A novel minimally invasive neurosurgical cranial fixation device for improved accuracy of intraventricular catheter placement: an experimental animal study by Atai Daniel, Matan Coronel, Segev Peer, Ben Grinshpan, Soner Duru, Jose L. Peiro, James L. Leach, Elena Abellán, Carolyn M. Doerning, David Zarrouk, Francesco T. Mangano

“…Abstract Background External ventricular drain (EVD) insertion is one of the most commonly performed neurosurgical procedures. Herein, we introduce a new concept of a cranial fixation device for insertion of EVDs, that reduces reliance on freehand placement and drilling techniques and provides a simple, minimally invasive approach that provides strong fixation to minimal thickness skulls. …”
Get full text

Altered functional brain connectivity in Dyt1 knock-in mouse models by R. Z. Adury, B. J. Wilkes, P. Girdhar, Y. Li, D. E. Vaillancourt, D. E. Vaillancourt, D. E. Vaillancourt

“…DYT1 dystonia is an early onset, generalized form of isolated dystonia characterized by sustained involuntary muscle co-contraction, leading to abnormal movements and postures. It is the most common hereditary form of primary dystonia, caused by a trinucleotide GAG deletion in the DYT1 gene, which encodes the TorsinA protein. …”
Get full text

Initial versus Subsequent Injury and Illness and Temporal Trends Among Professional Hockey Players by Chelsea Martin, Allison Lieb, John Tokish, Ellen Shanely, Stefan Kluzek, Gary Collins, Garrett Bullock

“…The groin/hip/thigh was the most commonly injured body region with an IR of 1.14 per 1000 AGEs (95%CI:1.06-1.21), followed by the head/neck (0.72 per 1000 AGEs, 95%CI:0.66-0.78). …”
Get full text

Tick-borne encephalitis: students’ attitude and knowledge analysis by R. Mineikytė, G. Navickaitė, J. Valaikienė

“…The fact that TBE incidence in Lithuania is high (>11 cases per 100 000 per year) was known only to 58 (14.4%) respondents, 159 (39.4%) answered that the incidence is medium (2–10 cases per 100 000 per year). The most commonly named complications of TBE were paralysis and paresis – 327 (81%) students. 3 respondents (1%) thought that TBE is a dis ease without any complications. …”
Get full text

Navigating barriers and embracing facilitators of connection: insights from peer recovery specialists working with individuals with substance use disorder and criminal justice invo... by Rebecca Sutter-Barrett, Nancy R.B. Spencer, Nora Elnahas, Rebecca Hurd, Margaret Delaney, Aman Bivens

“…Jail-specific restrictions was the most common barrier to connection with 91.30% of transcripts referencing at least one code for jail-specific restrictions; 73.91% of all transcripts indicated social determinants of health insecurities; 56.52% of all peer recovery specialist transcripts experienced clients in withdrawal; 52.17% of all transcripts identified lack of client engagement; 43.48% of all transcripts identified disconnection as a barrier; and 34.78% of all transcripts indicated adverse peer recovery specialist experiences. …”
Get full text

Early experience of Sacubitril–Valsartan in heart failure with reduced ejection fraction in real‐world clinical setting by Charlotte Nordberg Backelin, Michael Fu, Charlotta Ljungman

“…Of the initiated patients, 59% reached target dose of Sac/Val, and 15% discontinued due to adverse effects. The most common cause of discontinuation was benign gastrointestinal adverse effects, followed by elevated creatinine, malaise, and vertigo. …”
Get full text

Time to recovery of neonatal sepsis and its predictors in public hospitals of North Shoa Zone, Central Ethiopia by Befekadu Tesfaye Oyato, Teshome Ketema Sime, Tirunesh Debele, Husen Zakir Abasimel, Fikadu Tolesa Alemu, Samuel Boja Asfaw, Wuletaw Tadesse Mekonnin, Hana Israel Gesisa, Elleni Tesfaye Kebede

“…Abstract Background Neonatal sepsis remains one of the most common causes of morbidity and mortality among neonates in developing countries. …”
Get full text

First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors by Ignacio I Wistuba, Mamta Kalra, Linus Backert, Martin Wermke, Edwin R Parra, Jason John Luke, Apostolia M Tsimberidou, Sebastian Bunk, Mohammad B Hossain, Andrea Mayer-Mokler, Arun Satelli, Norbert Hilf, Steffen Walter, Cedrik M Britten, Van K Morris, Tobias A W Holderried, Winfried H Alsdorf, Katrin Wetzko, Borje S Andersson, Sandra Grund-Gröschke, Katrin Aslan, Anantha Marisetty, Swapna Satam, Jens Hukelmann, M Alper Kursunel, Karine Pozo, Andreas Acs, Melissa Baumeister, Claudia Wagner, Oliver Schoor, Ali S Mohamed, Delfi Krishna

“…Eligible patients underwent leukapheresis, T cells were isolated, transduced with lentiviral vector carrying MAGEA1-specific TCR and following lymphodepletion (fludarabine/cyclophosphamide), infused with a median of 1.4×109 specific T cells (range, 0.086×109–2.57×109) followed by interleukin 2.Safety of IMA202 No DLT was observed. The most common grade 3–4 adverse events were cytopenias, that is, neutropenia (81.3%), lymphopenia (75.0%), anemia (50.0%), thrombocytopenia (50.0%) and leukopenia (25.0%). 13 patients experienced cytokine release syndrome, including one grade 3 event. …”
Get full text

Corticostriatal glutamate‐mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model by Xinxin Jiang, Min Sun, Yitong Yan, Yanhua Wang, Xinyu Fan, Jing Wei, Ke Wang, Peirong Liang, Zirui Wang, Jihan Wang, Xiaomin Wang, Jun Jia

“…Targeting glutamatergic neurons with EA holds promise as a non‐dopaminergic intervention for managing motor symptoms and abnormal neural activity with PD. Key points EA commonly protects dopaminergic neuronsby reducing neuroinflammation, oxidative stress, and apoptosis. …”
Get full text

Impacts of medical and non-medical cannabis on the health of older adults: Findings from a scoping review of the literature. by Dianna Wolfe, Kim Corace, Claire Butler, Danielle Rice, Becky Skidmore, Yashila Patel, Premika Thayaparan, Alan Michaud, Candyce Hamel, Andra Smith, Gary Garber, Amy Porath, David Conn, Melanie Willows, Hanan Abramovici, Kednapa Thavorn, Salmaan Kanji, Brian Hutton

“…Included studies met age-related inclusion criteria or involved a priori identified health conditions common among older adults. Records were screened using a liberal accelerated approach and data charting was performed independently by two reviewers. …”
Get full text

Isolation of Extended-Spectrum β-lactamase- (ESBL-) Producing Escherichia coli and Klebsiella pneumoniae from Patients with Community-Onset Urinary Tract Infections in Jimma Univer... by Mengistu Abayneh, Getnet Tesfaw, Alemseged Abdissa

“…The occurrence of multidrug resistance to the third-generation cephalosporins, aminoglycosides, fluoroquinolones, trimethoprim-sulfamethoxazole, and tetracyclines is more common among ESBL producers. Thus, detecting and reporting of ESBL-producing organisms have paramount importance in the clinical decision-making.…”
Get full text

Karakteristik Penderita Dispepsia Fungsional yang Mengalami Kekambuhan di Bagian Ilmu Penyakit Dalam RSUP Dr. M. Djamil Padang, Sumatera Barat Tahun 2011 by Yui Muya, Arina Widya Murni, Rahmatina B Herman

“…<br />Kata kunci: dispepsia fungsional, karakteristik penderita, kekambuhan</p><p> </p><p>Abstract<br />Dyspepsia is one of the common health problems that found by the doctors in daily practice. …”
Get full text

Point of Care Ultrasound Guided Management of Lateral Ankle Sprains: A Case Series by Matthew Bush, Jon Umlauf, Bryan Pickens

“…# Background Lateral ankle sprain (LAS) is a common injury with incidence rates reported at 7.2 per 1000 person-years. …”
Get full text

Impact of Comorbidities on the Severity of Disease & Outcome in Children with COVID 19 at a Tertiary Care Pediatric Hospital, Rawalpindi. by Rai Muhammad Asghar, Muddassar Sharif, Khalid Saheel, Isfandyar Khan, Abid Hussain, Rai Rijjal Ashraf

“…Comorbidities were present in 70 patients     (64.2%).CHD was the most common co-morbid condition (n=18, 16.5%). Most of the patients experienced mild to moderate symptoms (n=64.2%) while severe symptoms were found in (n=35.8%) patients. 27 patients (24.8%) required Ventilatory support, and of these 20 patients (18.3%) had underlying co-morbidity. …”
Get full text

A Small Increase in Serum Creatinine within 48 h of Hospital Admission Is an Independent Predictor of In-Hospital Adverse Outcomes in Patients with ST-Segment Elevation Myocardial... by Jiajia Zhu, Wenxian Liu, Jiang Li, Changsheng Ma, Dong Zhao

“…Acute kidney injury (AKI) is a common complication of percutaneous coronary intervention (PCI) that has been associated with high morbidity and mortality in patients with STEMI. …”
Get full text

Clinical Features, Endoscopic Findings, and Predictive Factors for Mortality in Tissue-Invasive Gastrointestinal Cytomegalovirus Disease between Immunocompetent and Immunocompromis... by Panu Wetwittayakhlang, Natthapat Rujeerapaiboon, Poowadon Wetwittayakhlung, Pimsiri Sripongpun, Nannapat Pruphetkaew, Sawangpong Jandee, Naichaya Chamroonkul, Teerha Piratvisuth

“…Tissue-invasive gastrointestinal cytomegalovirus (TI-GI CMV) disease is common in immunocompromised patients, but the increasing prevalence in immunocompetent patients has been reported. …”
Get full text

Efficacy of carbonyl cyanide-3-chlorophenylhydrazone in combination with antibiotics against Mycobacterium abscessus by Jifang Zheng, Qiang Liu, Haoran Wang, Fengmin Huo, Junnan Jia, Hairong Huang, Suting Chen

“…This study aimed to determine its synergistic antimicrobial effects when combined with commonly used antibiotics. The M. abscessus reference strain and 39 clinical isolates were collected. …”
Get full text

Accuracy Assessment of Nonlinear Seismic Displacement Demand Predicted by Simplified Methods for the Plateau Range of Design Response Spectra by Pierino Lestuzzi, Lorenzo Diana

“…Alternative approaches using linear computation with increased damping ratio are common in other parts of the world. The accuracy of three methods for seismic displacement demand prediction is carefully examined for the plateau range of Type-1 soil class response spectra of Eurocode 8. …”
Get full text

«Talgenism» in the Digital Age: A Domestic History of cMOOC by M. A. Babaeva, E. B. Golubev

“…Siemens and S. Downs have common key features. Despite the time and geographical gap (Russia, 1918 and Canada, 2008), each of these technologies makes it possible a fundamentally new learning process focused on the needs of a student, the organization of which is practically unattainable with a traditional class-lesson or lecture-seminar system. …”
Get full text

Vision impairment in boys recruited to the iREAD study by Jonathan Levine, Ravid Doron, Lisa A. Ostrin, Einat Shneor

“…Abstract Background Uncorrected refractive error is reported to be the most common cause globally of vision impairment in school age children. …”
Get full text