‘Antibiotics are like gold’: a qualitative study of patient perspectives on the use of antibiotics without a prescription by Larissa Grigoryan, Michael K Paasche-Orlow, Roger Zoorob, Lindsey A Laytner, Patricia Chen, Barbara Wells Trautner, Susan Nash, Ashley Collazo, Fabrizia Faustinella, Kiara Olmeda, Azalia Mancera

“…Background Using antibiotics without a prescription (non-prescription use) is common in the USA and contributes to antibiotic misuse, potentially harming individuals and threatening public health. …”
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Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma by Yunxi Chen, Eva Jin, Mohamed Abdouh, Éric Bonneil, Daniel Alexander Jimenez Cruz, Thupten Tsering, Qianqian Zhou, Aurélie Fuentes-Rodriguez, Alexandra Bartolomucci, Alicia Goyeneche, Solange Landreville, Miguel N. Burnier, Julia V. Burnier

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The impact of elective spine surgery in Canada for degenerative conditions on patient reported health-related quality of life outcomes by Ragavan Manoharan, Nisaharan Srikandarajah, Jean-Christophe Murray, Christopher Nielsen, Supriya Singh, Sean Christie, Michael M.H. Yang, Michael Weber, Bernard Larue, Adrienne Kelly, Jerome Paquet, Raphaele Charest-Morin, Guy Hogan, Andrew Glennie, Henry Anh, Eugene Wai, Nicolas Dea, Neil Mason, Kenneth Thomas, Charles Fisher, Hamilton Hall, Christopher Bailey, Mayilee Canizares, Yoga Raja Rampersaud

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Hairy vetch influence on nitrous oxide and nitrate leaching losses during corn growing seasons in reduced and no-till systems by Ashani Thilakarathne, Madhabi Tiwari, Oladapo Adeyemi, Amanda Weidhuner, Pawan Kumar, Gurbir Singh, Jon Schoonover, Karl Williard, Karla Gage, Amir Sadeghpour

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Acceptability, feasibility, and factors affecting implementation of a gender-sensitivity training for HIV providers and staff in Uganda: a mixed methods, quasi-experimental control... by K M. Sileo, R K. Wanyenze, A Anecho, R L. Luttinen, K Weston, B Mukasa, S C. Mukama, S H. Vermund, S L. Dworkin, J F. Dovidio, B S. Taylor, T S. Kershaw

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Survival analysis of patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed radiotherapy and immunotherapy by Peng Xu, Dongmei Liu, Jie Zhou, Zhengyi Tang, Shuo Wang, Yecai Huang, Mei Feng, Shun Lu, Jinyi Lang, Lucia Clara Orlandini

“…Systemic treatment was determined by the multidisciplinary team, with a programmed cell death-1 (PD-1) inhibitor combined with chemotherapy as the primary approach. …”
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Phenylethyl isothiocyanate mitigates drug-induced liver injury in mice by inhibiting hepatocyte pyroptosis through the NLRP3-caspase-1-GSDMD pathway by Ning An, Xiaoru Wang, Jia Qin, Meng Cheng, Mei Bai, Jingcai Cheng, Qiang Xu, Xuefeng Wu

“…However, emerging evidence suggests that cell pyroptosis, a form of programmed cell death associated with inflammation, may serve as a common mechanistic pathway in DILI pathogenesis.Methods: To investigate the role of pyroptosis in DILI, we established a murine model of DILI using triptolide and evaluated the therapeutic potential of phenethyl isothiocyanate (PEITC), a naturally occurring compound, in mitigating liver injury through the modulation of hepatocyte pyroptosis. …”
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Emergency department visits among people with cancer: Frequency, symptoms, and characteristics by Michael Shayne Gallaway, Nimi Idaikkadar, Eric Tai, Behnoosh Momin, Elizabeth A. Rohan, Julie Townsend, Mary Puckett, Sherri L. Stewart

“…Percentages were higher among women (50.1%) than men (49.5%) and among adults aged ≥65 years (53.6%) than among those ≤64 years (45.7%). The most common presenting symptoms were pain (19.1%); gastrointestinal (13.8%), respiratory (11.5%), and neurologic (5.3%) complaints; fever (4.9%); injury (4.1%); and bleeding (2.4%). …”
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Thyroid disorders as predictors of cemiplimab efficacy in recurrent/metastatic cervical cancer: real-world evidence from Poland by Renata Pacholczak-Madej, Renata Pacholczak-Madej, Maja Lisik-Habib, Radosław Mądry, Monika Szarszewska, Zuzanna Borysiewicz, Katarzyna Gabalewicz, Ewa Iwańska, Wiktor Szatkowski, Mirosława Puskulluoglu, Jerzy Jakubowicz, Paweł Blecharz

“…Immune-related adverse events (irAEs) have been suggested as potential predictors of response, but evidence in cervical cancer is limited.MethodsWe conducted an ambispective, multicenter observational study of 37 patients with r/mCC treated with cemiplimab within Poland’s national rescue access program. Baseline characteristics, treatment outcomes, and irAEs were analyzed. …”
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Technological Education and Engineering Pedagogy by D. P. Danilaev, N. N. Malivanov

“…The operation of this cluster will contribute to the rapid spread of modern technologies and it will provide their accessibility and continuity of technological education in school, as well as in secondary vocational and higher education. The common information space will ensure to provide the coordination of instrumental training elements, to compare methods and develop personality-oriented approaches with the help of distance technologies. …”
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PHENOTYPIC FEATURES OF ENDOMETRIAL CANCER AND MSI IN COLON AND BLOOD SERUM by S. M. Kartashov, E. M. Oleshko

“…PCR was performed by the standard procedure using Tertsik-2 programmable thermal cycler produced by DNA – Technology LTD, Russia. …”
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Bionomics of Aedes mosquito species in three eco-epidemiological settings of Cameroon and their susceptibilities profiles to insecticides by Ms Bertille Djapoum, Ms Gisele Aurelie Foko Dadji, Mr Borel DJIAPPI-TCHAMEN, Mr Christophe ANTONIO-NKONDJIO

“…The tolerance and resistance observed could be due to the use of insecticides such as sprays and reminders, which are becoming more and more common(Nchoutpouen et al., 2019). Conclusion: The implementation of surveillance and control programmes for arbovirus vectors is urgent required in view of the increase in cases of arboviroses. …”
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SMART DShot: Secure Machine-Learning-Based Adaptive Real-Time Timing Correction by Hyunmin Kim, Zahid Basha Shaik Kadu, Kyusuk Han

“…Through comprehensive evaluation encompassing 32,000 Monte Carlo test iterations (500 per scenario × 16 scenarios × 4 algorithms) across 16 distinct operational scenarios and PolarFire SoC Field-Programmable Gate Array (FPGA) implementation, we demonstrate exceptional performance with 88.3% attack detection rate, only 2.3% false positive incidence, and substantial vulnerability mitigation reducing Common Vulnerability Scoring System (CVSS) severity from High (7.3) to Low (3.1). …”
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Social Structure, Educational Attainment and Admission to Law School by Alex Ziegert

“…Here more narrowly tailored government programmes can be shown to be reasonably successful. …”
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Addressing racial and ethnic disparities in premature exits from permanent supportive housing among residents with substance use disorders by Talia J. Panadero, Sonya Gabrielian, Marissa J. Seamans, Lillian Gelberg, Jack Tsai, Taylor Harris

“…Substance use disorders (SUDs) are common contributing factors towards premature, unwanted (“negative”) PSH exits; little is known about racial/ethnic differences in negative PSH exits among residents with SUDs. …”
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Experience in Diagnostic of HIV Drug Resistance in the Mekong Delta Region, Vietnam: A Comparative Analysis Before and After the COVID-19 Pandemic by Huynh Hoang Khanh Thu, Alexandr N. Schemelev, Yulia V. Ostankova, Vladimir S. Davydenko, Diana E. Reingardt, Ton Tran, Le Chi Thanh, Thi Xuan Lien Truong, Areg A. Totolian

“…Triple-class resistance was identified only in 2022 (17.81%). The most common mutations included M184I/V, D67N, K103N, Y181C, and V82A/S/T, with D67N rising significantly from 3.13% to 21.92%. …”
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A decade of 10-valent pneumococcal conjugate vaccine use in Lithuania: trends in invasive pneumococcal serotype dynamics by Aurelija Petrutienė, Jekaterina Sinotova, Nijolė Pupienienė, Raminta Marcinonytė, Indrė Padvilikytė, Jelena Razmuk, Svajūnė Muralytė, Svajūnė Muralytė, Aistė Bulavaitė, Milda Plečkaitytė

“…From 2018 onward, serotype 19A became the second most common serotype among adults aged 18–64 years, while its increase among children was less apparent, likely due to the low number of pediatric isolates.ConclusionThis is the first study in Lithuania to demonstrate that the childhood vaccination program reduced IPD caused by vaccine serotypes in children and unvaccinated adults through indirect protection. …”
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Ferroptosis Transcriptional Regulation and Prognostic Impact in Medulloblastoma Subtypes Revealed by RNA-Seq by Christophe Desterke, Yuanji Fu, Jenny Bonifacio-Mundaca, Claudia Monge, Pascal Pineau, Jorge Mata-Garrido, Raquel Francés

“…Medulloblastoma (MB) is the most common malignant brain tumor in children, typically arising during infancy and childhood. …”
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Cultural and behavioral drivers of zoonotic disease transmission and persistence among diverse pastoralist communities in East Africa by Dismas C.O. Oketch, Ruth Njoroge, Tonny O. Ngage, Asha Abdikadir Omar, Abdulai Magarre, Raphael Pasha, John Gachohi, Samuel Waiguru Muriuki, Samoel Ashimosi Khamadi, Ali Duba Boru, Boku Bodha, Lydia Kilowua, Nazaria Wanja Nyaga, Humphrey Kariuki Njaanake, Eunice Kamaara, Walter Jaoko, M. Kariuki Njenga, Eric Osoro, Dalmas Omia

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Perception of health and illness and quality of life after total thyroidectomy for differentiated thyroid carcinoma: the PERSAM study by Elena Groff, Beatrice Soccal, Fabiola Carrossa, Federica Vianello, Sara Talomo, Alessandra Feltrin, Giovanni Scarzello, Honoria Ocagli, Dario Gregori, Matteo Martinato

“…BackgroundDifferentiated thyroid carcinoma is the most common endocrine neoplasm; several studies have shown that individuals perceive the disease as being more severe than it actually is, resulting in a reduced quality of life. …”
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