Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…Funding: The Boneca laboratory was supported by the following programmes: Investissement d’Avenir program, Laboratoire d’Excellence “Integrative Biology of Emerging Infectious Diseases” (ANR-10-LABX-62-IBEID) and by R&D grants from Danone and MEIJI. …”
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Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma by Lei Yang, Qing Zhou, Bo Zhang, Yi-Long Wu, Zhi-Hong Chen, Wen-zhao Zhong, Fen Wang, Yun-Ting He, Song Dong, Xue-Wu Wei, Wei-Dong Chen, Xiao-Rong Yang, Xue-Meng Shang

“…Backgrounds Immunotherapy is less effective in patients with epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC). Lower programmed cell death-ligand 1 (PD-L1) expression and tumor mutation burden (TMB) are reported to be the underlying mechanism. …”
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Dual diagnosis of UQCRFS1-related mitochondrial complex III deficiency and recessive GJA8-related cataracts by Elizabeth E. Blue, Samuel J. Huang, Alyna Khan, Katie Golden-Grant, Brenna Boyd, Elisabeth A. Rosenthal, Madelyn A. Gillentine, Leah R. Fleming, David R. Adams, Lynne Wolfe, Aimee Allworth, Michael J. Bamshad, Nikeisha J. Caruana, Sirisak Chanprasert, Jingheng Chen, Nitsuh Dargie, Daniel Doherty, Marisa W. Friederich, Fuki M. Hisama, Martha Horike-Pyne, Jessica C. Lee, Tonia E. Donovan, Daniella H. Hock, Kathleen A. Leppig, Danny E. Miller, Ghayda Mirzaa, Jane Ranchalis, Wendy H. Raskind, Cole R. Michel, Richard Reisdorph, Ulrike Schwarze, Sam Sheppeard, Samuel Strohbehn, David A. Stroud, Virginia P. Sybert, Mark H. Wener, Andrew B. Stergachis, Christina T. Lam, Gail P. Jarvik, Katrina M. Dipple, Johan L.K. Van Hove, Ian A. Glass

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Decreased telomerase activity and shortened telomere length in infants whose mothers have gestational diabetes mellitus and increased severity of telomere shortening in male infant... by Shuhua Liu, Shuhua Liu, Shuhua Liu, Liping Xu, Yan Cheng, Dehong Liu, Dehong Liu, Dehong Liu, Bin Zhang, Bin Zhang, Bin Zhang, Xianxia Chen, Xianxia Chen, Xianxia Chen, Mingming Zheng, Mingming Zheng, Mingming Zheng

“…ObjectiveGestational diabetes mellitus (GDM) is a common complication during pregnancy and increases the risk of metabolic diseases in offspring. …”
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Physical Activity, Sleep, and Quality of Life in Pulmonary Arterial Hypertension: Novel Insights From Wearable Devices by Andrew M. Hughes, Alisha Lindsey, Jeffrey Annis, Kelly Burke, Hiral Master, Luke G. Silverman‐Lloyd, Jonah D. Garry, Michael J. Blaha, Erika S. Berman Rosenzweig, Robert P. Frantz, Paul M. Hassoun, Evelyn M. Horn, Jane A. Leopold, Franz P. Rischard, Brett Larive, Nicholas S. Hill, Serpil C. Erzurum, Gerald J. Beck, Anna R. Hemnes, Evan L. Brittain

“…ABSTRACT Reduced functional capacity and poor sleep quality are common in pulmonary arterial hypertension (PAH). Wearable devices are an emerging, user‐friendly tool to capture activity and sleep information. …”
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Quality failures in Energy- saving renovation projects in Northern China by Yuting Qi

“…The detailed analysis of these causes in Northern China concludes that the “Incomplete construction site survey” is ranked as the highest level of the impacts on quality, and the most common cause is “Incomplete building information in projects”. …”
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The current status and prospects of gut microbiota combined with PD-1/PD-L1 inhibitors in the treatment of colorectal cancer: a review by Min Deng, Xiaoyu Li, Huiming Wu, Dingwen Xue, Yize Wang, Renkai Guo, Yipeng Cui, Chenfei Jin, Fei luo, Huiyu Li

“…Abstract Background Colorectal cancer (CRC) is a common malignant tumor. Immune checkpoint inhibitors (ICIs), particularly those targeting programmed cell death protein 1(PD-1) and programmed cell death ligand 1(PD-L1), have shown promising potential in the treatment of CRC. …”
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TMEM115: a promising marker for glioma immunotherapy and prognosis by Hang Yin, Hang Yin, Feng Wang, Feng Wang, Haiyan Xu, Haiyan Xu, Manyu Xu, Manyu Xu, Pengpeng Lu, Pengpeng Lu, Xiaojing Zhang, Lei Yang, Bing Lu, Pingping Sun, Jianfei Huang, Jianfei Huang

“…BackgroundGlioma is a common malignant primary brain tumor characterized by a highly immunosuppressive tumor microenvironment and unfavorable prognosis. …”
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The efficacy and safety of a novel PD‐1/CTLA‐4 bispecific antibody cadonilimab (AK104) in advanced non‐small cell lung cancer: A multicenter retrospective observational study... by Hongxin Li, Wen Zhao, Chengming Li, Hongchang Shen, Meiying Li, Chengjun Wang, Chunyan Han, Cuihua Yi, Jun Wang, Xue Meng, Lian Liu, Shuwen Yu, Jisheng Li

“…Treatment‐related adverse events (TRAEs) and immune‐related AEs occurred in 63.4% and 22% patients, respectively. The most common TRAEs included gamma‐glutamyl transferase elevation (17.1%), coughing (14.6%), and fatigue (12.2%). …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…[xiii] Only 7 percent of renal transplant programs use formal criteria for subjective psychosocial assessments, while no pediatric solid organ transplant programs use formal, explicit, or uniform review to assess developmental delays and psychosocial support.…”
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Chronic health consequences of the COVID-19 pandemic on school workers: a cross-sectional post-pandemic analysis by Louise C Mâsse, Michael A Irvine, David M Goldfarb, Sheila F O’Brien, Liam Golding, Allison W Watts, Collette O’Reilly, Daniel Coombs, Mark Pitblado, Sirui Li, Pascal Lavoie

“…New-onset chronic symptoms were also more common in women (OR=1.6 (95% CI: 1.1 to 2.4)) and staff with a pre-existing health condition (OR=1.9 (95% CI: 1.4 to 2.5)). …”
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About relevance of fundamentalisation of mathematical training of students of the pedagogical directions during the digital era by E. A. Perminov, D. D. Gadjiev, M. M. Abdurazakov

“…To address these challenges, culturological educational models, which form common cultural ideas of modern mathematics according to the principle of a cultural conformity, have to be the predominant in education, but not competency-based attitudes focused on narrow specialisation. …”
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Intrinsic capacity and its associations with incident dependence and mortality in 10/66 Dementia Research Group studies in Latin America, India, and China: A population-based cohor... by Martin J Prince, Daisy Acosta, Mariella Guerra, Yueqin Huang, K S Jacob, Ivonne Z Jimenez-Velazquez, A T Jotheeswaran, Juan J Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Isaac Acosta, Rosie Mayston, Zhaorui Liu, Jorge J Llibre-Guerra, A Matthew Prina, Adolfo Valhuerdi

“…ICOPE might be usefully integrated into community programmes for detecting and case managing chronic diseases including hypertension and diabetes.…”
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Expression and clinical significance of PD-L1, B7-H3, B7-H4 and VISTA in craniopharyngioma by Lin Wang, Jianguo Xu, Yuelong Wang, Shasha Zhao, Xin Tang, Liangxue Zhou, Aiping Tong, Jinlong Yang, Jiaojiao Deng, Tingyue Zhou, Zerong Tian, Jinhao Yang, Hongxu Chen

“…Background Craniopharyngioma (CP) is a common refractory tumor of the central nervous system. …”
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Single-cell transcriptomics link gene expression signatures to clinicopathological features of gonadotroph and lactotroph PitNET by T. Elise Potthoff, Carolin Walter, Daniela Jeising, Daniel Münter, Archana Verma, Eric Suero Molina, Walter Stummer, Martin Dugas, Wolfgang Hartmann, Matthias Dottermusch, Lea Altendorf, Ulrich Schüller, Sophia Scheuermann, Christian Seitz, Thomas K. Albert, Kornelius Kerl

“…Abstract Background Pituitary neuroendocrine tumors (PitNET) are among the most common intracranial tumors. Despite a frequent benign course, aggressive behavior can occur. …”
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Comprehensive characterization of PD-L1 expression and immunotherapy-related genomic biomarkers in early- versus advanced-stage non-small cell lung cancer by Yujie Chen, Peiyuan Wang, Rong Lian, Mingming Yuan, Pengli Yu, Hao He, Peng Chen, Hang Zhou, Weijie Chen, Derong Zhang, Hui Lin, Shuoyan Liu, Feng Wang

“…Abstract Background Programmed death-ligand 1 (PD-L1) expression is a key biomarker for predicting the efficacy of immune checkpoint inhibitors (ICIs). …”
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Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

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Role of Post-Operative Rehabilitation in TM Joint Arthritis: Functional Outcomes of Interposition Trapeziectomy vs. Prosthesis by Camillo Fulchignoni, Silvia Pietramala, Leopoldo Arioli, Emanuele Gerace, Domenico De Mauro, Giulia Frittella, Elisa Di Dio, Mirko Grauso, Gianfranco Merendi, Lorenzo Rocchi

“…<b>Background</b>: Trapeziometacarpal (TM) joint arthritis is a common condition causing pain and functional limitations, particularly in activities requiring pinch and grip strength. …”
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Essential newborn care practices at health facilities and homes in Ethiopia: a cross-sectional study by Tadesse Guadu, Kassahun Alemu, Joanna Schellenberg, Della Berhanu, Seblewengel Lemma, Atkure Defar, Theodros Getachew, Girum Taye, Solomon Shiferaw, Zewditu Abdissa, Amare Tariku, Meseret Zelalem, Lars Åke Persson

“…Thermal care, cord care, and provision of vaccines at birth were relatively more common in Addis Ababa, while first-hour breastfeeding initiation was higher in the Oromia region. …”
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Neuroblastoma response to RAS-MAPK inhibitors and APR-246 (eprenetapopt) co-treatment is dependent on SLC7A11 by Vid Mlakar, Ina Oehme, Ina Oehme, Laurence Lesne, Sara Najafi, Sara Najafi, Sara Najafi, Marc Ansari, Marc Ansari, Fabienne Gumy-Pause, Fabienne Gumy-Pause

“…BackgroundWe previously demonstrated that APR-246 (eprenetapopt) could be an efficient treatment option against neuroblastoma (NB), the most common pediatric extracranial solid tumor. APR-246’s mechanism of action is not completely understood and can differ between cell types. …”
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