PTHrP-induced hypercalcemic psychosyndrome under combined anti-PD-L1 and anti-EGFR inhibition in penile squamous cell carcinoma – A case report by Lea Jessica Albrecht, Viktor Grünwald, Jürgen C. Becker, Ralf Gutzmer, Livia Asan, Ellen Uslar, Alexandra Eilers, Anne-Christine Müseler, Alexander Roesch, Dirk Schadendorf, Lisa Zimmer, Elisabeth Livingstone

“…Endocrinopathies are common adverse events of immune checkpoint inhibitor (ICI) therapy, but only few reports describe ICI-induced hypercalcemia. …”
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A validated heart-specific model for splice-disrupting variants in childhood heart disease by Robert Lesurf, Jeroen Breckpot, Jade Bouwmeester, Nour Hanafi, Anjali Jain, Yijing Liang, Tanya Papaz, Jane Lougheed, Tapas Mondal, Mahmoud Alsalehi, Luis Altamirano-Diaz, Erwin Oechslin, Enrique Audain, Gregor Dombrowsky, Alex V. Postma, Odilia I. Woudstra, Berto J. Bouma, Marc-Phillip Hitz, Connie R. Bezzina, Gillian M. Blue, David S. Winlaw, Seema Mital

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fMRI BOLD and MEG theta power reflect complementary aspects of activity during lexicosemantic decision in adolescents with ASD by M. Wilkinson, R.J. Jao Keehn, A.C. Linke, Y. You, Y. Gao, K. Alemu, A. Correas, B.Q. Rosen, J.S. Kohli, L. Wagner, A. Sridhar, K. Marinkovic, R.-A. Müller

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Fingolimod synergizes with anti-PD-1 radioimmunotherapy in an experimental multiple sclerosis model through enhanced lymph node retention and CD8+ T cell depletion by Connor Frank, Kevin J. H. Allen, Wojciech Dawicki, Michael C. Levin, Michael C. Levin, Michael C. Levin, Michael C. Levin, Ekaterina Dadachova

“…A targeted approach aimed at depleting only activated T lymphocytes, which play a key role in disease progression, would be optimal. Programmed cell death protein 1 (PD-1) is an inhibitory receptor expressed on exhausted and recently activated T cells. …”
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Clinicians’ attitudes and knowledge of medicinal cannabis in opioid dependence treatment clinics in New South Wales, Australia by Laila Parvaresh, Llewellyn Mills, Jaleh Gholami, Louisa Jansen, Nazila Jamshidi, Kate Baker, Christopher Tremonti, Marguerite Tracy, Adrian Dunlop, Nicholas Lintzeris

“…Abstract Background There are no prior studies investigating the attitudes and knowledge of opioid treatment program (OTP) clinicians on prescribed medicinal cannabis in OTP clients. …”
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Revolutionizing oncology care: pioneering AI models to foresee pneumonia-related mortality by Qunzhe Ding, Yi Zhang, Zihao Zhang, Peijie Huang, Rui Tian, Zhigang Zhou, Ruilan Wang, Yun Xie

“…Additionally, our model was validated using a cohort of cancer patients from our institution and deployed via a free-access software interface.ResultsThe most common cancers resulting in pneumonia-related deaths were prostate (n=7300) and breast (n=5107) cancers, followed by lung and bronchus (n=2839) cancers. …”
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RETRACTED: Postoperative Pulmonary Complications in Patients With Transcatheter Tricuspid Valve Implantation—Implications for Physiotherapists by Peng-Ming Yu, Peng-Ming Yu, Yu-Qiang Wang, Ze-Ruxing Luo, Raymond C. C. Tsang, Oystein Tronstad, Oystein Tronstad, Jun Shi, Ying-Qiang Guo, Alice Y. M. Jones

“…Despite a 3-day prehabilitation protocol and standard post-operative physiotherapy, PPCs were common among patients after TTVI and significantly impacted on hospital and short-term recovery and outcomes. …”
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Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study by Gregory A Daniels, Sigrun Hallmeyer, Mark Grose, Jon Richards, Mark Faries, Brendan D Curti, Kim A Margolin, Yiwei Zhang, Lynn Feun, Anlong Li, John R Hyngstrom, Robert H I Andtbacka

“…Background Intratumoral administration of V937, a bioselected, genetically unmodified coxsackievirus A21, has previously demonstrated antitumor activity in patients with advanced melanoma as monotherapy and in combination with the programmed cell death 1 (PD-1) antibody pembrolizumab. …”
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Phase 1 first-in-human dose-escalation study of IMSA101, a novel cyclic di-nucleotide STING agonist, for patients with advanced solid tumor malignancies by Syed Kazmi, Lijun Sun, Justin Moser, Angela Alistar, Timothy A Yap, Edward Garmey, Teresa Mooneyham, Peter Vu, Jay Jacoby, Deva Mahalingam

“…IMSA101 1,200 µg (monotherapy) and 2,400 µg (combination therapy) doses, well-tolerated and associated with signs of antitumor activity, were selected as provisional RP2Ds. The most common IMSA101-related treatment-emergent adverse events (TEAEs) were injection site pain (8 (36.4%)) and fatigue (4 (18.2%)) for monotherapy and chills (3 (16.7%)), injection site pain (2 (11.1%)), and fever (2 (11.1%)) for combination therapy. …”
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Development and validation of a COVID-19 vaccination prediction model based on self-reporting results in Chinese older adults from September 2022 to November 2022: A nationwide cro... by Dong Liu, Yushi Zhang, Rui Liang, Jieping Lei, Ke Huang, Yaoda Hu, Liwen Fang, Luzhao Feng, Guangliang Shan, Min Wang, Yuanyuan Ding, Qian Gao, Ting Yang

“…It was common to see that older adults were reluctant to be vaccinated for coronavirus disease 2019 (COVID-19) in China. …”
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Impact of the COVID-19 Pandemic and the 2021 National Institute for Health and Care Excellence Guidelines on Public Perspectives Toward Myalgic Encephalomyelitis/Chronic Fatigue Sy... by Iliya Khakban, Shagun Jain, Joseph Gallab, Blossom Dharmaraj, Fangwen Zhou, Cynthia Lokker, Wael Abdelkader, Dena Zeraatkar, Jason W Busse

“…MethodsWe used the Twitter application programming interface to collect tweets related to ME/CFS posted between January 1, 2010, and January 30, 2024. …”
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Molecular characterization of methicillin-susceptible/resistant Staphylococcus aureus from bloodstream infections in northern Japan: The dominance of CC1-MRSA-IV, the emergence of... by Meiji Soe Aung, Masako Osada, Noriko Urushibara, Mitsuyo Kawaguchiya, Nobuhide Ohashi, Mina Hirose, Masahiko Ito, Kazuki Yamada, Kousuke Tada, Nobumichi Kobayashi

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Prognosis of Breast Cancer in European female adolescents and young adults (AYAs): EUROCARE-6 retrospective cohort results by Alice Bernasconi, Angela Toss, Emma Zattarin, Seyed Mohsen Mousavi, Marcel Blum, Claudia E. Kuehni, Alexander Katalinic, Jan Trallero, Elisabetta Rapiti, Luigino Dal Maso, Laura Botta, Silvia Rossi, Fedro Peccatori, Annalisa Trama

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Patterns of inter-populational and inter-individual variation in tolerance of sublethal progressive hypoxia and warming in the European seabass Dicentrarchus labrax by Julie J. H. Nati, Charles Rodde, Charles Rodde, Charles Rodde, Felipe R. Blasco, Felipe R. Blasco, Germain Salou, Alain Vergnet, Hugues de Verdal, Hugues de Verdal, Marc Vandeputte, François Allal, David J. McKenzie

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Dose assessment of medical exposure of radiographic dental studies by I. G. Shatskiy

“…The purpose of the study is to evaluate the effective doses of patients for the most common radiographic dental studies, comparing the obtained data with the literature and reference values given in the guidelines “Filling in the forms of the federal state statistical observation No. 3-DOZ” and are still often used for form filling instead of measured values. …”
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Effectiveness of a Mobile Health Intervention (DOT Selfie) in Increasing Treatment Adherence Monitoring and Support for Patients With Tuberculosis in Uganda: Randomized Controlled... by Juliet Nabbuye Sekandi, Esther Buregyeya, Sarah Zalwango, Damalie Nakkonde, Patrick Kaggwa, Trang Ho Thu Quach, David Asiimwe, Lynn Atuyambe, Kevin Dobbin

“…The VDOT group was provided with a smartphone equipped with an app, while the UCDOT group followed the routine monitoring practices outlined by the Uganda National TB Program. We tested the hypothesis that VDOT was more effective than UCDOT for monitoring medication adherence. …”
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Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

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Analysis of microsatellite and single nucleotide polymorphism within transcriptomic database in Cymbidium ensi folium by Li Xiaobai, Xiang Lin, Luo Jie, Qin Dehui, Sun Chongbo

“…Among these SNPs, C/T was the most common base substitution, followed by A/G. The two kinds of substitutions, C/T and A/G, accounted for 30.80% and 28.81% in all SNPs, respectively. …”
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New year, new ambitions! by Sheba Nakacubo Gitta

“…The topics were: How to write the methods section of your manuscript; study designs and sampling strategies, sample size determination for common epidemiological studies; how to write the discussion section of a manuscript; and how to write the introduction section of a scientific manuscript. …”
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Collaborative Care to Improve Quality of Life for Anxiety and Depression in Posttraumatic Epilepsy (CoCarePTE): Protocol for a Randomized Hybrid Effectiveness-Implementation Trial by Heidi M Munger Clary, Beverly M Snively, Christian Cagle, Richard Kennerly, James N Kimball, Halley B Alexander, Gretchen A Brenes, Justin B Moore, Robin A Hurley

“… BackgroundAnxiety and depression in people with epilepsy are common and associated with poor outcomes; yet, they often go untreated due to poor mental health specialist access. …”
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