Polyautoimmunity Reflecting Immune Dysregulation in Common Variable Immunodeficiency by Maria Giovanna Danieli, Giuseppe Murdaca, Cristina Mezzanotte, Ilaria Claudi, Elena Buti, Matteo Martini, Maria Beatrice Bilò, Sebastiano Gangemi, Gianluca Moroncini

“…<b>Background</b>: Common variable immunodeficiency (CVID) is the most frequent symptomatic inborn error of immunity (IEI) in adulthood. Other than recurrent infections, CVID may present with non-infectious complications such as enteropathy, lymphoproliferation, malignancy, and autoimmune diseases. …”
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Barriers to postnatal care utilization during the COVID-19 pandemic: a cross-sectional study of sociodemographic and spatial factors in Mexico City by Magalhi Robledo-Clemente, Juan Carlos Silva Godínez, Juan Carlos Silva Godínez, Lucía Daniela García Montes, Jorge Valencia-Ortega, Renata Saucedo

“…Maternal education showed no significant association. The spatial error term confirmed significant geographic dependencies (β = −0.153, p &lt; 0.001).ConclusionsGeographic location, occupation, and socioeconomic status significantly influence postnatal visit frequency during public health crises, while education plays a lesser role. …”
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Changes in Choroidal Thickness of Healthy Children during Myopia Progression over 4 Years: Boramae Myopia Cohort Study Report 5 by Jeong Hyun Lee, MD, MSc, Joo Young Shin, MD, PhD, Martha Kim, MD, PhD, Kyoung Min Lee, MD, PhD, Sohee Oh, PhD, Seok Hwan Kim, MD, PhD, Ho-Kyung Choung, MD, PhD, Jeeyun Ahn, MD, PhD

“…Main Outcome Measures: Spherical equivalent of refractive errors, axial length, and choroidal thickness. Results: A total of 46 eyes from 23 participants were included, with a mean baseline age of 9.6 ± 1.7 years. …”
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Selective IgG4 deficiency and autoimmune cytopenias by Maria Loutsou, Nikolaos Giannakoulas, Emmanouel Ηatzipantelis, Helen Pergantou, Athina Dettoraki, Vasiliki Antari, Aikaterini Michalopoulou, George Vassilopoulos, Styliani Sarrou, Vasiliki Kalaitzidou, Christos Hadjichristodoulou, Fani Kalala, Matthaios Speletas

“…Recent studies have linked these conditions to inborn errors of immunity (IEI), particularly in patients with recurrent and/or chronic forms. …”
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Clinical Implementation of Cone Beam Computed Tomography-Guided Online Adaptive Radiation Therapy in Whole Breast Irradiation by Koen J. Nelissen, MS, Wilko F.A.R. Verbakel, PhD, Judith G. Middelburg–van Rijn, MD, Barbara L.T. Rijksen, MD, Marjan A. Admiraal, PhD, Jorrit Visser, PhD, Jessica van der Himst, Karin N. Goudschaal, MS, Ewa Bucko, Ben J. Slotman, MD, Angelique R.W. van Vlaenderen, MS, Desiree H.J.G. van den Bongard, PhD, MD

“…Purpose: In postoperative breast irradiation, changes in the breast contour and arm positioning can result in patient positioning errors and offline replanning. This can lead to increased treatment burden and strain on departmental logistics because of the need for additional cone beam computed tomography (CBCT) images or even a new radiation therapy treatment plan (TP). …”
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Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adults by Shay Nemet, MD, Daniel Elbirt, MD, Ramon Cohen, MD, Keren Mahlab-Guri, MD, Shira Bezalel-Rosenberg, MD, Ilan Asher, MD, Aviv Talmon, MD, Limor Rubin, MD, Yaarit Ribak, MD, Ruslan Sergienko, MHA, Udi Nussinovitch, MD, PhD, Yuval Tal, MD, PhD, Oded Shamriz, MD

“…Outcomes included eosinophilic, autoimmune, autoinflammatory, and cardiovascular disorders (CVD), cancer, and inborn errors of immunity (IEI). A multivariable Cox regression model determined statistical significance (P < .05). …”
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Evaluating the effectiveness of mass drug administration on lymphatic filariasis transmission and assessment of post-mass drug administration surveillance in Nigeria’s Federal Capi... by Juliana Ajuma Amanyi-Enegela, Joseph Kumbur, Faizah Okunade, Donald Ashikeni, Rinpan Ishaya, Girija Sankar, William Enan Adamani, Moses Aderogba, Louise Makau-Barasa, Achai Emmanuel, Bosede Eunice Ogundipe, Chinwe Okoye, Babar Qureshi

“…Data collection adhered to standardized WHO guidelines, utilizing both paper-based and electronic data-capture tools to enhance accuracy and reduce human error. Results A total of 6,448 children participated in surveys across the four EUs, with gender distribution closely balanced (53% male, 47% female). …”
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Patient-specific fluid–structure simulations of anomalous aortic origin of right coronary arteriesCentral MessagePerspective by Michael X. Jiang, MD, MEng, Muhammad O. Khan, PhD, Joanna Ghobrial, MD, Ian S. Rogers, MD, Gosta B. Pettersson, MD, PhD, Eugene H. Blackstone, MD, Alison L. Marsden, PhD

“…After we tuned the distal coronary resistances to achieve a stress flow rate triple that at rest, the simulations adequately matched the measured iFRs (r = 0.85, root-mean-square error = 0.04). The intramural lumen remained narrowed with simulated stress and resulted in lower iFRs without needing external compression from the pulmonary root. …”
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Ocular Biometry in Preterm Newborns in the Neonatal Intensive Care Unit Environment of a Referral Hospital by Ricardo Salles Cauduro, MD, PhD, Nilva Simeren Bueno de Moraes, MD, PhD, Ana Lucia Goulart, MD, PhD, Norma Allemann, MD, PhD

“…Additional evaluation parameters included refraction using retinoscopy to determine the refractive error, indirect ophthalmoscopy with 28 diopter lenses, and pediatric biometric parameters recorded in the medical record. …”
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Combining a novel ensemble model and multiplex methylation SNaPshot assays for saliva age prediction and cross-platform data analysis by Benyang Xiao, Yuxiang Zhou, Zhirui Zhang, Xindi Wang, Jiali Xiang, Zhixin Lv, Miao Liao, Haibo Luo, Feng Song

“…Validated by an independent testing set consisting of 44 samples (13–66 years), the model achieved a mean absolute error (MAE) of 4.39 years, outperforming some advanced linear and nonlinear models. …”
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Evaluation of the Accuracy of FreeStyle Libre 2 for Glucose Monitoring in White New Zealand Rabbits by Minseok Choi, Yeon Chae, Jayeon Park, Yelim Lee, Kyung‐Mee Park, Dong‐Hyuk Jeong, Byeong‐Teck Kang, Taesik Yun, Hakhyun Kim

“…Conclusions There was limited agreement between the FSL2 and reference standard BG measurements. …”
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Automated post-run analysis of arrayed quantitative PCR amplification curves using machine learning [version 1; peer review: awaiting peer review] by David Garrett Brown, Darwin J. Operario, Lan Wang, Shanrui Wu, Daniel T. Leung, Eric R. Houpt, James A. Platts-Mills, Jie Liu, Ben J. Brintz

“…We used 5-fold cross-validation to tune the models and assessed performance using accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and mean absolute error (MAE). For external validation, we used 1,472 reactions previously analyzed by 17 laboratory scientists as part of an external quality assessment for a multisite study. …”
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Genome-wide association study of retinopathy in individuals without diabetes. by Richard A Jensen, Xueling Sim, Xiaohui Li, Mary Frances Cotch, M Kamran Ikram, Elizabeth G Holliday, Gudny Eiriksdottir, Tamara B Harris, Fridbert Jonasson, Barbara E K Klein, Lenore J Launer, Albert Vernon Smith, Eric Boerwinkle, Ning Cheung, Alex W Hewitt, Gerald Liew, Paul Mitchell, Jie Jin Wang, John Attia, Rodney Scott, Nicole L Glazer, Thomas Lumley, Barbara McKnight, Bruce M Psaty, Kent Taylor, Albert Hofman, Paulus T V M de Jong, Fernando Rivadeneira, Andre G Uitterlinden, Wan-Ting Tay, Yik Ying Teo, Mark Seielstad, Jianjun Liu, Ching-Yu Cheng, Seang-Mei Saw, Tin Aung, Santhi K Ganesh, Christopher J O'Donnell, Mike A Nalls, Kerri L Wiggins, Jane Z Kuo, Blue Mountains Eye Study GWAS Team, CKDGen Consortium, Cornelia M van Duijn, Vilmundur Gudnason, Ronald Klein, David S Siscovick, Jerome I Rotter, E Shong Tai, Johannes Vingerling, Tien Y Wong

“…SNP, rs12155400, in the histone deacetylase 9 gene (HDAC9) on chromosome 7, was associated with retinopathy in analysis of participants without hypertension, -1.3±0.23 (beta ± standard error), p = 6.6×10(-9). Evidence suggests this was a false positive finding. …”
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Reliability and Accuracy of Linear Position Transducers During the Bench Press and Back Squat: Implications for Velocity-Based Training by Raynier Montoro-Bombú, Armando Costa, Paulo Malico Sousa, Valter Pinheiro, Pedro Forte, Luis Monteiro, Alex S. Ribeiro, Luis Rama

“…For all variables, the absolute reliability presented significant values (<i>p</i> ≤ 0.05), with an intraclass correlation coefficient ≥ 0.995, a 95% confidence interval between 0.992–0.999, a coefficient of variation ≤ 10%, and a standard error of the mean ≤ 0.031. <b>Conclusions:</b> Scientists and coaches can use the LPT device as a reliable tool for monitoring velocity-based training by providing rigorous measurements of ∆S, MPV, PV, and T–PV during BP and SQ exercises. …”
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Investigation of a Novel Noninvasive Risk Analytics Algorithm With Laboratory Central Venous Oxygen Saturation Measurements in Critically Ill Pediatric Patients by Sarah A. Teele, MD, MSHPEd, Avihu Z. Gazit, MD, Craig Futterman, MD, William G. La Cava, PhD, David S. Cooper, MD, MPH, MBA, Steven M. Schwartz, MD, MS, Joshua W. Salvin, MD, MPH

“…Interpretation remains subjective and vulnerable to error. Recognition of patient’s evolving clinical status as well as the impact of therapeutic interventions may be delayed. …”
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Electrocardiogram Abnormality Detection Using Machine Learning on Summary Data and Biometric Features by Kennette James Basco, Alana Singh, Daniel Nasef, Christina Hartnett, Michael Ruane, Jason Tagliarino, Michael Nizich, Milan Toma

“…Traditional interpretation methods are manual, time-consuming, and prone to error. Machine learning offers a promising alternative for automating the classification of electrocardiogram abnormalities. …”
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Diagnostic informative value of liquid-based cytology optimized with genetic methods for the differential diagnosis of precancerous and malignant diseases of the cervix by O. I. Kit, A. Yu. Maksimov, M. Yu. Timoshkova, E. A. Lukbanova, N. A. Petrusenko, D. S. Potemkin, E. V. Verenikina, A. N. Shevchenko, M. M. Kecheryukova

“…Statistical analysis was performed using descriptive statistics methods with the calculation of the mean and standard error of the mean. The mean values were compared with the help of the Mann-Whitney test.Results. …”
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Effect of birth asphyxia on neonatal blood glucose during the early postnatal life: A multi-center study in Hubei Province, China by Chun-Hua Liu, Hong-Yan Liu, Si-Cong Peng, Sha Pan, Zhi-Ting Wan, Su-Ying Wu, Chao-Ce Fang, Rong Jiao, Wen-Xiang Wang, Bin Gan, Shu-JieYang, Ju-Fang Tan, Xiao-Fang Zhu, Ping-Li She, Qi-Hong Fan, Min Yang, Ji-Jian Xie, Jie Sun, Ling Zeng, Lian-Hong Zhang, Hui-Rong Xu, Yan-Ni Li, Ping-Feng Zhang, Wei Lu, Xian-Tao Yang, Xiong-Fei Xiao, Hong-Li Li, Zheng-Liang Rao, Chuang Gao, Ya-Hui Luo, Hong Chen, Ming-Jin Yu, Xiao-Ying Luan, Yu-Rong Huang, Shi-Wen Xia

“…Neonatal blood glucose values at postnatal 1, 2, 6, and 12 h (time error within 0.5 h was allowed) were gathered from the medical records. …”
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Assessment of Corneal Biomechanical Properties and Intraocular Pressure in Myopic Spanish Healthy Population by María A. del Buey, Laura Lavilla, Francisco J. Ascaso, Elena Lanchares, Valentín Huerva, José A. Cristóbal

“…CH and IOPcc were weakly but significantly correlated with SE (r=0.171, P=0.002 and r=-0.131, P=0.021, resp.). Conclusions. Present study showed only a very weak, but significant, correlation between CH and refractive error, with CH being lower in both moderately and highly myopic eyes than that in the emmetropic and low myopic eyes. …”
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Beyond the homozygous paradigm: symptomatic partial biotinidase deficiency in a heterozygous child—first case report from Nepal by Jagdish Kunwar, Bijay Kunwar, Anup Ghimire, Aramva Bikram Adhikari, Binay Aryal, Sachchu Thapa, Bina Prajapati Manandhar

“…MRI, EEG was done thinking of the inborn error of metabolism. A whole exome sequencing identified a heterozygous pathogenic variant in the BTD gene (c.38_44delinsTCC, p.Cys13Phefs*36), and retrospective enzyme assay confirmed partial biotinidase deficiency (3.20 nmol/min/mL; ~25% of mean normal activity). …”
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