Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma by Maria Eduarda de Castro, Gustavo Forlin de Siqueira, Jean Ferrante Mariano, Marina Malta Letro Kizys, Lucieli Ceolin, Fernando Augusto Soares, Rodrigo Natal, Humberto Carneiro, Rodrigo Nalio Ramos, Rodrigo Nalio Ramos, Laura Sterian Ward, Niels Olsen Saraiva Camara, Cleber Pinto Camacho, Cleber Pinto Camacho, Flavia de Oliveira Facuri Valente, Susan Chow Lindsey, Diego Dias dos Santos, Cristiane Damas Gil, João Roberto Maciel Martins, Rui Monteiro de Barros Maciel, Lucas Leite Cunha, Lucas Leite Cunha

Get full text

Ipatasertib combined with non-taxane chemotherapy for patients with previously treated advanced triple-negative breast cancer: the PATHFINDER phase IIa trial by Elena López-Miranda, Jose Manuel Pérez-García, María Gión, Nuria Ribelles, Patricia Cortez-Castedo, José Luis Alonso-Romero, María Martínez García, Santiago González-Santiago, Begoña Bermejo, Serafín Morales, Vicente Carañana, Laia Garrigós, Melissa Fernández-Pinto, Silvia García-Vicente, Alicia Garcia-Sanz, Arnau Mena-Molina, Olga Boix, Daniel Alcalá-López, Antonio Llombart-Cussac, Javier Cortés

Get full text

Optimal 2D Placement of Virtual Objects in Physical Space for Augmented Reality Applications by M. V. Alpatova, Yu. V. Rudyak

“…Starting from the 2nd row, to calculate the displacement, the presence of potential neighbors who were a row higher and had common areas along X with the object being processed, was checked. …”
Get full text

Psychometric evaluation of EQ-5D-5L in OHCA survivors from the TTM2 trial: a post hoc analysis by Mattias Bohm, Kristofer Årestedt, Susann Ullén, Niklas Nielsen, Josef Dankiewicz, Hans Friberg, Erik Blennow Nordström, Alain Cariou, Janus Christian Jakobsen, Anders Morten Grejs, Matthias Haenggi, Naomi E. Hammond, Katarina Heimburg, Thomas R. Keeble, Christoph Leithner, Christian Rylander, Johan Undén, Matt P. Wise, Tobias Cronberg, Gisela Lilja

Get full text

Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis by Charlotte Maserumule, Charlotte Passemar, Olivia S.H. Oh, Kriztina Hegyi, Karen Brown, Aaron Weimann, Adam Dinan, Sonia Davila, Catherine Klapholz, Josephine Bryant, Deepshikha Verma, Jacob Gadwa, Shivankari Krishnananthasivam, Kridakorn Vongtongsalee, Edward Kendall, Andres Trelles, Martin L. Hibberd, Joaquín Sanz, Jorge Bertol, Lucia Vázquez-Iniesta, Kaliappan Andi, S. Siva Kumar, Diane Ordway, Rafael Prados-Rosales, Paul A. MacAry, R. Andres Floto

Get full text

Intersecting impact of CAG repeat and huntingtin knockout in stem cell-derived cortical neurons by Jennifer T. Stocksdale, Matthew J. Leventhal, Stephanie Lam, Yu-Xin Xu, Yang Oliver Wang, Keona Q. Wang, Reuben Thomas, Zohreh Faghihmonzavi, Yogindra Raghav, Charlene Smith, Jie Wu, Ricardo Miramontes, Kanchan Sarda, Heather Johnston, Min-Gyoung Shin, Terry Huang, Mikelle Foster, Mariya Barch, Naufa Amirani, Chris Paiz, Lindsay Easter, Erse Duderstadt, Vineet Vaibhav, Niveda Sundararaman, Dan P. Felsenfeld, Thomas F. Vogt, Jennifer Van Eyk, Steve Finkbeiner, Julia A. Kaye, Ernest Fraenkel, Leslie M. Thompson

Get full text

Glucocorticoid boluses followed by tocilizumab in giant cell arteritis patients: effects on peripheral blood monocytes and lymphocytes by Cecilia Catellani, Martina Bonacini, Alessandro Rossi, Ilaria Ferrigno, Ilaria Ferrigno, Veronica Buia, Chiara Marvisi, Chiara Marvisi, Giulia Cassone, Mariagrazia Catanoso, Gabriella Di Tommaso, Luigi Boiardi, Rexhep Durmo, Annibale Versari, Massimiliano Casali, Giulia Besutti, Giulia Besutti, Lucia Spaggiari, Alessandro Zerbini, Francesco Muratore, Francesco Muratore, Carlo Salvarani, Carlo Salvarani, Stefania Croci

Get full text

Family‐centred care interventions for children with chronic conditions: A scoping review by Andrea J. Chow, Ammar Saad, Zobaida Al‐Baldawi, Ryan Iverson, Becky Skidmore, Isabel Jordan, Nicole Pallone, Maureen Smith, Pranesh Chakraborty, Jamie Brehaut, Eyal Cohen, Sarah Dyack, Jane Gillis, Sharan Goobie, Cheryl R. Greenberg, Robin Hayeems, Brian Hutton, Michal Inbar‐Feigenberg, Shailly Jain‐Ghai, Sara Khangura, Jennifer J. MacKenzie, John J. Mitchell, Zeinab Moazin, Stuart G. Nicholls, Amy Pender, Chitra Prasad, Andreas Schulze, Komudi Siriwardena, Rebecca N. Sparkes, Kathy N. Speechley, Sylvia Stockler, Monica Taljaard, Mari Teitelbaum, Yannis Trakadis, Clara Van Karnebeek, Jagdeep S. Walia, Kumanan Wilson, Beth K. Potter

Get full text

Risks of postmetachronous malignancies in patients with Hodgkin lymphoma after radio- and chemotherapy by A. A. Danilenko, S. V. Shakhtarina, V. V. Pavlov

“…RT volume and total focal dose were identical to those of independent RT according to “radical” program. 3rd group – 348 patients received treatment from 1999 to 2013 consisting of CT according to first-line scheme and RT of lesions and related areas with reduced total focal dose (20–30 Gy) exposure.Multifield RT was used. …”
Get full text

Analysis of operability parameter changes in neoadjuvant treatment with chemotherapy and anti-PD-1/PD-L1 by M Sereno, A Collazo-Lorduy, Y Garitaonaindia, D Gómez de Antonio, J Baena Espinar, C Aguado de la Rosa, P Cruz Castellanos, S Falagán Martínez, LE Chara Valverde, R López-Castro, A López-Martin, J Rubio-Pérez, A Gómez Rueda, C Traseira Puchol, X Mielgo Rubio, B Losada Vila, J Rogado, E Bernal Hertfelder, L Gutiérrez Sainz, JL Campo-Cañaveral, I Romano, I. Thuissard, G Rubio Romero, E Casado Sáenz

Get full text

The Importance of Dust Distribution in Ionizing-photon Escape: NIRCam and MIRI Imaging of a Lyman Continuum-emitting Galaxy at z ∼ 3.8 by Zhiyuan Ji, Stacey Alberts, Yongda Zhu, Eros Vanzella, Mauro Giavalisco, Kevin Hainline, William M. Baker, Andrew J. Bunker, Jakob M. Helton, Jianwei Lyu, Pierluigi Rinaldi, Brant Robertson, Charlotte Simmonds, Sandro Tacchella, Christina C. Williams, Christopher N. A. Willmer, Joris Witstok

“…Anisotropic LyC escape may be a common feature in the early Universe, which must be properly incorporated to constrain the epoch of reionization.…”
Get full text

Dissecting the link between PD-1/PD-L1-based immunotherapy and cancer pain: mechanisms, research implications, and artificial intelligence perspectives by Marco Cascella, Brigida Miranda, Carmen Gagliardi, Lucia Santaniello, Milena Mottola, Alida Mancusi, Laura Ferrara, Federica Monaco, Francesca Gargano, Francesco Perri, Alessandro Ottaiano, Maurizio Capuozzo, Ornella Piazza, Stefano Pepe, Anna Crispo, Agostino Guida, Giovanni Salzano, Giustino Varrassi, Luigi Liguori, Francesco Sabbatino, The TRIAL Group

“…Cancer-related pain represents one of the most common complaints of cancer patients especially for those with advanced-stage of disease and/or bone metastases. …”
Get full text

Adoptive cell therapy with tumor-infiltrating lymphocytes in combination with nivolumab in patients with advanced melanoma by D. König, B. Kasenda, M. Sandholzer, A. Chirindel, A. Zingg, R. Ritschard, H. Thut, K. Glatz, E.A. Kappos, D. Schaefer, C. Kettelhack, J. Passweg, K. Baur, A. Holbro, A. Buser, D. Lardinois, L.T. Jeker, N. Khanna, F. Stenner, M.S. Matter, N. Rodrigues Mantuano, M. Binder, A. Zippelius, H. Läubli

“…All patients had hematologic adverse events (AEs). Most common non-hematologic AEs were fever and cytokine release syndrome. …”
Get full text

JWST Validates HST Distance Measurements: Selection of Supernova Subsample Explains Differences in JWST Estimates of Local H 0 by Adam G. Riess, Dan Scolnic, Gagandeep S. Anand, Louise Breuval, Stefano Casertano, Lucas M. Macri, Siyang Li, Wenlong Yuan, Caroline D. Huang, Saurabh Jha, Yukei S. Murakami, Rachael Beaton, Dillon Brout, Tianrui Wu, Graeme E. Addison, Charles Bennett, Richard I. Anderson, Alexei V. Filippenko, Anthony Carr

“…Explicitly accounting for common supernovae, the three-method JWST result is H _0 = 72.6 ± 2.0, similar to H _0 = 72.8 expected from HST Cepheids in the same galaxies. …”
Get full text

Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade... by Lucie Heinzerling, Michael Fluck, Caroline Robert, Celeste Lebbe, Erika Richtig, Sven D Koch, Ulrike Gnad-Vogt, Tobias Seibel, Thomas Eigentler, Juan Martin-Liberal, Sebastian Ochsenreither, Peter Mohr, Patrick Terheyden, Carsten Weishaupt, Michael Erdmann, Lukas Koch, Ainara Soria, Igor Samoylenko, Jürgen Krauß, Peter Brossart, Franz Georg Bauernfeind, Marina Gonzalez, Peter Wengenmayer, Ioannis Thomas, Artem Poltoratskiy, Marina Sekacheva, Beate Schmitt-Bormann, Gianluca Quintini, Martin Falk, Paula Codó, Arjun Oberoi, Jana Hess, Yulia Semiletova, Casilda Llacer Perez, Oliver Schönborn-Kellenberger

“…The MTD was not formally reached and the RD for expansion was 600 µg. Common treatment-emergent adverse events were fever (57%), chills (37%) and fatigue (25%). …”
Get full text

Real-world data of cadonilimab in recurrent or metastatic cervical cancer in China: a multicentric study by Jian Chen, Haijuan Yu, Yingtao Lin, Dan Hu, Li Liu, Renliang Fan, Jianping Zou, Lele Zang, Yao Lin, Rong Lin, Dezhao Chen, Xiaoying Weng, Fenfang Shen, Shaoyu Wang, Wei Zeng, Qihua Tian, Yun Yi, Yuanfeng Chen, Jinjin Miao, Bo Zhang, Yinxia Zou, Fengming Gao, Fengming Gao, Rong Lian, Lin Yang, Yang Sun

“…Moreover, combined therapy of cadonilimab and radiotherapy was identified as an independent prognostic factor for both OS and PFS. The most common grade 3 or worse adverse event was anemia (28 [20.1%]), decreased white blood cell count (24 [17.2%]), and decreased neutrophil count (20 [14.4%]). …”
Get full text

Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial by Jess Kerr-Gaffney, Zohra Zenasni, Kimberley Goldsmith, Nahel Yaziji, Huajie Jin, Alessandro Colasanti, John Geddes, David Kessler, R Hamish McAllister-Williams, Allan H Young, Alvaro Barrera, Lindsey Marwood, Rachael W Taylor, Helena Tee, Anthony J Cleare

“…Lithium and quetiapine are two of the most commonly used treatments in the National Health Service to add on to antidepressants. …”
Get full text

Balancing the benefits and risks of colchicine use among patients with atherosclerotic cardiovascular disease: an umbrella review of meta-analyses of randomised controlled trialsRe... by Rui-Han Bao, Na Zhao, Xiao-Feng Jiang, Zi-Han Cong, Jun Liu, Long-Dan Kang, Yu-Han Chen, Jia-Nan Sun, Wei-Yi Xing, Jia-Xin Liu, Xue-Li Bai, Hai-Chen Lv, Jing-Ying Zhao, Qi-Peng Ma, Ting-Ting Gong, Qi-Jun Wu

“…Funding: This work was supported by the Liaoning Revitalization Talents Program, Outstanding Youth Scientific Talent Project of Dalian, and Outstanding Scientific Fund of Shengjing Hospital.…”
Get full text

Phase 2 study of cemiplimab in patients with metastatic cutaneous squamous cell carcinoma: primary analysis of fixed-dosing, long-term outcome of weight-based dosing by Dirk Schadendorf, Ralf Gutzmer, Thomas Eigentler, Israel Lowy, Vladimir Jankovic, Elizabeth Stankevich, Anna C Pavlick, Danny Rischin, Michael R Migden, Annette M Lim, Chrysalyne D Schmults, Nikhil I Khushalani, Brett G M Hughes, Lara A Dunn, Leonel Hernandez-Aya, Anne Lynn S Chang, Badri Modi, Axel Hauschild, Claas Ulrich, Brian Stein, Jessica L Geiger, Murad Alam, Emmanuel Okoye, Melissa Mathias, Jocelyn Booth, Siyu Li, Matthew G Fury, Alexander Guminski

“…Background Cemiplimab, a high-affinity, potent human immunoglobulin G4 monoclonal antibody to programmed cell death-1 demonstrated antitumor activity in a Phase 1 advanced cutaneous squamous cell carcinoma (CSCC) expansion cohort (NCT02383212) and the pivotal Phase 2 study (NCT02760498). …”
Get full text

Efficacy and safety of neoadjuvant sintilimab, oxaliplatin and capecitabine in patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: early... by Yan Wang, Ning Li, Jing Zhang, Ying Liu, Zhongqi Li, Nong Xu, Zhimin Ma, Yafei Zhang, Haiping Jiang, Xiongfei Yu, Mei Kong, Donghui Zhou, Weibin Wang, Haohao Wang, Haiyong Wang, Kuifeng He, Yimin Lu, Kui Zhao, Ziran Li, Yisen Wang, Lisong Teng

“…However, the role of anti-programmed cell death protein-1 treatment in the neoadjuvant setting remains unclear. …”
Get full text