MSC-derived extracellular vesicles: Precision miRNA delivery for overcoming cancer therapy resistance by Ahsas Goyal, Muhammad Afzal, Kavita Goyal, Subbulakshmi Ganesan, Mukesh Kumari, S. Sunitha, Aniruddh Dash, Suman Saini, Mohit Rana, Gaurav Gupta, Haider Ali, Ling Shing Wong, Vinoth Kumarasamy, Vetriselvan Subramaniyan

“…Carrying a variety of molecules, including microRNAs, small interfering RNAs, long non-coding RNAs, proteins, lipids, and DNA, these vesicles are positioned as promising cancer treatment options. …”
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The complete chloroplast genome sequence of Begonia pedatifida by Huan Li, Tianlei Zhang, Jiale Liang, Xuan Tang, Zhuoyu Chenyang, Rong Zhu, Ying Chen, Qishan Kuang, Rongjie Huang, Hanbin Yin, Xingyu Zeng, Yongle Liu, Zhitian Du, Kerui Huang, Lei Sun

“…The chloroplast genome structure of B. pedatifida reveals a circular molecule with a length of 169,606 bp, including a large single copy (LSC) region of 76,086 bp, a small single copy (SSC) region of 18,314 bp, and a pair of inverted repeats (IRS) region of 37,603 bp. …”
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Neospora caninum infection specifically suppresses the expression of a host lncRNA XR_001919077.1 to facilitate parasite propagation by modulating host cell mitochondrial function... by Shan-Shan Zhao, De-Liang Tao, Jin-Ming Chen, Ming-Yi Zhang, Xin Yang, Jun-Ke Song, Qun Liu, Guang-Hui Zhao

“…Recent advances in N. caninum research have revealed aberrant expression of long non-coding RNA (lncRNA) profiles in infected caprine endometrial epithelial cells. …”
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EVALUATION OF EXPRESSION OF 4 MIRNAS IN CYTOLOGICAL SAMPLES AS AN ADDITIONAL METHOD OF CERVICAL CANCER DIAGNOSIS by P. A. Arkhangelskaya, R. B. Samsonov, T. A. Shtam, M. S. Knyazeva, M. K. Ivanov, S. E. Titov, N. N. Kolesnikov, E. V. Bakhidze, I. V. Berlev, A. А. Mikhetko, S. L. Vorobyev, A. V. Malek

“…The method is based on analysis of small non-coding RNA molecules (miRNAs) extracted from the material of traditional Pap smears. …”
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Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma by Peng Luo, Zhenfa Zhang, Lianmin Zhang, Pengpeng Zhang, Mengzhe Zhang, Jianlan Liu, Zhaokai Zhou

“…Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell lung cancer. Although immune checkpoint inhibitors (ICIs) have brought new treatment options for advanced patients, a considerable proportion still shows limited response. …”
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Cloning, phylogenetic analysis, tissue expression profiling, and functional roles of NPC1L1 in chickens, quails, and ducks by Xin Shu, Ziwei Chen, Hui Wang, Bingjie Xu, Li Liu, Jilong Zhang, Xiaotong Zheng, Jianfei Chen

“…The Niemann-Pick C1-Like 1 (NPC1L1) protein, primarily expressed in the epithelial cells of the small intestine, is essential for cholesterol absorption from both dietary intake and biliary secretion. …”
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MicroRNA-122 overexpression suppresses the colon cancer cell proliferation by downregulating the astrocyte elevated gene-1/metadherin oncoprotein by Sarubala Malayaperumal, Sushmitha Sriramulu, Ganesan Jothimani, Antara Banerjee, Hong Zhang, Shabana Thabassum Mohammed Rafi, Ilangovan Ramachandran, Rajesh Kanna NR, Xiao-Feng Sun, Surajit Pathak

“…Background MicroRNAs (miRNAs) are small non-coding RNAs that regulate essential cellular functions, such as cell adhesion, proliferation, migration, invasion, and programmed cell death, and therefore, alterations in miRNAs can contribute to carcinogenesis. …”
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Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta by Alessia Gallo, Josè Camilla Sammartino, Roberta Vazzana, Roberto Giambruno, Claudia Carcione, Nicola Cuscino, Salvatore Castelbuono, Vitale Miceli, Matteo Bulati, Daniele Lilleri, Irene Cassaniti, Pier Giulio Conaldi, Fausto Baldanti

“…Finally, we observed a significant deregulation of 3 main types of non-coding RNAs (ncRNAs): long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and small nucleolar RNAs (snoRNAs), some of which are common to coronaviruses, and some specific to SARS-CoV-2. …”
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piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization by Ruyue Wang, Fan Li, Yudong Lin, Zeyi Lu, Wenqin Luo, Zhehao Xu, Ziwei Zhu, Yi Lu, Xudong Mao, Yang Li, Zhinian Shen, Haohua Lu, Yining Chen, Liqun Xia, Mingchao Wang, Lifeng Ding, Gonghui Li

“…Abstract PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, are widely expressed in eukaryotes and deregulated in several pathologies, including cancer. …”
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Serotonin receptor 5-HT2A as a potential target for HCC immunotherapy by Han Chong Toh, Olaf Rotzschke, Yi Wen Tan, Nicholas Da Zhi Ang, Wendy Lee, Ser Mei Koh, Rong En Tay, Charmaine Min Ho, Hui Chien Tay, Daniel Z Lopez, Qiao Rui Na, Kim Peng Tan, Jackwee Lim, Maichan Lau, Laurent Rénia

“…Hence, identifying new key molecular pathways suppressing T-cell responses within the liver is critical for the rational design of more effective combination immunotherapies for HCC.Methods We identified the 5-HT2A serotonin receptor as a potential target for HCC immunotherapy in a chemical screening approach and validated that targeting 5-HT2A signaling could be a viable approach for HCC immunotherapy via in vitro and in vivo studies.Results Disruption of 5-HT2A signaling using either a selective antagonist small molecule, ketanserin, or by knockout of its coding gene Htr2a augments the cytotoxic effector phenotype of mouse CD8 T cells activated in vitro with immunosuppressive liver non-parenchymal cells. …”
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Developing a syndromic surveillance tool to support the epidemiological investigation into paediatric acute hepatitis of unknown aetiology in England by Alex J. Elliot, Helen E. Hughes, Christopher Bennett, Thomas C. Hughes, Kirsty Challen, Conall H. Watson, Sema Mandal, Gillian E. Smith, Daniel Todkill

“…Results From 2 April 2018 to 31 December 2021, there were small sporadic numbers of daily ED attendances for ‘liver conditions’ in children with no observed secular trends or seasonality across the 1 to 4 and 5 to 14 years age groups. …”
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Emergency Medicine Around the World: Analysis of the 2019 American College of Emergency Physicians International Ambassador Country Reports by Andrés M. Patiño, Jeffrey Chen, Elizabeth L. DeVos, J. Austin Lee, Kate Anderson, Michaela Banks, Kimberly Herard, Ramu Kharel, Sean Kivlehan, Christian Arbelaez

“…We performed inductive coding of qualitative data for themes. Results Sixty‐three out of 78 countries’ teams (80%) responded to the survey. …”
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Advancing Real-World Evidence Through a Federated Health Data Network (EHDEN): Descriptive Study by Clair Blacketer, Martijn J Schuemie, Maxim Moinat, Erica A Voss, Montse Camprubi, Peter R Rijnbeek, Patrick B Ryan

“…However, the heterogeneity of European health care systems, data capture methods, coding standards, and governance structures poses challenges for generating robust and reproducible real-world evidence. …”
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Overexpression of miR-21-5p as a potential pathogenesis marker for ovarian endometriosis by Mohamed Mahmoud, Amr Ahmed WalyEldeen, Mohamed A. Samie, Ahmed M. Sadek, Sayed Elakhras, Mohamed Samir, Osama Ahmed, Rasha Mohamed Samir Sayed, Ahmed Abdelaziz Baiomy, Sherif Abdelaziz Ibrahim, Hebatallah Hassan

“…MicroRNAs (miRNAs) are small, non-coding RNAs that epigenetically control the physiological and pathological processes of different diseases, including endometriosis. …”
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Exploring the effect of LncRNA DANCR to regulate the Keap1‐Nrf2/ARE pathway on oxidative stress in rheumatoid arthritis by Shaohong Cai, Yue Sun, Yuan Wang, Zhangying Lin

“…This study focused on investigating the effects of LncRNA differentiation antagonizing nonprotein coding RNA (DANCR) regulation of Keap1‐Nrf2/ARE pathway on inflammation and oxidative stress in RA. …”
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Microsurgical and endovascular treatment of large and giant aneurysms of the anterior circulation: A systematic review by Alejandra Mosteiro, Leire Pedrosa, Marta Codes, Luís Reyes, Mariano Werner, Sergio Amaro, Joaquim Enseñat, Ana Rodríguez-Hernández, Marlien Aalbers, Jeroen Boogaarts, Ramon Torné

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A model to analyze foodsheds and self-sufficiency (case study: Tehran province) by Maryam Akbarpoor, Hadi Veisi, Abdolmajid Mahdavi Damghani, Mohammadreza Nazari

“…Calculation of threshold production was done with Matlab using conditional programming and coding. Excel, Matlab, and GIS were used in this research. …”
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Epidemiology, disease burden and costs of Duchenne muscular dystrophy in Germany: an observational, retrospective health claims data analysis by Joanna Diesing, Janbernd Kirschner, Astrid Pechmann, Jörg König, Leonie Kunk, Tarcyane Barata Garcia, Carolina Schwedhelm, Carsta Militzer-Horstmann, Ivonne Hänsel, Agnes Kisser

“…Cost and resource utilization estimations are based on small sample sizes or self-reported data, limiting generalizability and adds the potential for recall bias. …”
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Hsa-miRNA-16-5p Of Urinary Exosomes A Reliable Biosignature Effective For Prostate Cancer Screening by Weng WH, Chiou YE, Zeng WZ, Chen MH, Pang ST

“…Wen-Hui Weng,1 Yueh-Er Chiou,2 Wen-Zhen Zeng,1 Ming-Hui Chen,1 See-Tong Pang3 1Department of Chemical Engineering and Biotechnology and Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei City, Taiwan; 2Department of Nursing, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; 3Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKou Branch, Taoyuan, TaiwanCorrespondence: See-Tong Pang, Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, LinKou Branch, No. 5, Fuxing Street, Guishan District, Taoyuan, 33305, Taiwan, Tel +886-3-3281200, Email jacobpang@cgmh.org.twIntroduction: MicroRNAs (miRNAs) are small, non-coding RNA molecules critical for cellular function, growth, and development. …”
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Phylogeny and taxonomy of a new clade of Australian Heliozelidae in the genus Prophylactis Meyrick, 1897 (Lepidoptera, Adeloidea) pollinating Boronia (Rutaceae: Sapindales) by Douglas J. Hilton, D. Andy Young, Liz Milla, Mengjie Jin, Stephen Wilcox, Qike Wang, Verena C. Wimmer, Jinny Chang, Henning Kallies, Andie Hall, Marina Watowich, Carly A. Busch, Jordan Wilcox, Aileen Swarbrick, Marlene Walter, Don Sands, Davina Paterson, David C. Lees, Marco F. Duretto, Adnan Moussalli, Mike Halsey, Axel Kallies

“…Heliozelidae are a group of small monotrysian moths with a near world-wide distribution. …”
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