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  1. 25241

    Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a viciou... by Yin Jin, Apostolia Topaloudi, Sudhanshu Shekhar, Guangxin Chen, Alicia Nicole Scott, Bryce David Colon, Petros Drineas, Chris Rochet, Peristera Paschou

    Published 2025-01-01
    “…Abstract Dementia refers to an umbrella phenotype of many different underlying pathologies with Alzheimer’s disease (AD) being the most common type. Neuropathological examination remains the gold standard for accurate AD diagnosis, however, most that we know about AD genetics is based on Genome-Wide Association Studies (GWAS) of clinically defined AD. …”
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  2. 25242

    Protective Effect of Conditioned Medium of Immortalized Human Stem Cells from Exfoliated Deciduous Teeth Against Hair Graying Caused by X-Ray Irradiation via Its Antioxidative Acti... by Yasuhiro Katahira, Eri Horio, Natsuki Yamaguchi, Jukito Sonoda, Miu Yamagishi, Satomi Miyakawa, Fumihiro Murakami, Hideaki Hasegawa, Izuru Mizoguchi, Takayuki Yoshimoto

    Published 2025-01-01
    “…Hair graying is one of the common visible signs of human aging, resulting from decreased or abolished melanogenesis due to the depletion of melanocyte stem cells through excess accumulation of oxidative stress. …”
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  3. 25243

    MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial by Mrinal Gounder, Melissa Johnson, Rebecca S. Heist, Geoffrey I. Shapiro, Sophie Postel-Vinay, Frederick H. Wilson, Elena Garralda, Gerburg Wulf, Caroline Almon, Salah Nabhan, Elia Aguado-Fraile, Peng He, Mathilde Romagnoli, Mohammad Hossain, Rohini Narayanaswamy, Amel Sadou-Dubourgnoux, Michael Cooper, Vasileios Askoxylakis, Howard A. Burris, Josep Tabernero

    Published 2025-01-01
    “…Reversible increases in liver function tests, thrombocytopenia, anemia and fatigue were common treatment-related toxicities. Two partial responses were observed; five additional patients achieved radiographically confirmed stable disease for ≥16 weeks. …”
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  4. 25244

    Molecular detection and genomic characterization of Samak Micromys paramyxovirus-1 and -2 in Micromys minutus, Republic of Korea by Augustine Natasha, Sarah E. Pye, Seung Hye Cho, Haryo Seno Pangestu, Jieun Park, Kyungmin Park, Sara P. Prayitno, Bohyeon Kim, Jong Sun Lee, Jongwoo Kim, Shailesh Budhathoki, Yeonsu Oh, Jin-Won Song, Carolina B. López, Jun Gyo Suh, Won-Keun Kim

    Published 2024-10-01
    “…However, it is unknown whether Paramyxoviridae is present in Micromys minutus, another common rodent. Method Here, we screened M. minutus collected from the Gangwon Province in the ROK for paramyxoviruses using nested polymerase chain reaction and confirm positive samples by next-generation metagenomic sequencing. …”
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  5. 25245

    Characterization of Integrons and Quinolone Resistance in Clinical Escherichia coli Isolates in Mansoura City, Egypt by Shaymaa H. Abdel-Rhman, Rehab M. Elbargisy, Dina E. Rizk

    Published 2021-01-01
    “…Escherichia coli is a common pathogen in both humans and animals. Quinolones are used to treat infections caused by Gram-negative bacteria, but resistance genes emerged. …”
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  6. 25246

    Accusations and Law Articles Prediction in the Field of Environmental Protection by Sihan Leng, Xiaojun Kang, Qingzhong Liang, Xinchuan Li, Yuanyuan Fan

    Published 2024-12-01
    “…Legal judgment prediction is a common basic task in the field of Legal AI, aimed at using deep domain models to predict the outcomes of judicial cases, such as charges, legal provisions, and other related tasks. …”
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  7. 25247

    Computationally secure steganography based on speech synthesis by Menghan LI, Kejiang CHEN, Weiming ZHANG, Nenghai YU

    Published 2022-06-01
    “…The steganography theory of computing security has been proposed for a long time, but it has not been widely adopted for mainstream steganography using multimedia data as a carrier.The reason is that the prerequisite for calculating secure steganography is to obtain the accurate distribution of the carrier or to accurately sample according to the carrier distribution.However, naturally collected images and audio/video cannot meet this prerequisite.With the development of deep learning technology, various machine-generated media such as image generation and synthesized speech, have become more and more common on the Internet and then generated media has become a reasonable steganography carrier.Steganography can use normal generated media to cover up secret communications, and pursue in distinguishability from normal generated media.The distribution learned by some generative models is known or controllable, which provides an opportunity to push computational security steganography for practical use.Taking the widely used synthetic speech model as an example, a computationally secure symmetric key steganography algorithm was designed and implemented.The message was decompressed into the synthetic audio according to the decoding process of arithmetic coding based on the conditional probability of sample points, and the message receiver had the same generation model to complete the message extraction by reproducing the audio synthesis process.The public key steganography algorithm was additionally designed based on this algorithm, which provided algorithmic support for the realization of full-flow steganographic communication.Steganographic key exchange ensured the security of steganographic content and the security of steganographic behavior was also achieved.The theoretical analysis showed that the security of the proposed algorithm is determined by the randomness of the embedded message.And the steganography analysis experiment further verified that the attacker cannot distinguish the synthesized carrier audio from the encrypted audio.…”
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  8. 25248

    Investigation of the effects of Afyonkarahisar Region hot springs water on blood calcium and some hormon levels in experimentally-created osteoporosis in rats by Bülent Elitok, Tolgahan Saygin, Yavuz Ulusoy, Bahadir Kilinç

    Published 2021-07-01
    “…Today, one of the most common non-communicable diseases, which, according the World Health Organization experts, dominates the structure of human morbidity and mortality is osteoporosis. …”
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  9. 25249

    xCT as a potential marker for neuroendocrine cells in high-risk prostate cancer and the relation to AL122023.1-miR-26a/30d/30e axis. by Elena D Wilhelm, Jaroslaw T Dankert, Marc Wiesehöfer, Sven Wach, Mathias Wagner, Martin Spahn, Marianna Kruithof-de Julio, Gunther Wennemuth

    Published 2025-01-01
    “…Prostate cancer is the second most common type of cancer in male worldwide. Stromal-epithelial interaction is thought to have a major impact on cancer development and progression. …”
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  10. 25250

    Odevixibat treatment in a child with hypoplastic left heart syndrome and severe cholestatic pruritus: a case report by Rainer Ganschow, Christof Maucksch, Peter Rauschkolb, Martin B. E. Schneider

    Published 2025-01-01
    “…Liver-related abnormalities are commonly observed in patients with congenital heart disease, and these may lead to secondary manifestations such as pruritus. …”
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  11. 25251

    Otolaryngology exposure in a longitudinal integrated clerkship setting by Grace Margaret Scott, Corliss Ann Elizabeth Best, Damian Christopher Micomonaco

    Published 2017-07-01
    “…This study looks to quantify the level of exposure students are receiving in OtoHNS at NOSM and to assess their comfort level with diagnosing and treating common otolaryngologic conditions. Methods A structured 13-item survey was administered to second, third and fourth year medical students at NOSM. …”
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  12. 25252

    Identifying the Primary Kinetic Factors Influencing the Anterior–Posterior Center of Mass Displacement in Barbell Squats: A Factor Regression Analysis by Diwei Chen, Dong Sun, Fengping Li, Dongxu Wang, Zhanyi Zhou, Zixiang Gao, Yaodong Gu

    Published 2025-01-01
    “…Background: Barbell squats are commonly used in strength training, but the anterior–posterior displacement of the Center of Mass (COM) may impair joint stability and increase injury risk. …”
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  13. 25253

    Scalable and Privacy-Preserving Inter-AS Routing Through Machine-Learning-Based Graph Pruning by Davide Andreoletti, Cristina Rottondi, Silvia Giordano, Andrea Bianco

    Published 2025-01-01
    “…Recently, protocols for computing the shortest path between a source and a destination (i.e., a common policy in routing tasks) in a privacy-preserving manner have been proposed. …”
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  14. 25254

    PROFILE OF INCOMPATIBLE REACTIONS TO PACKED RED CELL TRANSFUSION IN PATIENTS WITH CHRONIC KIDNEY DISEASE AT SANGLAH HOSPITAL by I Nyoman Arsana, Ni Nyoman Sri Puspa Adi, Ni Ketut Ayu Juliasih

    Published 2023-07-01
    “…Packed Red Cell (PRC) transfusions were a common way to replace the kidneys' function in filtration. …”
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  15. 25255

    Glucagon-like peptide 1 receptor agonists in obesity treatment - a literature review by Aleksander Jentkiewicz, Esmail Haj Obeid, Jakub Ulrych, Jan Krupa, Maciej Malinowski, Michał Krasowski, Alicja Kalinowska, Wiktoria Pietras, Adrian Kozieł, Zofia Kurek

    Published 2025-02-01
    “…Clinical trials consistently demonstrate significant weight loss, positive action on cardiovascular risk and better glycemic control. All GLP-1 RAs have common side effects which are gastrointestinal disorders, and gallbladder-related issues, but their safety profiles are acceptable.   …”
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  16. 25256

    Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP by Bilin Zhao, Shuang Zheng, Gaoxiang Yang, Zhijun He, Jiewei Deng, Lijuan Luo, Xinyan Li, Tiangang Luan

    Published 2025-01-01
    “…Aryl organophosphorus flame retardants (aryl-OPFRs), commonly used product additives with close ties to daily life, have been regrettably characterized by multiple well-defined toxicity risks. …”
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  17. 25257

    Educational Needs assessment (and Exposure Rate) of Emergency Medicine Technicians - One Step toward Accountable Education by farzaneh zarei, ghobad moradi, reza pira

    Published 2024-10-01
    “…This study was conducted to determine the educational needs of emergency medicine technicians (common and important signs, symptoms, and diseases) to be used in the revision of the curriculum based on accountability. …”
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  18. 25258

    Phonologisches Bewusstsein bei einem polnisch-amerikanischen Kind mit Legasthenie. Eine Fallstudie by Rafał Młyński, Agata Guzek

    Published 2025-02-01
    “…The empirical portion contains the methodology, assessment instruments, data analysis, and their interpretation chosen by the authors. …”
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  19. 25259

    Modeling the Effects of Formulary Exclusions: How Many Patients Could Be Affected by a Specific Exclusion? by Anne M. Sydor, Emily Bergin, Jonathan Kay, Erik Stone, Robert Popovian

    Published 2024-03-01
    “…**Conclusion:** Substitution with a nonequivalent treatment is common in formularies currently in use and is not without substantial consequences for hundreds of thousands of patients. …”
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  20. 25260

    Interplay of aurora kinase a functional residues and Epstein-barr Nuclear Antigen 1 in Epstein-barr virus associated Gastric cancer using AGS cells by Nidhi Varshney, Siddharth Singh, Meenakshi Kandpal, Vaishali Saini, Erle S. Roberston, Hem Chandra Jha

    Published 2025-01-01
    “…Aurora Kinase A is a major mitotic protein kinase that regulates mitotic progression; overexpression and hyperactivation of AURKA commonly promote genomic instability in many tumours. …”
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