Population genetics reveal potential threats from low maternal genetic diversity in wild Asian elephants in China by Minhui Shi, Yinping Tian, Yongjing Tang, Haimeng Li, Jishan Wang, Yue Ma, Xin Liu, Ahimsa Campos-Arceiz, Fei Chen, Tianming Lan

“…These elephants occur in small, fragmented populations and face significant threats from habitat loss and fragmentation. …”
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Effects of high CO2 treatment on green-ripening and peel senescence in banana and plantain fruits by Mu-bo SONG, Lu-ping TANG, Xue-lian ZHANG, Mei BAI, Xue-qun PANG, Zhao-qi ZHANG

“…Compared to the effect on plantains, 20% CO2 treatment delayed the decline in the chlorophyll florescence (Fv/Fm) values and in the mRNA levels of a gene coding small subunit of Rubisco (SSU), and postponed the disruption of the ultrastructure of chloroplast in the peel tissue of bananas, indicating that the senescence of the green cells in the exocarp layer was delayed by 20% CO2, to more extent in bananas than in plantains. …”
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Integrated promoter-capture Hi-C and Hi-C analysis reveals fine-tuned regulation of the 3D chromatin architecture in colorectal cancer by Ajay Kumar Saw, Ayush Madhok, Anupam Bhattacharya, Anupam Bhattacharya, Soumyadeep Nandi, Sanjeev Galande, Sanjeev Galande

“…We identified nine dysregulated genes, including long non-coding RNAs (MALAT1, NEAT1, FTX, and PVT1), small nucleolar RNAs (SNORA26 and SNORA71A), and protein-coding genes (TMPRSS11D, TSPEAR, and DSG4), all of which exhibited a substantial increase in expression in CRC cell lines compared to human embryonic stem cells (hESCs). …”
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MiR- 146b-5p inhibits Candida albicans-induced inflammatory response through targeting HMGB1 in mouse primary peritoneal macrophages by Jing Cheng, Xiaoxing Tian, Chuanxin Wu, Jiaojiao Wang, Huiling Liu, Sha Cheng, Hang Sun

“…We aimed to explore the regulation of small-molecule non-coding RNA (miRNA) for HMGB1 in C. albicans infection. …”
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Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study by Lieke M. Kuiper, Michelle M. J. Mens, Julia W. Wu, Jaap Goudsmit, Yuan Ma, Liming Liang, Albert Hofman, Trudy Voortman, M. Arfan Ikram, Jeroen G. J. van Rooij, Joyce B. J. van Meurs, Mohsen Ghanbari

“…Abstract Background MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally and show differential expression in various tissues with aging phenotypes. …”
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Development of Multiplex Assays for the Identification of Zoonotic <i>Babesia</i> Species by Ana Cláudia Calchi, Charlotte O. Moore, Lillianne Bartone, Emily Kingston, Marcos Rogério André, Edward B. Breitschwerdt, Ricardo G. Maggi

“…Because the 18S rRNA gene is highly conserved, obtaining an accurate diagnosis at the species level is difficult, particularly when the amplified DNA fragment is small. Also, due to its low copy number, sequencing of the product is often unsuccessful. …”
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Transcriptome-wide dynamics of m6A methylation in ISKNV and Siniperca chuatsi cells infected with ISKNV by Qijin Miao, Jing Jiang, Siyou Huang, Jie Gao, Qingqing Liu, Rui Zheng, Yiling Kang, Changjun Guo, Jianguo He, Junfeng Xie

“…The findings revealed that the m6A methylation peaks were located mainly in coding sequences (CDSs), with more than 90% of the transcripts containing 1–5 m6A peaks. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…The pilot feasibility study had a small sample size and hence modest power to detect group differences; the lack of an objective rating of intervention fidelity; the lack of a treatment as usual group to track the natural trajectory of child and parent behaviours over time; and the fact that although the researchers who coded the observational measure were blinded to intervention allocation, they were not blinded to time point. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…Inductive, deductive and retroductive thinking was used to code data with regards to contexts, mechanisms and/or their association with outcomes. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…The documents received through the survey were coded using a developed coding matrix to identify potential intervention components. …”
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THE IMPACT OF ADEQUATE PSYCHOPHARMACOTHERAPY ON THE EFFICIENCY OF TREATMENT IN PATIENTS WITH RHEUMATOID ARTHRITIS by A. A. Abramkin, T. A. Lisitsyna, D. Yu. Veltishchev, O. F. Seravina, O. B. Kovalevskaya, E. L. Nasonov

“…The diagnosis of MDs was based on the ICD-10 codes, by applying a semi-structured interview and the Hospital Anxiety and Depression Scale. …”
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EP 250108a/SN 2025kg: Observations of the Most Nearby Broad-line Type Ic Supernova Following an Einstein Probe Fast X-Ray Transient by Jillian C. Rastinejad, Andrew J. Levan, Peter G. Jonker, Charles D. Kilpatrick, Christopher L. Fryer, Nikhil Sarin, Benjamin P. Gompertz, Chang Liu, Rob A. J. Eyles-Ferris, Wen-fai Fong, Eric Burns, James H. Gillanders, Ilya Mandel, Daniele Bjørn Malesani, Paul T. O’Brien, Nial R. Tanvir, Kendall Ackley, Amar Aryan, Franz E. Bauer, Steven Bloemen, Thomas de Boer, Clécio R. Bom, Jennifer A. Chacón, Ken Chambers, Ting-Wan Chen, Ashley A. Chrimes, Joyce N. D. van Dalen, Valerio D’Elia, Massimiliano De Pasquale, Michael D. Fulton, Paul J. Groot, Rahul Gupta, Dieter H. Hartmann, Agnes P. C. van Hoof, Mark E. Huber, Luca Izzo, Wynn Jacobson-Galan, Páll Jakobsson, Albert Kong, Tanmoy Laskar, Thomas B. Lowe, Eugene A. Magnier, Elisabetta Maiorano, Antonio Martin-Carrillo, Lluis Mas-Ribas, Daniel Mata Sánchez, Matt Nicholl, Christopher J. Nixon, Samantha R. Oates, Gregory Paek, Jesse Palmerio, Diego Paris, Daniëlle L. A. Pieterse, Giovanna Pugliese, Jonathan A. Quirola Vasquez, Jan van Roestel, Andrea Rossi, Alicia Rouco Escorial, Ruben Salvaterra, Benjamin Schneider, Stephen J. Smartt, Ken Smith, Ian A. Smith, Shubham Srivastav, Manuel A. P. Torres, Chiara Ventura, Paul Vreeswijk, Richard Wainscoat, Yi-Jung Yang, Sheng Yang

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Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis by Mamidipudi Thirumala Krishna, Yogini H Jani, Iestyn Williams, Ruben Mujica-Mota, Rebecca Bestwick, Michele Siciliano, Robert Michael West, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Rachel Pollard, Nicola Jones, Louise Dunsmure, Mairead McErlean, Neil Powell, Chidanand C Hullur, Ariyur Balaji, Jonathan Sandoe, Amena Warner, Ron Daniels, Caroline Thomas, Siraj A Misbah, Louise Savic

“…The cost saving appears small in the short term and more research is needed to understand the long-term benefits. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…General practitioner feedback during tool development and small-scale user-testing in simulated consultation scenarios was favourable. …”
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Digital augmentation of aftercare for patients with anorexia nervosa: the TRIANGLE RCT and economic evaluation by Janet Treasure, Katie Rowlands, Valentina Cardi, Suman Ambwani, David McDaid, Jodie Lord, Danielle Clark Bryan, Pamela Macdonald, Eva Bonin, Ulrike Schmidt, Jon Arcelus, Amy Harrison, Sabine Landau

“…The statisticians remained partially blind (knowing only coded trial arm membership) until as late as possible into the primary analyses being conducted. …”
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Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation by Mohamed Abdel-Fattah, Christopher Chapple, Suzanne Breeman, David Cooper, Helen Bell-Gorrod, Preksha Kuppanda, Karen Guerrero, Simon Dixon, Nikki Cotterill, Karen Ward, Hashim Hashim, Ash Monga, Karen Brown, Marcus Drake, Andrew Gammie, Alyaa Mostafa, Rebecca Bruce, Victoria Bell, Christine Kennedy, Suzanne Evans, Graeme MacLennan, John Norrie

“…When modelled with imputation, a small but not statistically significant difference in QALYs of 0.011 (95% CI −0.044 to 0.065) was estimated in favour of the urodynamics group. …”
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