A Phase 3 Multicenter, Double‐Blind Study Comparing Efficacy, Safety, Immunogenicity, and Pharmacokinetics of Alkem's Biosimilar Teriparatide Versus Reference Teriparatide in Postm... by Nitin Kapoor, Thomas Paul, Rajeshwar Nath Srivastava, Saurabh Singh, Sunil Maheshwari, Vishal Patil, Awadhesh Kumar Yadav, Girish Bhatia, Sushil H. Mankar, Joe Joseph Cherian, Surabhi Maheshwari, Sudeepti Srivastava, Dattatray Pawar, Roshan Pawar, Amol Aiwale, Amitrajit Pal, Yogesh Rane, Vinayaka Shahavi, Akhilesh Sharma

“…The percent change from baseline to 48 weeks in lumbar spine BMD (least square mean [LSM] ± standard error [SE]) was 8.58% ± 0.85 in the biosimilar group and 8.02% ± 1.23 in the reference group. …”
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The Impact of Managerial Overconfidence on Expenses Classification Shifting: The Moderating Role of Comparability of Financial Statements by Farshid Riahi Dorcheh, Iraj Torabi

“…The research model is estimated through panel data by controlling the effects of industry and year by ordinary least squares method with robust standard error.   Finding The findings of the first hypothesis show that managers' overconfidence leads to an increase in expense classification shifting and a piecemeal decrease in classification shifting over time. …”
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Audit of immunoglobulin monitoring and hypogammaglobulinaemia after B cell targeted therapy in a paediatric cohort in a high immune disease prevalence Region by Khadija Karim, Omar Mostafa, Alaa Samarh, Sharon Bout-Tabaku, Buthaina Al-Adba, Ahmad Kaddourah, Abubakr Imam, Ibrahim Shatat, Bajes Hamad, Mahmoud Fawzi, Ruba Benini, Ayman Saleh, Tayseer Yousif, Areeg Ahmed, Yasmin El Bsat, Bernice Lo, Mohammed Yousuf Karim

“…Further testing revealed an underlying primary immune deficiency disorder/inborn error of immunity. Conclusion: Baseline IgG tests were almost always performed as per the guidance, illustrating close adherence by clinicians. …”
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Watershed Health Prediction based on Surface Water Quality Variables (Case Study: Taleghan Watershed) by Payam Ebrahimi, Ali Salajegheh, Mohsen Mohseni Saravi, Arash Malekian, Amir Sadoddin

“…In order to evaluate the generated model, three factors of determination coefficient, mean error of absolute and root mean square error were used. 3-Results and Discussion Using the obtained results, it was found that during investigated time, the use of normalized data provides different results than normal data. …”
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The Reliability of a Novel Structured Testing Device for Single-breath Lung Carbon Monoxide Uptake: A Randomized Comparison Crossover Study by Shihua Yao, Tuping Fu, Kuiqing Lin, Zhongping Wu, Shubing Chen, Liping Zhong, Beilan Shen, Yanqing Xie, Jiaying An, Xudong Wang, Wenting Liu, Xinxin Yu, Jinping Zheng, Yi Gao

“…Simulator test results showed MeAir had a CO error range of -3.80% to -1.00% and CH4 error range of -0.50–1.00%, while MasterScreen had a CO error range of -2.53–0.00% and CH4 error range of -1.83% to -0.63%, indicating superior CO detection by MasterScreen and better CH4 detection by MeAir. …”
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An Artificial Intelligence Generated Automated Algorithm to Measure Total Kidney Volume in ADPKD by Jonathan Taylor, Richard Thomas, Peter Metherall, Marieke van Gastel, Emilie Cornec-Le Gall, Anna Caroli, Monica Furlano, Nathalie Demoulin, Olivier Devuyst, Jean Winterbottom, Roser Torra, Norberto Perico, Yannick Le Meur, Sebastian Schoenherr, Lukas Forer, Ron T. Gansevoort, Roslyn J. Simms, Albert C.M. Ong

“…Conclusion: Our AI-based algorithm demonstrates performance comparable to manual segmentation. …”
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Measuring and estimation of suspended sediment variation using sediment rating curve approach in Mereg River by Sohila Aghabeigi Amin, Heidar Mirzaei

“…The rating curve of seasonal data cannot affect the accuracy of rating curves or reduce the relative error. 4-Conclusion During the study period, the hydrological regime of Merg River showed a lot of variability. …”
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Prediction of Soil Carbon Sequestration in Rangelands Regarding the Depth and Elevation of Sample Locations using Adaptive Neuro-Fuzzy Inference System (ANFIS) (Case Study: Lar Wat... by zeinab jafarian, zhila ghorbani

“…This result indicates the higher ability of the ANFIS model than the regression model in creating a relationship between input and output and its proximity to the measured values. Conclusion: The increase in the correlation coefficient and the reduction of the mean error deviation in the ANFIS method compared to the linear multivariate regression show that the ANFIS method is more successful in estimating the amount of soil CS under the effects of various factors in the studied land use. …”
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Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Irene F. Marques, Carola Domènech-Panicello, Madelon L. Geurtsen, Thanh T. Hoang, Rebecca Richmond, Kristen Polinski, Lea Sirignano, Christian M. Page, Anne-Claire Binter, Todd Everson, Amber Burt, Michael Deuschle, Maria Gilles, Fabian Streit, Sunni L. Mumford, Per Magnus, Irwin K. M. Reiss, Marijn J. Vermeulen, Stephanie H. Witt, Inês Chaves, Edwina Yeung, Stephanie J. London, Mònica Guxens, Janine F. Felix

“…Three CpGs were differentially methylated in relation to maternal night shift work during pregnancy at a false discovery rate adjusted P < 0.05: cg10945885 (estimate (β) 0.38%, standard error (SE) 0.07), cg00773359 (β 0.25%, SE 0.05), and cg21836426 (β − 0.29%, SE 0.05). …”
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Clinical features of focal choroidal excavation subtypes and their association with choroidal neovascularization by Yuhong Gan, Guiqin He, Yongyue Su, Yining Zhang, Xiongze Zhang, Hui Chen, Chengguo Zuo, Miaoling Li, Xuelin Chen, Feng Wen

“…Inflammatory FCE was associated with higher myopia (median refractive error:6.00 D, P < 0.001) and reduced choroidal thickness (P = 0.014), whereas pachychoroidal FCE showed increased choroidal thickness. …”
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Clinicopathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer over two decades: A population-based study. by Sandeep Samuel, Sarbajit Mukherjee, Nischala Ammannagari, Venkata K Pokuri, Boris Kuvshinoff, Adrienne Groman, Charles M LeVea, Renuka Iyer

“…All associations were considered statistically significant at an alpha error of 0.01.<h4>Results</h4>Out of 4738 cases, 217 adenosquamous/squamous (4.6%), 367 papillary (7.7%), and 4154 adenocarcinomas (87.7%) were identified. …”
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HSK21542 in patients with postoperative pain: two phase 3, multicentre, double-blind, randomized, controlled trials by Yinbo Zhong, Younian Xu, Qian Lei, Mengchang Yang, Saiying Wang, Xiaoling Hu, Haihui Xie, Yalan Li, Zhong Qin, Zhengfeng Gu, Jiaqiang Zhang, Yuexin Wang, Jinglei Wu, Haiying Wang, Yue Ming, Zhongyuan Xia, Haoyu Zhai, Ke Jiang, Peng Zhang, Zhiping Wang, Liangrong Wang, Lin Li, Zhigang Cheng, Huayong Jiang, Guonian Wang, Jingli Chen, Zhibin Zhao, Xiangdong Chen, Min Yan

“…Grade ≥3 treatment-emergent adverse events occurred in eight (5.9%) and three (2.3%) patients in the HSK21542 arm of HSK21542-301 and HSK21542-303, respectively. In conclusion, HSK21542 showed potent analgesic effect and was well tolerated in patients who underwent abdominal surgery and experienced postoperative pain.…”
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Mixed reality infrastructure based on deep learning medical image segmentation and 3D visualization for bone tumors using DCU-Net by Kun Wang, Yong Han, Yuguang Ye, Yusi Chen, Daxin Zhu, Yifeng Huang, Ying Huang, Yijie Chen, Jianshe Shi, Bijiao Ding, Jianlong Huang

“…Methods: We conducted experiments using a hospital dataset for bone tumor segmentation, used the optimized DCU-Net and 3D reconstruction technology to generate bone tumor models, and used set similarity (DSC), recall (R), precision (P), and 3D vertex distance error (VDE) to evaluate segmentation performance and 3D reconstruction effects. …”
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Exploration of key genes associated with oxidative stress in polycystic ovary syndrome and experimental validation by Qinhua Li, Qinhua Li, Qinhua Li, Lei Liu, Yuhan Liu, Yuhan Liu, Yuhan Liu, Yuhan Liu, Tingting Zheng, Tingting Zheng, Tingting Zheng, Ningjing Chen, Ningjing Chen, Ningjing Chen, Peiyao Du, Peiyao Du, Peiyao Du, Hong Ye, Hong Ye, Hong Ye

“…Based on the residuals and root mean square error of the three models, the best performance of RF was derived and 7 key genes (TNFSF10, CBL, IFNG, CP, CASP8, APOA1, and DDIT3) were identified. …”
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The Impact of Climate Change on the Content and Spatial Distribution of the Total Dissolved Solids in Bandar-e-Gaz Coastal Aquifer by Mohammad Mehdi Ansarifar, Meysam Salarijazi, Khalil Ghorbani, Abdolreza Kaboli

“…Besides, the mean of absolute error or MAPE was used to determine the precision of the model. …”
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Comparing the Efficiency of Sediment Rating Curve and ANN Models in Estimating River Bed-load by Jamal Mosaffaie, Amin Saleh pourjam, Mahmudreza Tabatabaei

“…This means that observed and estimated values ​​of the ANN model are closer together than SRC model, so estimations of ANN model are more accurate. The Root Mean Square Error index (RMSE) for ANN model is also smaller than the SRC model in all stations, so that the sum of five stations RMSE for ANN and SRC models were 2505.7 and 5195.3 respectively. …”
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Elevated thiamine level is associated with activating interaction between HIF-1α and SLC19A3 in experimental myopic guinea pigs by Zhongyu Ma, Jiawen Hao, Zhaohui Yang, Miao Zhang, Ruixue Zhang, Jizhao Xin, Bo Bao, Xuewei Yin, Xuewei Yin, Hongsheng Bi, Hongsheng Bi, Hongsheng Bi, Dadong Guo, Dadong Guo, Dadong Guo, Dadong Guo

“…Moreover, protein immunoprecipitation revealed a reciprocal relationship between HIF-1α and SLC19A3, and molecular docking showed their sites of action.ConclusionThe current study suggests that the choroidal tissue in myopic eyes is hypoxic and has metabolic abnormalities. …”
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Exploring the changes in functional connectivity of the limbic system in Patients with amnestic mild cognitive impairment treated by acupuncture based on fMRI by Han Yingmei, Li Yijie, Zhang Heng, Feng Ze, Li Weiqing, Zhang Hanxi, Yang Ming, Chu Bingyuan, Wang Feng

“…There were differences in the FC of Seed4, Seed29, and Seed30 in the sham-acupoint group, indicating that there were baseline differences among aMCI patient groups. (2) After acupuncture in the true-acupoint group, the FC between multiple seed points and brain regions decreased, while the differences before and after the intervention in the sham-acupoint group mostly did not pass the Family-Wise Error (FEW) correction. (3) Compared with the HC group, the FC of seed points in both the true-acupoint group and the sham-acupoint group mainly decreased after acupuncture. …”
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Comparison of the Performance Between the Montbiliard × Holstein Crossbred and Holstein Calves in Hot and Humid Areas by Pirouz Shakeri, Hassan Khamisabadi, Mehdi Bahrami Yekdangi, Mahdi Abasy Firouzjaei, Amir Ali Shakeri

“…However, the glucose concentration in the blood serum of M × H calves tended to be higher than in H calves (P = 0.06). Conclusion: In a fattening period of 6 months, M × H calves showed 14.0 % more weight gain and 17.1 % better FCR than H calves, while they had similar feed consumption. …”
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Investigating the Effect of Different Levels of Butyric Acid Glycerides and Clove Oil on Growth Performance, Blood Parameters and Tibia Bone Characteristics of Broiler Chickens by Seyyedeh azam khatami, Mir Daryoush Shakouri, Nemat Hedayat Evrigh

“…Also, the length of the tibia of broiler chickens was affected by the clove oil and the interaction effect of butyric acid glycerides and clove oil (p<0.05).Conclusion: In general, no synergistic effect was observed between butyric acid glycerides and clove oil on growth performance of chickens. …”
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