Barriers and enablers to implementing clinical practice guidelines in primary care: an overview of systematic reviews by Tao Wang, Xian-Liang Liu, Jing-Yu (Benjamin) Tan, Isabella Zhao

“…Six categories of barriers and enablers were identified, which include (1) political, social and culture factors, (2) institutional environment and resources factors, (3) guideline itself related factors, (4) healthcare provider-related factors, (5) patient-related factors and (6) behavioural regulation-related factors. The most commonly reported barriers within the above-mentioned categories were suboptimal healthcare networks and interprofessional communication pathways, time constraints, poor applicability of CPGs in real-world practice, lack of knowledge and skills, poor motivations and adherence, and inadequate reinforcement (eg, remuneration). …”
Get full text

Protocol for the economic evaluation of metacognitive therapy for cardiac rehabilitation participants with symptoms of anxiety and/or depression by Patrick Doherty, David Reeves, Gemma E Shields, Adrian Wells, Lora Capobianco, Anthony Heagerty, Deborah Buck, Linda M Davies

“…Psychological care is a common component of CR as symptoms of depression and/or anxiety are more prevalent in this population, however evidence for the cost-effectiveness of current interventions is limited. …”
Get full text

MiR- 146b-5p inhibits Candida albicans-induced inflammatory response through targeting HMGB1 in mouse primary peritoneal macrophages by Jing Cheng, Xiaoxing Tian, Chuanxin Wu, Jiaojiao Wang, Huiling Liu, Sha Cheng, Hang Sun

“…Background: Candida albicans (C. albicans) is one of the most common pathogens associated with deep fungal infection, which represents a serious threat to human health. …”
Get full text

Thermodynamic Analysis of CRDI-VCR Type Diesel Engine Fueled with Moringa Oleifera Biodiesel by Vasant Patel, Vyomesh Buch

“…The purpose of the present study is to examine the impact of Compression Ratio (CR) on energy and exergy efficiency of a Variable Compression Ratio (VCR) and Common Rail Direct Injection (CRDI) type diesel engine powered by a blend of diesel and biodiesel from Moringa oleifera. …”
Get full text

Radiography may not be accurate in assessing acute ankle sprains in children by Xiongtao Li, Xiantao Shen, Si Wang, Jie Sun, Zhaoting Liu

“…Abstract Background Acute ankle sprains are among the most common injuries in children and are often associated with chondral avulsion fractures and ligament injuries. …”
Get full text

Relations Between the Holy See and Lithuania: A 100-Year History by Haroldas Šinkūnas, Indrė Isokaitė-Valužė

“…However, the treaties of the Holy See concluded with Lithuania and Latvia have more common and more elaborated provisions than the agreement with Estonia, while some issues are relevant and, therefore, regulated in respect of merely a particular state.…”
Get full text

Genetic parameters and genome-wide association studies including the X chromosome for various reproduction and semen quality traits in Nellore cattle by Felipe E. de Carvalho, José Bento S. Ferraz, Victor B. Pedrosa, Elisangela C. Matos, Joanir P. Eler, Marcio R. Silva, José D. Guimarães, Fernando Bussiman, Barbara C. A. Silva, Henrique A. Mulim, Artur Oliveira Rocha, Andre C. Araujo, Hui Wen, Gabriel S. Campos, Luiz F. Brito

“…When performing genomic analyses, genetic markers located on the X chromosome have been commonly ignored despite the X chromosome being one of the largest chromosomes in the cattle genome. …”
Get full text

Rethinking village malaria workers in Cambodia: Perspectives from the communities, programme managers, and international stakeholders. by Long Heng Orng, Monnaphat Jongdeepaisal, Panarasri Khonputsa, Lek Dysoley, Siv Sovannaroth, Thomas J Peto, James J Callery, Christopher Pell, Richard J Maude, Marco Liverani

“…However, there was a clear demand in the communities for additional services including treatment for common illnesses, monitoring of blood pressure and blood sugar levels, and relief of general symptoms through medication, such as for fever, headache, and stomach pain. …”
Get full text

Examining cancer patient preferences during three stages of decision making and family involvement: a multicenter survey study in China by Siyu Yan, Danqi Wang, Qiao Huang, Yongbo Wang, Manru Fan, Hongyang Xue, Linxin Yu, Yinghui Jin

“…Equal participation was most common in family involvement in decision-making, followed by family-led and patient-led. 15.5% of patients reported a discrepancy between expected and actual family involvement. …”
Get full text

Determination of Seroprevalence and Risk Factors of Crimean–Congo Haemorrhagic Fever (CCHF) in the Endemic Region in Turkey: A Population-Based Cross-Sectional Study by Rıza Çıtıl, Mücahit Eğri, Yalçın Önder, Fazilet Duygu, Yunus Emre Bulut, Özkan Yaşayancan, Nagehan Yıldız Çeltek, Şafak Şahin

“…CCHF seroprevalence is still a common public health problem in Tokat, Turkey. Male gender, advanced age group, low-educated, low-income, farmers, animal husbandry, and history of tick contact were found to be risk factors for CCHF. …”
Get full text

Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes by Hailing Zhao, Haojun Zhang, Yan Wang, Tingting Zhao, Meihua Yan, Xi Dong, Qian Wang, Jialin Li, Liang Ma, Ping Li

“…Diabetic kidney disease (DKD) is one of the most common complications of diabetes and the leading cause of end-stage renal disease. …”
Get full text

Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis by Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu

“…Abstract Background Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20–30% of CRC patients already present with liver metastases. …”
Get full text

After biopolitics: True democracy as 21st century "lifeworld" by Koljević-Griffith Bogdana

“…., of Pax Americana, which simultaneously includes the project of the EU, is primarily manifested through numerous contemporary phenomena of biopolitics - from "humanitarian interventionism" to "wars against terrorism" and measures taken against COVID 19. The common ground for all phenomena is traced back to the "friend-enemy" distinction, as well as to politization of the body as the conditions which enabled de(con)struction of both homo politicus and democracy. …”
Get full text

Profesjonspraksis i møte med barnehagebarns fysiske aktivitet by Kathrine Bjørgen, Anne Holla Sivertsen, Karin Kippe

“…Collective awareness could contribute to a common understanding and motivation to promote physical activity among children. …”
Get full text

Prevalence of Preoperative Anxiety and Associated Factors Among Surgical Patients: Systematic Review and Meta-Analysis in Ethiopia by Magarsa Lami, Abraham Negash, Jerman Dereje, Ahmed Hiko, Sinetibeb Mesfin, Arsema Gebreyesus, Nano Belama, Nesredin Ahmed Omer, Bikila Balis, Usmael Jibro

“…Background: Preoperative anxiety is commonly characterized as a feeling of tension, apprehension, nervousness, distressing fear, and emotional discomfort preceding surgery. …”
Get full text

Direct effects of prolonged TNF-α and IL-6 exposure on neural activity in human iPSC-derived neuron-astrocyte co-cultures by Noah Goshi, Doris Lam, Chandrakumar Bogguri, Vivek Kurien George, Aimy Sebastian, Jose Cadena, Nicole F. Leon, Nicholas R. Hum, Dina R. Weilhammer, Nicholas O. Fischer, Heather A. Enright

“…Cognitive impairment is one of the many symptoms reported by individuals suffering from long-COVID and other post-viral infection disorders such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A common factor among these conditions is a sustained immune response and increased levels of inflammatory cytokines. …”
Get full text

Dual regulation of the levels and function of Start transcriptional repressors drives G1 arrest in response to cell wall stress by Mihai Spiridon-Bodi, Cristina Ros-Carrero, J. Carlos Igual, Mercè Gomar-Alba

“…Abstract Background Many different stress signaling pathways converge in a common response: slowdown or arrest cell cycle in the G1 phase. …”
Get full text

Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study by Christoph Schindler, Jacek Mikosiński, Pawel Mikosiński, Hanna-Riikka Kärkkäinen, Mirka Sanio, Jere Kurkipuro, Igor Mierau, Wesley Smith, Aki Vartiainen, Laurent Décory, Dirk Weber, Thomas Wirth, Juha Yrjänheikki, Sebastian Schellong, Haritha Samaranayake

“…Background: Diabetic foot ulcer (DFU) is a common and highly morbid complication of diabetes with high unmet medical needs. …”
Get full text

OBSERVATION OF THE NORMAL DEVELOPMENTAL PATTERN OF FETAL CEREBRAL SULCI BETWEEN 18 TO 32 WEEKS OF GESTATIONAL AGE BY USING ULTRASONOGRAPHY - A CORRELATIONAL STUDY BETWEEN TWO MATER... by Sujith Kumar Reddy Madithati, Sai Shankar Mankuzhy Gopalakrishnan, Santosh Chandrasekhar, Jenikar Paulraj, Archana Bala, Geeta Shankar

“…Neuronal migration disorders result when the post mitotic neurons fail to migrate from the ventricular zone to the cortical plate, resulting in a wide spectrum of cortical malformations. The most common clinical manifestations include severe psychomotor retardation, developmental delay, refractory seizures, and failure to thrive. …”
Get full text

Leucocytosis and Asymptomatic Urinary Tract Infections in Sickle Cell Patients at a Tertiary Hospital in Zambia by Taonga Musonda, Mildred Zulu, Mulemba Samutela, Annie Kalonda, Hamakwa Mantina, Pauline Okuku, Musalula Sinkala, Panji Nkhoma

“…Bacteriuria was found in 25% of participants. The most common bacterial isolates were Staphylococcus aureus (32%) and coagulase-negative Staphylococci (32%). …”
Get full text