Exosomal tsRNA-Gly-5-0007 may be used as a diagnostic marker for colorectal cancer by Zhe Zhang, Guanghao Li, Lei Li, Wenxiao Jiang, Shiwen Wang, Na Zhou, Xuan Zhao, Fanfeng Lin, Jie Zhang, Li Xie

“…Exosomes contain bioactive molecules such as RNA, which can participate in signal transduction between cells. tRF is a new type of non-coding small RNA, which plays an important role in the progression of cancer. …”
Get full text

Serum levels of miR-21, miR-23a, miR-142-5p, and miR-126 in chronic failure with reduced ejection fraction: a case-control study by Lukas Evin, Lukas Evin, Radka Sigutova, Radka Sigutova, Patrik Sulc, Eliska Kufova, Marian Branny, Jan Vaclavik, Jan Vaclavik, David Stejskal, David Stejskal

“…BackgroundMicroRNAs (miRNAs) are small non-coding RNA molecules that function as gene regulators in physiological processes, including proliferation, differentiation, and apoptosis. …”
Get full text

Acceptability of an Intervention to Prevent Older Adult Mistreatment Among Family Caregivers to Persons With Dementia: Multimethod Pilot Study by Kylie Meyer, Wenxing Wei, Jeanine Yonashiro-Cho, Susanna Mage, Sohee Kim, Elliane Irani, Christopher Burant, Zachary Gassoumis, Erin Gentry Lamb, Jaclene A Zauszniewski, Donna Benton

“…KINDER was revised to integrate 3 facilitated small group discussion sessions conducted by videoconference. …”
Get full text

Molecular genetics is on the guard of the law by L. I. Kucherenko, I. V. Pavliuk, O. V. Khromylova

“…With its help, scientists can study the structure and function of DNA, decode genetic codes, and develop new treatments. In the conditions of the modern world, where global crises, such as the war in Ukraine, occur more and more often, the role of molecular genetics goes far beyond standard medical tasks and becomes critically important for solving social, legal and humanitarian problems. …”
Get full text

Acceptability and barriers of a GP–physiotherapist partnership in the diagnosis and management of COPD in primary care: A qualitative study by Lisa Pagano, Zoe McKeough, Sally L. Wootton, Andrew S. L. Chan, Sriram Mahadev, Nicholas Zwar, Deborah Pallavicini, Sarah Dennis

“…Interviews were transcribed, coded and thematically analysed. Synthesis of the data was guided by the Theoretical Domains Framework for clinician interviews and the health belief model for patient interviews. …”
Get full text

Revealing sRNA expression profiles of NDM-5-producing CRKP and explore the role of sRNA207 in NDM-5-producing CRKP resistance by Chonghong Xie, Yibo Bai, Yan Li, Bing Cui, Guixue Cheng, Jianhua Liu, Yong liu, Xiaosong Qin

“…Therefore, it is urgent to develop new therapeutic targets and strategies. Non-coding small RNA (sRNA)-mediated RNA-based therapies offer a new direction for the treatment of bacterial infections, especially resistant bacteria. …”
Get full text

The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima. by Ariel D Chipman, David E K Ferrier, Carlo Brena, Jiaxin Qu, Daniel S T Hughes, Reinhard Schröder, Montserrat Torres-Oliva, Nadia Znassi, Huaiyang Jiang, Francisca C Almeida, Claudio R Alonso, Zivkos Apostolou, Peshtewani Aqrawi, Wallace Arthur, Jennifer C J Barna, Kerstin P Blankenburg, Daniela Brites, Salvador Capella-Gutiérrez, Marcus Coyle, Peter K Dearden, Louis Du Pasquier, Elizabeth J Duncan, Dieter Ebert, Cornelius Eibner, Galina Erikson, Peter D Evans, Cassandra G Extavour, Liezl Francisco, Toni Gabaldón, William J Gillis, Elizabeth A Goodwin-Horn, Jack E Green, Sam Griffiths-Jones, Cornelis J P Grimmelikhuijzen, Sai Gubbala, Roderic Guigó, Yi Han, Frank Hauser, Paul Havlak, Luke Hayden, Sophie Helbing, Michael Holder, Jerome H L Hui, Julia P Hunn, Vera S Hunnekuhl, LaRonda Jackson, Mehwish Javaid, Shalini N Jhangiani, Francis M Jiggins, Tamsin E Jones, Tobias S Kaiser, Divya Kalra, Nathan J Kenny, Viktoriya Korchina, Christie L Kovar, F Bernhard Kraus, François Lapraz, Sandra L Lee, Jie Lv, Christigale Mandapat, Gerard Manning, Marco Mariotti, Robert Mata, Tittu Mathew, Tobias Neumann, Irene Newsham, Dinh N Ngo, Maria Ninova, Geoffrey Okwuonu, Fiona Ongeri, William J Palmer, Shobha Patil, Pedro Patraquim, Christopher Pham, Ling-Ling Pu, Nicholas H Putman, Catherine Rabouille, Olivia Mendivil Ramos, Adelaide C Rhodes, Helen E Robertson, Hugh M Robertson, Matthew Ronshaugen, Julio Rozas, Nehad Saada, Alejandro Sánchez-Gracia, Steven E Scherer, Andrew M Schurko, Kenneth W Siggens, DeNard Simmons, Anna Stief, Eckart Stolle, Maximilian J Telford, Kristin Tessmar-Raible, Rebecca Thornton, Maurijn van der Zee, Arndt von Haeseler, James M Williams, Judith H Willis, Yuanqing Wu, Xiaoyan Zou, Daniel Lawson, Donna M Muzny, Kim C Worley, Richard A Gibbs, Michael Akam, Stephen Richards

“…For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. …”
Get full text

A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder by Jiawei Wang, Yujing Liu, Hongyu Li, Tuan P. Nguyen, John Lee Soto-Vargas, Rashaun Wilson, Weiwei Wang, TuKiet T. Lam, Chi Zhang, Chen Lin, Traumatic Stress Brain Research Group, David A. Lewis, Jill Glausier, Paul E. Holtzheimer, Matthew J. Friedman, Kenneth R. Williams, Marina R. Picciotto, Angus C. Nairn, John H. Krystal, Ronald S. Duman, Keith A. Young, Hongyu Zhao, Matthew J. Girgenti

“…We also coupled the proteomics data with transcriptomics and microRNA (miRNA) profiling from RNA-seq and small-RNA sequencing, respectively for the same cohort. …”
Get full text

Comprehensive analysis of 385 chloroplast genomes unveils phylogenetic relationships and evolutionary history in cassava by Junru Qu, Haitian Fu, Ying Zhao, Xiaohua Dai, Liyan Lu, Ying Liu, Ganhui Mo, Feng Wen, Jun Li, Deepak Bhanot, Roma Sarnaik Morghade, Jiten Yadav, Kaikai Meng

“…Among the remaining 382 plastomes, 131 genes (111 unique) were encoded, including 85 protein-coding genes, 38 tRNA genes, and eight rRNA genes. …”
Get full text

TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D3 metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway by Qianyi Qi, Bairong Chen, Jinran Wu, Jing Xu, Hongyi Bao, Kangfeng Jin, Lin Chen, Guang Zhu, Feng Wang

“…Background tRNA-derived small RNAs (tsRNAs), newly developed non-coding RNAs with specialized biological features, are aberrantly expressed in the majority of malignancies. …”
Get full text

Dietary supplement use in high-intensity functional training (HIFT) athletes by competition level by Jack Livingston, Sofea Smith, Kworweinski Lafontant, Claudia Gonzalez, Michelle Da Silva Barbera, Linh Nguyen, Susan Kampiyil, Jeffrey R. Stout, David H. Fukuda

“…Two coders performed inductive thematic analysis via consensus to reveal initial codes and final themes.Results The distribution of CL were: noncompetitive = 12 (25%), local = 30 (61%), regional = 4 (8%), national = 3 (6%). …”
Get full text

Perceived, objective, and applied numeracy among pregnant women engaged in home blood pressure monitoring in GhanaAJOG Global Reports at a Glance by Emma R. Lawrence, MD, Sanaya Irani, BS, Betty Nartey, MPH, Brittney Collins, BS, Elorm Segbedzi-Rich, MD, Andrea Pangori, MS, Titus K. Beyuo, MD, Cheryl A. Moyer, PhD, Jody R. Lori, PhD, Samuel A. Oppong, MD

“…On an adjusted linear regression, only scores on the numeracy scale had a significant yet small association with correctly identifying blood pressure monitor outputs (β 0.07, P=.025). …”
Get full text

Whole Genome Sequencing Reveals the Distribution of Resistance and Virulence Genes of an Enterohemorrhagic Escherichia coli O157∶H7 Strain from Swine by Yan ZHOU, Qiyang WAN, Shujiao ZHU, Hui ZHANG, Hongduo BAO, Ran WANG

“…There are 5 674 predicted protein-coding genes, including 22 rRNA (7 23S rRNA, 7 16S rRNA, 8 5S rRNA), 1 tmRNA, 102 tRNA genes and 282 small RNA molecules; 9 are predicted CRISPR sequences, 273 repeat sequences; KEGG, KEGG Pathway, NR, UniProt, GO, COG, Pfam, RefSeq and TIGERfams databases annotated 1 712, 1 693, 5 265, 5 264, 4 029, 4 294, 4 688, 5 252 and 2 741 genes respectively. …”
Get full text

LncRNA MIR503HG regulates NETs‐mediated NLRP3 inflammasome activation and NSCLC metastasis by enhancing the ubiquitination of C/EBPβ by Xin Ye, Chen Fang, Weiwei Hong, Xiaoying Qian, Biao Yu, Bingbiao Zhou, Xinyuan Yao, Dengying Chen, Chengsi Shu, Chuanhong Luo, Yong Wang, Yong Li

“…Abstract Background Neutrophil extracellular traps (NETs) are pivotal in the metastasis of non‐small cell lung cancer (NSCLC). Our previous research demonstrated that NETs facilitate NSCLC metastasis by triggering the stimulation of the NOD‐like receptor protein 3 (NLRP3) inflammasome, which is mediated through the suppression of the long non‐coding RNA MIR503HG. …”
Get full text

Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study by Lieke M. Kuiper, Michelle M. J. Mens, Julia W. Wu, Jaap Goudsmit, Yuan Ma, Liming Liang, Albert Hofman, Trudy Voortman, M. Arfan Ikram, Jeroen G. J. van Rooij, Joyce B. J. van Meurs, Mohsen Ghanbari

“…Abstract Background MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally and show differential expression in various tissues with aging phenotypes. …”
Get full text

Genome-Wide Association Study and Rare Variant Association Studies of Strabismus in the All of Us Research Program by Kyoung A Viola Lee, MPH, Corey Tesdahl, Inas F. Aboobakar, MD, Ashish Jain, PhD, Mayra Martinez Sanchez, PhD, Kimberly Jin, BA, Isdin Oke, MD, Mary C. Whitman, MD, PhD

“…Individuals of other ancestral groups were not included due to small numbers of strabismus-affected participants. …”
Get full text

Profiling of the serum MiRNAome in pediatric egyptian patients with wilms tumor by Fatma S. Mohamed, Fatma S. Mohamed, Deena Jalal, Youssef M. Fadel, Samir F. El-Mashtoly, Wael Z. Khaled, Wael Z. Khaled, Ahmed A. Sayed, Ahmed A. Sayed, Mohamed A. Ghazy, Mohamed A. Ghazy

“…Wilms tumor (WT) is a pediatric kidney cancer associated with poor outcomes in patients with unfavorable histological features such as anaplasia. Small non-coding RNAs, such as miRNAs, are known to be involved in WT pathogenesis. …”
Get full text

Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation by Joana R. Costa, Yang Li, Nurkaiyisah Zaal Anuar, David O’Connor, Sunniyat Rahman, Tanya Rapoz-D’Silva, Kent T.M. Fung, Rachael Pocock, Zhaodong Li, Stephen Henderson, Lingyi Wang, Mateja E. Krulik, Sara Hyseni, Nivedita Singh, George Morrow, Yanping Guo, Daisy O.F. Gresham, Javier Herrero, Richard G. Jenner, A. Thomas Look, Dennis Kappei, Marc R. Mansour

“…Summary: The TAL1 oncogene driving T cell lymphoblastic leukemia is frequently activated through mutated cis-regulatory elements, whereby small insertions or deletions (indels) create a binding site for the transcription factor MYB. …”
Get full text

The Anomalous Acceleration of PSR J2043+1711: Long-period Orbital Companion or Stellar Flyby? by Thomas Donlon II, Sukanya Chakrabarti, Michael T. Lam, Daniel Huber, Daniel Hey, Enrico Ramirez-Ruiz, Benjamin Shappee, David L. Kaplan, Gabriella Agazie, Akash Anumarlapudi, Anne M. Archibald, Zaven Arzoumanian, Paul T. Baker, Paul R. Brook, H. Thankful Cromartie, Kathryn Crowter, Megan E. DeCesar, Paul B. Demorest, Timothy Dolch, Elizabeth C. Ferrara, William Fiore, Emmanuel Fonseca, Gabriel E. Freedman, Nate Garver-Daniels, Peter A. Gentile, Joseph Glaser, Deborah C. Good, Jeffrey S. Hazboun, Mark Huber, Ross J. Jennings, Megan L. Jones, Matthew Kerr, Duncan R. Lorimer, Jing Luo, Ryan S. Lynch, Alexander McEwen, Maura A. McLaughlin, Natasha McMann, Bradley W. Meyers, Cherry Ng, David J. Nice, Timothy T. Pennucci, Benetge B. P. Perera, Nihan S. Pol, Henri A. Radovan, Scott M. Ransom, Paul S. Ray, Ann Schmiedekamp, Carl Schmiedekamp, Brent J. Shapiro-Albert, Ingrid H. Stairs, Kevin Stovall, Abhimanyu Susobhanan, Joseph K. Swiggum, Michael A. Tucker, Haley M. Wahl

Get full text

Characterization of CO1 and 18S rDNA genes from Indonesian native ornamental shrimp Caridina boehmei cultured in Jakarta by Ekky Ilham Romadhona, Novi Megawati, Handang Widantara, Sutanti Sutanti, Arif Rahman Ardiansyah, Kiki Mariya Dewi, Annisa Fitri Larassagita, Aditia Firman, Moh Risky, Rahmat Rahmat, Ayub Ayub

“…This study aimed to characterize cytochrome c oxidase subunit I (CO1) and small subunit ribosomal RNA (18S rDNA) genes. Shrimp samples were extracted, and DNA was amplified using CO1 and 18S rDNA primers. …”
Get full text