Mélanie Pruvost

“…., the discoveries of burials containing perinatal human remains have multiplied in many Gallic settlements in the south of France thanks to the improvement of excavation methods and the development of a specific technique applied the study of human remains in the field. …”
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Evaluation of Prayer Windows with Inscriptions Located Around the Mausoleum of Eyup Sultan by Saliha Tanık, Aliye Öten

“…The prayer windows were made near the graves of common people who were not considered religious leaders, even if they had a high social status, and buried in the cemeteries around Eyüp Sultan Tomb, and in the openings in the enclosure wall of these cemeteries, have been the subject of our study with their inscriptions ending with the request for Fatiha. …”
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Hubungan Kualitas Tidur dengan Prestasi Akademik Mahasiswa Program Studi Pendidikan Dokter Angkatan 2010 FK Universitas Andalas by Hanafi Nilifda, Nadjmir ., Hardisman .

“…The condition of sleep disorders commonly found among young adults, especially college students who can later cause a reduction in the concentration of learning and health problems. …”
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Propolis mouthwashes efficacy in managing gingivitis and periodontitis: a systematic review of the latest findings by Muhammed Al-Huda Ballouk, Mohamed Altinawi, Abeer Al-Kafri, Talar S. Zeitounlouian, Piotr S. Fudalej

“…Abstract Background and objectives Gingivitis and periodontitis are common periodontal diseases that can significantly harm overall oral health, affecting the teeth and their supporting tissues, along with the surrounding anatomical structures, and if left untreated, leading to the total destruction of the alveolar bone and the connective tissues, tooth loss, and other more serious systemic health issues. …”
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Prevalence of Myocardial Infarction With Obstructive and Non-Obstructive Coronary Arteries in a Middle-Aged Population With Chronic Airflow Limitation: A Cross-Sectional Study by Sundh J, Ekström M, Blomberg A, Lindberg E, Malinovschi A, Olin AC, Sköld CM, Torén K, Wollmer P, Östgren CJ, Jernberg T

“…MI-CAD was defined as a self-reported MI with coronary computed tomography angiography findings of previous revascularization or at least one significant coronary stenosis (> 50%), and MINOCA as self-reported MI with no previous revascularization and no significant coronary stenosis.Results: In total, 1735 (8.3%) of 20,882 included participants had CAL. MI-CAD was more common than MINOCA both in people with (2.8 vs 0.6%) and without CAL (1.2 vs 0.3%). …”
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Analisis Model Mental Mahasiswa dalam Pengembangan E-Learning Pemrograman Berbasis Gamifikasi Menggunakan Metode Agile UX by Retno Indah Rokhmawati, Fitra Abdurrachman Bachtiar, Fajar Pradana, Kharis Alfian

“…This research finds new needs related to Sign Up and Log in, Courses, Achievements, Exercises, Challenges, and common problems (navigation and layout). Based on the improvement design test, 15 students gave feedback indicating the quality improvement as follows: 24.1% improvement in learnability aspect, 20.5% improvement in intuitive efficiency aspect, 42% improvement in ease-of-use aspect, and 56% improvement on the aspect of the interactivity.   …”
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Physical health in young males and risk of chronic musculoskeletal, cardiovascular, and respiratory diseases by middle age: A population-based cohort study. by Aleksandra Turkiewicz, Karin Magnusson, Simon Timpka, Ali Kiadaliri, Andrea Dell'Isola, Martin Englund

“…We followed the participants through the Swedish National Patient Register for incidence of common musculoskeletal (osteoarthritis, back pain, shoulder lesions, joint pain, myalgia), cardiovascular (ischemic heart disease, atrial fibrillation), and respiratory diseases (asthma, chronic obstructive pulmonary disease, bronchitis). …”
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Hubungan Tindakan Pemberantasan Sarang Nyamuk (PSN) dengan Keberadaan Jentik Vektor Chikungunya di Kampung Taratak Paneh Kota Padang by Mutia Dwi Putri, Adrial Adrial, Lili Irawati

“…</p><p><strong>Kata kunci:</strong> PSN, jentik, vektor chikungunya</p><p> </p><p><strong><em>Abstract</em></strong></p><p>Taratak Paneh is the most common area of Chikungunya cases in 2012 (45 cases).The spreading of Chikungunya is influenced by environmental factor and practice of breading place eradication. …”
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IOP-lowering and neuroprotective treatment for glaucoma: reality and prospects by A.E. Egorov, N.G. Glazko, A.B. Movsisyan

“…Movsisyan^1,2 </p> <p> ¹Hospital for Disabled Veterans No. 2, Moscow, Russian Federation </p> <p> ²Pirogov Russian National Research Medical University, Moscow, Russian Federation </p> <p> ³City Clinical Hospital No. 15, Moscow, Russian Federation </p> <p> <i>Glaucoma is one of the most common chronic ocular disorders which results in irreversible eye damage. …”
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Assessment of Bowel Preparation Using Low-Volume Sulphate-Based Preparations in Comparison with Macrogols: A Multicenter, Randomized, Comparative Clinical Study of the 3rd Phase by E. D. Fedorov, V. V. Veselov, S. V. Kashin, E. V. Tikhomirova, A. V. Veselov, D. V. Zavyalov, A. Kornowski, T. E. Gorskaya, M. Volteau, T. Ponchon

“…Compliance with the drug use regime was higher in the OSS group than in the Macrogol group (95.7 % versus 82.3 %, respectively, p-value = 0.0011, ITT-population).The most common symptom reported in patients was nausea (27.9 % in the OSS group and 12.9 % in the Macrogol group). …”
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Faktor Risiko dan Faktor Pencetus yang Mempengaruhi Kejadian Asma pada Anak di RSUP Dr. M. Djamil Padang by Isnaniyah Usman, Eva Chundrayetti, Oea Khairsyaf

“…Based on these results, the incidence of asthma more common in men, largely influenced by changes in the weather and dust, most history of atopy in children is urticaria, parental history of atopy was highest in atopic dermatitis and maternal.…”
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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review by Goren S, Kidwai N, Aronow WS, Lanier GM

“…A phase III clinical trial reports that common side effects of the IV form of selexipag include headaches and irritation at the injection site. …”
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Targeted Next-Generation Sequencing in Pneumonia: Applications in the Detection of Responsible Pathogens, Antimicrobial Resistance, and Virulence by Liu B, Bao Z, Chen W, Xi X, Ge X, Zhou J, Zheng X, Zhang P, Deng W, Ding R, Zhou M, Fang J

“…A total of 144 virulence genes were detected for four common pathogens. And patients with virulence genes detected were of higher proportions of severe pneumonia (95.0% vs 42.9%, P = 0.009), acute respiratory distress syndrome (55.0% vs 0%, P = 0.022), and neutrophils (82.3% vs 62.2%, P = 0.026) than those not.Conclusion: In patients with pneumonia, tNGS could detect the responsible pathogens, AMR genes, and virulence genes simultaneously, serving as an efficient and cost-effective tool for the diagnosis, treatment, and severity indication of pneumonia.Keywords: targeted next-generation sequencing, pneumonia, pathogen, antimicrobial resistance, virulence…”
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Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis by Alisha Puri, Anita M. Lloyd, Aminu K. Bello, Marcello Tonelli, Sandra M. Campbell, Karthik Tennankore, Sara N. Davison, Stephanie Thompson

“…Plain-Language Summary: Frailty is a medical condition characterized by the loss of physiological reserve across multiple domains or an increased vulnerability to stress. Frailty is common among people with chronic kidney disease and is associated with poor health outcomes. …”
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Health-related quality of life and health state utility value in idiopathic pulmonary fibrosis: a systematic review and meta-analysis by Guixiang Zhao, Siyuan Lei, Ya Li, Zhenzhen Feng, Jiansheng Li

“…George’s Respiratory Questionnaire (SGRQ), EuroQoL Five Dimensions Questionnaire (EQ-5D), Short Form-36 (SF-36) and the King’s Brief Interstitial Lung Disease (KBILD) were the most common instruments, among which the EQ-5D included the HSUV and the visual analog scale (VAS). …”
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Karakteristik Klinis dan Patologis Karsinoma Nasofaring di Bagian THT-KL RSUP Dr.M.Djamil Padang by Shofi Faiza, Sukri Rahman, Aswiyanti Asri3 Asri

“…</p><p><strong>Kata kunci:</strong> karsinoma nasofaring, karakteristik klinis, histopatologi, padang</p><p> </p><p><strong><em>Abstract</em></strong></p><p><em>Nasopharyngeal carcinoma  is more frequent in China and Southeast Asia, including Indonesia, commonly with advance stages at diagnosis and has a poor prognosis.  …”
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Phenotypes of primary sclerosing cholangitis in children by M.B. Dyba, V.S. Berezenko

“…At disease onset, 40 % of children with PSC had liver fibrosis graded F3-F4 on METAVIR, with 24 % showing cirrhosis. The most common phenotype in children with PSC was a mixed one involving both large and small bile ducts (63 %). …”
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Genealogy of the Arab tribes living in Syria during the Caliphate of Imam Ali (AS)Typology of the Arab Tribes Living in the Levant during the Caliphate of Imam Ali (AS) Typology... by Akram sadat Hoseini, Yahya Mirhoseini

“…Their settlements were concentrated in Yemen, Hadramawt, Oman, and the surrounding areas, earning them the designation of "Yemenis". …”
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Designing an educational model based on identity development with an Iranian-Islamic approach for primary school students. by Ali Oladhamzehzadeh, masoumeh oladiyan, Mahmoud Safari

“…The basis of human and national identity means having a common awareness and feeling of belonging to the land of literature, language, religion, past achievements and heritage (Mehrabi Koshki et al, 2016). …”
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