First evidence of immunomodulation of the renin-angiotensin system through substance P/neurokinin 1 receptor: a case and control study in hypertension and cardiac patients by Ibrahim M. Alanazi, Riffat Mehboob, Ayesha Tariq, Sajid Hameed, Uzma Malik, Noreen Sarwar, Imran Shahid, Khurram Mehboob

“…Among those with hypertension and cardiac diseases, smoking, family history, and a diet heavy in salt were the most common risk factors. The study discovered substantial variations in SP and NK1R levels between hypertensive patients and a control group, suggesting a link between these neuropeptides and hypertension. …”
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The Mid-Twentieth Century Baby Boom and the Role of Social Influence. An Agent-Based Modelling Approach by Eli Nomes, André Grow, Jan Van Bavel

“…Yet, in those regions where larger family sizes were still common, the two-child norm contributed to a fertility decline. …”
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Multifunctional Proteins Bridge Mitosis with Motility and Cancer with Inflammation and Arthritis by Jihong Jiang, Rosaely Casalegno-Garduno, Helen Chen, Anita Schmitt, Michael Schmitt, Christopher A. Maxwell

“…While most secreted proteins contain defined signal peptides that direct their extracellular transport through the ER-Golgi pathway, nonclassical transport of leaderless peptides/proteins was first described 20 years ago and the mechanisms responsible for unconventional export of such proteins have been thoroughly reviewed. …”
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ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy by Yuexiu Wu, Yufeng Zuo, Rana Chakrabarti, Biao Feng, Shali Chen, Subrata Chakrabarti

“…Diabetic retinopathy is one of the most common causes of blindness in North America. Several signaling mechanisms are activated secondary to hyperglycemia in diabetes, leading to activation of vasoactive factors. …”
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The spectrum-efficacy correlation of Kai-Xin-San for cognition of Aβ42 transgenic Drosophila and verification of its active ingredients by Jinfu Wu, Hang Sun, Yiyang Zhao, Lian Lian, Hongsheng Bian, Yong Guo, Dan Li, Lili Huang

“…Finally, the spectrum-effect relationship between the KXS fingerprint and memory improvement was analyzed, with the active ingredients subjected to validation testing.ResultsThe results identified seventeen common peaks in the fingerprint, and eight active components were determined: polygalaxanthone III, 3-6-disinapoylsucrose, ginsenoside Rg1, ginsenoside Rb1, β-asarone, α-asarone, dehydrotumulosic acid, and dehydropachymic acid. …”
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DERECHO Y LITERATURA: HACIA LA HUMANIZACIÓN DEL DERECHO by Elvis Cotrado Cahui

“… El presente artículo explora la utilidad del movimiento denominado Law and Literature o Derecho y Literatura en sus dos vertientes: la tendencia romántica y la tendencia técnica; la primera es analizada con más amplitud y se la reconoce como auténticamente ligada al sistema jurídico romano germánico al cual nuestro ordenamiento está adscrito, mientras que la tendencia técnica, considerada también en nuestro ámbito por otra vertiente de pensamiento, se relaciona más con el sistema del common law. Asimismo, exploramos y analizamos el uso que se le da a este movimiento en la argumentación jurídica y en la motivación de sentencias. …”
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TIKSLIEJI MOKSLAI IR VISYBIŠKAS SOCIALINĖS TIKROVĖS SUPRATIMAS by Leo Näpinen

“…These concepts and methods can only be used for modelling social processes, whereas the modelling can start only after the social phenomenon has been understood by the common sense, philosophy and historical research. …”
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New Diagnostic Techniques for Esophageal Disorders by A Lazarescu

“…Esophageal disorders are common in the general population and can be associated with significant morbidity. …”
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Anti-TNF-α Monoclonal Antibody Therapy Improves Anemia through Downregulating Hepatocyte Hepcidin Expression in Inflammatory Bowel Disease by Weigang Shu, Zhi Pang, Chunjin Xu, Jian Lin, Gengfeng Li, Wei Wu, Suofeng Sun, Junxiang Li, Xiuling Li, Zhanju Liu

“…Anemia is one of the most common complications in patients with inflammatory bowel disease (IBD). …”
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A national framework for transition to precision medicine by Samaneh Karimi Esboei, Sepehr Ghazinoory, Fatemeh Saghafi

“…The results from the systematic review show that for the transition to PM, we must first move from common medicine to stratified medicine and then PM. …”
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Reconstructing the genetic structure of the Kazakh from clan distribution data by M. K. Zhabagin, О. Е. Balanovsky, Zh. M. Sabitov, A. Z. Temirgaliyev, A. T. Agdzhoyan, S. M. Koshel, Е. М. Ramankulov, E. V. Balanovska

“…For Central Asian populations, particularly Kazakh, the clan affiliation serves as a good marker: a set of papers demonstrated that many clans include mainly persons which biologically descent from a recent common ancestor. In this study, we analyzed a large (~4.2 million persons) dataset on quasigenetic markers - the geographic distribution of 50 Kazakh clans at the beginning of the 20th century, and compared the dataset with the direct data of the Y-chro-mosomal diversity in modern Kazakh populations. …”
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Prevalence and Associated Risk Factors of Sports-Related Orthopedic Injuries by Moaath Abdulaziz Alamir, Ahmed Hussain Alassaf, Naif Abdulaziz Almansour, Abdullah Mohammed Bin Jaylan, Khalid Awad Almutairi, Mohammad Abdullah Aldakail, Khaled Abdulkareem Alanzy

“…The knee was the most frequently injured location (27.2%), followed by the ankle (23.9%) and shoulder/arms (19.6%). The most common types of injuries were sprains (36.6%) and bruises (25.8%). …”
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Modelling of User Behaviour for Static Rebalancing of Bike Sharing System: Transfer of Demand from Bike-Shortage Stations to Neighbouring Stations by Roberta Costa Affonso, Florent Couffin, Patrice Leclaire

“…Bike sharing systems are becoming more and more common around the world. One of the main difficulties is to ensure the availability of bicycles in order to satisfy users. …”
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Comparisons of CVID and IgGSD: Referring Physicians, Autoimmune Conditions, Pneumovax Reactivity, Immunoglobulin Levels, Blood Lymphocyte Subsets, and HLA-A and -B Typing in 432 Ad... by James C. Barton, Luigi F. Bertoli, J. Clayborn Barton

“…Common variable immunodeficiency (CVID) and immunoglobulin (Ig) G subclass deficiency (IgGSD) are heterogeneous disorders characterized by respiratory tract infections, selective Ig isotype deficiencies, and impaired antibody responses to polysaccharide antigens. …”
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Towards recognition of peer violence in youth sports – the case of Vojvodina by Ivana Milovanović, Radenko Matić, Jovan Vuković, Milica Blagojević, Mladen Mikić, Dragan Marinković

“…The paper contains the results of the field research that the authors used in order to determine the existence and manifesting forms of peer pressure in youth sports. …”
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Eliminating Postoperative Nausea and Vomiting in Outpatient Surgery with Multimodal Strategies including Low Doses of Nonsedating, Off-Patent Antiemetics: Is “Zero Tolerance“ Achie... by Susan J. Skledar, Brian A. Williams, Manuel C. Vallejo, Patricia L. Dalby, Jonathan H. Waters, Ronald Glick, Michael L. Kentor

“…Our approach toward “zero tolerance” of PONV emphasizes liberal identification of and prophylaxis against common risks.…”
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Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges by Weigao Zhang, Hu Liu, Danyang Zhang, Yuguo Yi, Liang Tao, Yunfeng Zhu, Shuxian Huang, Xunan Zhao, Qianchao Shao, Peiqi Li, Yiwen Weng, Wei Lu, Jianfa Zhang, Haibing Zhang, Yuxin Chen, Dan Weng

“…Our results demonstrated that hepatocyte-specific deficiency of RIPK1 sensitized the liver to short-term fasting-induced liver injury and hepatocyte apoptosis in both male and female mice. Despite being a common physiological stressor that typically does not induce liver inflammation, short-term fasting triggered hepatic inflammation and compensatory proliferation in hepatocyte-specific RIPK1-deficient (Ripk1-hepKO) mice. …”
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Imaging pathology in archived cornea with Fuchs’ endothelial corneal dystrophy including tissue reprocessing for volume electron microscopy by Sayo Maeno, Philip N. Lewis, Robert D. Young, Yoshinori Oie, Kohji Nishida, Andrew J. Quantock

“…Abstract Fuchs’ endothelial corneal dystrophy (FECD) is a common sight-threatening condition characterised by pathological changes in the posterior cornea. …”
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Drug Target Investigation of <i>N</i>-<i>p</i>-Coumaroyl-<i>N</i>’-Caffeoylputrescine, a Naturally-Occurring Alkaloid Derived from <i>Saxifraga tangutica</i> by Chuang Liu, Jun Dang, Minchen Wu

“…To further identify its target, the drug affinity responsive target stability technique and multiple public databases were integrated to retrieve a total of 317 common targets from comprehensive screening. A further bioinformatics analysis not only identified 13 hub targets but also indicated PCC as having biological activities against cancer and affecting metabolic diseases. …”
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Prophylactic Role of Averrhoa carambola (Star Fruit) Extract against Chemically Induced Hepatocellular Carcinoma in Swiss Albino Mice by Ritu Singh, Jyoti Sharma, P. K. Goyal

“…Liver cancer remains one of the severe lethal malignancies worldwide and hepatocellular carcinoma (HCC) is the most common form. The current study was designed to evaluate the prophylactic role of the fruit of Averrhoa carambola (star fruit or Kamrak) on diethylnitrosamine- (DENA-) induced (15 mg/kg b.wt.; single i.p. injection) and CCl4-promoted (1.6 g/kg b.wt. in corn oil thrice a week for 24 weeks) liver cancer in Swiss albino mice. …”
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