Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites by Thomas Kayser, MD, BS, Ronald Smulders, MD, PhD, Tomohiro Kusawake, PhD, Erik Wambre, PhD, Gurunadh R. Chichili, PhD, Mary B. Blauwet, DrPH, Anna Spence, MS, Melanie Patton, BS, Rima Tabash, PhD, Hannah A. DeBerg, PhD, Sugandhika Khosa, MS, Philipp Badorrek, MD, Jens M. Hohlfeld, MD, Brian C. Ferslew, PharmD, PhD

“…Results: Twenty-eight adults (mean age, 26.9 years; 23 male participants), with 7 receiving 1 mg and 13 receiving 4 mg ASP2390, 8 receiving placebo, showed no serious adverse events or withdrawals due to treatment-emergent adverse events. The most common events were nasopharyngitis, coronavirus disease 2019, headache, fatigue, and diarrhea; fatigue and headache were the most frequent systemic reactions, and injection-site tenderness the most frequent local reaction. …”
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MicroRNAs signatures as potential molecular markers in mild cognitive impairment: a meta-analysis by Natalia Vargas-Rondón, Yeimy González-Giraldo, Ángela Y. García Fonseca, Janneth Gonzalez, Andrés Felipe Aristizabal-Pachon

“…Therefore, in this study, we conducted a meta-analysis to identify the miRNAs commonly deregulated in MCI, focusing on expression profiles in plasma, serum, and extracellular vesicle samples. …”
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Can Met-PET/CT Predict Sporadic Multiglandular Hyperparathyroidism? Report of a Case and Review of the Literature by Andreas Hillenbrand, Johannes Lemke, Doris Henne-Bruns, Ambros J. Beer, Vikas Prasad

“…Primary hyperparathyroidism (pHPT) is a common endocrine disorder of the parathyroid glands. …”
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THE EFFECTIVENESS OF ZINC AND RISEDRONATE ON BONE TURNOVER IN RAT MODEL OF OSTEOPOROSIS ASSESSED WITH THE EXPRESSION OF β-CROSSLAPS by Adam Fajar, Mohammad Rizal Chaidir, Dicky Mulyadi, Ahmad Ramdan, Yoyos Dias Ismiarto

“…Background: Osteoporosis prevalence in Indonesia is high. Risedronate commonly used for treating the osteoporosis. Unfortunately, long term therapy can cause hazardous adverse effect to the patient. …”
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Distinctive blood and salivary proteomics signatures in Qatari individuals at high risk for cardiovascular disease by Ghada Yousif, Selvasankar Murugesan, Mohamed Nadhir Djekidel, Annalisa Terranegra, Giusy Gentilcore, Jean Charles Grivel, Souhaila Al Khodor

“…Additionally, we identified eight common CVD-risk biomarkers shared between both plasma and saliva, demonstrating promising diagnostic tools for identifying individuals at high risk of developing CVD. …”
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Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis by Dan-Dan Yao, Xiao-Wei Yan, Yan Zhou, Zuo-Lin Li, Fang-Xin Qiu

“…Background Vascular calcification is common and progressive in patients with chronic kidney disease. …”
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Chemicals That Disrupt the Endocrine System and Their Effects on Behavior by Yousaf Khan1, Abdul Sattar1, Syed Amin Ullah1, Zia-Ur-Rehman2, Hakimullah3, Madeeha Bibi4, Hina Sarfraz1, Anila Mukhtiar1

“…The diseases that are commonly reported due to the action of the above chemicals and daily use items includes neurological disorders, behavioral disorders, metabolic dysfunction leading to obesity or weakness, thyroid dysfunction, reproductive disturbances and several others that can prove fatal and lead to cancer as well. …”
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Phosphorylation of histone H3Ser10 in plant cell division by D. B. Loginova, O. G. Silkova

“…Histones, the major protein components of chromatin, undergo post-translational modifications, which particularly affect the structural and functional organization of chromosomes. The most common post-translational modifications are phosphorylation, methylation, acetylation and ubiquitination. …”
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The Effect of Implementing Self-Compassion Program on Moral Injury of Nursing Students by Hanie Dahmardeh

“… Background: Self-compassion can have a significant role and impact on moral damage, and the positive components of self-compassion (self-kindness, common human sense, and mindfulness) reduce the negative effects of moral damage, so using self-compassion methods can reduce the moral damage caused to nursing students during their studies. …”
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Foodscape: A scoping review and a research agenda for food security-related studies. by Simon Vonthron, Coline Perrin, Christophe-Toussaint Soulard

“…Thus, although spatial analysis was the first approach to foodscapes, sociocultural, behavioral and systemic approaches are becoming more common. In the spatial approach, the term 'foodscape' is synonymous with 'food environment'. …”
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The quality and technological parameters of milk obtained from dairy cows with subclinical mastitis by Magdalena Zalewska, Paulina Brzozowska, Magdalena Rzewuska, Ewelina Kawecka-Grochocka, Daria M. Urbańska, Tomasz Sakowski, Emilia Bagnicka

“…ABSTRACT: Mastitis is one of the most common diseases in dairy cattle. It significantly reduces milk quality and yield, thus incurring economic losses for farmers. …”
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Can Cryptogonimids of the Same Genus Influence Each Other’s Level of Genetic Variation? by Ekaterina S. Tokarskaya, Yulia V. Tatonova, Haneef Ahmed Amissah, Polina G. Shumenko, Mikhail Yu. Shchelkanov

“…Trematodes of the genus <i>Exorchis</i> are parasites that are common in East and Southeast Asia. These parasites are known to infect fish, thus impacting aquaculture significantly. …”
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Prevalence of metabolic syndrome and its risk factors among the government bank’s employees of district Bijnor, Uttar Pradesh: A cross-sectional study by Ajay Kumar Prajapati, Ruchi Prajapati

“…Most of the participants were hypertensive 49 (76.6%), diabetic 16 (28.6%), and obese 37 (57.8%). Conclusion: Common concerns of male gender, increasing age and BMI, sedentary lifestyle, stress and positive family history should be considered for early identification and appropriate intervention to fight against the growing MetS epidemic.…”
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Educational interventions to improve pediatric emergency care: A qualitative assessment of the perspectives of African healthcare workers. by Emily A Hartford, Chris A Rees, Isaac Kihurani, Syeda Ra'ana Hussain, Elena Seifert, Alexis Schmid, Tigist Bacha, Carol C Chen, Megan L Schultz

“…Pediatric emergency care (PEC) training for health care workers (HCWs) is commonly offered in the form of short courses. This study gathers the perspectives of HCWs from eight African countries on how to best deliver and implement short training courses in PEC. …”
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Lights and Siren Transport and the Need for Hospital Intervention in Nontrauma Patients: A Prospective Study by Olivier Bertholet, Mathieu Pasquier, Elina Christes, Damien Wirths, Pierre-Nicolas Carron, Olivier Hugli, Fabrice Dami

“…The overtriage rate was 40.3%. The most common medical TCHI was the fast-track (65.2% of all TCHI). …”
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Sentiment analysis of the Hamas-Israel war on YouTube comments using deep learning by Ashagrew Liyih, Shegaw Anagaw, Minichel Yibeyin, Yitayal Tehone

“…Finding and monitoring comments, as well as manually extracting the information contained in them, is a difficult task due to the vast diversity of ideas on YouTube. …”
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Trends and Clinical Implications of Pediatric Pulmonary Function After Hematopoietic Stem Cell Transplantation: A Systematic Review by Xiaowei Zhao, Yuqi Zhao, Guoyu Ding, Xue Li, Xiaoyue Zhang, Yanli Leng, Hongmei Wang

“…Results Pulmonary dysfunction, particularly obstructive and restrictive ventilatory disorders, is common in pediatric HSCT recipients. Significant changes in PFT parameters, such as FEV1/FVC ratio and FEF25‐75%, were observed. …”
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Quantifying soil surface erosion by Philippe, Pierre, Benahmed, Nadia

“…A conceptual framework is then required to correctly define soil’s erodibility, which is defined as an intrinsic property of the material through an empirical erosion law. In the most commonly accepted approach, this erodibility combines two distinct parameters: an erosion initiation threshold, generally chosen as a critical shear stress, and an erosion kinetic coefficient. …”
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Single-Cell Analyses Reveal Necroptosis’s Potential Role in Neuron Degeneration and Show Enhanced Neuron-Immune Cell Interaction in Parkinson’s Disease Progression by Xiaomei Zeng, Zhifen Han, Kehan Chen, Peng Zeng, Yidan Tang, Lijuan Li

“…Parkinson’s disease (PD) is a common neuron degenerative disease among the old, characterized by uncontrollable movements and an impaired posture. …”
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Transcription Factor FXR Activates DHRS9 to Inhibit the Cell Oxidative Phosphorylation and Suppress Colon Cancer Progression by Jinlai Zhao, Yigang Wang, Yang Wang, Jianchao Gao, Haichao Yang, Xiaotang Wu, Hua Li

“…Background. Colon cancer is a common gastrointestinal malignancy. It has been discovered that Farnesoid X receptor (FXR) plays an imperative regulatory role in multitype cancers in recent years. …”
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