Complement Activation: An Emerging Player in the Pathogenesis of Cardiovascular Disease by Angela M. Carter

“…An increasing body of evidence supports a functional role for complement activation in the pathogenesis of CVD through pleiotropic effects on endothelial and haematopoietic cell function and haemostasis. …”
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Complement C3 inhibition reduces complement activation in clinical platelet concentrates but does not counteract platelet storage lesions by Linnea I. Andersson, Per Sandgren, Dick J. Sjöström, Camilla Mohlin, Kim Hägerström, Ivar Tjernberg, Tom Eirik Mollnes, Per H. Nilsson

“…While C3 inhibition effectively reduced complement activation in stored platelet concentrates, it did not mitigate platelet storage lesions.…”
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Zinc supplementation inhibits complement activation in age-related macular degeneration. by Dzenita Smailhodzic, Freekje van Asten, Anna M Blom, Frida C Mohlin, Anneke I den Hollander, Johannes P H van de Ven, Ramon A C van Huet, Joannes M M Groenewoud, Yuan Tian, Tos T J M Berendschot, Yara T E Lechanteur, Sascha Fauser, Chris de Bruijn, Mohamed R Daha, Gert Jan van der Wilt, Carel B Hoyng, B Jeroen Klevering

“…Furthermore, we investigated the effect of zinc on complement activation in vitro. …”
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Complement activation drives the phagocytosis of necrotic cell debris and resolution of liver injury by Sofie Vandendriessche, Matheus Silvério Mattos, Emilia Laura Bialek, Sara Schuermans, Paul Proost, Pedro Elias Marques

“…Using human neutrophils, we showed that absence of C3 or C1q caused a reduction in the volume of necrotic debris that is phagocytosed, indicating that complement promotes effective debris uptake in mice and humans. …”
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Complement activation by the artificial surface of cardiopulmonary bypass is a persistent clinical problem by Joel David Bierer, Roger Stanzel, Mark Henderson, Tony El-Rabahi, John Sapp, Pantelis Andreou, Jean S. Marshall, David Conrad, David Horne

“…Circuit exposure time was a predictor of only C3a concentration in multivariable generalized linear mixed-effects models. Despite modern biocompatibility technology, there is significant alternative complement activation during ex-vivo sanguineous CPB prime preparation. …”
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The stability of complement-mediated bactericidal activity in human serum against Salmonella. by Colette M O'Shaughnessy, Adam F Cunningham, Calman A Maclennan

“…Up to three freeze-thaw cycles had no effect on the persistence of bactericidal activity and hemolytic complement assays confirmed no effect on complement function. …”
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Plasma and complement proteins are essential for the antimicrobial activity of canine platelet lysate by Melikasadat Mollabashi, Melikasadat Mollabashi, Alonza Klopfer, Alonza Klopfer, Thainá Lunardon, Thainá Lunardon, Nikolia Darzenta, Nikolia Darzenta, Emily Davis, Matt Murray, Scarlett M. Sumner, Maria C. Naskou, Maria C. Naskou

“…Additionally, platelets possess antimicrobial properties, which can be influenced by their manufacturing process, platelet and leukocyte concentration, activation method, and the presence of plasma and complement. …”
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Luciferase complementation based-detection of G-protein-coupled receptor activity by Hideaki Yano, Ning Sheng Cai, Jonathan A Javitch, Sergi Ferré

“…Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects. …”
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Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients by Iván Ferraz-Amaro, Iván Ferraz-Amaro, Sergio Santos-Concepción, Javier Castro-Hernández, Maria Vanesa Hernández-Hernández, Beatriz Tejera Segura, Cristina Luna, Esmeralda Delgado-Frias, Federico Díaz-González, Federico Díaz-González, Federico Díaz-González

“…The decrease in the alternative pathway was significant at weeks 12 and 24, but not at week 52 of TCZ treatment. TCZ had no effect on the lectin cascade throughout the follow-up.ConclusionTCZ reduces the activity of the classical and alternative pathways of the complement system in RA patients regardless of the improvement in disease activity. …”
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Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS‐mutant Cancers by Yafang Wang, Lansong Xu, Lijun Ling, Mingyue Yao, Shangxuan Shi, Chengcheng Yu, Yingnian Li, Jie Shen, Hualiang Jiang, Chengying Xie

“…Co‐targeting of CDK9 and KRAS/MAPK signaling pathways eliminates ERK‐MYC activation and prevents feedback activation mediated by receptor tyrosine kinases, leading to more effective control of KRAS‐mutant cancers and overcoming KRASi resistance. …”
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Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina by Marcus Karlstetter, Jens Kopatz, Alexander Aslanidis, Anahita Shahraz, Albert Caramoy, Bettina Linnartz‐Gerlach, Yuchen Lin, Anika Lückoff, Sascha Fauser, Katharina Düker, Janine Claude, Yiner Wang, Johannes Ackermann, Tobias Schmidt, Veit Hornung, Christine Skerka, Thomas Langmann, Harald Neumann

“…Its pathophysiology is linked to reactive oxygen species (ROS) and activation of the complement system. Sialic acid polymers prevent ROS production of human mononuclear phagocytes via the inhibitory sialic acid‐binding immunoglobulin‐like lectin‐11 (SIGLEC11) receptor. …”
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Cobalt Protoporphyrin IX Attenuates Antibody-Mediated, Complement-Dependent Podocyte Injury: Role of Cobalt and Porphyrin Moieties by Elias A. Lianos, Gia Nghi Phung, Jianping Zhou, Mukut Sharma

“…Metalloporphyrins (MPs) that induce heme oxygenase (HO)-1 were shown to attenuate complement-mediated glomerular injury, with cobalt protoporphyrin IX (CoPPIX) being the most effective. …”
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Terminal complement complexes with or without C9 potentiate antimicrobial activity against Neisseria gonorrhoeae by Evan R. Lamb, Alison K. Criss

“…Complement activation generates the membrane attack complex (MAC), a 10–11 nm diameter pore formed by complement proteins C5b through C8 and polymerized C9. …”
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NRICM101 in combatting COVID-19 induced brain fog: Neuroprotective effects and neurovascular integrity preservation in hACE2 mice by Cher-Chia Chang, Yea-Hwey Wang, Jiin-Cherng Yen, Chia-Ching Liaw, Keng-Chang Tsai, Wen-Chi Wei, Wen-Fei Chiou, Chun-Tang Chiou, Kuo-Tong Liou, Yuh-Chiang Shen, Yi-Chang Su

“…This is achieved by the inhibition of S1 protein-induced complement activation, which in turn leads to the prevention of damage to the neurovasculature and the subsequent death of neurons.…”
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Proteomic analysis of laser captured tubular tissues reveals complement activation and mitochondrial dysfunction in autoimmune related kidney diseases by Mengyun Xiao, Xianggeng Chi, Xiaohui Zhu, Zigan Xu, Yaoshuang Zou, Yue Peng, Shaodong Luan, Jingjing Dong, Yong Dai, Lianghong Yin

“…This study underscores the importance of complement activation and mitochondrial dysfunction in the pathogenesis of ARKDs, and proposes CFB as a potential therapeutic target to inhibit complement activation and mitigate tubular damage. …”
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Increased Autoreactivity of the Complement-Activating Molecule Mannan-Binding Lectin in a Type 1 Diabetes Model by Jakob Appel Østergaard, Marieta Milkova Ruseva, Talat Habib Malik, Ingeborg Torp Hoffmann-Petersen, Matthew Caleb Pickering, Steffen Thiel, Troels Krarup Hansen

“…We hypothesized that MBL activates complement upon binding within the diabetic glomerulus. …”
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Complement and Coagulation Cascade Activation Regulates the Early Inflammatory Mechanism of Resistance of Suckling Lambs Against <i>Haemonchus contortus</i> by José Gabriel G. Lins, Alessandro F. T. Amarante

“…The complement may act as a mediator of the innate immunity, and its activation in Santa Ines is associated with the classical, the lectin, and the alternative pathway. …”
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The Role of Snake Venom Proteins in Inducing Inflammation Post-Envenomation: An Overview on Mechanistic Insights and Treatment Strategies by Sudharshan Rao, Nisha Reghu, Bipin Gopalakrishnan Nair, Muralidharan Vanuopadath

“…In addition, the role of venom proteins in activating various inflammatory pathways, including the complement system, inflammasomes, and sterile inflammation are also summarized. …”
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No relationship between non-IgE-mediated mechanisms (complement activation or direct activation of mast cells and basophils) during diclofenac etalhyaluronate (SI-613/ONO-5704)-ind... by Shuhei Takada, Dai Muramatsu, Yasuaki Isoda, Yamato Sasaki, Kei Toyama, Keiji Yoshioka

“…Human plasma, CHO-K1 cells stably expressing MRGPRX2, the human mast cell line LAD2, and the human basophil leukemia cell line KU812 were used for these evaluations. No effect of DEH treatment was found on complement activation, MRGPRX2 agonist activity, direct mast cell activation, or direct basophil activation. …”
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C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients by Valeria Guaschino, Donata Santarsiero, Sara Gastoldi, Joshua M. Thurman, V. Michael Holers, Shelia M. Violette, Fei Liu, Kelly C. Fahnoe, Chiara Guarinoni, Ariela Benigni, Giuseppe Remuzzi, Marina Noris, Sistiana Aiello

“…We demonstrate that anti-C3d-antibody conjugated with CR11-10, or CR11-17, or FH1–5 effectively prevented aHUS serum-induced complement activation on HMEC-1, outperforming their non-targeted soluble counterparts. …”
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