Which clinical trial designs and statistical approaches have been used in assessments of orphan maintenance by the European Medicines Agency between 2012 and 2022? A cross-sectiona... by Fabian Windfuhr, Kristina Larsson, Theodor Framke, Florian Lasch

“…Indirect comparisons are the most common approach for comparing the new orphan medicinal product to a relevant comparator (44%, 182/418), followed by qualitative comparisons (39%, 162/418) and direct comparisons (18%, 74/418). …”
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Regulatory signatures involved in the cell cycle pathway contribute to egg production heterosis in chicken by Jingwei Yuan, Yuanmei Wang, Yanyan Sun, Yunlei Li, Aixin Ni, Qin Li, Hanhan Yang, Xinying Xu, Yunhe Zong, Hui Ma, Jilan Chen

“…By using weighted gene co-expression network analysis (WGCNA), we obtained multiple gene co-expression modules that were significantly correlated with egg number for each group. The common KEGG pathways including apelin signaling pathway, cell cycle, ribosome, spliceosome and oxidative phosphorylation, were screened for the 2 crossbreds. …”
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Increasing prevalence of thyroid autoimmunity in childhood type 1 diabetes in the pre-COVID but not during the COVID era by Vivien Herczeg, Eszter Muzslay, Diána Czipó, Lili Terkovics, Johanna Takács, Réka Garai, Réka Garai, Fanni Kovács, Andrea Luczay, Anna Körner, Péter Tóth-Heyn

“…Among our children with TA, 28.5% exhibited clinically relevant thyroid-stimulating hormone (TSH) abnormalities (most commonly subclinical hypothyroidism) and/or were prescribed thyroid medication. …”
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Intestinal obstruction caused by disseminated mycobacterium avium complex disease following solid organ transplantation: a case report by Akane Mita, Sho Nakakubo, Yusuke Nishimura, Hideki Shima, Masaaki Watanabe, Tsuyoshi Shimamura, Satoshi Konno

“…Abstract Background Mycobacterium avium complex (MAC) is a common pathogen causing non-tuberculous mycobacterial infections, primarily affecting the lungs. …”
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Effect of Ethylmethacrylate and Isobutylmethacrylate on Surface Hardness and Surface Roughness of Heat-Cure Ocular Acrylic Resins by Hiba Munaf Hadi, Ayad I. Haddad, Firas Abd kati

“… Background Acrylic resin is a commonly utilized material in clinical practice, including:  maxillofacial prosthesis Interim prostheses, repair dentures, reline, orthodontic equipment, and record bases are only a few examples of possible applications. …”
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Evaluation of a Low-threshold Exercise And Protein supplementation intervention for Women (LEAP-W) experiencing homelessness and addiction: Protocol for a single-arm mixed methods... by Fiona Kennedy, Deirdre Murray, Clíona Ní Cheallaigh, Roman Romero-Ortuno, Julie Broderick

“…Addiction, as a coping mechanism for prior trauma, is common among people who are homeless and can have a gendered dimension. …”
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How do leaf functional traits influence above-ground tree carbon in tropical hill forests of Bangladesh? by Ariful Khan, Md Rezaul Karim, Mohammed A.S. Arfin-Khan, Md. Shamim Reza Saimun, Fahmida Sultana, Sharif A. Mukul

“…Additionally, the effects of two common environmental variables—solar radiation and mean annual temperature (MAT)—were significant (p < 0.05) predictors of AGTC at the landscape level but not at the site level. …”
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Gedunin Mitigates <i>Cutibacterium acnes</i>-Induced Skin Inflammation by Inhibiting the NF-κB Pathway by Ju Kyoung Sim, Ye Ji Heo, Jin Hak Shin, Seon Sook Kim, Su Ryeon Seo

“…Gedunin, a limonoid derived from <i>Azadirachta indica</i> (commonly known as neem), is renowned for its antifungal, antimalarial, anticancer, anti-inflammatory, and neuroprotective effects. …”
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The challenges of using Escherichia coli as a host in recombinant insulin production by Muhammad Taher

“… Diabetes mellitus is a metabolic disease characterised by elevation of blood glucose level which leads to serious damage to the blood vessels, eyes, heart, kidney, and nerves affecting about 830 million people worldwide. The most common diabetes is type 2 which usually happened in adults when the body becomes resistant to insulin, or the body does not produce enough insulin. …”
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Acoustic and perceptual impact of face masks on speech: A scoping review. by Gursharan Badh, Thea Knowles

“…All but five articles that reported on perceptual outcomes showed a common trend that wearing a face mask was associated with poorer speech intelligibility. …”
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Characterization of Congolese Woody Biomass and Its Potential as a Bioenergy Source by Maryse D. Nkoua Ngavouka, Tania S. Mayala, Dick H. Douma, Aaron E. Brown, James M. Hammerton, Andrew B. Ross, Gilbert Nsongola, Bernard M’Passi-Mabiala, Jon C. Lovett

“…This study assesses and characterizes six woody biomass (WB) species commonly harvested in the Republic of Congo: <i>Millettia laurentii</i> (WB1), <i>Millettia eetveldeana</i> (WB2), <i>Hymenocardia ulmoides</i> (WB3), <i>Markhamia tomentosa</i> (WB4), <i>Pentaclethra eetveldeana</i> (WB5), and <i>Hymenocardia acida</i> (WB6). …”
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Conservation of wild western honey bees Apis Mellifera in the Polissia natural zone of Ukraine: history, sources of nectar and pollen by Sichenko O., Kryvyi M., Horchanok A., Kuzmenko O., Tytariova O.

“…Pollen of Potentilla erecta L, Frangula alnus L, Lamium purpureum L, as species with the longest flowering season, remain available almost throughout the honey collection season, and the anemophilic pollen-producing tree of the Fagaceae family Quercus robur L is a common source of pollen for honey bees in Polissia forests.…”
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Diabetic ketoacidosis and hyperglycemic hyperosmolar state are associated with higher in-hospital mortality and morbidity in diabetes patients hospitalized with ST-elevation myocar... by Turki Almutairi, Soha Dargham, Amin Jayyousi, Jassim Al Suwaidi, Charbel Abi Khalil

“…Cardiovascular disease was the most common etiology of readmission in all patients. The incidence of non-STEMI was the highest in DKA patients, and the incidence of STEMI was the highest in the HHS group.…”
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Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation by Wei Xu, Hao Lv, Yaxin Xue, Xiaofeng Shi, Shaotian Fu, Xiaojun Li, Chuandong Wang, Danyang Zhao, Dong Han

“…Abstract Background Hypertrophic scar (HS) is a common fibrotic skin disorder characterized by the excessive deposition of extracellular matrix (ECM). …”
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A Contemporary Insight Into the Seroepidemiology of Herpes Simplex Virus Infection in the Sub-Himalayan Region by Sangeeta Deka, Mithilesh Kumar Jha, Pratima Gupta, Putul Mahanta, Deepjyoti Kalita

“…Infection by human herpes simplex virus type 1 and type 2 (HSV-1/2) is common globally though with wide regional variability. …”
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Modified National Early Warning Scores (MNEWS) for Predicting the Outcomes of Suspected Sepsis Patients; A Prospective Cohort Study by Nipon Diskumpon, Busabong Ularnkul, Winchana Srivilaithon, Pariwat Phungoen, Kiattichai Daorattanachai

“… Introduction: The National Early Warning Score (NEWS) is commonly used to identify patients at high mortality risk. …”
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Development of Nutrient-Rich Injera Using Amaranthus Leaf/Grain and Teff Flours: A Study on Nutritional Value, Sensory Characteristics, and Storage Stability by Betelhem Abera, Ramesh Duraisamy, Tewodros Birhanu, Beyene Gurbo, Ketemaw Salelign

“…Teff (Eragrostis tef, Zucc) is the smallest grain commonly cultivated in Ethiopia and Eritrea and is used mainly to prepare pancake-like staple food called flatbread (Injera). …”
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Evaluation of the Prognostic Value of Red Cell Distribution Width to Total Serum Calcium Ratio in Patients with Acute Pancreatitis by Tian-Yong Han, Tao Cheng, Bo-Fu Liu, Ya-Rong He, Pan Pan, Wen-Tao Yang, Qiang-Lai, Yu Cao

“…Acute pancreatitis (AP) is a sudden inflammatory process in the pancreas with variable involvement of nearby organs or other organ systems, and it is a common cause for hospitalization of gastrointestinal origin. …”
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Patterns of prescription opioid use in Swiss emergency department patients and its association with outcome: a retrospective analysis by Aristomenis K Exadaktylos, Gregor Lindner, Georg-Christian Funk, Bertram K Woitok, Petra Büttiker, Svenja Ravioli

“…In 25 cases (1.3%), admission to the ED was due to opioid intoxication.Conclusions Daily prescription opioid use is common in patients presenting to the ED. The use of prescription opioids is associated with adverse outcomes, whereas intoxication is a minor issue in the studied population.…”
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MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer by Shamima Afrin Ruma, Rufus Vinod, Shruti Jain, Kaisa Huhtinen, Johanna Hynninen, Janne Leivo, Kim Pettersson, Karin Sundfeldt, Kamlesh Gidwani

“…Our results call for further validation in larger EOC cohorts preferentially with early stage ovarian cancers and all major histotypes against commonly occurring benign conditions.…”
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