Recognition and management of community-acquired acute kidney injury in low-resource settings in the ISN 0by25 trial: A multi-country feasibility study. by Etienne Macedo, Ulla Hemmila, Sanjib Kumar Sharma, Rolando Claure-Del Granado, Henry Mzinganjira, Emmanuel A Burdmann, Jorge Cerdá, John Feehally, Fredric Finkelstein, Guillermo García-García, Vivekanand Jha, Norbert H Lameire, Euyhyun Lee, Nathan W Levin, Andrew Lewington, Raúl Lombardi, Michael V Rocco, Eliah Aronoff-Spencer, Marcello Tonelli, Karen Yeates, Giuseppe Remuzzi, Ravindra L Mehta, ISN 0by25 Trial Study Group

“…Hypertension was the most common comorbidity (418/2,101; 20%). At enrollment, 197/2,101 (9.4%) had CKD, and 1,199/2,101 (57%) had AKD. …”
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COMMENTARY: LEARNER-BASED LISTENING AND TECHNOLOGICAL AUTHENTICITY by Richard Robin

“…Others such as Randall's ESL Cyber Listening Lab or the NCLRC’s Simplified Russian Radio Site (created by the author of this article) resort to semi-authentic audio.On the other hand, commonly available technological fixes can be called upon for greater degrees of remediation. …”
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Preindustrial-to-present-day changes in atmospheric carbon monoxide: agreement and gaps between ice archives and global model reconstructions by X. Faïn, S. Szopa, V. Naïk, P. Martinerie, D. M. Etheridge, D. M. Etheridge, R. H. Rhodes, C. M. Trudinger, C. M. Trudinger, V. V. Petrenko, K. Fourteau, P. Place, P. Place

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TRIAGE-GS: protocol for a randomised controlled trial of a genomics-first approach to rare disease diagnosis for patients awaiting assessment by a clinical geneticist by Christian R Marshall, Sonya Elango, Salma Shickh, Raymond H Kim, Kym M Boycott, Wendy J Ungar, Jasmin Bhawra, Viji Venkataramanan, Robin Z Hayeems, Gregory Costain, Caitlin Chisholm, Taila Hartley, Roberto Mendoza-Londono, Martin Somerville, Oana Caluseriu, Stacy Hewson, Kaitlin J Stanley, Meredith K Gillespie, Natalie del Signore, Gordon McSheffrey, Sarah L Sawyer, Alexandre White-Brown, Stephanie Telesca

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I’m Co-development of a Post-Acute Care Intervention for Frailty using Information and Communication technology (PACIFIC): a development process protocol by Jean-Eric Tarride, Justin Lee, Andrew P Costa, Elizabeth Alvarez, Cynthia Lokker, Maura Marcucci, Louise Lafortune, Jacob Crawshaw, Parminder Raina, Laura N Anderson, Jinhui Ma, Darryl Leong, Lauren E Griffith, Luciana Macedo, Alexandra Papaioannou, Jackie Bosch, Ayse Kuspinar, Rebecca Ganann, Henry Yu-Hin Siu, Kathryn Fisher, Marla Beauchamp, Steven R Bray, Anthea Innes, Carol Bassim, Jasdeep Dhillon, Constance Dupuis, Milena Head, Karen Mosleh, Rachel Roy

“…While some available interventions have been developed with end-user engagement, fully involving older people who are pre-frail or frail in the design of interventions has been less common. Multi-component community-based interventions that address the needs of older adults and their care partners with potential implementation barriers informed by healthcare providers, community partners and health system decision makers are needed. …”
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Dampak Pemberian Pupuk Hayati dan NPK Terhadap Emisi CO2 Pada Perkebunan Kelapa Sawit Di Lahan Gambut by Dika Riyani, Evi Gusmayanti, Muhammad Pramulya

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Efficacy, safety, and biomarker analysis of first-line immune checkpoint inhibitors with chemotherapy versus chemotherapy for advanced gastric cancer: a multicenter, retrospective... by Xue Zhang, Xin Dai, Aina Liu, Meili Sun, Lei Cong, Jing Liang, Zimin Liu, Zhen Li, Jinling Zhang, Jing Lv, Fangli Cao, Linli Qu, Haiyan Liu, Lu Yue, Yi Zhai, Fujun Yang, Jiahui Chu, Shuang Wang, Qian Xu, Jianyuan Zhou, Shulun Nie, Miao Huang, Ruitao Xu, Qiushi Wang, Xinyu Song, Di Zhang, Zhaodi Nan, Song Li, Lian Liu

“…Abstract Background Recent phase III randomized controlled trials have demonstrated that first-line immune checkpoint inhibitors (ICIs) improve prognosis in advanced HER-2-negative gastric cancer patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) higher than 5. …”
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Infant Type Ia Supernovae from the KMTNet. I. Multicolor Evolution and Populations by Yuan Qi Ni, Dae-Sik Moon, Maria R. Drout, Youngdae Lee, Patrick Sandoval, Jeehye Shin, Hong Soo Park, Sang Chul Kim, Kyuseok Oh

“…We conduct a systematic analysis of the early multiband light curves and colors of 19 Type Ia supernovae (SNe) from the Korea Microlensing Telescope Network SN Program, including 16 previously unpublished events. …”
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Can Ileostomy Reversal Be Safely Performed by Surgical Residents? by Michał Kisielewski, Magdalena Pisarska-Adamczyk, Natalia Dowgiałło-Gornowicz, Łukasz Nawacki, Wojciech Serednicki, Mateusz Wierdak, Jerzy Wilczek, Kamil Safiejko, Marcin Juchimiuk, Marian Domurat, Jacek Pierko, Mateusz Mucha, Wojciech Fiedorowicz, Michał Wysocki, Maurycy Ladziński, Michał Zdrojewski, Tomasz Sachańbiński, Tomasz Wojewoda, Victoria Chochla, Karol Tkaczyński, Michał Jankowski, Wojciech M. Wysocki

“…In terms of severity, minor complications (Clavien–Dindo grades 1 and 2) were more common in the specialist group (<i>p</i> < 0.05). …”
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Multidisciplinary management of patients diagnosed with von Hippel-Lindau disease: A practical review of the literature for clinicians by Alessandro Larcher, Federico Belladelli, Giuseppe Fallara, Isaline Rowe, Umberto Capitanio, Laura Marandino, Daniele Raggi, Jody Filippo Capitanio, Michele Bailo, Rosangela Lattanzio, Costanza Barresi, Sonia Francesca Calloni, Maurizio Barbera, Valentina Andreasi, Giorgia Guazzarotti, Giovanni Pipitone, Paola Carrera, Andrea Necchi, Pietro Mortini, Francesco Bandello, Andrea Falini, Stefano Partelli, Massimo Falconi, Francesco De Cobelli, Andrea Salonia

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Addressing Hypertension and Diabetes through Community-Engaged Systems (ANDES) in Puno, Peru: rationale and study protocol for a hybrid type 2 effectiveness and implementation rand... by Lindsay J. Underhill, Kendra N. Williams, Lucy Cordova-Ascona, Karina Campos, Lisa de las Fuentes, Mark D. Huffman, Joel Gittelsohn, Kenneth B. Schechtman, Zoila Vela-Clavo, Carla Tarazona-Meza, Laura K. Beres, Parker K. Acevedo, Abigail Barker, Nishadi Rajapakse, Makeda Williams, Veronica Tonwe, Aaloke Mody, Raquel Hurtado, Juan Carlos Mendoza, Gonzalo Cuentas, Elvin H. Geng, William Checkley, Victor G. Dávila-Román, Stella M. Hartinger-Peña

“…Abstract Background Hypertension is the most common cardiovascular disease in Peru despite the availability of cost-effective, evidence-based treatment. …”
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First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

“…Dose-limiting toxicities were limited, no maximum tolerated dose was reached, and the maximum administered dose of 1500mg was selected for dose expansion. The most common adverse events reported in monotherapy-treated patients were fatigue, anemia, and nausea, and those in combination therapy-treated patients were pruritus, fatigue, nausea, and anemia. …”
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Previous treatment decreases efficacy of pralsetinib in RET fusion-positive non-small-cell lung cancer by Lei Wang, Yafei You, Wenzhuo He, Yu Hou, Lan Li, Li Wang, Chang Jiang, Jiahong Yi, Yaoxiong Xia, Liangping Xia

“…The most common AEs was increased aspartate aminotransferase (39.3%).ConclusionPralsetinib was effective in RET fusion-positive NSCLC with tolerable AEs in real-world practice. …”
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Digital strategies to promote crowdsourcing open calls for co-creating HIV interventions: a youth community-based participatory approach by Olaoluwaposi Ogunlana, Peter Kalulu, Ucheoma Nwaozuru, Olufunto A. Olusanya, Oluwayemisi T. Olaoluwa, Temitope Ojo, Titilola Gbaja-Biamila, Chiyere Arinze, Lateef Akeem, Lauren Fidelak, Chisom Obi-Jeff, Oliver C. Ezechi, Joseph D. Tucker, Joseph D. Tucker, Juliet Iwelunmor

“…IntroductionThe HIV epidemic disproportionately affects adolescents and young adults (AYA), yet their engagement in HIV programming remains limited. Digital strategies, such as social media campaigns, engage a diverse range of AYA to co-create HIV interventions, but their effectiveness is less known. …”
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Pembrolizumab monotherapy for previously treated metastatic HER2-negative breast cancer with germline APOBEC3B deletion: results of the phase II AUROR studyResearch in context by Gwo Fuang Ho, Soo Chin Lee, Anita Zarina Bustam, Adlinda Alip, Nur Fadhlina Abdul Satar, Marniza Saad, Rozita Abdul Malik, Siew Eng Lim, Samuel G.W. Ow, Andrea Wong, Wan-Qin Chong, Yvonne L.E. Ang, Audrey Weng Yan Lee, Siti Norhidayu Hasan, Nabilah Tuan Zaid, Kian Boon Law, Yok Yong Toh, Hooi Chiao Tan, Bawani Selvam, Joanna Lim, Jia-Wern Pan, Soo Hwang Teo

“…Summary: Background: A common germline deletion polymorphism in the APOBEC3B gene increases the rate of somatic hypermutation in breast cancer, which in turn is associated with greater neoantigen burden and immune activation. …”
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Longitudinal associations between amyloid and symptoms of depression and anxiety in subjective cognitive decline: the impact of personality characteristics by Calvin Trieu, Calvin Trieu, Calvin Trieu, Mardou S. S. A. van Leeuwenstijn, Mardou S. S. A. van Leeuwenstijn, Lisa-Marie Schlüter, Lisa-Marie Schlüter, Jarith L. Ebenau, Jarith L. Ebenau, Inge M. W. Verberk, Inge M. W. Verberk, Sietske A. M. Sikkes, Sietske A. M. Sikkes, Sietske A. M. Sikkes, Sander C. J. Verfaillie, Sander C. J. Verfaillie, Sander C. J. Verfaillie, Elsmarieke van de Giessen, Charlotte E. Teunissen, Wiesje M. van der Flier, Wiesje M. van der Flier, Argonde C. van Harten, Argonde C. van Harten

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Phase II study of nivolumab in patients with genetic alterations in DNA damage repair and response who progressed after standard treatment for metastatic solid cancers (KM-06) by Jae Ho Byun, Jeeyun Lee, Kyong Hwa Park, Eun Joo Kang, Sang Joon Shin, In Gyu Hwang, Ju Won Kim, Hyo Jin Lee, Ji Yoon Lee, Jason K Sa, Sook Ryun Park, Jung Sun Kim, Yu Jung Kim, Woo Kyun Bae, Won Jin Chang, Eun-Ok Kim

“…Background Immune-modulating antibodies targeting programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) have demonstrated promising antitumor efficacy in various types of cancers, especially highly mutated ones. …”
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Safety and efficacy of AMG 820, an anti-colony-stimulating factor 1 receptor antibody, in combination with pembrolizumab in adults with advanced solid tumors by Jeanne Tie, Dirk Jäger, Victor Moreno, Dirk Nagorsen, Gloria Juan, Kyriakos P Papadopoulos, Anthony J Olszanski, Erik Rasmussen, Nehal Lakhani, Albiruni RA Razak, James M Cleary, Michael Boyer, Emiliano Calvo Aller, William Edenfield, R Donald Harvey, Annemie Rutten, Manish A Shah, David P Ryan, Hansen Wong, Neelesh Soman, Marie-Anne Damiette Smit

“…Almost all patients (99.1%) had AEs, 87.9% with grade ≥3 AEs. The most common AEs were increased aspartate aminotransferase (59.5%), fatigue (48.3%), periorbital/face edema (48.3%), and rash/maculopapular rash (37.1%). …”
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The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons by Jace Jones-Tabah, Kathy He, Nathan Karpilovsky, Konstantin Senkevich, Ghislaine Deyab, Isabella Pietrantonio, Thomas Goiran, Yuting Cousineau, Daria Nikanorova, Taylor Goldsmith, Esther del Cid Pellitero, Carol X.-Q. Chen, Wen Luo, Zhipeng You, Narges Abdian, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Lior Greenbaum, Sharon Hassin-Baer, Roy N. Alcalay, Austen Milnerwood, Thomas M. Durcan, Ziv Gan-Or, Edward A. Fon

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Percepción del consumo de cannabis en población adolescente: metasíntesis de estudios cualitativos by Julia Rey-Brandariz, Ana Teijeiro, Mónica Pérez-Ríos, Cristina Candal-Pedreira, Andrea Vila Fariñas, Nerea Mourino, Beatriz Casal Acción, Leonor Varela-Lema

“…It is considered that this information may be necessary for the development of prevention programmes with the dissemination of information on the effects of consumption.…”
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