An artificial intelligence approach to palaeogeographic studies: a case study of the Late Ordovician brachiopods of Laurentia by Akbar Sohrabi

“…In contrast to Hiscobeccus, which was common in the palaeo-equatorial epicontinental seas, Rhynchotrema species were common and diverse in the continental margins and platforms of the pericratonic region of Laurentia. …”
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High-flow nasal cannula therapy versus continuous positive airway pressure for non-invasive respiratory support in paediatric critical care: the FIRST-ABC RCTs by Padmanabhan Ramnarayan, Alvin Richards-Belle, Karen Thomas, Laura Drikite, Zia Sadique, Silvia Moler Zapata, Robert Darnell, Carly Au, Peter J Davis, Izabella Orzechowska, Julie Lester, Kevin Morris, Millie Parke, Mark Peters, Sam Peters, Michelle Saull, Lyvonne Tume, Richard G Feltbower, Richard Grieve, Paul R Mouncey, David Harrison, Kathryn Rowan

“…Background Despite the increasing use of non-invasive respiratory support in paediatric intensive care units, there are no large randomised controlled trials comparing two commonly used non-invasive respiratory support modes, continuous positive airway pressure and high-flow nasal cannula therapy. …”
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Risk Prediction Model for High Myopia in Primary and Secondary School Students: Based on Nested Case-control Study by CHEN Shenglan, ZHENG Yongtao, HU Wangcheng, NI Zuowei, XIA Bing, YE Chunmei, DU Chixin, CHEN Xiaodan

“…Myopia status among the students was monitored in accordance with the National Monitoring and Intervention Program for Common Diseases and Health-Related Factors in Students. …”
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Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China by Yongxiang Wang, Xiaolei Han, Xianda Zhang, Zhonglin Zhang, Lin Cong, Shi Tang, Tingting Hou, Cuicui Liu, Xiaojuan Han, Qinghua Zhang, Jianli Feng, Ling Yin, Lin Song, Yi Dong, Rui Liu, Yuanjing Li, Tiia Ngandu, Miia Kivipelto, Heather Snyder, Maria Carrillo, Jonas Persson, Laura Fratiglioni, Lenore J Launer, Jianping Jia, Yifeng Du, Chengxuan Qiu

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Impact of social isolation on mortality and morbidity in 20 high-income, middle-income and low-income countries in five continents by Annika Rosengren, Thandi Puoane, Karen E Yeates, Rajeev Gupta, S V Subramanian, Koon Teo, Sumathy Rangarajan, Scott A Lear, Rasha Khatib, Rafael Diaz, Alvaro Avezum, Andrzej Szuba, Khalid F Alhabib, Jephat Chifamba, Salim Yusuf, Omar Rahman, Pamela Serón, Antonio L Dans, Manmeet Kaur, Roya Kelishadi, Ismail Rosnah, Afzalhussein Yusufali, Ryo Naito, Darryl P Leong, Shrikant Ishver Bangdiwala, Shofiqul Islam, Weida Liu, Yibing Zhu, Yundong Sheng, Kubilay Karsidag, Leela Itty Amma K R, Syed Iqbal Azam

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Atezolizumab consolidation in patients with high-risk diffuse large B-cell lymphoma in complete remission after R-CHOP by Marcel Nijland, Djamila E. Issa, Johanna A. A. Bult, Dries Deeren, Gerjo A. Velders, Marten R. Nijziel, Yorick Sandberg, Vibeke Vergote, Margriet Oosterveld, Rob Fijnheer, Rolf E. Brouwer, Rinske S. Boersma, Kalung Wu, Laurens Nieuwenhuizen, Joost S. P. Vermaat, Roel J. W. van Kampen, Wim E. Terpstra, Sylvia Snauwaert, Marjolein W. van der Poel, Eva de Jongh, Marc F. Durian, Leonie Strobbe, Aart Beeker, Alain Gadisseur, Roos S. van Rijn, Otto Visser, Jeanette K. Doorduijn, Tjeerd J. F. Snijders, Matthijs H. Silbermann, Daphne de Jong, Martine Chamuleau, Rogier Mous, Hilde Jalving, Heleen Visser-Wisselaar, Sonja Jansen van de Bergh, Gerben J. C. Zwezerijnen, Edwin Bremer, Mirian Brink, Arjan Diepstra, Dana A. Chitu, Harry R. Koene, Josée M. Zijlstra

“…Secondary end points included overall survival (OS) and safety (Common Terminology Criteria for Adverse Events version 4.0). …”
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Worldwide patterns and trends in ovarian cancer incidence by histological subtype: a population-based analysis from 1988 to 2017Research in context by Yi-Fan Wei, Li Ning, Yi-Lin Xu, Jing Ma, Dong-Run Li, Zan-Fei Feng, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Peng Li, Yong-Pei Yu, Dong-Hui Huang, Xiao-Ying Li, Song Gao, Chun-Qing Lin, Ting-Ting Gong, Qi-Jun Wu, Jing-He Lang

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Impact of Institutional Monthly Volume of Transcatheter Edge-to-Edge Repair Procedures for Significant Mitral Regurgitation: Evidence from the GIOTTO-VAT Study by Nicola Corcione, Paolo Ferraro, Filippo Finizio, Michele Cimmino, Michele Albanese, Alberto Morello, Giuseppe Biondi-Zoccai, Paolo Denti, Antonio Popolo Rubbio, Francesco Bedogni, Antonio L. Bartorelli, Annalisa Mongiardo, Salvatore Giordano, Francesco De Felice, Marianna Adamo, Matteo Montorfano, Francesco Maisano, Giuseppe Tarantini, Francesco Giannini, Federico Ronco, Emmanuel Villa, Maurizio Ferrario, Luigi Fiocca, Fausto Castriota, Angelo Squeri, Martino Pepe, Corrado Tamburino, Arturo Giordano

“…These findings inform on the importance of operator experience and center expertise in achieving state-of-the-art results with TEER, while confirming the usefulness of the proctoring approach when naïve centers begin a TEER program.…”
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Efficacy and safety of narlumosbart, an anti-RANKL monoclonal antibody, in postmenopausal women with osteoporosis: a multi-center, randomized, double-blind, placebo- and active-con... by Yue Chi, Yukun Li, Qun Cheng, Hanqing Cai, Yuhong Zeng, Hui Sheng, Bing Song, Hongmei Li, Lin Shen, Min Li, Ying Xing, Mei Cheng, Yujin Ma, Difei Wang, Mei Zhu, Weiping Lu, Shuang Yan, Xueyuan Zhang, Jing Yuan, Baofang Yang, Jun Li, Juan Wang, Zhufeng Wu, Weibo Xia

“…Treatment-emergent adverse events (TEAEs) were observed in 91.9% of patients in the pooled narlumosbart groups, and 92.9% in both the placebo and the denosumab groups. Most common TEAEs were decreased vitamin D levels (34.1% [pooled narlumosbart] vs. 35.7% [placebo] vs. 33.3% [denosumab]), COVID-19 (38.2% vs. 40.5% vs. 35.7%), and increased serum parathyroid hormone (22.8% vs. 14.3% vs. 19.0%). …”
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Catalysing change in health and medical research policy: an Australian case study of deliberative democracy to reform sex and gender policy recommendations by Sue Haupt, Cheryl Carcel, Lily Halliday, Saraid Billiards, Lyn Carson, Kyle Redman, Scott Lappan-Newton, Karin R. Aubrey, Xander Bickendorf, Jane E. Bourke, Michael Buchert, Jessica Da Gama Duarte, Ayan Dasvarma, Thomas F. E. Drake-Brockman, Thomas F. E. Drake-Brockman, Thomas F. E. Drake-Brockman, Thomas F. E. Drake-Brockman, Kerryn Drysdale, Stephen C. C. Dymock, Laura N. Eadie, Laura N. Eadie, Melanie Eckersley-Maslin, Melanie Eckersley-Maslin, Melanie Eckersley-Maslin, Moritz Falk Eissmann, James Fazio, Bridget G. Haire, Melinda Holder, Nicole Kleppe, Ken Knight, Jonathan Mauclair, Celine Northcott, Brian G. G. O. Oliver, Tracy A. O'Mara, Ken Pang, Steven Philpot, Tertia D. Purves-Tyson, Jacob Stewart-Olsen, Lauren Ursich, Natalia Vukelic, Marina H. Yakou, Bronwyn Graham, Bronwyn Graham, Severine Lamon, Rachel Huxley, Kelly Thompson, Kelly Thompson, Keziah Bennett-Brook, Christine Jenkins, Christine Jenkins, Zoe Wainer, Zoe Wainer, Mark Woodward, Mark Woodward, Louise Chappell, Robyn Norton, Robyn Norton

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Bridging radiotherapy before chimeric antigen receptor T cells for B-cell lymphomas: an ILROG multicenter study by Nikhil Yegya-Raman, John P. Plastaras, Christopher M. Wright, Monica Chelius, Siqi Zhang, Jonathan A. Baron, Harper Hubbeling, Austin J. Sim, Timothy J. Robinson, Michael D. Jain, Brandon Imber, Beatrice Fregonese, Joachim Yahalom, Colton Ladbury, Savita Dandapani, Chelsea C. Pinnix, Jillian R. Gunther, Penny Q. Fang, Susan Y. Wu, Bouthaina S. Dabaja, Joanna C. Yang, Jessica Chew, Steve Braunstein, Sumi Sinha, Nathan M. Delinger, Susan Sun, Stephanie A. Terezakis, Gukan Sakthivel, Louis S. Constine, Amit K. Chowdhry, Patrick M. Reagan, Skyler Burke, Yolanda D. Tseng, Michael J. LaRiviere, Amit Maity, Stephen J. Schuster, Elise A. Chong, Nicholas B. Figura

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Insights from the global education survey on the use of VR-haptics in dental education by Sompop Bencharit, Barry Quinn, Maria F. Sittoni-Pino, Santiago Arias-Herrera, Simona-Georgiana Schick, Sarah Rampf, Samantha Byrne, Muhammad A. Shazib, Ulf Örtengren, Walter Yu Hang Lam, Mikko Liukkonen, David Rice, Masako Nagasawa, Amitha Ranauta, Sobia Zafar, Kinga Bágyi, Thomas J. Greany, Amirul Faiz Luai, Amirul Faiz Luai, Marit Øilo, Gitana Rederiene, Rebecca Stolberg, Gülsün Gül, Jorge Tricio, Reinhard Chun Wang Chau, Mihaela Pantea, Murat Mutluay, Peter Lingström, Ophir Klein, Ophir Klein, Sıla Nur Usta, Liisa Suominen, Liisa Suominen, Szabolcs Felszeghy

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The effect of Plant Growth Promoting Rhizohacteria on activities of antioxidative enzymes, physiological characteristics and root growth of four chickpea (Cicer arietinum L.) culti... by Rahim Naseri, Abbas Soleymani Fard, Amir Mirzaei, Fereshteh Darabi, Amin Fathi

“…The data were analyzed statistically by SAS program and the data means were compared by Duncan's multiple range test (DMRT).   …”
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Effectiveness of interventions for improving educational outcomes for people with disabilities in low‐ and middle‐income countries: A systematic review by Xanthe Hunt, Ashrita Saran, Howard White, Hannah Kuper

“…The category of interventions most represented across studies was ‘Educational attainment support’, for instance, a reading comprehension intervention that combined strategy instruction (graphic organisers, visual displays, mnemonic illustrations, computer exercises, predicting, inference, text structure awareness, main idea identification, summarisation, and questioning) for children with dyslexia. The second most common category of intervention was ‘Accessible learning environments’, for instance, programmes which aimed to improve social skills or to reduce rates of victimisation of children with disabilities in schools. …”
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Oxaliplatin, ATR inhibitor and anti-PD-1 antibody combination therapy controls colon carcinoma growth, induces local and systemic changes in the immune compartment, and protects ag... by Henri-Alexandre Michaud, Nathalie Bonnefoy, François Quenet, Julien Faget, Diego Tosi, Celine Gongora, Olivia Sgarbura, Alexandra Fauvre, Chiara Ursino, Veronique Garambois, Elodie Culerier, Louis-Antoine Milazzo, Nadia Vezzio-Vié, Laura Jeanson, Candice Marchive, Augusto Faria Andrade, Eve Combes, Salima Atis, Gérald Lossaint, Lakhdar Khellaf, Ileana Corbeau, Nadine Houede

“…Background Colorectal cancer (CRC) is the third most common cancer type and one of the leading causes of cancer-related death worldwide. …”
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Combination of spatial transcriptomics analysis and retrospective study reveals liver infection of SARS-COV-2 is associated with clinical outcomes of COVID-19Research in context by Shiqi Chen, Yi Zhang, Asha Ashuo, Shu Song, Lunzhi Yuan, Weixia Wang, Cong Wang, Zunguo Du, Yangtao Wu, Dan Tan, Chenlu Huang, Jingna Chen, Yaming Li, Jinjin Bai, Huilin Guo, Zehong Huang, Yi Guan, Ningshao Xia, Zhenghong Yuan, Jiming Zhang, Quan Yuan, Zhong Fang

“…Summary: Background: Liver involvement is a common complication of coronavirus disease 2019 (COVID-19), especially in hospitalized patients. …”
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Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation by Ang Lin, Sven Brandau, Stephan Lang, Luca Cassetta, Kirsten Bruderek, Joanna Skrzeczynska-Moncznik, Oktawia Osiecka, Xiaoying Hu, Ida Marie Rundgren, Kim Santegoets, Utku Horzum, Ana Godinho-Santos, Gennadiy Zelinskyy, Thalia Garcia-Tellez, Sunčica Bjelica, Bartłomiej Taciak, Astrid Olsnes Kittang, Benedikt Höing, Michael Dixon, Verena Müller, Jochen Sven Utikal, Derya Karakoç, Kerim Bora Yilmaz, Emilia Górka, Lubomir Bodnar, Olympia Evdoxia Anastasiou, Christine Bourgeois, Robert Badura, Monika Kapinska-Mrowiecka, Mirjana Gotic, Mark ter Laan, Esther Kers-Rebel, Magdalena Król, Juan Francisco Santibañez, Michaela Müller-Trutwin, Ulf Dittmer, Ana Espada de Sousa, Güneş Esendağlı, Gosse Adema, Karin Loré, Elisabeth Ersvær, Viktor Umansky, Jeffrey W Pollard, Joanna Cichy

“…PMN-MDSC expansion was more pronounced in cancer compared with infection and inflammation. Programmed death-ligand 1 was primarily expressed in M-MDSC and e-MDSC and was not upregulated as a consequence of disease. …”
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Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22 by Scott McComb, Mehdi Arbabi-Ghahroudi, Kevin A. Hay, Brian A. Keller, Sharlene Faulkes, Michael Rutherford, Tina Nguyen, Alex Shepherd, Cunle Wu, Anne Marcil, Annie Aubry, Greg Hussack, Devanand M. Pinto, Shannon Ryan, Shalini Raphael, Henk van Faassen, Ahmed Zafer, Qin Zhu, Susanne Maclean, Anindita Chattopadhyay, Komal Gurnani, Rénald Gilbert, Christine Gadoury, Umar Iqbal, Dorothy Fatehi, Anna Jezierski, Jez Huang, Robert A. Pon, Mhairi Sigrist, Robert A. Holt, Brad H. Nelson, Harold Atkins, Natasha Kekre, Eric Yung, John Webb, Julie S. Nielsen, Risini D. Weeratna

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Master protocol for a series of cohort-based randomized controlled trials to test tools to communicate research results to study participants and others with relevant lived experie... by Brett D. Thombs, Claire Adams, Elsa-Lynn Nassar, Marie-Eve Carrier, Meira Golberg, Kanika Bharthi, Amanda Wurz, Annabelle South, Linda Kwakkenbos, Sabrina Hoa, Danielle B. Rice, Geneviève Guillot, Amanda Lawrie-Jones, Maureen Sauvé, Susan J. Bartlett, Catherine Fortune, Amy Gietzen, Karen Gottesman, Marie Hudson, Laura K. Hummers, Vanessa L. Malcarne, Maureen D. Mayes, Michelle Richard, James Stempel, Robyn K. Wojeck, Kathleen Blagrave, Jill T. Boruff, Vanessa Cook, Nicole Culos-Reed, Ole Fröbert, Katie Gillies, Vera Granikov, Lars G. Hemkens, Elizabeth Yakes Jimenez, Agnes Kocher, Catarina Leite, Mathew A. W. T. Lim, Nancy Maltez, John Michalski, Tracy Mieszczak, Mwidimi Ndosi, Janet Pope, François Rannou, Ken Rozee, Sharon E. Straus, Matthew R. Sydes, Lehana Thabane, John Varga, Tami Yap, Merrick Zwarenstein, Luc Mouthon, Andrea Benedetti, SPIN Investigators

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Epidemic characteristics and effectiveness of vaccine intervention on rotavirus infection: a real-world observational study in Zhejiang Province, China by Ziping Miao, Yuxia Du, Anqi Dai, Mengya Yang, Can Chen, Rui Yan, Jian Gao, Yijuan Chen, Kexin Cao, Daixi Jiang, Xiaobao Zhang, Xiaoyue Wu, Mengsha Chen, Yue You, Wenkai Zhou, Dingmo Chen, Jiaxing Qi, Shiyong Zhao, Xianyao Lin, Shigui Yang, RIDPHE Group, Shigui Yang, Xudong Zhou, Peige Song, Ning Zhang, Hao Lei, Junfang Xu, Jianbing Wang

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