Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study by Yanwen Xu, Hanyu Zhu, Yuqi Su, Zhizhi Chen, Chuanliu Wang, Ming Yang, Feifei Jiang, Yunping Li, Yongming Xu

“…ObjectiveIntracerebral hemorrhage (ICH) is a common cerebrovascular disease characterized by high mortality and disability rates. …”
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Dentoskeletal effects of aesthetic and conventional twin block appliances in the treatment of skeletal class II malocclusion: a randomized controlled trial by Mohamed Najati Alsilq, Mohamed Youssef

“…Abstract Twin block appliances are commonly used to treat skeletal class II malocclusion. …”
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Clinical characteristics and outcomes of patients with chondroblastoma undergoing surgery with various adjuvant procedures: a retrospective study of 59 cases by Toru Hirozane, Tetsuya Sekita, Eisuke Kobayashi, Tomoaki Mori, Naofumi Asano, Toru Udaka, Takashi Tajima, Rumi Nakagawa, Kazutaka Kikuta, Akira Yoshiyama, Hideo Morioka, Itsuo Watanabe, Ukei Anazawa, Michiro Susa, Keisuke Horiuchi, Yoshihisa Suzuki, Takeshi Morii, Robert Nakayama

“…Methods This retrospective study examined 59 patients followed up at our hospitals for ≥ 1 year after surgery during 1990–2020. The most common lesion site was the epiphyses of long bones (42 cases, 71%), including the femur, tibia, and humerus. …”
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Numbness and Weakness Recovered at a Less Extent in Patients with Lumbar Disc Herniation after Percutaneous Endoscopic Lumbar Discectomy by Yuming Wang, Fuqiang Gao, Haibo Zou

“…Patients with lumbar disc herniation (LDH) may present with motor disorders and various sensory disorders, among which pain and numbness are the most common ones. Percutaneous endoscopic lumbar discectomy (PELD) is reported to be both safe and effective. …”
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Integrating Genomic Selection and a Genome-Wide Association Study to Improve Days Open in Thai Dairy Holstein Cattle: A Comprehensive Genetic Analysis by Akhmad Fathoni, Wuttigrai Boonkum, Vibuntita Chankitisakul, Sayan Buaban, Monchai Duangjinda

“…Days open (DO) is a critical economic and reproductive trait that is commonly employed in genetic selection. Making improvements using conventional genetic techniques is exceedingly challenging. …”
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Pattern of Refractive Error among Patients attending a Tertiary Care Hospital in Southern Assam, India: A Cross-sectional Study by Nilanjan Kaushik Thakur, Ruma Das Debsikdar, Srawani Sarkar, Surabhi Prasad, S Lakshmi, Devajit Deka

“…The proportion of UREs was found to be 12%, with hypermetropia being the most common refractive error, followed by myopia. These findings underscore the need for targeted intervention programmes to improve access to corrective lenses and address vision impairment among these communities.…”
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RECIST 1.1 versus mRECIST for assessment of tumour response to molecular targeted therapies and disease outcomes in patients with hepatocellular carcinoma: a systematic review and... by Yao Yang, Yuping Bai, Hongli Yu, Qiang Zhu, Xiaoyu Xie, Yuemin Feng

“…Objectives Response Evaluation Criteria in Solid Tumours version 1.1 (RECIST 1.1) and modified RECIST (mRECIST) are commonly used to assess tumour response. Which one is better to evaluate efficacy after molecular targeted therapies in hepatocellular carcinoma (HCC) patients is still controversial. …”
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Signs of Nervous System Sensitization in Female Runners with Chronic Patellofemoral Pain by Brian J. Eckenrode, David M. Kietrys, Allison Brown, J. Scott Parrott, Brian Noehren

“…# Background Patellofemoral pain (PFP) is a common overuse injury among runners, affecting females at a higher rate than males. …”
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Study of cardiovascular risk in type 2 diabetic patients in the acute phase of the coronavirus infection and post-COVID period on the background of therapy with sodium-glucose cotr... by N.M. Kushnarоva, O.V. Zinych, A.A. Shuprovych, K.P. Komisarenko

“…The relevance of finding optimal methods for treatment of people with type 2 diabetes (T2DM) who had coronavirus disease 2019 (COVID-19) is due to the fact that these conditions have a number of common pathogenetic mechanisms that cause complications of both diseases. …”
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Characteristics of suicide prevention apps: a content analysis of apps available in Canada and the UK by Lydia Sequeira, Gillian Strudwick, Karen Lascelles, Hwayeon Danielle Shin, Laura Bennett-Poynter, Samantha Groves, Jessica Kemp

“…All identified apps included content from at least one of the domains of the Essential Features Framework. The most commonly included domains were sources of suicide prevention support, and information about suicide. …”
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Assessing awareness and treatment knowledge of preventable blindness in rural and urban South African communities by Z Kiva, J E Wolvaardt

“…These findings should provide some value to those who provide primary healthcare services in rural areas as there is a clear opportunity for patient education and health promotion regarding the causes and symptoms of these common preventable causes of blindness. Addressing this knowledge gap regarding the causes and symptoms of blindness and the treatment options is a critical first step for awareness programmes in rural areas. …”
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Evaluation of hydro-chemical facies and surface water quality dynamics using multivariate statistical approaches in Southern Nigeria by E. A Ubuoh, F. U Nwogu, E. Q Ossai-Abeh, J. C Ikwuemesi, A. O Oke, J. D Umoh

“…Ionic ratios of Ca2+ and Mg2+ 1, Ca2+ and HCO2− [1:2], Ca2+ + Mg2+ and HCO3− + SO42− [1:1], revealed dissolution of dolomite as their common origin, with total cations in wet and dry seasons ranging between 43 and 57% and total anions: 37.3–62.7, with dry season dominance. …”
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Evaluation of the Urine POC-CCA Test Accuracy in the Detection of Schistosoma mansoni Infection: A Systematic Review and Meta-Analysis by Getaneh Alemu, Endalkachew Nibret

“…Schistosomiasis is a common public health problem throughout the world and Schistosoma mansoni is the most prevalent species in Africa. …”
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Prognostic Utility of Prechemoradiotherapy Albumin-to-Alkaline Phosphatase Ratio in Unresectable Locally Advanced Pancreatic Carcinoma Patients by Veysel Haksoyler, Erkan Topkan

“…At a median follow-up of 14.8 months (range: 3.2-85.7), the median PFS and OS times were 7.5 (95% confidence interval (CI): 6.0-9.0) and 14.9 months (95% CI: 11.9-17.9), respectively. The ideal common AAPR cutoff was identified at the rounded 0.46 (area under the curve: 72.3%; sensitivity: 71.2%; specificity: 70.3%) point that dichotomized the patients into two groups: low AAPR (L-AAPR; N=71) and high AAPR (H-AAPR; N=65) groups, respectively. …”
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Comparison of Healthcare Encounters and Drug Persistence in Patients With Pulmonary Arterial Hypertension Receiving Oral Selexipag, Inhaled Iloprost, or Parenteral Treprostinil: A... by Ci Song, Peter Kunovszki, Amélie Beaudet

“…No head-to-head clinical trials have compared outcomes between the 3 different PGI~2~-pathway drugs most commonly available in countries with advanced healthcare: oral selexipag, inhaled iloprost, and parenteral (subcutaneous or intravenous) treprostinil. …”
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Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

“…Abstract Introduction Many interventional strategies are commonly used to treat chronic low back pain (CLBP), though few are specifically intended to target the distinct underlying pathomechanisms causing low back pain. …”
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Comparing standard treatment of moderate to severe obstructive sleep apnoea to add-on acetazolamide treatment: An open-label randomised controlled trial by Anurag Tripathi, Ved Prakash, Hemant Kumar, Mohammad Arif, Atul Tiwari, Sachin Kumar, Mrityunjaya Singh, Deepak Sharma, Shubhra Srivastava

“…Background and Objective: Obstructive sleep apnea (OSA) is a common condition, featured by repetitive upper airway collapse during sleep manifested with poor quality of life and co-morbidities. …”
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Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma by Metoboroghene O. Mowoe, Metoboroghene O. Mowoe, Hisham Allam, Joshua Nqada, Marc Bernon, Karan Gandhi, Sean Burmeister, Urda Kotze, Miriam Kahn, Christo Kloppers, Suba Dharshanan, Zafirah Azween, Pamela Maimela, Paul Townsend, Eduard Jonas, Jonathan M. Blackburn, Jonathan M. Blackburn

“…Autoantibodies (AAbs) in principle make attractive biomarkers as they arise early in disease, report on disease-associated perturbations in cellular proteomes, and are static in response to other common stimuli, yet are measurable in the periphery, potentially well in advance of the onset of clinical symptoms.MethodsHere, we used high-throughput, custom cancer antigen microarrays to identify a clinically relevant autoantibody biomarker combination able to differentially detect PDAC. …”
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Feasibility, reliability, usability, and satisfaction of a digital medical device (ZEMY) for symptom management in patients treated for breast cancer: a single-arm interventional s... by Luis Teixeira, Christelle Levy, David Coeffic, Rim Ghorbal, Julien Dupin, Nazario Esposito, Olfa Derbel

“…This study aimed to assess the feasibility, reliability, usability, and satisfaction of a digital medical device (ZEMY) for patients’ self-monitoring of symptoms commonly experienced during breast cancer treatment and to enhance interaction with healthcare professionals. …”
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Association of Light’s Criteria with Pleural Fluid Procalcitonin Levels and Ultrasound Thorax with its Impact on the Management of Pleural Effusion: A Cross-sectional Study by BK Likhitha, Keertivardhan D Kulkarni, Madhav Mahawar

“…The study found that complex septate findings were the most common Ultrasonography (USG) feature, with thin septations being the most frequent, followed by anechoic findings. …”
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