Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK by Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen

“…Abstract Neovascular age‐related macular degeneration (NVAMD) is a common retinal disease causing vision loss in the elderly. …”
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A Narrative-Gamified Mental Health App (Kuamsha) for Adolescents in Uganda: Mixed Methods Feasibility and Acceptability Study by Julia R Pozuelo, Christine Nabulumba, Doreen Sikoti, Meghan Davis, Joy Louise Gumikiriza-Onoria, Eugene Kinyanda, Bianca Moffett, Alastair van Heerden, Heather A O'Mahen, Michelle Craske, Munshi Sulaiman, Alan Stein

“… BackgroundMany adolescents in Uganda are affected by common mental disorders, but only a few affordable treatment options are available. …”
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Continuous quality improvement across a South Australian health service and the role it plays in a learning health system: a qualitative study by Mia Bierbaum, Susan Hillier, Louise A. Ellis, Robyn Clay-Williams, Angie Goodrich, Robert Padbury, Peter Hibbert

“…Abstract Introduction Continuous quality improvement (CQI) initiatives are commonly used to enhance patient safety and quality of care. …”
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Microalgal-mediated circular reuse of polymer membrane manufacturing wastewater by Sebastian Overmans, Barbara Bastos de Freitas, Martin Gede, Claudia Oviedo, Gyorgy Szekely, Kyle J Lauersen

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Targeting autophagy and plasminogen activator inhibitor-1 increases survival and remodels the tumor microenvironment in glioblastoma by Sophie G. Shifman, Jennifer L. O’Connor, Daniel P. Radin, Aryan Sharma, Laura Infante, Francesca Ferraresso, Christian J. Kastrup, Daniel A. Lawrence, Stella E. Tsirka

“…Abstract Background Glioblastoma (GBM), the most common and aggressive type of primary brain tumor, engages multiple survival mechanisms, including autophagy. …”
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Characterization of extracellular vesicle-associated DNA and proteins derived from organotropic metastatic breast cancer cells by Amélie Nadeau, Thupten Tsering, Mohamed Abdouh, Laura Kienzle, Jenna Cleyle, Lorne Taylor, Noélie Douanne, Kyle Dickinson, Peter M. Siegel, Julia V. Burnier

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Swimming Exercise Pretreatment Attenuates Postoperative Delirium‐Like Behavior in Type 2 Diabetic Rats by Enhancing Mitochondrial Biogenesis Through Activation of SIRT2 Deacetylati... by Kaixi Liu, Lei Chen, Xinning Mi, Qian Wang, Yitong Li, Jingshu Hong, Xiaoxiao Wang, Yue Li, Yanan Song, Yi Yuan, Jie Wang, Dengyang Han, Taotao Liu, Ning Yang, Xiangyang Guo, Zhengqian Li

“…ABSTRACT Postoperative delirium (POD) is a common postsurgical complication that seriously affects patients' prognosis and imposes a heavy burden on families and society. …”
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Non-specific neck pain (cervicalgia). Guidelines of the Russian Society for the Study of Pain (RSSP) by V. A. Parfenov, N. N. Yakhno, M. L. Kukushkin, O. S. Davydov, M. V. Churyukanov, V. A. Golovacheva, G. Yu. Evzikov, A. I. Isaikin, M. A. Bakhtadze, L. A. Medvedeva, P. P. Kalinsky, V. A. Shirokov

“…Neck pain (NP) is one of the most common complaints of patients in outpatient practice and is predominantly non-specific (musculoskeletal) in nature. …”
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Analysis of arrhythmic episodes in patients with implanted cardioverter defibrillators and a high risk of sudden cardiac death by A. S. Postol, N. M. Neminushchi, A. V. Ivanchenko, V. V. Lyashenko, S. A. Mishanin, А. B. Vygovsky, Yu. A. Schneider

“…To analyze arrhythmic events, according to the programming data of implanted cardioverter defibrillators (ICD), with the view of minimizing shock effects.Material and methods. …”
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Parsimonious and explainable machine learning for predicting mortality in patients post hip fracture surgery by Fouad Trad, Bassel Isber, Ryan Yammine, Khaled Hatoum, Dana Obeid, Mohammad Chahine, Rachid Haidar, Ghada El-Hajj Fuleihan, Ali Chehab

“…To ensure the models’ decision-making is compatible with clinical decisions and common practices, we applied explainability techniques such as SHAP to reveal the patterns learned by the models. …”
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Necrotizing Fasciitis: A Retrospective Review of the Microbiological Aspects and Factors Associated with Multi-Drug Resistance from a Saudi Tertiary Care Hospital by Abd El-Hamid El-Kady R, Ahmed Mansour A, ElGuindy AMF

“…The lower extremities were the most common site for NF (36.8%). Overall, monomicrobial NF (58%) was more frequent than the polymicrobial type (42%). …”
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Improvement of Nanopore sequencing provides access to high quality genomic data for multi-component CRESS-DNA plant viruses by Daniel H. Otron, Denis Filloux, Andy Brousse, Murielle Hoareau, Babbitha Fenelon, Cécile Hoareau, Emmanuel Fernandez, Fidèle Tiendrébéogo, Jean-Michel Lett, Justin S. Pita, Philippe Roumagnac, Pierre Lefeuvre

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Language anxiety: understanding past research and new directions with d/Deaf, DeafBlind, and hard of hearing communities by Christina Kim, Laurel Aichler, Tiffany Bridgett, Onudeah Nicolarakis, Shilpa Hanumantha Lacy, Rachel Sortino, Poorna Kushalnagar, Poorna Kushalnagar, Rachel Pizzie

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Predicting cardiac adverse events in patients receiving immune checkpoint inhibitors: a machine learning approach by Tomas G Neilan, Judith Mueller, Samuel Peter Heilbroner, Reed Few, Jitesh Chalwa, Francois Charest, Somasekhar Suryadevara, Christine Kratt, Andres Gomez-Caminero, Brian Dreyfus

“…Therefore, we created a machine learning (ML) model to predict cardiac events in this at-risk population.Methods We leveraged the CancerLinQ database curated by the American Society of Clinical Oncology and applied an XGBoosted decision tree to predict cardiac events in patients taking programmed death receptor-1 (PD-1) or programmed death ligand-1 (PD-L1) therapy. …”
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RNA-Seq Identification of Peanut Callus-Specific Promoters and Evaluation of Base-Editing Efficiency by Lulu Xue, Han Liu, Huanhuan Zhao, Pengyu Qu, Xiaona Li, Xiaobo Wang, Bingyan Huang, Ziqi Sun, Suoyi Han, Xiaodong Dai, Wenzhao Dong, Lei Shi, Xinyou Zhang

“…These findings provide valuable tools for improving the biosafety of CRISPR-based genome editing in peanut breeding programs.…”
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Oropharyngeal detection of specific gut-derived Enterobacterales is associated with increased respiratory infection risk in older adults by Sophie J. Miller, Sophie J. Miller, Frank Zhang, Steven L. Taylor, Steven L. Taylor, Andrew P. Shoubridge, Andrew P. Shoubridge, Erin Flynn, Egi Vasil, Egi Vasil, Richard J. Woodman, Lito E. Papanicolas, Lito E. Papanicolas, Lito E. Papanicolas, Geraint B. Rogers, Geraint B. Rogers

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Quality of Care of Adult Patients With Allergic Diseases in Urban, Rural, and Remote Primary Care Sites in the Philippines by Carol Stephanie C. Tan-Lim, Robbi Miguel G. Falcon, Jeremiah F. Feliciano, Michael B. Fong MD, Mark Anthony U. Javelosa, Leonila F. Dans, Iris Thiele C. Isip-Tan, Josephine T. Sanchez, Mia P. Rey, Antonio Miguel L. Dans

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Visual impairments associated with the treatment of malignant tumors of the female reproductive system: a literature review and practical recommendations for oncogynecologists by Y. A. Chuikova, O. A. Odintsova, D. V. Skalozub, A. G. Antonyuk, A. A. Kabartai, A. N. Nurmamatova, R. M. Azimov, P. A. Snatenkova, A. A. Silantyev, S. R. Osina, D. S. Minasyan, S. A. Lashevich, I. A. Isaeva, E. A. Rukhlyadyeva

“…Particular attention is paid to the most common and clinically significant toxicities, including uveitis, keratitis, dry eye syndrome, macular edema, retinopathy, optic neuritis, and rarer but severe complications such as retinal vein occlusion and retinal detachment. …”
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Pathologic complete response after Sintilimab combined with FOLFOX therapy in MSI-H type patients with locally advanced GC: a case report by Xiaoke Wang, Xiaoke Wang, Yuanhui Gu, Lin Yi, Tao Wu, Tao Wu, Ling Wang, Jiao Tian, Yuyuan Lu, Penghui Jin, Xin Yang, Yan Yang

“…As one of the most common gastrointestinal tumors, Gastric Cancer (GC) poses a serious threat to human health due to its high morbidity and mortality. …”
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Driver mutations in GNAQ and GNA11 genes as potential targets for precision immunotherapy in uveal melanoma patients by Sandra García-Mulero, Roberto Fornelino, Marco Punta, Stefano Lise, Mar Varela, Luis P. del Carpio, Rafael Moreno, Marcel Costa-García, Dietmar Rieder, Zlatko Trajanoski, Alena Gros, Ramón Alemany, Josep María Piulats, Rebeca Sanz-Pamplona

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