Revealing the critical state and identifying individualized dynamic network biomarker for type 2 diabetes through advanced analysis methods on individual basis by Peiyu Li, Shaowen Jing, Guo Tian, Jing Jiang

“…In the early stages of complex diseases, obvious symptoms are usually not observable, but there is a commonality: there is a brief state of predisease between the progression from normal state to disease state, which usually includes three stages: normal state, critical state of predisease, and disease state. …”
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High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril by Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright

“…Studies of patient-derived brain tissues have concluded that these inclusions are associated with Parkinson’s disease, the second most common neurodegenerative disorder, and other synuclein-related diseases called synucleinopathies. …”
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Clinical Profile and Risk Factors of Group B Streptococcal Colonization in Mothers from the Eastern District of China by Jin Jiao, Weiwei Wu, Feng Shen, Zhongyuan Liu, Huiru Zhou, Gang Fan, Yuxia Zhou

“…Resistance was the highest for erythromycin (80.2%), followed by clindamycin (75.0%), levofloxacin (65.1%), and tetracycline (57.6%). The most common serotype identified was Ia (61.0%), followed by III (29.7%), VI (4.6%), II (3.5%), VII (0.6%), and a nontypeable strain. …”
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Physiological responses to water deficiency in bread wheat (Triticum aestivum L.) lines with genetically different leaf pubescence by S. V. Osipova, A. V. Rudikovskii, A. V. Permyakov, E. G. Rudikovskaya, M. D. Permyakova, V. V. Verkhoturov, T. A. Pshenichnikova

“…The aim of the work was to assess resistance of common wheat genotypes with different composition and allelic state of genes that determine the leaf pubescence phenotype. …”
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Characterization of Clinical Isolates of Enterococci with Special Reference to Glycopeptide Susceptibility at a Tertiary Care Center of Eastern Nepal by Aasish Karna, Ratna Baral, Basudha Khanal

“…They bear the potential to exhibit resistance against all commonly used antibiotics either by inherent or acquired mechanism, posing a therapeutic challenge. …”
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Prevalence and Molecular Characterization of Cysticercus tenuicollis Isolated from Some Intermediate Host in Kurdistan-Iraq by Abdullah Ahmed Hama, Rostam Hama Zorab, Fatima Mohammed Ali, Awaz M. Salih, Amer Abdullah Hassan

“…Cysticercus tenuicollis (C. tenuicollis) is the larval stage infection of Taenia hydatigena, a common tapeworm of dogs and other Canidae, which has a wide range of intermediate hosts including sheep, goat, cattle, deer, camel, horse, human and other wild ruminants, the disease spreads through a contaminated water, soil and food with feces of infected dogs or other carnivores, T. hydatigena lives in the intestinal of the definitive host (carnivores) and excretes a huge number of eggs with feces daily. …”
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Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs) by Jeffrey J. Yu, Daniel B. Azzam, Marilyn Chwa, Kevin Schneider, Jang-Hyeon Cho, Chinhui Hsiang, Henry Klassen, M. Cristina Kenney, Jing Yang

“…While several treatment options exist for the exudative form of AMD, there are currently no FDA-approved treatments for the more common nonexudative (atrophic) form. Mounting evidence suggests that mitochondrial damage and retinal pigment epithelium (RPE) cell death are linked to the pathogenesis of AMD. …”
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Lebanese Dentists’ Preparedness to Deal With Medical Emergencies in Their Clinics: A National Survey by Antoine Choufani, Marianne Moussallem, Julia Bou Dib, Michèle Kosremelli Asmar, Joumana Stephan Yeretzian

“…Vasovagal reactions, hypoglycemia, and orthostatic hypotension were common emergencies. While 69.0% felt capable of managing minor issues, confidence dropped for major emergencies and specific procedures. …”
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Diagnostic value of interferon-γ release assay in patients with COPD complicated with pulmonary tuberculosis by Yanxiao Rong, Haibin Wang, Yuanyuan Su, Qian Wang, Xuepei Sun, Wei Wang

“…Abstract Background The common diagnostic methods for tuberculosis have been showing reduced sensitivity among chronic obstructive pulmonary disease patients. …”
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Evaluation of three-dose fosfomycin tromethamine in the treatment of patients with urinary tract infections: an uncontrolled, open-label, multicentre study by Shan Chen, Yong Yang, Bo Yang, Ming Chen, Kai Zhang, Yi Wang, Lu-Dong Qiao, Bo Zheng, Hong-Feng Guo, Yuan-Jie Niu, Ben-Kang Shi, Wei-Min Yang, Xiao-Kun Zhao, Xiao-Feng Gao

“…The overall efficacy rates (day 15) were 95.29% (81/85), 77.78% (28/36) and 64.52% (20/31), respectively. 20/356 (5.6%) patients reported drug-related AEs, the most common being diarrhoea. No serious drug-related AEs were reported.Conclusions This fosfomycin tromethamine dosing regimen showed clinical and microbiological efficacy with some AEs and good tolerability in patients with acute uncomplicated cystitis, recurrent lower urinary tract infection and complicated lower urinary tract infection.…”
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Co-creating and hosting PxP: a conference about patient engagement in research for and by patient partners by Dawn P. Richards, Hetty Mulhall, Joletta Belton, Savia de Souza, Trudy Flynn, Alex Haagaard, Linda Hunter, Amy Price, Sara Riggare, Janice Tufte, Rosie Twomey, Karim M. Khan

“…Abstract Research projects, initiatives and conferences that include patients as partners rather than as participants are becoming more common. Including patients as partners (what we will call ‘patient partners’) is an approach called patient engagement or involvement in research, and we will call it patient engagement throughout this paper. …”
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Participatory research towards the control of snakebite envenoming and other illnesses in a riverine community of the Western Brazilian Amazon. by Alícia Patrine Cacau Santos, Evellyn Antonieta Rondon Tomé Silva, Hiran Sátiro Souza da Gama, Jady Shayenne Mota Cordeiro, Ana Paula Silva Oliveira, Jéssica Albuquerque Araújo, Rafaela Nunes Dávila, Hélio Afonso Amazonas Júnior, Altair Seabra Farias, Jacqueline Almeida Gonçalves Sachett, Vinícius Azevedo Machado, Wuelton Marcelo Monteiro, Felipe Leão Gomes Murta

“…The qualitative analysis identified three main themes: Snakebites in the Community, which focused on personal experiences with snakes; Common Health Problems, which addressed other health issues faced by community members; and Community Defining Solutions, which discussed strategies and solutions proposed by the community to address these challenges.…”
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An Analysis of Transportation Mode Choice in Bitung City Using Structural Equation Modeling by Lucia Ingrid Regina Lefrandt, Charles S. C. Punuhsingon

“…Motorbikes were the most common regarding vehicle ownership, with 60% of respondents owning one. …”
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Methods to appraise available evidence and adequacy of data from a systematic literature review to conduct a robust network meta-analysis of treatment options for patients with hos... by Laura Puzniak, Ryan Dillon, Thomas Lodise

“…(range, 1.6-49%) were the most common causative pathogens. We identified relevant RCTs for most standard-of-care agents approved for HABP/VABP, which provided a comprehensive evidence base. …”
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Responsiveness Index versus the RASS-Based Method for Adjusting Sedation in Critically Ill Patients by Johanna E. Wennervirta, Mika O. K. Särkelä, Markus M. Kaila, Ville Pettilä

“…Hypertension was more common in the RI group (p=0.01). RI group patients were in the target RI level 22% of the time and RASS group patients had 57% of scores within the target RASS level. …”
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Assessment of Malaysia-wide PM2.5 Forecasts from a Global Model by Zhixian Tan, Mohd Talib Latif, Matthew J. Ashfold

“…In Malaysia, transboundary ‘haze’ episodes with elevated PM2.5 concentrations linked to fires are common, causing health and economic harms. To reduce impacts, forecasting PM2.5 can enable effective PM2.5 management and decision-making. …”
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Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

“…Background: Reports indicate that depression is a common mental health issue following traumatic brain injury (TBI). …”
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Predictive Factors of Concerns about Falling in People with Parkinson’s Disease: A 3-Year Longitudinal Study by Magnus Lindh-Rengifo, Stina B. Jonasson, Niklas Mattsson, Susann Ullén, Maria H. Nilsson

“…Fear of falling (FOF) is more common in people with Parkinson’s disease (PD) than in healthy controls. …”
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Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures by Caitlin C. Clements, Anne-Michelle Engelstad, Carol L. Wilkinson, Carly Hyde, Megan Hartney, Alexandra Simmons, Helen Tager-Flusberg, Shafali Jeste, Charles A. Nelson

“…These results highlight the challenge of using resting state EEG features as biomarkers in trials with neurodevelopmental disabilities when epilepsy and anti-epileptic medication are common.…”
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Lymph Node Adiposity and Metabolic Dysfunction-Associated Steatotic Liver Disease by Jessica M. Rubino, Natalie Yanzi Ring, Krishna Patel, Xiaoqing Xia, Todd A. MacKenzie, Roberta M. diFlorio-Alexander

“…<b>Objective</b>: Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as the most common chronic liver disease, is soon to be the leading indication for liver transplantation; however, the diagnosis may remain occult for decades. …”
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