Safety and feasibility of anlotinib in children with high risk, recurrent or refractory sarcomas: an open-label, single-centre, single-arm, phase Ia/Ib trialResearch in context by Suying Lu, Yi Que, Dongyang Liu, Feifei Sun, Xueting Yao, Liting Deng, Jing Zhan, Junting Huang, Ruiqing Cai, Xin Wang, Shixing Zhu, Zijun Zhen, Jia Zhu, Juan Wang, Yizhuo Zhang

“…AEs were reported in all patients, with most being grade 1 or 2 in severity. The most common AEs of any grade were hypothyroidism (58.8%, 20/34), diarrhoea (41.2%, 14/34) and abdominal pain (38.2%, 13/34). …”
Get full text

Hemoglobin Concentrations and Prevalence of Anemia During Pregnancy: Results from the Brazilian Maternal and Child Nutrition Consortium by Nathalia Cristina de Freitas-Costa, Thais Rangel Bousquet Carrilho, Paula Normando da Costa, Helena M Constante, Elizabeth Fujimori, Ana Paula Sayuri Sato, Gilberto Kac, Adauto Emmerich Oliveira, Alane Cabral Menezes de Oliveira, Ana Paula Esteves Pereira, Ana Paula Sayuri Sato, Antônio Augusto Moura da Silva, Carolina Abreu de Carvalho, Caroline de Barros Gomes, Claudia Leite de Moraes, Claudia Saunders, Cristina Garcia de Lima Parada, Daniela Saes Sartorelli, Dayana Rodrigues Farias, Denise Cavalcante de Barros, Denise Petrucci Gigante, Djanilson Barbosa dos Santos, Edson Theodoro dos Santos Neto, Elisa Maria de Aquino Lacerda, Elizabeth Fujimori, Fernanda Garanhani de Castro Surita, Flávia Farias Lima, Gilberto Kac, Helena Mendes Constante, Iracema de Mattos Paranhos Calderon, Isabel Oliveira Bierhals, Isaac Suzart Gomes-Filho, Jane de Carlos Santana Capelli, Jerusa da Mota Santana, José Guilherme Cecatti, Juliana dos Santos Vaz, Juraci Almeida Cesar, Katrini Guidolini Martinelli, Lívia Castro Crivellenti, Luana Patrícia Marmitt, Marco Fabio Mastroeni, Maria Angélica A Nunes, Maria Antonieta de Barros Leite Carvalhaes, Maria do Carmo Leal, Maria Inês Schmidt, Maria Fernanda Larcher de Almeida, Mayra Pacheco Fernandes, Michael Eduardo Reichenheim, Michele Drehmer, Mônica Araujo Batalha, Nathalia Cristina de Freitas-Costa, Patricia de Carvalho Padilha, Renato Passini Junior, Renato Teixeira Souza, Silmara Salete de Barros Silva Mastroeni, Silvia Regina Dias Medici Saldiva, Sílvio O M Prietsch, Simone Seixas da Cruz, Sirlei Siani Morais, Sotero Serrate Mengue, Thaís Rangel Bousquet Carrilho, Vera Lúcia Bosa

Get full text

Switch to mania after acute antidepressant treatment for bipolar depression: a systematic review and network meta-analysis of randomised controlled trialsResearch in context by Vincenzo Oliva, Michele De Prisco, Enrico La Spina, Sofia Paolucci, Giovanna Fico, Gerard Anmella, Diego Hidalgo-Mazzei, Andrea Murru, Maurizio Pompili, Michele Fornaro, Marco Solmi, Ayşegül Yildiz, Stefan Leucht, Eduard Vieta, Joaquim Radua

Get full text

Development and validation of a conventional MRI-based model to predict cerebral palsy in infants (aged 6–24 months) with periventricular white matter injury: a multicentre, retros... by Tingting Huang, Jie Zheng, Heng Liu, Haoxiang Jiang, Chao Jin, Xianjun Li, Liang Wu, Lei Zhang, Congcong Liu, Yitong Bian, Miaomiao Wang, Fan Wu, Xin Zhao, Shengli Shi, Fei Wang, Mengxuan Li, Linlin Zhu, Yuying Feng, Gang Zhang, Jian Yang

“…Summary: Background: Periventricular white matter injury (PVWMI) is the most common form of brain injury and the leading cause of cerebral palsy (CP). …”
Get full text

Clinical, immune cell, and genetic features predicting survival and long-term response to first-line chemo-immunotherapy treatment for non-small cell lung cancer by Liling Huang, Haohua Zhu, Liyuan Dai, Yu Feng, Xinrui Chen, Zucheng Xie, Xingsheng Hu, Yutao Liu, Xuezhi Hao, Lin Lin, Hongyu Wang, Shengyu Zhou, Jiarui Yao, Le Tang, Xiaohong Han, Yuankai Shi

“…Methods In this study, we retrospectively summarized the survival outcome of 319 patients with locally advanced or metastatic NSCLC who received anti-programmed cell death protein-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) based therapy from January 1st, 2018 to February 28th, 2022 at the Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College. …”
Get full text

Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study by A. Biaggi, V. Zonca, C. Anacker, V. Begni, F. Benedetti, A. Bramante, A. Braniecka, V. Brenna, M. Bulgheroni, C. Buss, L. Cavaliere, C.A.M. Cecil, A.C. Couch, D. de Barra, H. El Marroun, S. Entringer, R. Grassi-Oliveira, M. Jackowska, A. Korosi, P.J.C. Kwant, J. Lahti, K. Lekadir, I. Mansuy, F. Manuella, M. Marizzoni, U. Meyer, C. Monk, S. Nakić Radoš, C.M. Pariante, B.J.A. Pollux, K. Priestley, K. Räikkönen, J. Richetto, M.A. Riva, L.M. Rothmann, V. Simonetti, B. Vai, A.C. Vernon, M. Žutić, A. Cattaneo

Get full text

Sonic hedgehog medulloblastomas are dependent on Netrin-1 for survival by Julie Talbot, Joanna Fombonne, Jacob Torrejon, Benjamin R. Babcock, Leon F. McSwain, Nicolas Rama, Ludovica Lospinoso Severini, Emma Bonerandi, Veronique Marsaud, Flavia Bernardi, Tarek Gharsalli, Catherine Guix, Benjamin Ducarouge, Verena Neururer, Irene Basili, Audrey L. Mercier, Hua Yu, Antoine Forget, Emilie Indersie, Sophie Leboucher, Judith Souphron, Konstantin Okonechnikov, Wanchen Wang, Daisuke Kawauchi, Brandon J. Wainwright, Didier Frappaz, Pascale Varlet, Christelle Dufour, Kevin Beccaria, Thomas Blauwblomme, Loredana Martignetti, Lucia Di Marcotullio, Stéphanie Puget, François Doz, Franck Bourdeaut, Julien Masliah-Planchon, Timothy R. Gershon, Patrick Mehlen, Olivier Ayrault

Get full text

Associations of plasma SMOC1 and soluble IL6RA levels with the progression from mild cognitive impairment to dementia by Xavier Morató, Raquel Puerta, Amanda Cano, Adelina Orellana, Itziar de Rojas, María Capdevila, Laura Montrreal, Maitée Rosende-Roca, Pablo García-González, Claudia Olivé, Fernando García-Gutiérrez, Josep Blázquez, Andrea Miguel, Raúl Núñez-Llaves, Vanesa Pytel, Montserrat Alegret, María Victoria Fernández, Marta Marquié, Sergi Valero, Jose Enrique Cavazos, Santos Mañes, Mercè Boada, Alfredo Cabrera-Socorro, Agustín Ruiz

Get full text

O2- CHARACTERIZATION OF STEATOTIC LIVER DISEASE AND THE ROLE OF GENETIC BACKGROUND IN LATIN AMERICA by LUIS ANTONIO DÍAZ PIGA, Carolina Aguilera, Gustavo Ayares, Francisco Idalsoaga, Mauricio Pizarro, Fernando Javier Barreyro, Sebastián Marciano, Jorge Martínez Morales, Cristiane Villela-Nogueira, Nathalie Leite, Claudia Alves Couto, Rafael Theodoro, Mísia Joyner de Sousa Dias Monteiro, Mario G. Pessoa, Mario Reis Alvares-da-Silva, Fátima Higuera de la Tijera, Adelina Lozano, Pedro Montes, Graciela Castro-Narro, Constanza D. Sabate, Manuel Mendizabal, Francisco Barrera, Daniel Cabrera, Mazen Noureddin, Naim Alkhouri, Winston Dunn, Zobair Younossi, Jeffrey V. Lazarus, Rohit Loomba, Claudia Pinto Marques Souza de Oliveira, Adrian Gadano, Marco Arrese, Juan Pablo Arab

Get full text

Evaluating the level of digitalization of the innovation process with artificial intelligence approach in the digital transformation of knowledge-based companies by ali Bagheri, reza radfar, sepehr ghazinoory

“…Questionnaires were sent through the Press Line program and within social network groups, and for some through phone and email. …”
Get full text

German S3 guideline “actinic keratosis and cutaneous squamous cell carcinoma” – Long version of the update 2023 by Ulrike Leiter, Markus V. Heppt, Theresa Steeb, Mareike Alter, Teresa Amaral, Andrea Bauer, Falk G. Bechara, Jürgen C. Becker, Eckhard W. Breitbart, Helmut Breuninger, Thomas Diepgen, Thomas Dirschka, Thomas Eigentler, A.K. Stephan El Gammal, Moritz Felcht, Michael J. Flaig, Markus Follmann, Klaus Fritz, Stephan Grabbe, Rüdiger Greinert, Ralf Gutzmer, Axel Hauschild, Uwe Hillen, Stephan Ihrler, Swen Malte John, Lukas Kofler, Oliver Koelbl, Albrecht Krause-Bergmann, Klaus Kraywinkel, Steffen Krohn, Thomas Langer, Carmen Loquai, Christoph R. Löser, Peter Mohr, Dorothée Nashan, Monika Nothacker, Christina Pfannenberg, Carmen Salavastru, Lutz Schmitz, Eggert Stockfleth, Rolf-Markus Szeimies, Claas Ulrich, Susanne Voelter-Mahlknecht, Dirk Vordermark, Michael Weichenthal, Julia Welzel, Kai Wermker, Susanne Wiegand, Claus Garbe, Carola Berking

Get full text

Escaping Helium and a Highly Muted Spectrum Suggest a Metal-enriched Atmosphere on Sub-Neptune GJ 3090 b from JWST Transit Spectroscopy by Eva-Maria Ahrer, Michael Radica, Caroline Piaulet-Ghorayeb, Eshan Raul, Lindsey Wiser, Luis Welbanks, Lorena Acuña, Romain Allart, Louis-Philippe Coulombe, Amy Louca, Ryan MacDonald, Morgan Saidel, Thomas M. Evans-Soma, Björn Benneke, Duncan Christie, Thomas G. Beatty, Charles Cadieux, Ryan Cloutier, René Doyon, Jonathan J. Fortney, Anna Gagnebin, Cyril Gapp, Hamish Innes, Heather A. Knutson, Thaddeus Komacek, Joshua Krissansen-Totton, Yamila Miguel, Raymond Pierrehumbert, Pierre-Alexis Roy, Hilke E. Schlichting

Get full text

Efficacy and safety of perioperative sintilimab plus platinum-based chemotherapy for potentially resectable stage IIIB non-small cell lung cancer (periSCOPE): an open-label, single... by Xiangyang Yu, Chujian Huang, Longde Du, Chunguang Wang, Yikun Yang, Xin Yu, Shengcheng Lin, Chenglin Yang, Hongbo Zhao, Songhua Cai, Zhe Wang, Lixu Wang, Xiaotong Guo, Baihua Zhang, Zhentao Yu, Jie He, Kai Ma

“…Twelve patients (44.4%) in the per-protocol (PP) population achieved an MPR, including six patients (22.2%) with a pCR. The most common postoperative complications were atrial fibrillation (6, 22.2%), pneumonitis (5, 18.5%), and heart failure (4, 14.8%); no deaths occurred within 90 days after surgery. …”
Get full text

The Featherweight Giant: Unraveling the Atmosphere of a 17 Myr Planet with JWST by Pa Chia Thao, Andrew W. Mann, Adina D. Feinstein, Peter Gao, Daniel Thorngren, Yoav Rotman, Luis Welbanks, Alexander Brown, Girish M. Duvvuri, Kevin France, Isabella Longo, Angeli Sandoval, P. Christian Schneider, David J. Wilson, Allison Youngblood, Andrew Vanderburg, Madyson G. Barber, Mackenna L. Wood, Natasha E. Batalha, Adam L. Kraus, Catriona Anne Murray, Elisabeth R. Newton, Aaron Rizzuto, Benjamin M. Tofflemire, Shang-Min Tsai, Jacob L. Bean, Zachory K. Berta-Thompson, Thomas M. Evans-Soma, Cynthia S. Froning, Eliza M.-R. Kempton, Yamila Miguel, J. Sebastian Pineda

Get full text

Is it Time to Recognize Political Anxiety as a Social Determinant of Health? by Brandon Ambrosino

“…So, even though you might be sitting down with your family to watch an anodyne program like Jeopardy, you’ll likely see some sort of “attack ad” — the very name of which tells you that it’s been created to foster hostility.  …”
Get full text

SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: multicentre cohort study by Judith Breuer, Catherine F Houlihan, Nick Freemantle, David Partridge, Gaia Nebbia, Jacqui Prieto, Gee Yen Shin, Andrew Copas, Oliver Stirrup, Kenneth Laing, Rachel Williams, Helen Wheeler, Paul Randell, Ana da Silva Filipe, Maria-Teresa Cutino-Moguel, Tommy Rampling, Tabassum Khan, James Price, Eleni Nastouli, Katie Johnson, Sharon Glaysher, Scott Elliott, Helen Umpleby, Emanuela Pelosi, Emma Thomson, Cristina Venturini, Anna Riddell, Alison Cox, Andrew C Hayward, Malin Bergström, David Harrington, Charlotte Williams, Tanzina Haque, Dianne Irish, Adrienn Angyal, Marios Margaritis, Moira Spyer, Florencia Boshier, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela Beckett, Themoula Charalampous, Raghavendran Kulasegaran Shylini, Beatrix Kele, Irene Monahan, Guy Mollett, Matthew Parker, Sunando Roy, Joshua Taylor, Sophie Weller, Eleri Wilson-Davies, Phillip Wade, Joseph Hughes, Tabitha Mahungu, Cassie Pope, Samuel Robson, Kordo Saeed, Thushan de Silva, Luke Snell, Adam A Witney, James Blackstone, Leanne Hockey, Georgia Marley, Christine Peters, Flavia Flaviani, Bindi Patel, Tom G S Williams, Rahul Batra, Jonathan D Edgeworth, Pinglawathee Madona, Jennifer Hart, Juanita Pang, Helena Tutill, Nadua Bayzid, Marius Cotic, Luke Green, Benjamin Lindsey, Amy State, Alison Cope, Peijun Zhang, Max Whiteley, Marta Gallis Ramalho, Stella Christou, Stavroula Louka, Hailey Hornsby, Benjamin Foulkes, Paige Wolverson, Joe Heffer, Nikki Smith, Salman Goudarzi, Chris Fearn, Kate Cook, Katie Loveson, Adhyana Mahamana, Buddhini Samaraweera, Siona Silveira, Stephen Aplin, Sarah Jeremiah, Matthew Harvey, Thea Sass, Ngee Keong Tan, Claudia Cardoso Pereira, Dan Frampton, Matt Byott, Judith Heaney, Emilie Sanchez, Stavroula M Paraskevopoulou

Get full text

Is it Time to Recognize Political Anxiety as a Social Determinant of Health? by Brandon Ambrosino

“…So, even though you might be sitting down with your family to watch an anodyne program like Jeopardy, you’ll likely see some sort of “attack ad” — the very name of which tells you that it’s been created to foster hostility.  …”
Get full text

Where do we want the glaciological community to be in 2073? Equality, diversity and inclusion challenges and visions from the 2023 Karthaus Summer School by Lena Nicola, Rebekka Frøystad, Antonio Juarez-Martinez, Maxence Menthon, Ana Carolina Moraes Luzardi, Katherine A. Turner, Sally F. Wilson, Nanna B. Karlsson, Tim van den Akker, Aminat Ambelorun, Malena Andernach, Mike Bentley, Gianluca Bianchi, Lawrence Bird, Charlotte Carter, Andrés Castillo-Llarena, Niall Bennet Coffey, Eliza Dawson, Sophie de Roda Husman, Olaf Eisen, Thomas Gregov, Ian Hewitt, Marte Hofsteenge, Lokesh Jain, Megan James, Franka Jesse, Mikkel Langgaard Lauritzen, George Lu, Michaela Mühl, Violet Patterson, Frank Pattyn, Carleen Reijmer, Charlotte Rahlves, Niklas Richter, Therese Rieckh, Florina R. Schalamon, Simon Schöll, Shashwat Shukla, Kristiina Verro, Ricarda Winkelmann, Christian Wirths, Benjamin Keisling

Get full text

Effectiveness of a brief multicomponent intervention to improve physical activity level and functional capacity in fibromyalgia and chronic fatigue syndrome (Synchronize+) by Carme Martín-Borràs, Carme Martín-Borràs, Carme Martín-Borràs, Carme Martín-Borràs, Gemma González Serra, Gemma González Serra, Noèlia Carrasco-Querol, Oriol Sansano-Nadal, Oriol Sansano-Nadal, Oriol Sansano-Nadal, Nerea Bueno Hernández, Pau Bestraten del Pino, Pau Bestraten del Pino, Marta Pastor Cazalla, Marta Pastor Cazalla, Rosa Caballol Angelats, Rosa Caballol Angelats, Pilar Montesó-Curto, Pilar Montesó-Curto, Pilar Montesó-Curto, Elisabet Castro Blanco, Macarena Pozo Ariza, José Fernández-Sáez, José Fernández-Sáez, M. Rosa Dalmau Llorca, M. Rosa Dalmau Llorca, Alessandra Queiroga Gonçalves, Alessandra Queiroga Gonçalves, Carina Aguilar Martín, Carina Aguilar Martín

“…Low cardiorespiratory fitness and muscle function with habitual intolerance to efforts are common characteristics of FM and CFS. This study aimed to examine the effect of a brief multicomponent intervention based on physical activity (PA), nutrition, and chronobiology on movement behaviors (PA, sedentary and sleep time), muscle strength, and cardiorespiratory capacity.Methodsrandomized controlled trial was conducted in primary healthcare in Catalonia. …”
Get full text

Transthyretin amyloid cardiomyopathy in France: A cross-sectional multi-centre study (333 patients) by Thibaud Damy, Erwan Donal, Olivier Lairez, Jean-Christophe Eicher, Mounira Karoubi, Jean-Noël Trochu, Jocelyn Inamo, Gilbert Habib, François Roubille, Albert Hagège, Flore Morio, Eve Cariou, Jérôme Adda, Vincent Algalarrondo, Agathe Coste, Mathilde Bartoli, Jérémie Rudant, Lara Salvi, Bruno Francou, Anne Guiochon-Mantel, David Adams, Jean-Christophe Antoine, Shahram Attarian, Pascal Cintas, Raul Juntas Morales, Emmeline Lagrange, Laurent Magy, Martial Mallaret, Yann Péréon, Philippe Petiot, Cécile Cauquil, Céline Labeyrie, Andoni Echaniz-Laguna, Guilhem Sole, Céline Tard, Silvia Oghina, Philippe Charron, Michel Slama

“…Biopsies were performed on nearly 90% of patients with most of them being positive. The most common biopsy sites were salivary glands (137 biopsies) and cardiac tissues (77 biopsies). …”
Get full text