Urine complement analysis implies complement activation is involved in membranous nephropathy by Yingxue Xu, Yingxue Xu, Yi Li, Yong Zhang, Guisen Li, Guisen Li

“…BackgroundThe onset and progression of membranous nephropathy (MN) have been associated with complement activation, yet the overall characteristics of this activation in the kidneys remain unclear. …”
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Two complementing in vivo selection systems based on CCA-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases by Karolin Wellner, Josefine Gnauck, Dorian Bernier, Stephan H. Bernhart, Heike Betat, Mario Mörl

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Zinc supplementation inhibits complement activation in age-related macular degeneration. by Dzenita Smailhodzic, Freekje van Asten, Anna M Blom, Frida C Mohlin, Anneke I den Hollander, Johannes P H van de Ven, Ramon A C van Huet, Joannes M M Groenewoud, Yuan Tian, Tos T J M Berendschot, Yara T E Lechanteur, Sascha Fauser, Chris de Bruijn, Mohamed R Daha, Gert Jan van der Wilt, Carel B Hoyng, B Jeroen Klevering

“…Furthermore, we investigated the effect of zinc on complement activation in vitro. AMD patients with high levels of complement catabolism at baseline exhibited a steeper decline in serum complement activation (p<0.001) during the three month zinc supplementation period compared to patients with low complement levels. …”
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Association between circulatory complement activation and hypertensive renal damage: a case–control study by Zhongli Wang, Tingting Zhang, Xinyu Wang, Jianlong Zhai, Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Yifang Guo

“…Objective The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.Methods Serum complement C3, complement Factor H (CFH) and AP activation were assessed in 66 participants with established essential hypertension with renal damage (RD). …”
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Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS‐mutant Cancers by Yafang Wang, Lansong Xu, Lijun Ling, Mingyue Yao, Shangxuan Shi, Chengcheng Yu, Yingnian Li, Jie Shen, Hualiang Jiang, Chengying Xie

“…Mechanistically, CDK9 inhibition leads to compensatory activation of ERK‐MYC signaling, accompanied by the recovery of proto‐oncogenes, upregulation of immediate early genes (IEGs), stimulation of the complement C1r‐C3‐C3a cascade, and induction of tumor immunosuppression. …”
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Systematic Review of the Link Between Oxford MEST-C Classification and Complement Activation in IgA Nephropathy by Gabriel Ștefan, Eric Alamartine, Christophe Mariat, Nicolas Maillard

“…Methods: We adhered to the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines and conducted a systematic review, utilizing databases like MEDLINE (PubMed), Embase, Scopus, and Cochrane from January 2016 (year of updated MEST-C classification) to January 2023. We specifically selected studies that employed established methods to evaluate complement activation and the MEST-C classification. …”
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Prediction of activity of low-molecular inhibitors of the classic complement pathway using computational screening approach by D. M. Karlinsky, A. P. Kaplun, M. E. Popov

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Complement and Coagulation Cascade Activation Regulates the Early Inflammatory Mechanism of Resistance of Suckling Lambs Against <i>Haemonchus contortus</i> by José Gabriel G. Lins, Alessandro F. T. Amarante

“…Our data identified potential markers for resistance trait selection in sheep, such as C3 (complement C3), F3 (tissue factor), F5 (coagulation factor V), CFB (complement factor B), and CFI (complement factor I). …”
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C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients by Valeria Guaschino, Donata Santarsiero, Sara Gastoldi, Joshua M. Thurman, V. Michael Holers, Shelia M. Violette, Fei Liu, Kelly C. Fahnoe, Chiara Guarinoni, Ariela Benigni, Giuseppe Remuzzi, Marina Noris, Sistiana Aiello

“…Atypical hemolytic uremic syndrome (aHUS) is a rare and severe thrombotic microangiopathy caused by genetic or acquired abnormalities leading to activation of the complement alternative pathway on cell surfaces. …”
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Mapping autoantibody targets of full-length C-reactive protein in systemic lupus erythematosus: importance for neutrophil function and classical complement activation by Jesper Karlsson, Lina Wirestam, Hanna Duàn, Suhana Ahmad, Daniel Appelgren, Helena Enocsson, Jonas Wetterö, Christopher Sjöwall

“…Furthermore, we show that patients with anticardiolipin IgG and/or anti-β2GPI IgG antibodies have a higher number of positive CRP epitopes, and some CRP autoantibody-specificities associate with antiphospholipid antibodies, disease activity, and classical complement activation. In addition, one identified motif was selected, synthesized, and used for studying neutrophil function. …”
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Identification of the Fanconi Anemia Complementation Group I Gene, FANCI by Josephine C. Dorsman, Marieke Levitus, Davy Rockx, Martin A. Rooimans, Anneke B. Oostra, Anneke Haitjema, Sietske T. Bakker, Jûrgen Steltenpool, Dezsö Schuler, Sheila Mohan, Detlev Schindler, Fré Arwert, Gerard Pals, Christopher G. Mathew, Quinten Waisfisz, Johan P. de Winter, Hans Joenje

“…We found a candidate, KIAA1794 on chromosome 15q25-26, to be mutated in 8 affected individuals previously assigned to complementation group I. Western blots of endogenous FANCI indicated that functionally active KIAA1794 protein is lacking in FA-I individuals. …”
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Development and validation of a method for the determination of the specific activity of recombinant monoclonal antibody eculizumab by D. I. Zybin, A. S. Seregin, A. D. Askretkov, N. V. Orlova, Yu. A. Seregin, A. I. Prostyakova, D. V. Kapustin

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Effect of Co-Curricular Activities on Students’ Academic Performance in Selected Secondary Schools in Kabale Municipality. by Muhumuza, Aston

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The Complement System: An Important New Therapeutic Target in IgA Nephropathy by Karshana J. Kalyanaraman, Joshua M. Thurman

“…If multiple complement inhibitory drugs receive approval for IgA nephropathy, these biomarkers may be useful for selecting the most appropriate drug for an individual patient. …”
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Finerenone Alleviates Over-Activation of Complement C5a-C5aR1 Axis of Macrophages by Regulating G Protein Subunit Alpha i2 to Improve Diabetic Nephropathy by Zi-Han Li, Zi-Jun Sun, Sydney C. W. Tang, Ming-Hui Zhao, Min Chen, Dong-Yuan Chang

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Ligands and carriers for enhancing immune activity: Mechanisms of action and prospects for applications in medicine and biotechnology by S. S. Gogina, A. M. Stoinova

“…Antibodies, as key components of adaptive immunity, play a crucial role in pathogen neutralization and can be utilized as targets for immunotherapy. Cytokines and complement proteins serve multiple functions, including immune cell activation, antiviral activity, and regulation of inflammatory processes. …”
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AMY-101 as complement C3 inhibitor for periodontitis therapy: mechanisms, efficacy, and clinical translation by Jialun Li, Jialun Li, Zhi Xu, Wayne Nishio Ayre, Xiaohan Liu, Xiaohan Liu

“…AMY-101, a selective inhibitor of complement C3, has demonstrated significant potential in modulating complement activity and mitigating periodontal inflammation. …”
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Acute induction of interleukin-6 and biphasic changes of serum complement C3 by carrageenan in mice by K. Tateda, T. Matsumoto, K. Yamaguchi

“…Carrageenan has been widely used as an irritant to evoke inflamm ation in animals or to selectively deplete m acrophages in vivo. Although precise understanding of carrageenan activity is a prerequisite for the experimental use of this polysaccharide, the effects of this agent on host-biological systems are still poorly understood. …”
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Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH). by Hugh P Morgan, Haydyn D T Mertens, Mara Guariento, Christoph Q Schmidt, Dinesh C Soares, Dmitri I Svergun, Andrew P Herbert, Paul N Barlow, Jonathan P Hannan

“…It selectively inhibits amplification of C3b, the activation-specific fragment of the abundant complement component C3, in fluid phase and on self-surfaces and accelerates the decay of the alternative pathway C3 convertase, C3bBb. …”
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Unique target binding by the C-terminal region of FHR1 provides a new perception of aHUS pathology by Luce Perie, Selina Stippa, Christoph Saffer, Christoph Saffer, Andrea Hartmann, Mathias Mörgelin, Svante L. H. Zipfel, Marc Thilo Figge, Marc Thilo Figge, Thorsten Wiech, Christine Skerka, Peter F. Zipfel, Peter F. Zipfel

“…Notably, wild-type FHR1LA selected C3d, while pathogenic aHUS-associated alterations FHR1SV selected C3b. …”
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