ALK Family Inhibitor A83-01 Promotes the Proliferation of Mouse Male Germline Stem Cells (mGSCs) Under Serum- and Feeder-Free Conditions by Meng YU, Long WANG, Yue HU, Zhi-min LIAN, Jin-lian HUA

“…A83-01 is a selective inhibitor of the TGF-β type I receptor ALK, which inhibits the TGF-β-induced epithelial-to-mesenchymal transition (EMT) via the inhibition of Smad2 phosphorylation. …”
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CRISPR-Cas9-based electrochemical biosensor for the detection of katG gene mutations in isoniazid-resistant tuberculosis by Dika Apriliana Wulandari, Muhammad Ihda Hamlu Liwaissunati Zein, Salma Nur Zakiyyah, Safri Ishmayana, Mehmet Ozsoz, Yeni Wahyuni Hartati, Irkham

“…The selected gRNA achieved the highest on-target score of 61.2 and an off-target score of 49.0 at cut position 2928, with a PAM sequence of AGG. …”
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Remediation of Hg-Contaminated Groundwater via Adsorption on Supramolecular Polymers in Batch Process and Column Test by Zongwu Wang, Wei Liu, Xiaoyan Sun, Qing Zhang, Jiapu Ji, Yimeng Yan, Jianhui Sun

“…The batch test study demonstrated that the SP can efficiently adsorb Hg from groundwater with superior selectivity and a high uptake capacity (up to 926.1 ± 165.3 mg g⁻¹). …”
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Repurposing FDA-Approved Agents to Develop a Prototype <i>Helicobacter pylori</i> Shikimate Kinase (HPSK) Inhibitor: A Computational Approach Using Virtual Screening, MM-GBSA Calcu... by Abdulaziz H. Al Khzem, Tagyedeen H. Shoaib, Rua M. Mukhtar, Mansour S. Alturki, Mohamed S. Gomaa, Dania Hussein, Nada Tawfeeq, Mohsina Bano, Mohammad Sarafroz, Raghad Alzahrani, Hanin Alghamdi, Thankhoe A. Rants’o

“…While current therapies face challenges from rising antibiotic resistance, particularly to clarithromycin, alongside treatment complexity and costs, the World Health Organization has prioritized the development of new antibiotics to combat this high-risk pathogen. …”
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Integrated multi-omics reveals the impact of ruminal keystone bacteria and microbial metabolites on average daily gain in Xuzhou cattle by Yingying Jiang, Zhenjiang An, Wenjie Li, Shuwen Xia, Qiang Ding, Jifeng Zhong, Huili Wang, Yan Xu, Kunlin Chen, Yangyang Shen

“…ABSTRACT The rumen microbiome plays a crucial role in determining the metabolic and digestive efficiency of livestock. Despite its crucial role, the impact of the rumen microbiome on average daily gain (ADG) in Xuzhou cattle remains underexplored. …”
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Human Serum Albumin and Human Serum Albumin Nanoparticles as Carriers of 10-(2′-Pyrimidyl)-3,6-diazaphenothiazine: In Vitro Spectroscopic Studies by Aleksandra Owczarzy, Karolina Kulig, Beata Morak-Młodawska, Małgorzata Jeleń, Tammam Muhammetoglu, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk

“…Additionally, this compound is characterized by selectivity of action towards MCF-7 breast cancer and has low cytotoxicity towards normal cells. …”
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Determination of malachite green in sediment by ultra performance liquid chromatography-mass spectrometry by Mei Guangming, Guo Yuanming, Zhang Xiaojun, Yan Zhongyong, Li Peipei, You Juju, Ding Yueping

“…The current researches mainly focus on the determination of MG in aquatic products, rarely in sediment. Due to the matrix complex of sediment, sample pretreatment technology is the key technology. …”
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Transfer of Periodic Phenomena in Multiphase Capillary Flows to a Quasi-Stationary Observation Using U-Net by Bastian Oldach, Philipp Wintermeyer, Norbert Kockmann

“…Miniaturization promotes the efficiency and exploration domain in scientific fields such as computer science, engineering, medicine, and biotechnology. …”
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Deep Learning-Based Seedling Row Detection and Localization Using High-Resolution UAV Imagery for Rice Transplanter Operation Quality Evaluation by Yangfan Luo, Jiuxiang Dai, Shenye Shi, Yuanjun Xu, Wenqi Zou, Haojia Zhang, Xiaonan Yang, Zuoxi Zhao, Yuanhong Li

“…However, the working environment of rice transplanters in paddy fields is complex, and data obtained solely from GPS devices installed on agricultural machinery cannot directly reflect the specific information of seedlings, making it difficult to accurately evaluate the quality of rice transplanter operations. …”
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Results of Water Inflow Elimination in Wells Draining Gas Сondestate Deposits by E. Vaganov, S. Sokhoshko, A. Sarancha, E. Levitina, I. Krasnov, T. Kharitonova

“…At the initial stage of LPW implementation, a water-repellent agent is used, which has selective filterability in the most permeable and watered reservoir intervals. …”
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Technical note: Flow cytometry assays for the detection, counting and cell sorting of polyphosphate-accumulating bacteria by C. Bouquet, H. Billard, H. Billard, C. C. Bidaud, J. Colombet, J. Colombet, Y.-T. Chang, J. Artigas, I. Batisson, K. Benzerara, F. Skouri-Panet, E. Duprat, A.-C. Lehours

“…The potential of flow cytometry to quantify and sort polyphosphate-accumulating bacteria in complex environmental samples, including soil, freshwater and sediments, was also examined. …”
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Bioherbicides: revolutionizing weed management for sustainable agriculture in the era of One-health by Taqi Raza, Muhammad Farhan Qadir, Shakeel Imran, Zobia Khatoon, Muhammad Yahya Khan, Mouna Mechri, Waleed Asghar, Muhmmad Ishaq Asif Rehmani, Sergio de los Santos Villalobos, Tooba Mumtaz, Rashid Iqbal

“…To develop an effective bioherbicide, specific and complex types of interaction have been developed between targeted weeds and biological agents. …”
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Laser-Induced Breakdown Spectroscopy Quantitative Analysis Using a Bayesian Optimization-Based Tunable Softplus Backpropagation Neural Network by Xuesen Xu, Shijia Luo, Xuchen Zhang, Weiming Xu, Rong Shu, Jianyu Wang, Xiangfeng Liu, Ping Li, Changheng Li, Luning Li

“…Laser-induced breakdown spectroscopy (LIBS) has played a critical role in Mars exploration missions, substantially contributing to the geochemical analysis of Martian surface substances. However, the complex nonlinearity of LIBS processes can considerably limit the quantification accuracy of conventional LIBS chemometric methods. …”
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Identification of novel antioxidant and anti-inflammatory peptides from bovine hemoglobin by computer simulation of enzymolysis, molecular docking and molecular dynamics by Xuan-Ying Xin, Chao-Hui Ruan, Yi-Hui Liu, Huai-Na Jin, Sung-Kwon Park, Sun-Jin Hur, Xiang-Zi Li, Seong-Ho Choi

“…Due to the structural diversity and complex mechanisms of action of bioactive peptides, screening for specific functional peptides is often challenging. …”
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Evaluation criteria of centralization options in the architecture of multicomputer systems with traps and baits by Antonina Kashtalian, Sergii Lysenko, Anatoliy Sachenko, Bohdan Savenko, Oleg Savenko, Andrii Nicheporuk

“…New mathematical models were developed for the criteria for operational efficiency, stability, integrity and security in relation to the system center, which, unlike the known mathematical models for evaluating system centers for selecting the next options for centralization, are presented in analytical expressions that take into account the features of the types of centralization in the system architecture, indicators of operational efficiency, stability, integrity and security in relation to the system center and allow forming on their basis an objective function for evaluating options for centralization in systems, the feature of which is the hiding of components with the system center from detection by attackers. …”
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Sensitivity analysis of the INRA 2018 feeding system for ruminants by hybrid local and global approaches: Comparing the contribution of dietary input variables to multiple response... by Seoyoung Jeon, Tristan Senga Kiessé, Sophie Lemosquet, Pierre Nozière

“…The sensitivity of 5 selected animal responses (output variables) to input variables was analyzed: DMI, milk protein yield (MPY), energy in methane (ECH4), nitrogen utilization efficiency (NUE), and the ratio between urine and total N excretion (UN/TN). …”
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Synergistic use of multi-sensor satellite data for mapping crop types and land cover dynamics from 2021 to 2023 in Northeast Thailand by Savittri Ratanopad Suwanlee, Surasak Keawsomsee, Emma Izquierdo-Verdiguier, Álvaro Moreno-Martínez, Sarawut Ninsawat, Jaturong Som-ard

“…The significant challenges persist in accurately classifying crop types in highly fragmented cropland regions characterized by small field sizes, complex landscapes, and highly frequent cloud cover. …”
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Analysis of Meteorological Fluctuations and Long-Term Drought Assessment in the Southern Coasts of Iran: An Observational and Climate Modeling Approach by Seyed Hassan Alavinia, Mahdi Salmanpour, Atefeh Abkar

“…Conclusions: The analysis of the SPI (Standardized Precipitation Index) with observational data demonstrated that drought patterns in this region are complex and influenced by multiple factors, including changes in atmospheric systems, oceanic circulation patterns, and human activities. …”
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Experimental Investigation on Energy Dissipation in Diversion Tunnel at the Head of Canal by ZHONG Kun, YAN Fu-gen, GUO Jian-hua, YI Shun, LI Min-kang

“…[Objective] The flow patterns of energy dissipation inside tunnels are complex, and theoretical calculations cannot meet design requirements. …”
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Multiple active site metal-based catalysts for C-N coupling reactions and the beyond by Mingzheng Shao, Yangbo Ma, Yuecheng Xiong, Liang Guo, Yunhao Wang, Guozhi Wang, Fu Liu, Fengkun Hao, Xiang Meng, Xintao Ma, Zhanxi Fan

“…However, the low Faradaic efficiency and poor selectivity of C-N coupling reactions, arisen from obscure understanding of the complex multi-step reactions and competitive side reactions, hinder their practical applications. …”
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