Efficacy and safety of intravenous ferric carboxymaltose in the treatment of Restless Legs Syndrome: a systematic review and meta-analysis by Ayesha Khan, Harsh Kumar, Kuldeep Dalpat Rai, Anzel Saeed, Jawad Ishtiaq, Muhammad Tanveer Alam, Sakshi Chawla, Md Ariful Haque, Md Ariful Haque

“…Adverse events were more common in the FCM group, particularly nausea, but no significant differences were found for severe adverse events.ConclusionIn conclusion, intravenous ferric carboxymaltose significantly reduces Restless Legs Syndrome symptoms, especially in patients with confirmed iron deficiency. …”
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Perspectives of Midwives and Nurse Practitioners in Kentucky on Exercise Counseling During Pregnancy: A Qualitative Study by Madhawa Perera, Taniya S. Nagpal, Maire M. Blankenship, Danilo V. Tolusso, Jordyn M. Cox, Dilini Prashadika, Mark Schafer, Rachel A. Tinius

“…The framework method was employed to identify common themes in the responses from participants. …”
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Verification of Lactobacillus brevis tolerance to simulated gastric juice and the potential effects of postbiotic gamma-aminobutyric acid in streptozotocin-induced diabetic mice by Amro Abdelazez, Heba Abdelmotaal, Smith Etareri Evivie, Maha Bikheet, Rokayya Sami, Hassan Mohamed, Xiangchen Meng

“…As recommended, L. brevis should be commonly distributed as a postbiotic GABA in pharmaceutical and nutritional applications.…”
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Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis by Mariarita Spampinato, Cesarina Giallongo, Sebastiano Giallongo, Enrico La Spina, Andrea Duminuco, Lucia Longhitano, Rosario Caltabiano, Lucia Salvatorelli, Giuseppe Broggi, Elisabetta P. Pricoco, Vittorio Del Fabro, Ilaria Dulcamare, Antonio Massimo DI Mauro, Alessandra Romano, Francesco Di Raimondo, Giovanni Li Volti, Giuseppe A. Palumbo, Daniele Tibullo

“…Abstract Background Clonal myeloproliferation and fibrotic transformation of the bone marrow (BM) are the pathogenetic events most commonly occurring in myelofibrosis (MF). There is great evidence indicating that tumor microenvironment is characterized by high lactate levels, acting not only as an energetic source, but also as a signaling molecule. …”
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Interhospital Patient Transfers from the Emergency Department: A Retrospective, Observational Study by Ali Cankut Tatlıparmak

“…Conclusion: The most common reason for transfer was cardiac events. Increasing the cardiology facilities and equipment of the hospital could reduce the number of interhospital patient transfers.…”
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Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions. by Zac Sandy, Zijuan Wang, Deepak Behera, Benjamin M Foster, Finlay A Martin, Kira Brüninghoff, Kathleen M Cain, Wolfgang Dörner, Maria Jose Cabello-Lobato, Josep V Forment, Matthew J Cliff, Igor Larrosa, Perdita Barran, Duncan L Smith, Henning D Mootz, Christine K Schmidt

“…The resultant covalent bonds can withstand even the harshest washing conditions, allowing for the removal of indirect binders whilst retaining and capturing weak and transient interactors that are commonly lost during wash steps. This technique is widely applicable and highly effective for identifying site-selective non-covalent interactors. …”
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Intestinal Organoids in Colitis Research: Focusing on Variability and Cryopreservation by Talke F. zur Bruegge, Andrea Liese, Sören Donath, Stefan Kalies, Maike Kosanke, Oliver Dittrich-Breiholz, Sandra Czech, Verena N. Bauer, André Bleich, Manuela Buettner

“…In recent years, stem cell-derived organoids have become a cell culture standard that is widely used for studying various scientific issues that were previously investigated through animal experiments and using common tumor cell lines. After their initial hype, concerns regarding their standardization have been raised. …”
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Java deserialization gadget chain discovery method based on hybrid analysis by Yongxing WU, Libo CHEN, Kaida JIANG

“…Java deserialization vulnerabilities have become a common threat to Java application security nowadays.Finding out the gadget chain determines whether this type of vulnerability can be exploited.Due to the large code space of Java applications and dependent libraries and the polymorphism of Java itself, manual analysis of Java deserialization gadget chains consumes a lot of time and effort and it is highly dependent on the experienced knowledge.Therefore, it is crucial to study how to efficiently and accurately automate the discovery of gadget chains.Java deserialization gadget chain discovery method based on hybrid analysis was proposed.Call graph based on the variable declaration type was constructed, and then the deserialization entry functions that may reach the dangerous functions were screened using the call graph analysis.The screened entry functions were used as the entry point of the hybrid information flow analysis.The hybrid information flow analysis was carried out for both pointer and tainted variables.The tainted objects created implicitly were marked.The tainted information and the pointer information were propagated simultaneously to construct the hybrid information flow graph.The reachability of external taint data propagation to the dangerous function was judged based on the hybrid information flow graph.The corresponding deserialization gadget chain was constructed according to the taint propagation path.The hybrid analysis took into account the efficiency of call graph analysis and the accuracy of hybrid information flow analysis.The corresponding static analysis tool, namely GadgetSearch, was implemented based on the proposed hybrid analysis method.In the experimental evaluation, GadgetSearch had lower false positive and lower false negative than the existing tool GadgetInspector on four datasets of Ysoserial, Marshalsec, Jackson historical CVE, and XStream historical CVE.Additionally, GadgetSearch also found multiple undisclosed gadget chains.The experimental results show that the proposed method can efficiently and accurately discover the Java deserialization gadget chain in multiple practical Java applications.…”
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Herbivore functions in the hot-seat: Resilience of Acanthurus triostegus to marine heatwaves. by Taylor Souza, Jeroen Brijs, Leon Tran, Larry Crowder, Jacob L Johansen

“…Here we evaluate the consequences of thermal stress on the capacity of a common herbivorous coral reef fish (Acanthurus triostegus) to control finely filamentous matrices of Caulerpa sertularioides and C. verticillata algae in Hawai'i, by characterizing in-vivo changes in metabolic demands, diurnal foraging rates, activity patterns and individual condition in a laboratory setting during winter (24.0±0.1°C), summer (27.5±0.1°C), and at the peak of a representative marine heatwave, (31.0±0.1°C). …”
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Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (IMMENSE study): study protocol for a randomised controlled trial by Liv Mathiesen, Jeanette Schultz Johansen, Kjerstin Havnes, Kjell H. Halvorsen, Stine Haustreis, Lillann Wilsgård Skaue, Elena Kamycheva, Kirsten K. Viktil, Anne Gerd Granås, Beate H. Garcia

“…Introduction Drug-related problems (DRPs) are common in the elderly, leading to suboptimal therapy, hospitalisations and increased mortality. …”
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The adaptation and evaluation of psychometric properties of the Lithuanian versions of the Faux Pas Recognition and Strange Stories tests by A. Jasionis, G. Jasionytė, R. Mameniškienė

“…One of the main subdomains of social cognitive functions, Theory of Mind (ToM), involves the ability to understand other people’s thoughts, intentions, emotions, and predict their behaviour. ToM deficit is common in many neurological and mental disorders. …”
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Influenza forecasting in human populations: a scoping review. by Jean-Paul Chretien, Dylan George, Jeffrey Shaman, Rohit A Chitale, F Ellis McKenzie

“…Two studies compared distinct modeling approaches using common data, 2 assessed model calibration, and 1 systematically incorporated expert input. …”
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Prevalence of Three-Rooted Deciduous Mandibular Molars in the Children of Northwestern Iran by Maryam Khosrozadeh, Maryam Mostafavi, Mohammad Hassan Hamrah, Elham Niknejad

“…Regarding recent improvements in common knowledge and the importance of maintaining primary teeth until eruption of succedaneous teeth, identifying the morphology of primary teeth and probable variations is of great importance to achieve optimal therapeutic outcome. …”
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Deep Learning-Based Dynamic Stable Cluster Head Selection in VANET by Muhammad Asim Saleem, Zhou Shijie, Muhammad Umer Sarwar, Tanveer Ahmad, Amarah Maqbool, Casper Shikali Shivachi, Maham Tariq

“…A deep recurrent learning network, commonly known as long short-term memory (LSTM), is trained for the probability of detection with various signals and noise conditions. …”
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Autologous Peripheral Blood-Derived Orthobiologics for the Management of Shoulder Disorders: A Review of Current Clinical Evidence by Ashim Gupta, Nicola Maffulli

“…Abstract Introduction A multidisciplinary approach is recommended to manage shoulder pain, the third most common musculoskeletal disorder, but traditional modalities have limitations, providing only temporary symptomatic pain relief instead of targeting the underlying pathophysiology. …”
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Assessing the inflammation in pediatric MOGAD: Significance of CSF HMGB1 and related biomarkers by Xin Wang, Ruibin Zhao, Jiayu Fan, Chong Liu, Li Zhang, Huafang Yang, Weiyi Wang

“…Background and purposeMyelin-oligodendrocyte glycoprotein antibody associated disease (MOGAD) is a common inflammatory disease of the central nervous system (CNS) in children that can lead to demyelination. …”
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Assessment of Maternal Satisfaction and Associated Factors among Parturients Who Underwent Cesarean Delivery under Spinal Anesthesia at University of Gondar Comprehensive Specializ... by Samuel Debas Bayable, Seid Adem Ahmed, Girmay Fitiwi Lema, Debas Yaregal Melesse

“…Spinal anesthesia is the most common anesthetic technique for cesarean delivery. …”
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Subacromial Pain Syndrome in Breast Cancer Survivors—Are Structural Shoulder Changes Verified by Ultrasound Clinically Relevant? by Ivana Klarić-Kukuz, Jure Aljinović, Blaž Barun, Marko Roki, Benjamin Benzon, Danijela Budimir Mršić, Maja Marinović Guić, Ana Poljičanin

“…<b>Background/Objectives</b>: Shoulder pain is a common treatment outcome in breast cancer survivors. …”
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A New Concept Proposal of the Tidal Level Designed for the Security of Coastal Levee during Storm Surge — Taking the Lingdingyang Estuary as an Example by LI Bin, HE Yong, FANG Shenguang

“…Based on the analysis of the design frequency tidal levels,storm surge water increase and flood inflow upstream of control stations in Lingdingyang Estuary over years,it showed that the tidal levels of designed frequency of 0.5%~2.0% raised from 0.2 to 1.0 m in recent years,the extreme storm surge elevations exceed 2.5 m commonly,and the current tidal level difference of adjacent design frequency was less than 0.2 m.During the emergence of the extreme storm surge elevation in the estuary flood upstream would not be appeared simutaneously,while the moderate tide was most likely encounterred.Therefore,there were some problems in the application of design frequency tidal levels in estuarine waters,such as the small tidal level difference between adjacent frequencies,the severe frequency jump of tide level during strong typhoon,and the failure to directly reflect the leading role of the extreme storm surge elevation in the elevation design of coastal levee.The concept of the tidal levels designed for storm surge security of coastal levee was proposed in the paper,which were composed of multi-year average high tidal level and the maximum extreme storm surge elevation,clearly and easily to be used.It highlights the main role played by coastal levee to resist the disaster by strong storm surge.The calculated values were close to and slightly more than the designed tidal levels of 100~200 year return period of main stations in the mouth of Lingdingyang estuary,Shiziyang water area and delta river network area after reviewed in 2020,proving its safety and reliability.The reviewed tidal levels of designed frequency in the Chiwan station in 2020 were likely too high by analysis preliminarily.The tidal level designed for storm surge security of coastal levee could be widely used in reinforcement design,safety risk assessment in storm surge and storm surge disaster warning and response.…”
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Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma by Amir Hossein Alizadeh Bahmani, Mahmoud I. Abdel-Aziz, Simone Hashimoto, Corinna Bang, Susanne Brandstetter, Paula Corcuera-Elosegui, Andre Franke, Mario Gorenjak, Susanne Harner, Parastoo Kheiroddin, Leyre López-Fernández, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Antoaneta A. Toncheva, Christine Wolff, Michael Kabesch, Aletta D. Kraneveld, Susanne J. H. Vijverberg, Anke H. Maitland-van der Zee, on behalf of the SysPharmPediA consortium

“…<b>Background/Objectives</b>: Metered-dose inhalers (MDIs) and dry powder inhalers (DPIs) are common inhaled corticosteroid (ICS) inhaler devices. …”
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