CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients by Molly S. Cook, Ellen King, Katie R. Flaherty, Khadiza Siddika, Sophie Papa, Reuben Benjamin, Anna Schurich

“…Summary: Chimeric antigen receptor (CAR)-T cell therapy has led to unprecedented success in treating relapsed/refractory diffuse large B cell lymphoma (DLBCL). The most common CAR-T cell products currently in the clinic for DLBCL differ in their co-stimulation moiety, containing either CD28 or 4-1BB, which initiate distinct signaling pathways. …”
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DEVELOPMENT OF OPTIMAL EXPERIMENTAL THERAPEUTIC REGIMENS ADMINISTRATION OF IMMOBILIZED INTERFERON α-2b by O. G. Shitikova, E. Yu. Sherstoboev, N. V. Masnaya, M. G. Danilets, E. S. Trofimova, A. A. Ligacheva, P. G. Madonov, D. N. Kinsht, K. I. Ershov, M. A. Shilova

“…The development of optimal experimental therapeutic schemes of immobilized interferon α-2b (production of JSC «Siberian Center for Pharmacology and Biotechnology», Novosibirsk) administration was conducted in the frame of the common program of pre-clinical study. The drug being studied was administered intragastrically for 3, 5 and 7 days in the therapeutic dose (1.8 × 105 IU/kg).  …”
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Questionnaire Survey on the Current Use of Brain Docks and Their Compliance with Guidelines in Japan by Hiroshi KONDO, Fusao IKAWA, Takeshi HARA, Masashi KUWABARA, Daizo ISHII, Hidekazu TOMIMOTO, Nobutaka HORIE

“…Neurosurgeons were the most common professionals who provided explanations to the patients, followed by outpatient physicians who used the interpretation result as a reference. …”
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Predicting outcomes following endovascular aortoiliac revascularization using machine learning by Ben Li, Badr Aljabri, Derek Beaton, Leen Al-Omran, Mohamad A. Hussain, Douglas S. Lee, Duminda N. Wijeysundera, Ori D. Rotstein, Charles de Mestral, Muhammad Mamdani, Mohammed Al-Omran

“…Abstract Endovascular aortoiliac revascularization is a common treatment option for peripheral artery disease that carries non-negligible risks. …”
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Partial response to treatment with ALK inhibitor in a patient with SQSTM1-ALK fusion positive lung adenocarcinoma by Brenda Paola Rodriguez Arroyo, Alvaro Mondragón-Cardona, Rafael Adrián Pacheco-Orozco, Andrea Tamayo, Juan Camilo Moreno, Juan Camilo Baena-Valencia

“…Introduction: Lung cancer is the second most common cancer worldwide and the leading cause of cancer deaths; non-small cell lung cancer (NSCLC) constitutes about 85% of lung cancer cases, with ALK fusions representing 3–6% of them. …”
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From Web Resources to Agricultural Ontology: a Method for Semi-Automatic Construction by Yuan-yuan WEI, Ru-jing WANG, Yi-min HU, Xue WANG

“…The reason for ontology being so popular is in large part due to what they promise: a shared and common understanding of some domain that can be communicated across people and computers. …”
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Use of a synthesized mathematical model to describe the probability of curing early-stage breast cancer by L. Ya. Klepper, I. A. Gladilina, V. L. Ushkova, O. V. Kozlov, I. V. Vysotskaya

“…Breast cancer (ВС) is a common malignant disease of the female reproductive system. …”
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Investigating socioeconomic inequality in the incidence of breast cancer in Iran: Interprovincial analysis and comparison by Bahman Ahadinezhad, Aisa Maleki, mohammad amerzadeh, bahareh mohtashamzadeh, mahdi safdari, Omid Khosravizadeh

“…Background and Aim: Breast cancer has been identified as the most common cancer and the fifth leading cause of cancer death in the world. …”
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Single-cell profiling aligns CD56bright and cytomegalovirus-induced adaptive natural killer cells to a naïve-memory relationship by M. Kazim Panjwani, Simon Grassmann, Rosa Sottile, Jean-Benoît Le Luduec, Theodota Kontopoulos, Kattria van der Ploeg, Joseph C. Sun, Katharine C. Hsu, Katharine C. Hsu

“…We identified immature precursors to the Adaptive NK cells that are equally present in both CMV+ and CMV- individuals, resolved an Adaptive transcriptional state distinct from most mature NK cells and sharing a common gene program with the immature CD56bright population, and demonstrated retention of proliferative capacity and acquisition of superior IFNγ production in the Adaptive population. …”
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Design and Enhancing Security Performance of Image Cryptography System Based on Fixed Point Chaotic Maps Stream Ciphers in FPGA by Ahmed Amir Salih, Zaid Abdulsattar Abdulrazaq, Harith Ghanim Ayoub

“…The most common chaotic maps-based cryptography involved in this work are Logistic, Lozi and Tent. …”
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High school teachers’ awareness of anxiety and depression in adolescents: cross-country analysis by Nazish Imran, David M. Ndetei, Rodrigo Nel Cordoba Rojas, Afzal Javed

“…School teachers are in a good position to identify common mental health problems in adolescents. However, their mental health literacy levels remain unclear. …”
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Survey on available treatment for acute kidney injury in the Southern African Development Community and Nigeria: are we ready for zero deaths by 2025 in sub-Saharan Africa? by Emmanuel E Effa, Erika Jones, Brian L Rayner, Ikechi G Okpechi, Michael Schmitz, Peter J Heering

“…Intermittent haemodialysis was the most common modality available (91.7% of facilities), sustained low-efficiency dialysis in 50%, continuous therapies in 35% and peritoneal dialysis in 33.3%. …”
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A transligamentous approach for lateral osteochondral defect: A case report by Gregory Rose, DPM MPH, Gabrielle Uptegraph, DPM, Anthony Schwab, DPM MS, Rebecca Varney, DPM, Corine Creech, DPM FACFAS

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Unlocking tiny titans: 360 view of the quantum dots nanotechnology for dental applications by Tasneem Alluhaidan, Tasneem Alluhaidan, Isadora Martini Garcia, Meghan Alexis, Masoumah Qaw, Masoumah Qaw, Fabrício Mezzomo Collares, Mary Ann Williams, Mary Anne S. Melo, Mary Anne S. Melo

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Retrospective secondary data analysis to identify high-cost users in inpatient department of hospitals in Thailand, a middle-income country with universal healthcare coverage by Yot Teerawattananon, Yi Wang, Wanrudee Isaranuwatchai, Waranya Rattanavipapong, Nitichen Kittiratchakool, Rukmanee Butchon, Jadej Thammatacharee

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Safety and effectiveness of dose-sparing strategies for intramuscular seasonal influenza vaccine: a rapid scoping review by Sharon E Straus, Jesmin Antony, Andrea C Tricco, Carole Lunny, Patricia Rios, Chantal Williams, Naveeta Ramkissoon

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Procedure for Reliable and Long-Lasting Ex Vivo Recordings of Sciatic Nerve Activity in Mice by Shani Berkowitz, Zehavit Goldberg, Amir Dori, Nicola Maggio, Efrat Shavit-Stein, Jérôme Devaux

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Vaccination as a Game: Behavioural Dynamics, Network Effects, and Policy Levers—A Comprehensive Review by Pedro H. T. Schimit, Abimael R. Sergio, Marco A. R. Fontoura

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Long-Term Multimodal Exercise Intervention for Patients with Frontotemporal Lobar Degeneration: Feasibility and Preliminary Outcomes by Miyuki Nemoto, Kiyotaka Nemoto, Hiroyuki Sasai, Shinji Higashi, Miho Ota, Tetsuaki Arai

“…This study aimed to evaluate the feasibility of a multimodal exercise program for FTLD and to examine preliminary changes in the clinical outcomes of the program in FTLD. …”
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Evaluating the Usability of Inertial Measurement Units for Measuring and Monitoring Activity Post-Stroke: A Scoping Review by Aishwarya Shenoy, Manvir Singh Samra, Karen Van Ooteghem, Kit B. Beyer, Sherri Thomson, William E. McIlroy, Janice J. Eng, Courtney L. Pollock

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